| Published Application/Species/Dilution | Reference |
|---|
- western blot (knockout validation); mouse; fig 1b
| Deng X, Zhang W, O-Sullivan I, Williams J, Dong Q, Park E, et al. FoxO1 inhibits sterol regulatory element-binding protein-1c (SREBP-1c) gene expression via transcription factors Sp1 and SREBP-1c. J Biol Chem. 2012;287:20132-43 pubmed publisher |
- immunocytochemistry; mouse; 1:150; fig 2
| Luo C, Liao W, Dadi S, Toure A, Li M. Graded Foxo1 activity in Treg cells differentiates tumour immunity from spontaneous autoimmunity. Nature. 2016;529:532-6 pubmed publisher |
- western blot; human; fig 4
| Agarwal S, Bell C, Taylor S, Moran R. p53 Deletion or Hotspot Mutations Enhance mTORC1 Activity by Altering Lysosomal Dynamics of TSC2 and Rheb. Mol Cancer Res. 2016;14:66-77 pubmed publisher |
- western blot; human; 1:500; fig 9
| E L, Swerdlow R. Lactate's effect on human neuroblastoma cell bioenergetic fluxes. Biochem Pharmacol. 2016;99:88-100 pubmed publisher |
- western blot; mouse; fig 1c
| Krishnan N, Krishnan K, Connors C, Choy M, Page R, Peti W, et al. PTP1B inhibition suggests a therapeutic strategy for Rett syndrome. J Clin Invest. 2015;125:3163-77 pubmed publisher |
- western blot; human; 1:500
| Stefanetti R, Lamon S, Wallace M, Vendelbo M, Russell A, Vissing K. Regulation of ubiquitin proteasome pathway molecular markers in response to endurance and resistance exercise and training. Pflugers Arch. 2015;467:1523-37 pubmed publisher |
- western blot; mouse
- western blot; rat
| Jaishy B, Zhang Q, Chung H, Riehle C, Soto J, Jenkins S, et al. Lipid-induced NOX2 activation inhibits autophagic flux by impairing lysosomal enzyme activity. J Lipid Res. 2015;56:546-61 pubmed publisher |
- immunoprecipitation; human
- western blot; human
| Tanaka T, Iino M. Knockdown of Sec8 promotes cell-cycle arrest at G1/S phase by inducing p21 via control of FOXO proteins. FEBS J. 2014;281:1068-84 pubmed publisher |
- western blot; human; 1:500; fig 10c
| Lu T, Aron L, Zullo J, Pan Y, Kim H, Chen Y, et al. REST and stress resistance in ageing and Alzheimer's disease. Nature. 2014;507:448-54 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; 1:100
| Harman J, Richburg J. Cisplatin-induced alterations in the functional spermatogonial stem cell pool and niche in C57/BL/6J mice following a clinically relevant multi-cycle exposure. Toxicol Lett. 2014;227:99-112 pubmed publisher |
- western blot; human; fig 4a
- western blot; mouse; fig 3a
| Zheng X, Zhai B, Koivunen P, Shin S, Lu G, Liu J, et al. Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase. Genes Dev. 2014;28:1429-44 pubmed publisher |
- western blot; mouse; 1:500
| E L, Burns J, Swerdlow R. Effect of high-intensity exercise on aged mouse brain mitochondria, neurogenesis, and inflammation. Neurobiol Aging. 2014;35:2574-83 pubmed publisher |
- western blot; human; 1:500
| Stefanetti R, Zacharewicz E, Della Gatta P, Garnham A, Russell A, Lamon S. Ageing has no effect on the regulation of the ubiquitin proteasome-related genes and proteins following resistance exercise. Front Physiol. 2014;5:30 pubmed publisher |
- western blot; mouse; fig 5
| Tan S, Shui G, Zhou J, Shi Y, Huang J, Xia D, et al. Critical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled AKT-FOXO1 signaling pathway. Autophagy. 2014;10:226-42 pubmed publisher |
- western blot; mouse; fig 2a
| Chu Y, Gomez Rosso L, Huang P, Wang Z, Xu Y, Yao X, et al. Liver Med23 ablation improves glucose and lipid metabolism through modulating FOXO1 activity. Cell Res. 2014;24:1250-65 pubmed publisher |
- western blot; mouse; 1:1000
| Zhang Y, Zhang X, Gao L, Liu Y, Jiang D, Chen K, et al. Growth/differentiation factor 1 alleviates pressure overload-induced cardiac hypertrophy and dysfunction. Biochim Biophys Acta. 2014;1842:232-44 pubmed publisher |
