| Published Application/Species/Dilution | Reference |
|---|
- western blot; human; fig 1
| Strickland S, Vande Pol S. The Human Papillomavirus 16 E7 Oncoprotein Attenuates AKT Signaling To Promote Internal Ribosome Entry Site-Dependent Translation and Expression of c-MYC. J Virol. 2016;90:5611-21 pubmed publisher |
- western blot; human; fig 3
| Baietti M, Simíček M, Abbasi Asbagh L, Radaelli E, Lievens S, Crowther J, et al. OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination. EMBO Mol Med. 2016;8:288-303 pubmed publisher |
- western blot; mouse; fig s4
| Fagnocchi L, Cherubini A, Hatsuda H, Fasciani A, Mazzoleni S, Poli V, et al. A Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity. Nat Commun. 2016;7:11903 pubmed publisher |
- western blot; human; 1:2000; fig s1
| Diz-Muñoz A, Thurley K, Chintamen S, Altschuler S, Wu L, Fletcher D, et al. Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil Migration. PLoS Biol. 2016;14:e1002474 pubmed publisher |
- western blot; human; 1:1000; fig 5
| Speer S, Li Z, Buta S, Payelle-Brogard B, Qian L, Vigant F, et al. ISG15 deficiency and increased viral resistance in humans but not mice. Nat Commun. 2016;7:11496 pubmed publisher |
- western blot; human; 1:2000; tbl 1
| Jansson D, Scotter E, Rustenhoven J, Coppieters N, Smyth L, Oldfield R, et al. Interferon-γ blocks signalling through PDGFRβ in human brain pericytes. J Neuroinflammation. 2016;13:249 pubmed |
- western blot; mouse; 1:1000; fig 5
| Huang G, Yang X, Chen K, Xing J, Guo L, Zhu L, et al. Porf-2 Inhibits Neural Stem Cell Proliferation Through Wnt/β-Catenin Pathway by Its GAP Domain. Front Cell Neurosci. 2016;10:85 pubmed publisher |
- western blot; rat; 1:1000; fig 6
| Puchert M, Adams V, Linke A, Engele J. Evidence for the involvement of the CXCL12 system in the adaptation of skeletal muscles to physical exercise. Cell Signal. 2016;28:1205-1215 pubmed publisher |
- western blot; human; fig 4
| Tzani I, Ivanov I, Andreev D, Dmitriev R, Dean K, Baranov P, et al. Systematic analysis of the PTEN 5' leader identifies a major AUU initiated proteoform. Open Biol. 2016;6: pubmed publisher |
- western blot; human; fig 5
| Heynen G, Nevedomskaya E, Palit S, Jagalur Basheer N, Lieftink C, Schlicker A, et al. Mastermind-like 3 controls proliferation and differentiation in neuroblastoma. Mol Cancer Res. 2016;: pubmed |
- western blot; human; 1:1000; fig 5
| Amato K, Wang S, Tan L, Hastings A, Song W, Lovly C, et al. EPHA2 Blockade Overcomes Acquired Resistance to EGFR Kinase Inhibitors in Lung Cancer. Cancer Res. 2016;76:305-18 pubmed publisher |
- western blot; human; 1:1000; fig 7
| Joo M, Park J, Yoo H, Lee B, Chun H, Lee S, et al. The roles of HOXB7 in promoting migration, invasion and anti-apoptosis in gastric cancer. J Gastroenterol Hepatol. 2016;: pubmed publisher |
- western blot; mouse; fig 5
| Nikonova A, Deneka A, Eckman L, Kopp M, Hensley H, Egleston B, et al. Opposing Effects of Inhibitors of Aurora-A and EGFR in Autosomal-Dominant Polycystic Kidney Disease. Front Oncol. 2015;5:228 pubmed publisher |
- western blot; human; fig 3
| Shen Y, Zeng L, Novosyadlyy R, Forest A, Zhu A, Korytko A, et al. A bi-functional antibody-receptor domain fusion protein simultaneously targeting IGF-IR and VEGF for degradation. MAbs. 2015;7:931-45 pubmed publisher |
| Hatfield I, Harvey I, Yates E, Redd J, Reiter L, Bridges D. The role of TORC1 in muscle development in Drosophila. Sci Rep. 2015;5:9676 pubmed publisher |
- western blot; rat; 1:1000; fig 5
