CHOP (L63F7) Mouse mAb | Cell Signaling Technology 2895 product information

product summary

company name :

Cell Signaling Technology

product type :

antibody

product name :

CHOP (L63F7) Mouse mAb

catalog :

2895

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

L63F7

reactivity :

human, mouse, rat, bovine

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, In-Cell Western

more info or order :

Cell Signaling Technology product webpage

citations: 152

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; mouse; loading ...; fig 1d western blot; mouse; 1:1000; loading ...; fig 2g	Lee Y, Gil E, Jeong I, Kim H, Jang J, Choung Y. Heat Shock Factor 1 Prevents Age-Related Hearing Loss by Decreasing Endoplasmic Reticulum Stress. Cells. 2021;10: pubmed publisher
western blot; mouse; loading ...; fig 3a	Bhattarai K, Kim H, Chaudhary M, Ur Rashid M, Kim J, Kim H, et al. TMBIM6 regulates redox-associated posttranslational modifications of IRE1α and ER stress response failure in aging mice and humans. Redox Biol. 2021;47:102128 pubmed publisher
western blot; human; 1:1000; fig 5i	Lin J, Liu H, Fukumoto T, Zundell J, Yan Q, Tang C, et al. Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer. Nat Commun. 2021;12:5321 pubmed publisher
western blot; mouse; loading ...; fig 5c	Yan M, Wang Z, Xia T, Jin S, Liu Y, Hu H, et al. Enhancement of TEX264-Mediated ER-Phagy Contributes to the Therapeutic Effect of Glycycoumarin against APA Hepatotoxicity in Mice. Biomedicines. 2021;9: pubmed publisher
immunohistochemistry - frozen section; bovine; 1:250; loading ...; fig 3e western blot; bovine; 1:1000; loading ...; fig 3c	Chen F, Sheng L, Xu C, Li J, Ali I, Li H, et al. Ufbp1, a Key Player of Ufm1 Conjugation System, Protects Against Ketosis-Induced Liver Injury via Suppressing Smad3 Activation. Front Cell Dev Biol. 2021;9:676789 pubmed publisher
western blot; mouse; loading ...; fig 2f	Liu Q, Wu J, Zhang X, Li X, Wu X, Zhao Y, et al. Circulating mitochondrial DNA-triggered autophagy dysfunction via STING underlies sepsis-related acute lung injury. Cell Death Dis. 2021;12:673 pubmed publisher
western blot; human; loading ...; fig 4a	Hua Y, Zhang K, Sheng J, Ning Z, Li Y, Shi W, et al. NUCB1 Suppresses Growth and Shows Additive Effects With Gemcitabine in Pancreatic Ductal Adenocarcinoma via the Unfolded Protein Response. Front Cell Dev Biol. 2021;9:641836 pubmed publisher
immunohistochemistry; mouse; loading ...; fig 1d western blot; mouse; 1:1000; loading ...; fig 1c	Yin S, Li L, Tao Y, Yu J, Wei S, Liu M, et al. The Inhibitory Effect of Artesunate on Excessive Endoplasmic Reticulum Stress Alleviates Experimental Colitis in Mice. Front Pharmacol. 2021;12:629798 pubmed publisher
western blot; mouse; loading ...; fig 2a	Liu X, Jiang J, Liao Y, Tang I, Zheng E, Qiu W, et al. Combination Chemo-Immunotherapy for Pancreatic Cancer Using the Immunogenic Effects of an Irinotecan Silicasome Nanocarrier Plus Anti-PD-1. Adv Sci (Weinh). 2021;8:2002147 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 5b	Liang X, Yan Z, Ma W, Qian Y, Zou X, Cui Y, et al. Peroxiredoxin 4 protects against ovarian ageing by ameliorating D-galactose-induced oxidative damage in mice. Cell Death Dis. 2020;11:1053 pubmed publisher
