product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Di-Methyl-Histone H3 (Lys36) (C75H12) Rabbit mAb
catalog :
2901
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
antigen modification :
methylated
clone name :
C75H12
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, chromatin immunoprecipitation, immunohistochemistry - paraffin section
more info or order :
Cell Signaling Technology product webpage
citations: 13
Published Application/Species/Sample/DilutionReference
  • chromatin immunoprecipitation; mouse; loading ...; fig 2f
Fang Y, Tang Y, Zhang Y, Pan Y, Jia J, Sun Z, et al. The H3K36me2 methyltransferase NSD1 modulates H3K27ac at active enhancers to safeguard gene expression. Nucleic Acids Res. 2021;49:6281-6295 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:2000; loading ...; fig e2j
Yuan G, Flores N, Hausmann S, Lofgren S, Kharchenko V, Angulo Ibáñez M, et al. Elevated NSD3 histone methylation activity drives squamous cell lung cancer. Nature. 2021;590:504-508 pubmed publisher
  • western blot; mouse; loading ...; fig 2e
Weinberg D, Papillon Cavanagh S, Chen H, Yue Y, Chen X, Rajagopalan K, et al. The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape. Nature. 2019;573:281-286 pubmed publisher
  • immunohistochemistry; human; 1:500; fig 3
  • western blot; human; loading ...; fig 4a
Papillon Cavanagh S, Lu C, Gayden T, Mikael L, Bechet D, Karamboulas C, et al. Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas. Nat Genet. 2017;49:180-185 pubmed publisher
  • western blot; human; fig 2
García Carpizo V, Sarmentero J, Han B, Grana O, Ruiz Llorente S, Pisano D, et al. NSD2 contributes to oncogenic RAS-driven transcription in lung cancer cells through long-range epigenetic activation. Sci Rep. 2016;6:32952 pubmed publisher
  • chromatin immunoprecipitation; human; loading ...; fig 2a
  • immunocytochemistry; human; 1:2000; loading ...; fig s3c
  • western blot; human; loading ...; fig 1a
Fang D, Gan H, Lee J, Han J, Wang Z, Riester S, et al. The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas. Science. 2016;352:1344-8 pubmed publisher
  • western blot; human; fig 1
Hernando H, Gelato K, Lesche R, Beckmann G, Koehr S, Otto S, et al. EZH2 Inhibition Blocks Multiple Myeloma Cell Growth through Upregulation of Epithelial Tumor Suppressor Genes. Mol Cancer Ther. 2016;15:287-98 pubmed publisher
  • western blot; human; fig 2
Carlson S, Moore K, Sankaran S, Reynoird N, Elias J, Gozani O. A Proteomic Strategy Identifies Lysine Methylation of Splicing Factor snRNP70 by the SETMAR Enzyme. J Biol Chem. 2015;290:12040-7 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:1000
Saloura V, Cho H, Kiyotani K, Alachkar H, Zuo Z, Nakakido M, et al. WHSC1 promotes oncogenesis through regulation of NIMA-related kinase-7 in squamous cell carcinoma of the head and neck. Mol Cancer Res. 2015;13:293-304 pubmed publisher
LeRoy G, Oksuz O, Descostes N, Aoi Y, Ganai R, Kara H, et al. LEDGF and HDGF2 relieve the nucleosome-induced barrier to transcription in differentiated cells. Sci Adv. 2019;5:eaay3068 pubmed publisher
Agathocleous M, Meacham C, Burgess R, Piskounova E, Zhao Z, Crane G, et al. Ascorbate regulates haematopoietic stem cell function and leukaemogenesis. Nature. 2017;549:476-481 pubmed publisher
Balasooriya G, Johnson J, Basson M, Rawlins E. An FGFR1-SPRY2 Signaling Axis Limits Basal Cell Proliferation in the Steady-State Airway Epithelium. Dev Cell. 2016;37:85-97 pubmed publisher
Wen L, Chen Y, Zeng L, Zhao F, Li R, Liu Y, et al. Triptolide induces cell-cycle arrest and apoptosis of human multiple myeloma cells in vitro via altering expression of histone demethylase LSD1 and JMJD2B. Acta Pharmacol Sin. 2012;33:109-19 pubmed publisher
product information
SKU :
2901S
Product-Name :
Di-Methyl-Histone H3 (Lys36) (C75H12) Rabbit mAb
Size :
100 ul
Price-(USD) :
274 USD
Species-x-Reactivity :
H, M, R, Mk
Applications :
Immunofluorescence (Immunocytochemistry)
Product-Category :
Chromatin Regulation / Nuclear Function
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
17
Host :
Rabbit
Target :
H3 (Lys37) dimethylate
Primary-Protein :
H3
Alt-Names :
H3 histone family, member A,H3/A,H31,H3FA,H3FB,H3FC,H3FD,H3FF,H3FH,H3FI,H3FJ,H3FK,H3FL,HIST1H3A,HIST1H3B,HIST1H3C,HIST1H3D,HIST1H3E,HIST1H3F,HIST1H3G,HIST1H3H,HIST1H3I,HIST1H3J,Histone H3.1,Histone H3/a,Histone H3/b,Histone H3/c,Histone H3/d,Histone H3/f,Histone H3/h,Histone H3/i,Histone H3/j,Histone H3/k,Histone H3/l,histone 1, H3a,histone cluster 1, H3a
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.