| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot knockout validation; human; 1:1000; loading ...; fig 5h, 5i
| Bajpai R, Sharma A, Achreja A, Edgar C, Wei C, Siddiqa A, et al. Electron transport chain activity is a predictor and target for venetoclax sensitivity in multiple myeloma. Nat Commun. 2020;11:1228 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 1a
| Arai S, Varkaris A, Nouri M, Chen S, Xie L, Balk S. MARCH5 mediates NOXA-dependent MCL1 degradation driven by kinase inhibitors and integrated stress response activation. elife. 2020;9: pubmed publisher |
- western blot; human; fig 2n
| Simula L, Corrado M, Accordi B, Di Rita A, Nazio F, Antonucci Y, et al. JNK1 and ERK1/2 modulate lymphocyte homeostasis via BIM and DRP1 upon AICD induction. Cell Death Differ. 2020;: pubmed publisher |
| Wei J, Long L, Zheng W, Dhungana Y, Lim S, Guy C, et al. Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy. Nature. 2019;576:471-476 pubmed publisher |
- western blot; human; 1:500; fig 4a
| Hagenbuchner J, Obsilova V, Kaserer T, Kaiser N, Rass B, Psenakova K, et al. Modulating FOXO3 transcriptional activity by small, DBD-binding molecules. elife. 2019;8: pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 6c
| Sun B, Zhao X, Ming J, Liu X, Liu D, Jiang C. Stepwise detection and evaluation reveal miR-10b and miR-222 as a remarkable prognostic pair for glioblastoma. Oncogene. 2019;38:6142-6157 pubmed publisher |
- western blot; human; loading ...; fig 4f
| Pan C, Jin L, Wang X, Li Y, Chun J, Boese A, et al. Inositol-triphosphate 3-kinase B confers cisplatin resistance by regulating NOX4-dependent redox balance. J Clin Invest. 2019;129:2431-2445 pubmed publisher |
- western blot; mouse; loading ...; fig s3i
| He M, Chaurushiya M, Webster J, Kummerfeld S, Reja R, Chaudhuri S, et al. Intrinsic apoptosis shapes the tumor spectrum linked to inactivation of the deubiquitinase BAP1. Science. 2019;364:283-285 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; loading ...; fig 6b
- immunohistochemistry - paraffin section; human; loading ...; fig 3e
| Haikala H, Anttila J, Marques E, Raatikainen T, Ilander M, Hakanen H, et al. Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy. Nat Commun. 2019;10:620 pubmed publisher |
- immunohistochemistry; mouse; 1:400; loading ...; fig 1a
- western blot; mouse; 1:1000; loading ...; fig 1e
| Hu K, Huang Q, Liu C, Li Y, Liu Y, Wang H, et al. c-Jun/Bim Upregulation in Dopaminergic Neurons Promotes Neurodegeneration in the MPTP Mouse Model of Parkinson's Disease. Neuroscience. 2019;399:117-124 pubmed publisher |
- flow cytometry; mouse; loading ...; fig 3b
| Mittelstadt P, Taves M, Ashwell J. Cutting Edge: De Novo Glucocorticoid Synthesis by Thymic Epithelial Cells Regulates Antigen-Specific Thymocyte Selection. J Immunol. 2018;200:1988-1994 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig s4a
| Mai W, Gosa L, Daniëls V, Ta L, Tsang J, Higgins B, et al. Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma. Nat Med. 2017;23:1342-1351 pubmed publisher |
- western blot; human; loading ...; fig 4c
| Vu L, Pickering B, Cheng Y, Zaccara S, Nguyen D, Minuesa G, et al. The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells. Nat Med. 2017;23:1369-1376 pubmed publisher |
- western blot; human; loading ...; fig 4c