western blot; rat; loading ...; fig 2d	Zhuan B, Wang X, Wang M, Li Z, Yuan Q, Xie J, et al. Hypoxia induces pulmonary artery smooth muscle dysfunction through mitochondrial fragmentation-mediated endoplasmic reticulum stress. Aging (Albany NY). 2020;12:23684-23697 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 3b	Drori A, Gammal A, Azar S, Hinden L, Hadar R, Wesley D, et al. CB1R regulates soluble leptin receptor levels via CHOP, contributing to hepatic leptin resistance. elife. 2020;9: pubmed publisher
western blot; human; 1:1000; loading ...; fig 5d	Ruan H, Li X, Xu X, Leibowitz B, Tong J, Chen L, et al. eIF4E S209 phosphorylation licenses myc- and stress-driven oncogenesis. elife. 2020;9: pubmed publisher
western blot; mouse; loading ...; fig 4a	Lee D, Kam M, Lee S, Lee H, Lee D. Peroxiredoxin 5 deficiency exacerbates iron overload-induced neuronal death via ER-mediated mitochondrial fission in mouse hippocampus. Cell Death Dis. 2020;11:204 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 2f western blot; human; 1:1000; loading ...; fig s6	von Roemeling C, Wang Y, Qie Y, Yuan H, Zhao H, Liu X, et al. Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity. Nat Commun. 2020;11:1508 pubmed publisher
western blot; human; loading ...; fig s1c	Park H, Shin D, Sim J, Aum S, Lee M. IRE1α kinase-mediated unconventional protein secretion rescues misfolded CFTR and pendrin. Sci Adv. 2020;6:eaax9914 pubmed publisher
western blot; rat; 1:1000; loading ...; fig 4a	Chai Y, Zhu K, Li C, Wang X, Shen J, Yong F, et al. Dexmedetomidine alleviates cisplatin‑induced acute kidney injury by attenuating endoplasmic reticulum stress‑induced apoptosis via the α2AR/PI3K/AKT pathway. Mol Med Rep. 2020;21:1597-1605 pubmed publisher
immunohistochemistry - paraffin section; mouse; loading ...; fig 2a western blot; mouse; loading ...; fig 1k	Lee H, Lee G, Kim H, Lee Y, Chae H. Phosphatidylinositol 3-kinase-δ controls endoplasmic reticulum membrane fluidity and permeability in fungus-induced allergic inflammation in mice. Br J Pharmacol. 2020;177:1556-1567 pubmed publisher
flow cytometry; human; loading ...; fig s2b	Merola J, Reschke M, Pierce R, Qin L, Spindler S, Baltazar T, et al. Progenitor-derived human endothelial cells evade alloimmunity by CRISPR/Cas9-mediated complete ablation of MHC expression. JCI Insight. 2019;4: pubmed publisher
western blot; human; 1:1000; loading ...; fig 4s1b	Shemorry A, Harnoss J, Guttman O, Marsters S, Komuves L, Lawrence D, et al. Caspase-mediated cleavage of IRE1 controls apoptotic cell commitment during endoplasmic reticulum stress. elife. 2019;8: pubmed publisher
immunohistochemistry - paraffin section; rat; 1:200; loading ...; fig 9c	Naughton M, McMahon J, Healy S, FitzGerald U. Profile of the unfolded protein response in rat cerebellar cortical development. J Comp Neurol. 2019;527:2910-2924 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 3c	Sun D, Zhang M, Li Y, Mei S, Qin J, Yan J. c‑Jun/Ap‑1 is upregulated in an Ang II‑induced abdominal aortic aneurysm formation model and mediates Chop expression in mouse aortic smooth muscle cells. Mol Med Rep. 2019;19:3459-3468 pubmed publisher
western blot; mouse; loading ...; fig 1h	Carugo A, Minelli R, Sapio L, Soeung M, Carbone F, Robinson F, et al. p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors. Cancer Cell. 2019;35:204-220.e9 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 2c	Wheeler M, Jaronen M, Covacu R, Zandee S, Scalisi G, Rothhammer V, et al. Environmental Control of Astrocyte Pathogenic Activities in CNS Inflammation. Cell. 2019;176:581-596.e18 pubmed publisher