| Yan G, Wang Q, Hu S, Wang D, Qiao Y, Ma G, et al. Digoxin inhibits PDGF-BB-induced VSMC proliferation and migration through an increase in ILK signaling and attenuates neointima formation following carotid injury. Int J Mol Med. 2015;36:1001-11 pubmed publisher |
- western blot; human; fig 5
| Wilson F, Johannessen C, Piccioni F, Tamayo P, Kim J, Van Allen E, et al. A functional landscape of resistance to ALK inhibition in lung cancer. Cancer Cell. 2015;27:397-408 pubmed publisher |
- western blot; mouse
- western blot; rat
| Jaishy B, Zhang Q, Chung H, Riehle C, Soto J, Jenkins S, et al. Lipid-induced NOX2 activation inhibits autophagic flux by impairing lysosomal enzyme activity. J Lipid Res. 2015;56:546-61 pubmed publisher |
- western blot; mouse; 1:1000; fig 1
| Morley T, Xia J, Scherer P. Selective enhancement of insulin sensitivity in the mature adipocyte is sufficient for systemic metabolic improvements. Nat Commun. 2015;6:7906 pubmed publisher |
- western blot; human; fig 9
- western blot; mouse; fig 2
| Wang S, Amato K, Song W, Youngblood V, Lee K, Boothby M, et al. Regulation of endothelial cell proliferation and vascular assembly through distinct mTORC2 signaling pathways. Mol Cell Biol. 2015;35:1299-313 pubmed publisher |
- western blot; human; fig 4a
| Vennin C, Spruyt N, Dahmani F, Julien S, Bertucci F, Finetti P, et al. H19 non coding RNA-derived miR-675 enhances tumorigenesis and metastasis of breast cancer cells by downregulating c-Cbl and Cbl-b. Oncotarget. 2015;6:29209-23 pubmed publisher |
- immunohistochemistry - free floating section; mouse; 1:2000
- western blot; mouse; 1:2000
| Philippou A, Minozzo F, Spinazzola J, Smith L, Lei H, Rassier D, et al. Masticatory muscles of mouse do not undergo atrophy in space. FASEB J. 2015;29:2769-79 pubmed publisher |
- western blot; human; 1:1000; fig 7
| Pickard A, McDade S, McFarland M, McCluggage W, Wheeler C, McCance D. HPV16 Down-Regulates the Insulin-Like Growth Factor Binding Protein 2 to Promote Epithelial Invasion in Organotypic Cultures. PLoS Pathog. 2015;11:e1004988 pubmed publisher |
- immunocytochemistry; human; 1:100; fig 4
| Koos B, Cane G, Grannas K, Löf L, Arngården L, Heldin J, et al. Proximity-dependent initiation of hybridization chain reaction. Nat Commun. 2015;6:7294 pubmed publisher |
- immunohistochemistry; human; 1:2000
| Jespersen J, Mikkelsen U, Nedergaard A, Thorlund J, Schjerling P, Suetta C, et al. Alterations in molecular muscle mass regulators after 8 days immobilizing Special Forces mission. Scand J Med Sci Sports. 2015;25:175-83 pubmed publisher |
- western blot; human; fig s4
| Kocher B, White L, Piwnica-Worms D. DAPK3 suppresses acini morphogenesis and is required for mouse development. Mol Cancer Res. 2015;13:358-67 pubmed publisher |
| Asano S, Arvapalli R, Manne N, Maheshwari M, Ma B, Rice K, et al. Cerium oxide nanoparticle treatment ameliorates peritonitis-induced diaphragm dysfunction. Int J Nanomedicine. 2015;10:6215-25 pubmed publisher |
- western blot; human; fig 1
| Li L, Qi L, Liang Z, Song W, Liu Y, Wang Y, et al. Transforming growth factor-β1 induces EMT by the transactivation of epidermal growth factor signaling through HA/CD44 in lung and breast cancer cells. Int J Mol Med. 2015;36:113-22 pubmed publisher |
- western blot; human; fig 6
| Artero-Castro A, Pérez-Alea M, Feliciano A, Leal J, Genestar M, Castellvi J, et al. Disruption of the ribosomal P complex leads to stress-induced autophagy. Autophagy. 2015;11:1499-519 pubmed publisher |
