product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Argonaute 2 (C34C6) Rabbit mAb
catalog :
2897
clonality :
monoclonal
host :
rabbit
conjugate :
nonconjugated
clone name :
C34C6
reactivity :
human, mouse, rat
application :
western blot, immunoprecipitation, RNA immunoprecipitation
citations: 27
Published Application/Species/Sample/DilutionReference
  • western blot; rat; 1:1000; loading ...; fig 4b
Rajgor D, Sanderson T, Amici M, Collingridge G, Hanley J. NMDAR-dependent Argonaute 2 phosphorylation regulates miRNA activity and dendritic spine plasticity. EMBO J. 2018;37: pubmed publisher
  • western blot; mouse; loading ...; fig 1e
Bottini S, Hamouda Tekaya N, Mategot R, Zaragosi L, Audebert S, Pisano S, et al. Post-transcriptional gene silencing mediated by microRNAs is controlled by nucleoplasmic Sfpq. Nat Commun. 2017;8:1189 pubmed publisher
  • western blot; rat; 1:500; loading ...; fig 5
Sadakierska Chudy A, Frankowska M, Miszkiel J, Wydra K, Jastrzębska J, Filip M. Prolonged Induction of miR-212/132 and REST Expression in Rat Striatum Following Cocaine Self-Administration. Mol Neurobiol. 2017;54:2241-2254 pubmed publisher
  • RNA immunoprecipitation; human; loading ...; fig 4c
Miyazaki Y, Du X, Muramatsu S, Gomez C. An miRNA-mediated therapy for SCA6 blocks IRES-driven translation of the CACNA1A second cistron. Sci Transl Med. 2016;8:347ra94 pubmed publisher
  • western blot; human; fig s3b
Warner M, Bridge K, Hewitson J, Hodgkinson M, Heyam A, Massa B, et al. S6K2-mediated regulation of TRBP as a determinant of miRNA expression in human primary lymphatic endothelial cells. Nucleic Acids Res. 2016;44:9942-9955 pubmed
  • western blot; human; loading ...; fig 7c
Chen C, Zhu C, Huang J, Zhao X, Deng R, Zhang H, et al. SUMOylation of TARBP2 regulates miRNA/siRNA efficiency. Nat Commun. 2015;6:8899 pubmed publisher
  • western blot; mouse; fig 3a
Galicia Vázquez G, Chu J, Pelletier J. eIF4AII is dispensable for miRNA-mediated gene silencing. RNA. 2015;21:1826-33 pubmed publisher
  • western blot; mouse; fig 6a
Tattikota S, Rathjen T, Hausser J, Khedkar A, Kabra U, Pandey V, et al. miR-184 Regulates Pancreatic β-Cell Function According to Glucose Metabolism. J Biol Chem. 2015;290:20284-94 pubmed publisher
  • western blot; human; 1:1000; fig 3
Gennarino V, Singh R, White J, De Maio A, Han K, Kim J, et al. Pumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by increasing wild-type Ataxin1 levels. Cell. 2015;160:1087-98 pubmed publisher
  • western blot; human
Koo C, Kobiyama K, Shen Y, LeBert N, Ahmad S, Khatoo M, et al. RNA polymerase III regulates cytosolic RNA:DNA hybrids and intracellular microRNA expression. J Biol Chem. 2015;290:7463-73 pubmed publisher
  • western blot; human
Cho S, Park J, Kang Y. AGO2 and SETDB1 cooperate in promoter-targeted transcriptional silencing of the androgen receptor gene. Nucleic Acids Res. 2014;42:13545-56 pubmed publisher
  • western blot; human
Iosue I, Quaranta R, Masciarelli S, Fontemaggi G, Batassa E, Bertolami C, et al. Argonaute 2 sustains the gene expression program driving human monocytic differentiation of acute myeloid leukemia cells. Cell Death Dis. 2013;4:e926 pubmed publisher
  • western blot; rat; 1:1000
García Pérez D, López Bellido R, Hidalgo J, Rodriguez R, Laorden M, Nunez C, et al. Morphine regulates Argonaute 2 and TH expression and activity but not miR-133b in midbrain dopaminergic neurons. Addict Biol. 2015;20:104-19 pubmed publisher