western blot; mouse; loading ...; fig 6a	Yin J, Wang Y, Chang J, Li B, Zhang J, Liu Y, et al. Apelin inhibited epithelial-mesenchymal transition of podocytes in diabetic mice through downregulating immunoproteasome subunits β5i. Cell Death Dis. 2018;9:1031 pubmed publisher
western blot; mouse; fig 2s3b	Scott C, Vossio S, Rougemont J, Gruenberg J. TFAP2 transcription factors are regulators of lipid droplet biogenesis. elife. 2018;7: pubmed publisher
western blot; human; loading ...; fig 3b	Kline C, Ralff M, Lulla A, Wagner J, Abbosh P, Dicker D, et al. Role of Dopamine Receptors in the Anticancer Activity of ONC201. Neoplasia. 2018;20:80-91 pubmed publisher
western blot; mouse; fig 7a	Zhang Z, Chu S, Wang S, Jiang Y, Gao Y, Yang P, et al. RTP801 is a critical factor in the neurodegeneration process of A53T α-synuclein in a mouse model of Parkinson's disease under chronic restraint stress. Br J Pharmacol. 2018;175:590-605 pubmed publisher
western blot; mouse; 1:1000; fig 9e	Lüningschrör P, Binotti B, Dombert B, Heimann P, Pérez Lara A, Slotta C, et al. Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease. Nat Commun. 2017;8:678 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 5a	Lee C, Hanna A, Wang H, Dagnino Acosta A, Joshi A, Knoblauch M, et al. A chemical chaperone improves muscle function in mice with a RyR1 mutation. Nat Commun. 2017;8:14659 pubmed publisher
western blot; human; 1:1000; loading ...; fig 4c	Amici D, Pinal Fernández I, Mázala D, Lloyd T, Corse A, Christopher Stine L, et al. Calcium dysregulation, functional calpainopathy, and endoplasmic reticulum stress in sporadic inclusion body myositis. Acta Neuropathol Commun. 2017;5:24 pubmed publisher
western blot; rat; loading ...; fig 6	Chambers T, Santiesteban L, Gomez D, Chambers J. Sab mediates mitochondrial dysfunction involved in imatinib mesylate-induced cardiotoxicity. Toxicology. 2017;382:24-35 pubmed publisher
western blot; human; loading ...; fig 3d	Li J, Yakushi T, Parlati F, MacKinnon A, Pérez C, Ma Y, et al. Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11. Nat Chem Biol. 2017;13:486-493 pubmed publisher
western blot; human; loading ...; fig 5a	Dufour F, Rattier T, Constantinescu A, Zischler L, MorlÃ© A, Ben Mabrouk H, et al. TRAIL receptor gene editing unveils TRAIL-R1 as a master player of apoptosis induced by TRAIL and ER stress. Oncotarget. 2017;8:9974-9985 pubmed publisher
western blot; mouse; loading ...; fig 4d	Chung H, Ryu D, Kim K, Chang J, Kim Y, Yi H, et al. Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis. J Cell Biol. 2017;216:149-165 pubmed publisher
western blot; mouse; loading ...; fig 3a	Tripathi M, Zhang C, Singh B, Sinha R, Moe K, DeSilva D, et al. Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by Vitamin B supplementation. Cell Death Dis. 2016;7:e2513 pubmed publisher
western blot; mouse; 1:3000; fig 4	Cheng Y, Cawley N, Yanik T, Murthy S, Liu C, Kasikci F, et al. A human carboxypeptidase E/NF-?1 gene mutation in an Alzheimer's disease patient leads to dementia and depression in mice. Transl Psychiatry. 2016;6:e973 pubmed publisher
western blot; mouse; loading ...; fig 8c	Baird L, Tsujita T, Kobayashi E, Funayama R, Nagashima T, Nakayama K, et al. A Homeostatic Shift Facilitates Endoplasmic Reticulum Proteostasis through Transcriptional Integration of Proteostatic Stress Response Pathways. Mol Cell Biol. 2017;37: pubmed publisher