| Taniguchi R, Fukushima H, Osawa K, Maruyama T, Yasuda H, Weih F, et al. RelB-induced expression of Cot, an MAP3K family member, rescues RANKL-induced osteoclastogenesis in alymphoplasia mice by promoting NF-κB2 processing by IKKα. J Biol Chem. 2014;289:7349-61 pubmed publisher |
| Solan J, Lampe P. Specific Cx43 phosphorylation events regulate gap junction turnover in vivo. FEBS Lett. 2014;588:1423-9 pubmed publisher |
- western blot; mouse; 1:2000; fig 2
| Moorwood C, Philippou A, Spinazzola J, Keyser B, Macarak E, Barton E. Absence of γ-sarcoglycan alters the response of p70S6 kinase to mechanical perturbation in murine skeletal muscle. Skelet Muscle. 2014;4:13 pubmed publisher |
| Fuller S, Richard A, Ribnicky D, Beyl R, Mynatt R, Stephens J. St. John's Wort Has Metabolically Favorable Effects on Adipocytes In Vivo. Evid Based Complement Alternat Med. 2014;2014:862575 pubmed publisher |
| Tersey S, Maier B, Nishiki Y, Maganti A, Nadler J, Mirmira R. 12-lipoxygenase promotes obesity-induced oxidative stress in pancreatic islets. Mol Cell Biol. 2014;34:3735-45 pubmed publisher |
- western blot; mouse; 1:1000
| Smithline Z, Nikonova A, Hensley H, Cai K, Egleston B, Proia D, et al. Inhibiting heat shock protein 90 (HSP90) limits the formation of liver cysts induced by conditional deletion of Pkd1 in mice. PLoS ONE. 2014;9:e114403 pubmed publisher |
- western blot; African green monkey
| Dunn C, Lampe P. Injury-triggered Akt phosphorylation of Cx43: a ZO-1-driven molecular switch that regulates gap junction size. J Cell Sci. 2014;127:455-64 pubmed publisher |
| Elliott V, Rychahou P, Zaytseva Y, Evers B. Activation of c-Met and upregulation of CD44 expression are associated with the metastatic phenotype in the colorectal cancer liver metastasis model. PLoS ONE. 2014;9:e97432 pubmed publisher |
| Du Y, Teng X, Wang N, Zhang X, Chen J, Ding P, et al. NF-κB and enhancer-binding CREB protein scaffolded by CREB-binding protein (CBP)/p300 proteins regulate CD59 protein expression to protect cells from complement attack. J Biol Chem. 2014;289:2711-24 pubmed publisher |
- western blot; rat; 1:1,000
| Hernandez A, Colvin E, Chen Y, Geiss S, Eller L, Fueger P. Upregulation of p21 activates the intrinsic apoptotic pathway in β-cells. Am J Physiol Endocrinol Metab. 2013;304:E1281-90 pubmed publisher |
| van der Hoeven D, Cho K, Ma X, Chigurupati S, Parton R, Hancock J. Fendiline inhibits K-Ras plasma membrane localization and blocks K-Ras signal transmission. Mol Cell Biol. 2013;33:237-51 pubmed publisher |
| Wang Y, Briz V, Chishti A, Bi X, Baudry M. Distinct roles for μ-calpain and m-calpain in synaptic NMDAR-mediated neuroprotection and extrasynaptic NMDAR-mediated neurodegeneration. J Neurosci. 2013;33:18880-92 pubmed publisher |
| Haeussler D, Pimentel D, Hou X, Burgoyne J, Cohen R, Bachschmid M. Endomembrane H-Ras controls vascular endothelial growth factor-induced nitric-oxide synthase-mediated endothelial cell migration. J Biol Chem. 2013;288:15380-9 pubmed publisher |
- western blot; human; 1:2,000
| Suetta C, Frandsen U, Jensen L, Jensen M, Jespersen J, Hvid L, et al. Aging affects the transcriptional regulation of human skeletal muscle disuse atrophy. PLoS ONE. 2012;7:e51238 pubmed publisher |
| Li J, Swope D, Raess N, Cheng L, Muller E, Radice G. Cardiac tissue-restricted deletion of plakoglobin results in progressive cardiomyopathy and activation of {beta}-catenin signaling. Mol Cell Biol. 2011;31:1134-44 pubmed publisher |
| Micel L, Tentler J, Tan A, Selby H, Brunkow K, Robertson K, et al. Antitumor activity of the MEK inhibitor TAK-733 against melanoma cell lines and patient-derived tumor explants. Mol Cancer Ther. 2015;14:317-25 pubmed publisher |