| Jelinek M, Kabelova A, Srámek J, Seitz J, Ojima I, Kovar J. Differing Mechanisms of Death Induction by Fluorinated Taxane SB-T-12854 in Breast Cancer Cells. Anticancer Res. 2017;37:1581-1590 pubmed |
- western blot; mouse; 1:1000; loading ...; fig 2c
| Ahmed S, Macara I. The Par3 polarity protein is an exocyst receptor essential for mammary cell survival. Nat Commun. 2017;8:14867 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 8b
| Yokoyama T, Kohn E, Brill E, Lee J. Apoptosis is augmented in high-grade serous ovarian cancer by the combined inhibition of Bcl-2/Bcl-xL and PARP. Int J Oncol. 2017;: pubmed publisher |
- western blot; human; loading ...; fig s4k
| Wang X, Cao W, Zhang J, Yan M, Xu Q, Wu X, et al. A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination. EMBO J. 2017;36:1243-1260 pubmed publisher |
- flow cytometry; mouse; fig 6j
| Knudson K, Pritzl C, Saxena V, Altman A, Daniels M, Teixeiro E. NFκB-Pim-1-Eomesodermin axis is critical for maintaining CD8 T-cell memory quality. Proc Natl Acad Sci U S A. 2017;114:E1659-E1667 pubmed publisher |
- flow cytometry; mouse; loading ...; fig 3a
| Hsu L, Cheng D, Chen Y, Liang H, Weiss A. Destabilizing the autoinhibitory conformation of Zap70 induces up-regulation of inhibitory receptors and T cell unresponsiveness. J Exp Med. 2017;214:833-849 pubmed publisher |
- western blot; human; loading ...; fig 2b
| Suzuki J, Nakajima W, Suzuki H, Asano Y, Tanaka N. Chaperone-mediated autophagy promotes lung cancer cell survival through selective stabilization of the pro-survival protein, MCL1. Biochem Biophys Res Commun. 2017;482:1334-1340 pubmed publisher |
- western blot; human; loading ...; fig s8d
| Kotschy A, Szlávik Z, Murray J, Davidson J, Maragno A, Le Toumelin Braizat G, et al. The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models. Nature. 2016;538:477-482 pubmed publisher |
- western blot; human; loading ...; fig 4b
| Wang C, Zhang F, Cao Y, Zhang M, Wang A, Xu M, et al. Etoposide Induces Apoptosis in Activated Human Hepatic Stellate Cells via ER Stress. Sci Rep. 2016;6:34330 pubmed publisher |
- western blot; human; loading ...; fig 4
| Bahr J, Robey R, Luchenko V, Basseville A, Chakraborty A, Kozlowski H, et al. Blocking downstream signaling pathways in the context of HDAC inhibition promotes apoptosis preferentially in cells harboring mutant Ras. Oncotarget. 2016;7:69804-69815 pubmed publisher |
- flow cytometry; mouse; loading ...; fig s2b
| Ladle B, Li K, Phillips M, Pucsek A, Haile A, Powell J, et al. De novo DNA methylation by DNA methyltransferase 3a controls early effector CD8+ T-cell fate decisions following activation. Proc Natl Acad Sci U S A. 2016;113:10631-6 pubmed publisher |
- western blot; human; loading ...; fig 5b,5c,6b,6c,6d
| Pomares H, Palmeri C, Iglesias Serret D, Moncunill Massaguer C, Saura Esteller J, Núñez Vázquez S, et al. Targeting prohibitins induces apoptosis in acute myeloid leukemia cells. Oncotarget. 2016;7:64987-65000 pubmed publisher |
- western blot; human; loading ...; fig 1c
| Weyhenmeyer B, Noonan J, Würstle M, Lincoln F, Johnston G, Rehm M, et al. Predicting the cell death responsiveness and sensitization of glioma cells to TRAIL and temozolomide. Oncotarget. 2016;7:61295-61311 pubmed publisher |
- flow cytometry; mouse; 1:200