western blot; human; loading ...; fig 4a	Sareddy G, Viswanadhapalli S, Surapaneni P, Suzuki T, Brenner A, Vadlamudi R. Novel KDM1A inhibitors induce differentiation and apoptosis of glioma stem cells via unfolded protein response pathway. Oncogene. 2017;36:2423-2434 pubmed publisher
western blot; mouse; loading ...; fig 4d	Newberry E, Xie Y, Kennedy S, Graham M, Crooke R, Jiang H, et al. Prevention of hepatic fibrosis with liver microsomal triglyceride transfer protein deletion in liver fatty acid binding protein null mice. Hepatology. 2017;65:836-852 pubmed publisher
western blot; rat; loading ...; fig 4a western blot; mouse; loading ...; fig 3b western blot; human; loading ...; fig 8a	Beauvais G, Bode N, Watson J, Wen H, Glenn K, Kawano H, et al. Disruption of Protein Processing in the Endoplasmic Reticulum of DYT1 Knock-in Mice Implicates Novel Pathways in Dystonia Pathogenesis. J Neurosci. 2016;36:10245-10256 pubmed
western blot; mouse; loading ...; fig 3a	Yang Z, Tsuchiya H, Zhang Y, Lee S, Liu C, Huang Y, et al. REV-ERB? Activates C/EBP Homologous Protein to Control Small Heterodimer Partner-Mediated Oscillation of Alcoholic Fatty Liver. Am J Pathol. 2016;186:2909-2920 pubmed publisher
western blot; rat; 1:500; fig 2a	Wu J, Hu G, Lu Y, Zheng J, Chen J, Wang X, et al. Palmitic acid aggravates inflammation of pancreatic acinar cells by enhancing unfolded protein response induced CCAAT-enhancer-binding protein ?-CCAAT-enhancer-binding protein ? activation. Int J Biochem Cell Biol. 2016;79:181-193 pubmed publisher
western blot; mouse; 1:1000; fig 5	Liu J, Ma Y, Sun C, Li S, Wang J. High Mobility Group Box1 Protein Is Involved in Endoplasmic Reticulum Stress Induced by Clostridium difficile Toxin A. Biomed Res Int. 2016;2016:4130834 pubmed publisher
immunohistochemistry - paraffin section; human; 1:1000; loading ...; fig 7c	Zhang L, Ren F, Zhang X, Wang X, Shi H, Zhou L, et al. Peroxisome proliferator-activated receptor alpha acts as a mediator of endoplasmic reticulum stress-induced hepatocyte apoptosis in acute liver failure. Dis Model Mech. 2016;9:799-809 pubmed publisher
western blot; human; 1:1000	Anta B, PÃ©rez RodrÃguez A, Castro J, GarcÃa DomÃnguez C, Ibiza S, MartÃnez N, et al. PGA1-induced apoptosis involves specific activation of H-Ras and N-Ras in cellular endomembranes. Cell Death Dis. 2016;7:e2311 pubmed publisher
western blot; human; fig 4	Dejesus R, Moretti F, McAllister G, Wang Z, Bergman P, Liu S, et al. Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62. elife. 2016;5: pubmed publisher
western blot; mouse; fig 4	Hamlin A, Basford J, Jaeschke A, Hui D. LRP1 Protein Deficiency Exacerbates Palmitate-induced Steatosis and Toxicity in Hepatocytes. J Biol Chem. 2016;291:16610-9 pubmed publisher
western blot; mouse; loading ...; fig s4a	Chaveroux C, Sarcinelli C, Barbet V, Belfeki S, Barthelaix A, Ferraro Peyret C, et al. Nutrient shortage triggers the hexosamine biosynthetic pathway via the GCN2-ATF4 signalling pathway. Sci Rep. 2016;6:27278 pubmed publisher
immunocytochemistry; human; 1:3000; loading ...; fig 3c	Trousil S, Kaliszczak M, Schug Z, Nguyen Q, Tomasi G, Favicchio R, et al. The novel choline kinase inhibitor ICL-CCIC-0019 reprograms cellular metabolism and inhibits cancer cell growth. Oncotarget. 2016;7:37103-37120 pubmed publisher