| Cebulla J, Huuse E, Pettersen K, van der Veen A, Kim E, Andersen S, et al. MRI reveals the in vivo cellular and vascular response to BEZ235 in ovarian cancer xenografts with different PI3-kinase pathway activity. Br J Cancer. 2015;112:504-13 pubmed publisher |
| Yuzefovych Y, Blasczyk R, Huyton T. Oncogenic acidic nuclear phosphoproteins ANP32C/D are novel clients of heat shock protein 90. Biochim Biophys Acta. 2015;1853:2338-48 pubmed publisher |
| Suo D, Park J, Harrington A, Zweifel L, Mihalas S, Deppmann C. Coronin-1 is a neurotrophin endosomal effector that is required for developmental competition for survival. Nat Neurosci. 2014;17:36-45 pubmed publisher |
| Li J, Huang J, Jeong J, Park S, Wei R, Peng J, et al. Selective TBK1/IKKi dual inhibitors with anticancer potency. Int J Cancer. 2014;134:1972-80 pubmed publisher |
| Shivaswamy V, Bennett R, Clure C, Ottemann B, Davis J, Larsen J, et al. Tacrolimus and sirolimus have distinct effects on insulin signaling in male and female rats. Transl Res. 2014;163:221-31 pubmed publisher |
| Schrader A, Popal W, Lilienthal N, Crispatzu G, Mayer P, Jones D, et al. AKT-pathway inhibition in chronic lymphocytic leukemia reveals response relationships defined by TCL1. Curr Cancer Drug Targets. 2014;14:700-12 pubmed |
| Veeriah S, Leboucher P, de Naurois J, Jethwa N, Nye E, Bunting T, et al. High-throughput time-resolved FRET reveals Akt/PKB activation as a poor prognostic marker in breast cancer. Cancer Res. 2014;74:4983-95 pubmed publisher |
| Iwashita J, Ito Y, Yokoo M, Takahashi S, Murata J. Akt induces down regulation of MUC5AC production in NCI-H292 human airway epithelial cells cultured on extracellular matrix. Biosci Biotechnol Biochem. 2014;78:212-21 pubmed publisher |
| Hu W, Jin L, Jiang C, Long G, Scolyer R, Wu Q, et al. AEBP1 upregulation confers acquired resistance to BRAF (V600E) inhibition in melanoma. Cell Death Dis. 2013;4:e914 pubmed publisher |
| de la Cueva A, Ramirez de Molina A, Alvarez-Ayerza N, Ramos M, Cebrian A, del Pulgar T, et al. Combined 5-FU and ChoKα inhibitors as a new alternative therapy of colorectal cancer: evidence in human tumor-derived cell lines and mouse xenografts. PLoS ONE. 2013;8:e64961 pubmed publisher |
| Liu C, Leclair P, Yap S, Lim C. The membrane-proximal KXGFFKR motif of α-integrin mediates chemoresistance. Mol Cell Biol. 2013;33:4334-45 pubmed publisher |
| Keysar S, Astling D, Anderson R, Vogler B, Bowles D, Morton J, et al. A patient tumor transplant model of squamous cell cancer identifies PI3K inhibitors as candidate therapeutics in defined molecular bins. Mol Oncol. 2013;7:776-90 pubmed publisher |
| RODRIGUEZ M, Potter D. CYP1A1 regulates breast cancer proliferation and survival. Mol Cancer Res. 2013;11:780-92 pubmed publisher |
| Aftimos P, Wiedig M, Langouo Fontsa M, Awada A, Ghanem G, Journe F. Sequential use of protein kinase inhibitors potentiates their toxicity to melanoma cells: a rationale to combine targeted drugs based on protein expression inhibition profiles. Int J Oncol. 2013;43:919-26 pubmed publisher |
| Strittmatter F, Walther S, Roosen A, Rutz B, Schlenker B, Limmer S, et al. Activation of protein kinase B/Akt by alpha1-adrenoceptors in the human prostate. Life Sci. 2012;90:446-53 pubmed publisher |
| Wu M, Katta A, Gadde M, Liu H, Kakarla S, Fannin J, et al. Aging-associated dysfunction of Akt/protein kinase B: S-nitrosylation and acetaminophen intervention. PLoS ONE. 2009;4:e6430 pubmed publisher |