- western blot; mouse; 1:1000; fig 3
| Lai M, Gonzalez Martin A, Cooper A, Oda H, Jin H, Shepherd J, et al. Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs. Nat Commun. 2016;7:12207 pubmed publisher |
- western blot; human; 1:1000; fig 5
| Bao H, Liu P, Jiang K, Zhang X, Xie L, Wang Z, et al. Huaier polysaccharide induces apoptosis in hepatocellular carcinoma cells through p38 MAPK. Oncol Lett. 2016;12:1058-1066 pubmed |
- flow cytometry; human; loading ...; fig 6
| Saha A, O Connor R, Thangavelu G, Lovitch S, Dandamudi D, Wilson C, et al. Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality. J Clin Invest. 2016;126:2642-60 pubmed publisher |
- western blot; human; fig 3
| Tagscherer K, Fassl A, Sinkovic T, Richter J, Schecher S, Macher Goeppinger S, et al. MicroRNA-210 induces apoptosis in colorectal cancer via induction of reactive oxygen. Cancer Cell Int. 2016;16:42 pubmed publisher |
- western blot; human; loading ...; fig 1c
| Matsumoto M, Nakajima W, Seike M, Gemma A, Tanaka N. Cisplatin-induced apoptosis in non-small-cell lung cancer cells is dependent on Bax- and Bak-induction pathway and synergistically activated by BH3-mimetic ABT-263 in p53 wild-type and mutant cells. Biochem Biophys Res Commun. 2016;473:490-6 pubmed publisher |
- western blot; mouse; 1:1000; fig 1e
| Waldeck K, Cullinane C, Ardley K, Shortt J, Martin B, Tothill R, et al. Long term, continuous exposure to panobinostat induces terminal differentiation and long term survival in the TH-MYCN neuroblastoma mouse model. Int J Cancer. 2016;139:194-204 pubmed publisher |
- western blot; human; 1:1000; fig 1
| Yu L, Wu W, Gu C, Zhong D, Zhao X, Kong Y, et al. Obatoclax impairs lysosomal function to block autophagy in cisplatin-sensitive and -resistant esophageal cancer cells. Oncotarget. 2016;7:14693-707 pubmed publisher |
| Luo C, Liao W, Dadi S, Toure A, Li M. Graded Foxo1 activity in Treg cells differentiates tumour immunity from spontaneous autoimmunity. Nature. 2016;529:532-6 pubmed publisher |
- western blot; human; fig 6
| Lub S, Maes A, Maes K, De Veirman K, De Bruyne E, Menu E, et al. Inhibiting the anaphase promoting complex/cyclosome induces a metaphase arrest and cell death in multiple myeloma cells. Oncotarget. 2016;7:4062-76 pubmed publisher |
- western blot; human; fig 6
| Jin H, Gonzalez Martin A, Miletic A, Lai M, Knight S, Sabouri Ghomi M, et al. Transfection of microRNA Mimics Should Be Used with Caution. Front Genet. 2015;6:340 pubmed publisher |
- western blot; human; fig 4
| Dupont T, Yang S, Patel J, Hatzi K, Malik A, Tam W, et al. Selective targeting of BCL6 induces oncogene addiction switching to BCL2 in B-cell lymphoma. Oncotarget. 2016;7:3520-32 pubmed publisher |
- western blot; human; loading ...; fig 1
| Nakajima W, Sharma K, Hicks M, Le N, Brown R, Krystal G, et al. Combination with vorinostat overcomes ABT-263 (navitoclax) resistance of small cell lung cancer. Cancer Biol Ther. 2016;17:27-35 pubmed publisher |
- western blot; mouse; loading ...; fig s8
- western blot; human; loading ...; fig 7b
| Moncunill Massaguer C, Saura Esteller J, Pérez Perarnau A, Palmeri C, Núñez Vázquez S, Cosialls A, et al. A novel prohibitin-binding compound induces the mitochondrial apoptotic pathway through NOXA and BIM upregulation. Oncotarget. 2015;6:41750-65 pubmed publisher |