western blot; mouse; 1:1000; fig 2d	Xu Z, Bu Y, Chitnis N, Koumenis C, Fuchs S, Diehl J. miR-216b regulation of c-Jun mediates GADD153/CHOP-dependent apoptosis. Nat Commun. 2016;7:11422 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 5h western blot; human; 1:1000; loading ...; fig 5h	Zanotto Filho A, Dashnamoorthy R, Loranc E, de Souza L, Moreira J, Suresh U, et al. Combined Gene Expression and RNAi Screening to Identify Alkylation Damage Survival Pathways from Fly to Human. PLoS ONE. 2016;11:e0153970 pubmed publisher
western blot; mouse; loading ...; fig 4a	Tamura Y, Matsunaga Y, Kitaoka Y, Hatta H. Effects of Heat Stress Treatment on Age-dependent Unfolded Protein Response in Different Types of Skeletal Muscle. J Gerontol A Biol Sci Med Sci. 2017;72:299-308 pubmed publisher
western blot; mouse; fig s3	Aaes T, Kaczmarek A, Delvaeye T, De Craene B, De Koker S, Heyndrickx L, et al. Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity. Cell Rep. 2016;15:274-87 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 6b	Soeda J, Mouralidarane A, Cordero P, Li J, Nguyen V, Carter R, et al. Maternal obesity alters endoplasmic reticulum homeostasis in offspring pancreas. J Physiol Biochem. 2016;72:281-91 pubmed publisher
western blot; mouse; 1:1000; fig 4	Zhao Y, Xu L, Qiao Z, Gao L, Ding S, Ying X, et al. YiXin-Shu, a ShengMai-San-based traditional Chinese medicine formula, attenuates myocardial ischemia/reperfusion injury by suppressing mitochondrial mediated apoptosis and upregulating liver-X-receptor Î±. Sci Rep. 2016;6:23025 pubmed publisher
western blot; human; loading ...; fig 4d	Saveljeva S, Cleary P, Mnich K, Ayo A, Pakos Zebrucka K, Patterson J, et al. Endoplasmic reticulum stress-mediated induction of SESTRIN 2 potentiates cell survival. Oncotarget. 2016;7:12254-66 pubmed publisher
western blot; mouse; fig 2e	Ro S, Xue X, Ramakrishnan S, Cho C, Namkoong S, Jang I, et al. Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis. elife. 2016;5:e12204 pubmed publisher
western blot; human; fig 3	Kline C, van den Heuvel A, Allen J, Prabhu V, Dicker D, El Deiry W. ONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2Î± kinases. Sci Signal. 2016;9:ra18 pubmed publisher
immunocytochemistry; human; loading ...; fig 6c western blot; human; loading ...; fig 6a	Baer A, Lundberg L, Swales D, Waybright N, Pinkham C, Dinman J, et al. Venezuelan Equine Encephalitis Virus Induces Apoptosis through the Unfolded Protein Response Activation of EGR1. J Virol. 2016;90:3558-72 pubmed publisher
immunohistochemistry - paraffin section; mouse; 1:300; fig 2 western blot; mouse; 1:1000; fig 4	Lin Y, Zhuang J, Li H, Zhu G, Zhou S, Li W, et al. Vaspin attenuates the progression of atherosclerosis by inhibiting ER stress-induced macrophage apoptosis in apoEâ€‘/â€‘ mice. Mol Med Rep. 2016;13:1509-16 pubmed publisher
western blot; human; fig 3	Yang B, Zhang M, Gao J, Li J, Fan L, Xiang G, et al. Small molecule RL71 targets SERCA2 at a novel site in the treatment of human colorectal cancer. Oncotarget. 2015;6:37613-25 pubmed publisher
western blot; human; 1:1000; fig 1	El Khattouti A, Selimovic D, Hannig M, Taylor E, Abd Elmageed Z, Hassan S, et al. Imiquimod-induced apoptosis of melanoma cells is mediated by ER stress-dependent Noxa induction and enhanced by NF-ÎºB inhibition. J Cell Mol Med. 2016;20:266-86 pubmed publisher
western blot; human; fig 3	Wang Y, Kuramitsu Y, Baron B, Kitagawa T, Tokuda K, Akada J, et al. CGK733-induced LC3 II formation is positively associated with the expression of cyclin-dependent kinase inhibitor p21Waf1/Cip1 through modulation of the AMPK and PERK/CHOP signaling pathways. Oncotarget. 2015;6:39692-701 pubmed publisher