Zhang T, Wu Y, Mullane P, Ji Y, Liu H, He L, et al. FUS Regulates Activity of MicroRNA-Mediated Gene Silencing. Mol Cell. 2018;69:787-801.e8 pubmed publisher
Habibian M, Yahyaee Anzahaee M, Lucic M, Moroz E, Martín Pintado N, Di Giovanni L, et al. Structural properties and gene-silencing activity of chemically modified DNA-RNA hybrids with parallel orientation. Nucleic Acids Res. 2018;46:1614-1623 pubmed publisher
Rajgor D, Fiuza M, Parkinson G, Hanley J. The PICK1 Ca2+ sensor modulates N-methyl-d-aspartate (NMDA) receptor-dependent microRNA-mediated translational repression in neurons. J Biol Chem. 2017;292:9774-9786 pubmed publisher
Carmona V, Cunha Santos J, Onofre I, Simões A, Vijayakumar U, Davidson B, et al. Unravelling Endogenous MicroRNA System Dysfunction as a New Pathophysiological Mechanism in Machado-Joseph Disease. Mol Ther. 2017;25:1038-1055 pubmed publisher
Ahuja D, Goyal A, Ray P. Interplay between RNA-binding protein HuR and microRNA-125b regulates p53 mRNA translation in response to genotoxic stress. RNA Biol. 2016;13:1152-1165 pubmed
Wallace J, Hu R, Mosbruger T, Dahlem T, Stephens W, Rao D, et al. Genome-Wide CRISPR-Cas9 Screen Identifies MicroRNAs That Regulate Myeloid Leukemia Cell Growth. PLoS ONE. 2016;11:e0153689 pubmed publisher
Josa Prado F, Henley J, Wilkinson K. SUMOylation of Argonaute-2 regulates RNA interference activity. Biochem Biophys Res Commun. 2015;464:1066-1071 pubmed publisher
Booy E, Howard R, Marushchak O, Ariyo E, Meier M, Novakowski S, et al. The RNA helicase RHAU (DHX36) suppresses expression of the transcription factor PITX1. Nucleic Acids Res. 2014;42:3346-61 pubmed publisher
Tattikota S, Rathjen T, McAnulty S, Wessels H, Akerman I, van de Bunt M, et al. Argonaute2 mediates compensatory expansion of the pancreatic β cell. Cell Metab. 2014;19:122-34 pubmed publisher
Ono M, Yamada K, Endo A, Avolio F, Lamond A. Analysis of human protein replacement stable cell lines established using snoMEN-PR vector. PLoS ONE. 2013;8:e62305 pubmed publisher
Johnsson P, Ackley A, Vidarsdottir L, Lui W, Corcoran M, Grander D, et al. A pseudogene long-noncoding-RNA network regulates PTEN transcription and translation in human cells. Nat Struct Mol Biol. 2013;20:440-6 pubmed publisher
Kim C, Vo M, Kim H, Lee H, Yoon N, Lee B, et al. Ectopic over-expression of tristetraprolin in human cancer cells promotes biogenesis of let-7 by down-regulation of Lin28. Nucleic Acids Res. 2012;40:3856-69 pubmed publisher
Léveillé N, Elkon R, Davalos V, Manoharan V, Hollingworth D, Oude Vrielink J, et al. Selective inhibition of microRNA accessibility by RBM38 is required for p53 activity. Nat Commun. 2011;2:513 pubmed publisher
Pei Y, Hancock P, Zhang H, Bartz R, Cherrin C, Innocent N, et al. Quantitative evaluation of siRNA delivery in vivo. RNA. 2010;16:2553-63 pubmed publisher
product information
SKU :
2897S
Product-Name :
Argonaute 2 (C34C6) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R, Mk
Applications :
Immunoprecipitation
Product-Category :
Translational Control
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
97
Host :
Rabbit
Target :
Ago2
Primary-Protein :
Ago2
Alt-Names :
AGO2,Argonaute2,EIF2C2,Eukaryotic translation initiation factor 2C 2,MGC3183,PAZ Piwi domain protein,PPD,Protein argonaute-2,Protein slicer,Q10,argonaute 2,eIF-2C 2,eIF2C 2,eukaryotic translation initiation factor 2C, 2,hAgo2
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.