- western blot; human; 1:1000; fig 2
| Lauková J, KozubÃk A, Hofmanová J, Nekvindová J, Sova P, Moyer M, et al. Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells. PLoS ONE. 2015;10:e0141020 pubmed publisher |
- immunohistochemistry - paraffin section; human
| Zhang L, Zhang S, Yao J, Lowery F, Zhang Q, Huang W, et al. Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth. Nature. 2015;527:100-104 pubmed publisher |
- western blot; human; loading ...; fig 6b
| Lavik A, Zhong F, Chang M, Greenberg E, Choudhary Y, Smith M, et al. A synthetic peptide targeting the BH4 domain of Bcl-2 induces apoptosis in multiple myeloma and follicular lymphoma cells alone or in combination with agents targeting the BH3-binding pocket of Bcl-2. Oncotarget. 2015;6:27388-402 pubmed publisher |
- western blot; human; fig 3
| Heinemann A, Cullinane C, De Paoli Iseppi R, Wilmott J, Gunatilake D, Madore J, et al. Combining BET and HDAC inhibitors synergistically induces apoptosis of melanoma and suppresses AKT and YAP signaling. Oncotarget. 2015;6:21507-21 pubmed |
- western blot; human; 1:5000; fig 4
| Dille S, Kleinschnitz E, Kontchou C, Nölke T, Häcker G. In contrast to Chlamydia trachomatis, Waddlia chondrophila grows in human cells without inhibiting apoptosis, fragmenting the Golgi apparatus, or diverting post-Golgi sphingomyelin transport. Infect Immun. 2015;83:3268-80 pubmed publisher |
- immunohistochemistry - paraffin section; dogs
- western blot; dogs
| Andersen N, Boguslawski E, Kuk C, Chambers C, Duesbery N. Combined inhibition of MEK and mTOR has a synergic effect on angiosarcoma tumorgrafts. Int J Oncol. 2015;47:71-80 pubmed publisher |
- western blot; human; 1:1000; fig 8
| Park J, Zhao L, Willingham M, Cheng S. Oncogenic mutations of thyroid hormone receptor β. Oncotarget. 2015;6:8115-31 pubmed |
- western blot; human; fig 2
| Vogel C, Smit M, Maddalo G, Possik P, Sparidans R, van der Burg S, et al. Cooperative induction of apoptosis in NRAS mutant melanoma by inhibition of MEK and ROCK. Pigment Cell Melanoma Res. 2015;28:307-17 pubmed publisher |
| Rayavarapu R, Heiden B, Pagani N, Shaw M, Shuff S, Zhang S, et al. The role of multicellular aggregation in the survival of ErbB2-positive breast cancer cells during extracellular matrix detachment. J Biol Chem. 2015;290:8722-33 pubmed publisher |
- western blot; human; fig 5
| Huang P, Hung S, Pao C, Wang T. N-(1-pyrenyl) maleimide induces bak oligomerization and mitochondrial dysfunction in Jurkat Cells. Biomed Res Int. 2015;2015:798489 pubmed publisher |
- western blot; human; 1:1000; fig 3
| Van Brocklyn J, Wojton J, Meisen W, Kellough D, Ecsedy J, Kaur B, et al. Aurora-A inhibition offers a novel therapy effective against intracranial glioblastoma. Cancer Res. 2014;74:5364-70 pubmed publisher |
- western blot; mouse; 1:1000; fig 6
| Eroglu B, Kimbler D, Pang J, Choi J, Moskophidis D, Yanasak N, et al. Therapeutic inducers of the HSP70/HSP110 protect mice against traumatic brain injury. J Neurochem. 2014;130:626-41 pubmed publisher |
| Nakajima W, Hicks M, Tanaka N, Krystal G, Harada H. Noxa determines localization and stability of MCL-1 and consequently ABT-737 sensitivity in small cell lung cancer. Cell Death Dis. 2014;5:e1052 pubmed publisher |