western blot; human; 1:1000; fig 3	Patel M, Jacobson B, Ji Y, Drees J, Tang S, Xiong K, et al. Vesicular stomatitis virus expressing interferon-Î² is oncolytic and promotes antitumor immune responses in a syngeneic murine model of non-small cell lung cancer. Oncotarget. 2015;6:33165-77 pubmed publisher
western blot; human; 1:1000; fig 7	Sakabe I, Hu R, Jin L, Clarke R, Kasid U. TMEM33: a new stress-inducible endoplasmic reticulum transmembrane protein and modulator of the unfolded protein response signaling. Breast Cancer Res Treat. 2015;153:285-97 pubmed publisher
western blot; human; loading ...; fig 5b	Sujobert P, Poulain L, Paubelle E, Zylbersztejn F, Grenier A, Lambert M, et al. Co-activation of AMPK and mTORC1 Induces Cytotoxicity in Acute Myeloid Leukemia. Cell Rep. 2015;11:1446-57 pubmed publisher
western blot; human; 1:1000; fig 3	Cheng H, Liang Y, Kuo Y, Chuu C, Lin C, Lee M, et al. Identification of thioridazine, an antipsychotic drug, as an antiglioblastoma and anticancer stem cell agent using public gene expression data. Cell Death Dis. 2015;6:e1753 pubmed publisher
western blot; human; fig 1	Hotokezaka Y, Katayama I, van Leyen K, Nakamura T. GSK-3Î²-dependent downregulation of Î³-taxilin and Î±NAC merge to regulate ER stress responses. Cell Death Dis. 2015;6:e1719 pubmed publisher
immunohistochemistry; mouse; fig 7	Linz A, Knieper Y, Gronau T, Hansen U, Aszodi A, Garbi N, et al. ER Stress During the Pubertal Growth Spurt Results in Impaired Long-Bone Growth in Chondrocyte-Specific ERp57 Knockout Mice. J Bone Miner Res. 2015;30:1481-93 pubmed publisher
western blot; human; fig 4	Cui J, Sun W, Hao X, Wei M, Su X, Zhang Y, et al. EHMT2 inhibitor BIX-01294 induces apoptosis through PMAIP1-USP9X-MCL1 axis in human bladder cancer cells. Cancer Cell Int. 2015;15:4 pubmed publisher
western blot; rat; 1:1000	Liu S, Sarkar C, Dinizo M, Faden A, Koh E, Lipinski M, et al. Disrupted autophagy after spinal cord injury is associated with ER stress and neuronal cell death. Cell Death Dis. 2015;6:e1582 pubmed publisher
western blot; mouse	Karner C, Esen E, Okunade A, Patterson B, Long F. Increased glutamine catabolism mediates bone anabolism in response to WNT signaling. J Clin Invest. 2015;125:551-62 pubmed publisher
western blot; human; 1:1000	Zanotto Filho A, Braganhol E, Klafke K, FigueirÃ³ F, Terra S, Paludo F, et al. Autophagy inhibition improves the efficacy of curcumin/temozolomide combination therapy in glioblastomas. Cancer Lett. 2015;358:220-31 pubmed publisher
western blot; human	Kim D, Park M, Choi J, Lim S, Choi H, Park S. Hyperglycemia-induced GLP-1R downregulation causes RPE cell apoptosis. Int J Biochem Cell Biol. 2015;59:41-51 pubmed publisher
western blot; human; fig 5	Davis A, Qiao S, Lesson J, Rojo de la Vega M, Park S, Seanez C, et al. The quinone methide aurin is a heat shock response inducer that causes proteotoxic stress and Noxa-dependent apoptosis in malignant melanoma cells. J Biol Chem. 2015;290:1623-38 pubmed publisher
western blot; mouse; fig 5	Arruda A, Pers B, ParlakgÃ¼l G, GÃ¼ney E, Inouye K, Hotamisligil G. Chronic enrichment of hepatic endoplasmic reticulum-mitochondria contact leads to mitochondrial dysfunction in obesity. Nat Med. 2014;20:1427-35 pubmed publisher