| Pavet V, Shlyakhtina Y, He T, Ceschin D, Kohonen P, Perala M, et al. Plasminogen activator urokinase expression reveals TRAIL responsiveness and supports fractional survival of cancer cells. Cell Death Dis. 2014;5:e1043 pubmed publisher |
| Crowther A, Gama V, Bevilacqua A, Chang S, Yuan H, Deshmukh M, et al. Tonic activation of Bax primes neural progenitors for rapid apoptosis through a mechanism preserved in medulloblastoma. J Neurosci. 2013;33:18098-108 pubmed publisher |
- western blot; human; 1:1000
| Geissler A, Haun F, Frank D, Wieland K, Simon M, Idzko M, et al. Apoptosis induced by the fungal pathogen gliotoxin requires a triple phosphorylation of Bim by JNK. Cell Death Differ. 2013;20:1317-29 pubmed publisher |
| Ma T, Galimberti F, Erkmen C, Memoli V, Chinyengetere F, SEMPERE L, et al. Comparing histone deacetylase inhibitor responses in genetically engineered mouse lung cancer models and a window of opportunity trial in patients with lung cancer. Mol Cancer Ther. 2013;12:1545-55 pubmed publisher |
| Wang L, Shen E, Luo L, Rabe H, Wang Q, Yin J, et al. Control of Germinal Center Localization and Lineage Stability of Follicular Regulatory T Cells by the Blimp1 Transcription Factor. Cell Rep. 2019;29:1848-1861.e6 pubmed publisher |
| Qian F, Hu Q, Tian Y, Wu J, Li D, Tao M, et al. ING4 suppresses hepatocellular carcinoma via a NF-κB/miR-155/FOXO3a signaling axis. Int J Biol Sci. 2019;15:369-385 pubmed publisher |
| Hu J, Deng F, Hu X, Zhang W, Zeng X, Tian X. Histone deacetylase SIRT6 regulates chemosensitivity in liver cancer cells via modulation of FOXO3 activity. Oncol Rep. 2018;40:3635-3644 pubmed publisher |
| Shi H, Liu C, Tan H, Li Y, Nguyen T, Dhungana Y, et al. Hippo Kinases Mst1 and Mst2 Sense and Amplify IL-2R-STAT5 Signaling in Regulatory T Cells to Establish Stable Regulatory Activity. Immunity. 2018;49:899-914.e6 pubmed publisher |
| Ottens K, Hinman R, Barrios E, Skaug B, Davis L, Li Q, et al. Foxo3 Promotes Apoptosis of B Cell Receptor-Stimulated Immature B Cells, Thus Limiting the Window for Receptor Editing. J Immunol. 2018;201:940-949 pubmed publisher |
| Ward A, Mir H, Kapur N, Gales D, Carriere P, Singh S. Quercetin inhibits prostate cancer by attenuating cell survival and inhibiting anti-apoptotic pathways. World J Surg Oncol. 2018;16:108 pubmed publisher |
| Liu R, King A, Bouillet P, Tarlinton D, Strasser A, Heierhorst J. Proapoptotic BIM Impacts B Lymphoid Homeostasis by Limiting the Survival of Mature B Cells in a Cell-Autonomous Manner. Front Immunol. 2018;9:592 pubmed publisher |
| Lochmann T, Floros K, Naseri M, Powell K, Cook W, March R, et al. Venetoclax Is Effective in Small-Cell Lung Cancers with High BCL-2 Expression. Clin Cancer Res. 2018;24:360-369 pubmed publisher |
| Song K, Niederst M, Lochmann T, Hata A, Kitai H, Ham J, et al. Epithelial-to-Mesenchymal Transition Antagonizes Response to Targeted Therapies in Lung Cancer by Suppressing BIM. Clin Cancer Res. 2018;24:197-208 pubmed publisher |
| Lu Y, Zhao X, Liu Q, Li C, Graves Deal R, Cao Z, et al. lncRNA MIR100HG-derived miR-100 and miR-125b mediate cetuximab resistance via Wnt/β-catenin signaling. Nat Med. 2017;23:1331-1341 pubmed publisher |
| Singh P, Roukounakis A, Frank D, Kirschnek S, Das K, Neumann S, et al. Dynein light chain 1 induces assembly of large Bim complexes on mitochondria that stabilize Mcl-1 and regulate apoptosis. Genes Dev. 2017;31:1754-1769 pubmed publisher |
| Sulkshane P, Teni T. BH3 mimetic Obatoclax (GX15-070) mediates mitochondrial stress predominantly via MCL-1 inhibition and induces autophagy-dependent necroptosis in human oral cancer cells. Oncotarget. 2017;8:60060-60079 pubmed publisher |
| Chen Z, Stelekati E, Kurachi M, Yu S, Cai Z, Manne S, et al. miR-150 Regulates Memory CD8 T Cell Differentiation via c-Myb. Cell Rep. 2017;20:2584-2597 pubmed publisher |
| Yang K, Blanco D, Neale G, Vogel P, Avila J, Clish C, et al. Homeostatic control of metabolic and functional fitness of Treg cells by LKB1 signalling. Nature. 2017;548:602-606 pubmed publisher |
| Conforti F, Zhang X, Rao G, De Pas T, Yonemori Y, Rodriguez J, et al. Therapeutic Effects of XPO1 Inhibition in Thymic Epithelial Tumors. Cancer Res. 2017;77:5614-5627 pubmed publisher |
| Pomeroy E, Lee L, Lee R, Schirm D, Temiz N, Ma J, et al. Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia. Oncogene. 2017;36:3263-3273 pubmed publisher |
| Prenek L, Boldizsár F, Kugyelka R, Ugor E, Berta G, Németh P, et al. The regulation of the mitochondrial apoptotic pathway by glucocorticoid receptor in collaboration with Bcl-2 family proteins in developing T cells. Apoptosis. 2017;22:239-253 pubmed publisher |
| Kotzin J, Spencer S, McCright S, Kumar D, Collet M, Mowel W, et al. The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan. Nature. 2016;537:239-243 pubmed publisher |
| Yang W, Cho H, Shin H, Chung J, Kang E, Lee E, et al. Accumulation of cytoplasmic Cdk1 is associated with cancer growth and survival rate in epithelial ovarian cancer. Oncotarget. 2016;7:49481-49497 pubmed publisher |
| Tao N, Zhou H, Tang H, Cai X, Zhang W, Ren J, et al. Sirtuin 3 enhanced drug sensitivity of human hepatoma cells through glutathione S-transferase pi 1/JNK signaling pathway. Oncotarget. 2016;7:50117-50130 pubmed publisher |
| Verboon L, Obulkasim A, de Rooij J, Katsman Kuipers J, Sonneveld E, Baruchel A, et al. MicroRNA-106b~25 cluster is upregulated in relapsed MLL-rearranged pediatric acute myeloid leukemia. Oncotarget. 2016;7:48412-48422 pubmed publisher |
| Li L, Chen X, Liu C, Lee L, Man C, Cheng S. Phytoestrogen Bakuchiol Exhibits In Vitro and In Vivo Anti-breast Cancer Effects by Inducing S Phase Arrest and Apoptosis. Front Pharmacol. 2016;7:128 pubmed publisher |
| Chen C, Dienhart J, Bolton E. Androgen-Sensitized Apoptosis of HPr-1AR Human Prostate Epithelial Cells. PLoS ONE. 2016;11:e0156145 pubmed publisher |
| Muter J, Brighton P, Lucas E, Lacey L, Shmygol A, Quenby S, et al. Progesterone-Dependent Induction of Phospholipase C-Related Catalytically Inactive Protein 1 (PRIP-1) in Decidualizing Human Endometrial Stromal Cells. Endocrinology. 2016;157:2883-93 pubmed publisher |
| Gonzalez Martin A, Adams B, Lai M, Shepherd J, Salvador Bernáldez M, Salvador J, et al. The microRNA miR-148a functions as a critical regulator of B cell tolerance and autoimmunity. Nat Immunol. 2016;17:433-40 pubmed publisher |
| Hu Y, Guo R, Wei J, Zhou Y, Ji W, Liu J, et al. Effects of PI3K inhibitor NVP-BKM120 on overcoming drug resistance and eliminating cancer stem cells in human breast cancer cells. Cell Death Dis. 2015;6:e2020 pubmed publisher |