immunohistochemistry - frozen section; mouse; 1:50	Nashine S, Liu Y, Kim B, Clark A, Pang I. Role of C/EBP homologous protein in retinal ganglion cell death after ischemia/reperfusion injury. Invest Ophthalmol Vis Sci. 2014;56:221-31 pubmed publisher
western blot; rat	Matsuo R, Morihara H, Mohri T, Murasawa S, Takewaki K, Nakayama H, et al. The inhibition of N-glycosylation of glycoprotein 130 molecule abolishes STAT3 activation by IL-6 family cytokines in cultured cardiac myocytes. PLoS ONE. 2014;9:e111097 pubmed publisher
western blot; mouse; 1:2000; loading ...; fig 6a	Feng X, Krogh K, Wu C, Lin Y, Tsai H, Thayer S, et al. Receptor-interacting protein 140 attenuates endoplasmic reticulum stress in neurons and protects against cell death. Nat Commun. 2014;5:4487 pubmed publisher
western blot; human	Zhang P, Gao K, Tang Y, Jin X, An J, Yu H, et al. Destruction of DDIT3/CHOP protein by wild-type SPOP but not prostate cancer-associated mutants. Hum Mutat. 2014;35:1142-51 pubmed publisher
western blot; human; fig 4	Lim Y, Lee D, Kalichamy K, Hong S, Michalak M, Ahnn J, et al. Sumoylation regulates ER stress response by modulating calreticulin gene expression in XBP-1-dependent mode in Caenorhabditis elegans. Int J Biochem Cell Biol. 2014;53:399-408 pubmed publisher
western blot; mouse	Maas N, Singh N, Diehl J. Generation and characterization of an analog-sensitive PERK allele. Cancer Biol Ther. 2014;15:1106-11 pubmed publisher
western blot; mouse; 1:1000; fig 3	Campos G, Schmidt Heck W, Ghallab A, Rochlitz K, Pütter L, Medinas D, et al. The transcription factor CHOP, a central component of the transcriptional regulatory network induced upon CCl4 intoxication in mouse liver, is not a critical mediator of hepatotoxicity. Arch Toxicol. 2014;88:1267-80 pubmed publisher
In-Cell Western; rat; 1:30; fig 1 immunocytochemistry; rat; 1:100; fig 4	Maier P, Zemoura K, Acu a M, Y venes G, Zeilhofer H, Benke D. Ischemia-like oxygen and glucose deprivation mediates down-regulation of cell surface ?-aminobutyric acidB receptors via the endoplasmic reticulum (ER) stress-induced transcription factor CCAAT/enhancer-binding protein (C/EBP)-homologous protein (CH. J Biol Chem. 2014;289:12896-907 pubmed publisher
western blot; mouse	Safren N, El Ayadi A, Chang L, Terrillion C, Gould T, BOEHNING D, et al. Ubiquilin-1 overexpression increases the lifespan and delays accumulation of Huntingtin aggregates in the R6/2 mouse model of Huntington's disease. PLoS ONE. 2014;9:e87513 pubmed publisher
western blot; human; fig 6	Rubio N, Verrax J, Dewaele M, Verfaillie T, Johansen T, Piette J, et al. p38(MAPK)-regulated induction of p62 and NBR1 after photodynamic therapy promotes autophagic clearance of ubiquitin aggregates and reduces reactive oxygen species levels by supporting Nrf2-antioxidant signaling. Free Radic Biol Med. 2014;67:292-303 pubmed publisher
immunohistochemistry - frozen section; rat; 1:200	Ní Fhlathartaigh M, McMahon J, Reynolds R, Connolly D, Higgins E, Counihan T, et al. Calreticulin and other components of endoplasmic reticulum stress in rat and human inflammatory demyelination. Acta Neuropathol Commun. 2013;1:37 pubmed publisher
western blot; human; fig sf1	de Poot S, Lai K, van der Wal L, Plasman K, Van Damme P, Porter A, et al. Granzyme M targets topoisomerase II alpha to trigger cell cycle arrest and caspase-dependent apoptosis. Cell Death Differ. 2014;21:416-26 pubmed publisher