| Zhang H, Zhan C, Ke J, Xue Z, Zhang A, Xu K, et al. EGFR kinase domain mutation positive lung cancers are sensitive to intrapleural perfusion with hyperthermic chemotherapy (IPHC) complete treatment. Oncotarget. 2016;7:3367-78 pubmed publisher |
| Klanova M, Andera L, Brazina J, Svadlenka J, Benesova S, Soukup J, et al. Targeting of BCL2 Family Proteins with ABT-199 and Homoharringtonine Reveals BCL2- and MCL1-Dependent Subgroups of Diffuse Large B-Cell Lymphoma. Clin Cancer Res. 2016;22:1138-49 pubmed publisher |
| Lee J, Park H, Park S, Ryu S, Meng W, Jurgensmeier J, et al. A Novel Small-Molecule Inhibitor Targeting CREB-CBP Complex Possesses Anti-Cancer Effects along with Cell Cycle Regulation, Autophagy Suppression and Endoplasmic Reticulum Stress. PLoS ONE. 2015;10:e0122628 pubmed publisher |
| Ono Y, Tanabe A, Nakamura Y, Yamamoto H, Hayashi A, Tanaka T, et al. A low-testosterone state associated with endometrioma leads to the apoptosis of granulosa cells. PLoS ONE. 2014;9:e115618 pubmed publisher |
| Keitel U, Scheel A, Thomale J, Halpape R, Kaulfuß S, Scheel C, et al. Bcl-xL mediates therapeutic resistance of a mesenchymal breast cancer cell subpopulation. Oncotarget. 2014;5:11778-91 pubmed |
| Denoyelle C, Lambert B, Meryet Figuière M, Vigneron N, Brotin E, Lecerf C, et al. miR-491-5p-induced apoptosis in ovarian carcinoma depends on the direct inhibition of both BCL-XL and EGFR leading to BIM activation. Cell Death Dis. 2014;5:e1445 pubmed publisher |
| Kovarova M, Koller B. PGE? promotes apoptosis induced by cytokine deprivation through EP3 receptor and induces Bim in mouse mast cells. PLoS ONE. 2014;9:e102948 pubmed publisher |
| Sharma N, Everingham S, Zeng L, Zhang Z, Kapur R, Craig A. Oncogenic KIT-induced aggressive systemic mastocytosis requires SHP2/PTPN11 phosphatase for disease progression in mice. Oncotarget. 2014;5:6130-41 pubmed |
| Frederick D, Salas Fragomeni R, Schalck A, Ferreiro Neira I, Hoff T, Cooper Z, et al. Clinical profiling of BCL-2 family members in the setting of BRAF inhibition offers a rationale for targeting de novo resistance using BH3 mimetics. PLoS ONE. 2014;9:e101286 pubmed publisher |
| Granato A, Hayashi E, Baptista B, Bellio M, Nobrega A. IL-4 regulates Bim expression and promotes B cell maturation in synergy with BAFF conferring resistance to cell death at negative selection checkpoints. J Immunol. 2014;192:5761-75 pubmed publisher |
| Floyd D, Zhang Y, Dey B, Kefas B, Breit H, Marks K, et al. Novel anti-apoptotic microRNAs 582-5p and 363 promote human glioblastoma stem cell survival via direct inhibition of caspase 3, caspase 9, and Bim. PLoS ONE. 2014;9:e96239 pubmed publisher |
| Reynolds C, Roderick J, LaBelle J, Bird G, Mathieu R, Bodaar K, et al. Repression of BIM mediates survival signaling by MYC and AKT in high-risk T-cell acute lymphoblastic leukemia. Leukemia. 2014;28:1819-27 pubmed publisher |
| Kshirsagar S, Binder E, Riedl M, Wechselberger G, Steichen E, Edelbauer M. Enhanced activity of Akt in Teff cells from children with lupus nephritis is associated with reduced induction of tumor necrosis factor receptor-associated factor 6 and increased OX40 expression. Arthritis Rheum. 2013;65:2996-3006 pubmed publisher |
| Potluri V, Noothi S, Vallabhapurapu S, Yoon S, Driscoll J, Lawrie C, et al. Transcriptional repression of Bim by a novel YY1-RelA complex is essential for the survival and growth of Multiple Myeloma. PLoS ONE. 2013;8:e66121 pubmed publisher |
| Yau I, Cato M, Jellusova J, Hurtado de Mendoza T, Brink R, Rickert R. Censoring of self-reactive B cells by follicular dendritic cell-displayed self-antigen. J Immunol. 2013;191:1082-90 pubmed publisher |
| Endo A, Koizumi H, Takahashi M, Tamura T, Tatsunami S, Watanabe Y, et al. A significant imbalance in mitosis versus apoptosis accelerates the growth rate of sessile serrated adenoma/polyps. Virchows Arch. 2013;462:131-9 pubmed publisher |
| Tzelepis F, Joseph J, Haddad E, MacLean S, Dudani R, Agenes F, et al. Intrinsic role of FoxO3a in the development of CD8+ T cell memory. J Immunol. 2013;190:1066-75 pubmed publisher |
| Santag S, Jager W, Karsten C, Kati S, Pietrek M, Steinemann D, et al. Recruitment of the tumour suppressor protein p73 by Kaposi's Sarcoma Herpesvirus latent nuclear antigen contributes to the survival of primary effusion lymphoma cells. Oncogene. 2013;32:3676-85 pubmed publisher |
| Sharma N, Kumar V, Everingham S, Mali R, Kapur R, Zeng L, et al. SH2 domain-containing phosphatase 2 is a critical regulator of connective tissue mast cell survival and homeostasis in mice. Mol Cell Biol. 2012;32:2653-63 pubmed publisher |
| Zhang L, Zhang H, Li L, Xiao Y, Rao E, Miao Z, et al. TSC1/2 signaling complex is essential for peripheral naïve CD8+ T cell survival and homeostasis in mice. PLoS ONE. 2012;7:e30592 pubmed publisher |
| Humphreys K, Cobiac L, Le Leu R, Van der Hoek M, Michael M. Histone deacetylase inhibition in colorectal cancer cells reveals competing roles for members of the oncogenic miR-17-92 cluster. Mol Carcinog. 2013;52:459-74 pubmed publisher |
| Clayton K, Podlesniy P, Figueiro Silva J, López Doménech G, Benitez L, Enguita M, et al. NP1 regulates neuronal activity-dependent accumulation of BAX in mitochondria and mitochondrial dynamics. J Neurosci. 2012;32:1453-66 pubmed publisher |
| Wang X, Wu Y, Tan L, Tian Z, Liu J, Zhu D, et al. Follicle-stimulating hormone regulates pro-apoptotic protein Bcl-2-interacting mediator of cell death-extra long (BimEL)-induced porcine granulosa cell apoptosis. J Biol Chem. 2012;287:10166-77 pubmed publisher |
| Faber A, Corcoran R, Ebi H, Sequist L, Waltman B, Chung E, et al. BIM expression in treatment-naive cancers predicts responsiveness to kinase inhibitors. Cancer Discov. 2011;1:352-65 pubmed publisher |
| Pritchard J, Gilbert L, Meacham C, Ricks J, Jiang H, Lauffenburger D, et al. Bcl-2 family genetic profiling reveals microenvironment-specific determinants of chemotherapeutic response. Cancer Res. 2011;71:5850-8 pubmed publisher |
| Ackermann J, Ashton G, Lyons S, James D, Hornung J, Jones N, et al. Loss of ATF2 function leads to cranial motoneuron degeneration during embryonic mouse development. PLoS ONE. 2011;6:e19090 pubmed publisher |
| Rubert J, Qian Z, Andraos R, Guthy D, Radimerski T. Bim and Mcl-1 exert key roles in regulating JAK2V617F cell survival. BMC Cancer. 2011;11:24 pubmed publisher |
| May K, Paton J, Paton A. Escherichia coli subtilase cytotoxin induces apoptosis regulated by host Bcl-2 family proteins Bax/Bak. Infect Immun. 2010;78:4691-6 pubmed publisher |