western blot; mouse; 1:1000	Kang E, Kwon I, Koo J, Kim E, Kim C, Lee J, et al. Treadmill exercise represses neuronal cell death and inflammation during A?-induced ER stress by regulating unfolded protein response in aged presenilin 2 mutant mice. Apoptosis. 2013;18:1332-1347 pubmed publisher
western blot; rat	Zhuo X, Wu Y, Ni Y, Liu J, Gong M, Wang X, et al. Isoproterenol instigates cardiomyocyte apoptosis and heart failure via AMPK inactivation-mediated endoplasmic reticulum stress. Apoptosis. 2013;18:800-10 pubmed publisher
western blot; human	Takayanagi S, Fukuda R, Takeuchi Y, Tsukada S, Yoshida K. Gene regulatory network of unfolded protein response genes in endoplasmic reticulum stress. Cell Stress Chaperones. 2013;18:11-23 pubmed publisher
chromatin immunoprecipitation; human western blot; human	Hsin I, Hsiao Y, Wu M, Jan M, Tang S, Lin Y, et al. Lipocalin 2, a new GADD153 target gene, as an apoptosis inducer of endoplasmic reticulum stress in lung cancer cells. Toxicol Appl Pharmacol. 2012;263:330-7 pubmed publisher
	Plana Bonamaisó A, López Begines S, Andilla J, Fidalgo M, Loza Alvarez P, Estanyol J, et al. GCAP neuronal calcium sensor proteins mediate photoreceptor cell death in the rd3 mouse model of LCA12 congenital blindness by involving endoplasmic reticulum stress. Cell Death Dis. 2020;11:62 pubmed publisher
	Fu D, Li P, Sheng Q, Lv Z. β-arrestin-2 enhances intestinal epithelial apoptosis in necrotizing enterocolitis. Aging (Albany NY). 2019;11:8294-8312 pubmed publisher
	Wu J, Chen Y, Dobbs N, Sakai T, Liou J, Miner J, et al. STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death. J Exp Med. 2019;: pubmed publisher
	Chidawanyika T, Sergison E, Cole M, Mark K, Supattapone S. SEC24A identified as an essential mediator of thapsigargin-induced cell death in a genome-wide CRISPR/Cas9 screen. Cell Death Discov. 2018;4:115 pubmed publisher
	Obr A, Kumar S, Chang Y, Bulatowicz J, Barnes B, Birge R, et al. Insulin-like growth factor receptor signaling in breast tumor epithelium protects cells from endoplasmic reticulum stress and regulates the tumor microenvironment. Breast Cancer Res. 2018;20:138 pubmed publisher
	BrohÃ©e L, Peulen O, Nusgens B, Castronovo V, Thiry M, Colige A, et al. Propranolol sensitizes prostate cancer cells to glucose metabolism inhibition and prevents cancer progression. Sci Rep. 2018;8:7050 pubmed publisher
	Fan R, Schrott L, Arnold T, Snelling S, Rao M, Graham D, et al. Chronic oxycodone induces axonal degeneration in rat brain. BMC Neurosci. 2018;19:15 pubmed publisher
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product information

SKU :

2895S

Product-Name :

CHOP (L63F7) Mouse mAb

Size :

100 ul

Price-(USD) :

235 USD

Species-x-Reactivity :

H, M, R

Applications :

Immunofluorescence (Immunocytochemistry)

Product-Category :

Protein Folding and Trafficking

Shipping-Temp :

AMBIENT

Storage-Temp :

-20°C

Product-Type :

Monoclonal Antibody

MW :

Host :

Mouse

Target :

CHOP

Primary-Protein :

CHOP

Alt-Names :

C/EBP homologous protein,C/EBP zeta,C/EBP-homologous protein,C/EBP-homologous protein 10,CCAAT/enhancer-binding protein homologous protein,CEBPZ,CHOP,CHOP-10,CHOP10,DDIT-3,DDIT3,DNA damage-inducible transcript 3 protein,DNA-damage-inducible transcript 3,GADD153,Growth arrest and DNA damage-inducible protein GADD153,MGC4154,growth arrest- and DNA damage-inducible

more info or order :

Cell Signaling Technology product webpage