| Dai J, Shen D, Bian Z, Zhou H, Gan H, Zong J, et al. IKKi deficiency promotes pressure overload-induced cardiac hypertrophy and fibrosis. PLoS ONE. 2013;8:e53412 pubmed publisher |
- western blot; human
- western blot; mouse
| Ravnskjaer K, Hogan M, Lackey D, Tora L, Dent S, Olefsky J, et al. Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects. J Clin Invest. 2013;123:4318-28 pubmed publisher |
| Shats I, Gatza M, Liu B, Angus S, You L, Nevins J. FOXO transcription factors control E2F1 transcriptional specificity and apoptotic function. Cancer Res. 2013;73:6056-67 pubmed publisher |
| Hawse W, Sheehan R, Miskov-Zivanov N, Menk A, Kane L, Faeder J, et al. Cutting Edge: Differential Regulation of PTEN by TCR, Akt, and FoxO1 Controls CD4+ T Cell Fate Decisions. J Immunol. 2015;194:4615-9 pubmed publisher |
| Zhu W, Tong H, Teh J, Wang M. Forkhead box protein O3 transcription factor negatively regulates autophagy in human cancer cells by inhibiting forkhead box protein O1 expression and cytosolic accumulation. PLoS ONE. 2014;9:e115087 pubmed publisher |
| Niedan S, Kauer M, Aryee D, Kofler R, Schwentner R, Meier A, et al. Suppression of FOXO1 is responsible for a growth regulatory repressive transcriptional sub-signature of EWS-FLI1 in Ewing sarcoma. Oncogene. 2014;33:3927-38 pubmed publisher |
| Yao W, Cai H, Li X, Li T, Hu L, Peng T. Endoplasmic reticulum stress links hepatitis C virus RNA replication to wild-type PGC-1α/liver-specific PGC-1α upregulation. J Virol. 2014;88:8361-74 pubmed publisher |
| Fardini Y, Masson E, Boudah O, Ben Jouira R, Cosson C, Pierre-Eugène C, et al. O-GlcNAcylation of FoxO1 in pancreatic β cells promotes Akt inhibition through an IGFBP1-mediated autocrine mechanism. FASEB J. 2014;28:1010-21 pubmed publisher |
| Kim J, Choi H, Cho E, Lee T. FoxO3a is an antimelanogenic factor that mediates antioxidant-induced depigmentation. J Invest Dermatol. 2014;134:1378-88 pubmed publisher |
| Wong C, Kaneda T, Hadi A, Morita H. Ceramicine B, a limonoid with anti-lipid droplets accumulation activity from Chisocheton ceramicus. J Nat Med. 2014;68:22-30 pubmed publisher |
| Roudier E, Milkiewicz M, Birot O, Slopack D, Montelius A, Gustafsson T, et al. Endothelial FoxO1 is an intrinsic regulator of thrombospondin 1 expression that restrains angiogenesis in ischemic muscle. Angiogenesis. 2013;16:759-72 pubmed publisher |
| Li Q, He H, Zhang Y, Li X, Guo X, Huo R, et al. Phosphoinositide 3-kinase p110δ mediates estrogen- and FSH-stimulated ovarian follicle growth. Mol Endocrinol. 2013;27:1468-82 pubmed publisher |
| Nakamura M, Takakura M, Fujii R, Maida Y, Bono Y, Mizumoto Y, et al. The PRB-dependent FOXO1/IGFBP-1 axis is essential for progestin to inhibit endometrial epithelial growth. Cancer Lett. 2013;336:68-75 pubmed publisher |
| Tejera M, Kim E, Sullivan J, Plisch E, Suresh M. FoxO1 controls effector-to-memory transition and maintenance of functional CD8 T cell memory. J Immunol. 2013;191:187-99 pubmed publisher |
| Cai K, Sewer M. Diacylglycerol kinase θ couples farnesoid X receptor-dependent bile acid signalling to Akt activation and glucose homoeostasis in hepatocytes. Biochem J. 2013;454:267-74 pubmed publisher |
| Haflidadóttir B, Larne O, Martin M, Persson M, Edsjö A, Bjartell A, et al. Upregulation of miR-96 enhances cellular proliferation of prostate cancer cells through FOXO1. PLoS ONE. 2013;8:e72400 pubmed publisher |
| Bohrer L, Liu P, Zhong J, Pan Y, Angstman J, Brand L, et al. FOXO1 binds to the TAU5 motif and inhibits constitutively active androgen receptor splice variants. Prostate. 2013;73:1017-27 pubmed publisher |
| Wei L, Wang M, Qu X, Mah A, Xiong X, Harris A, et al. Differential expression of microRNAs during allograft rejection. Am J Transplant. 2012;12:1113-23 pubmed publisher |
| Jothi M, Nishijo K, Keller C, Mal A. AKT and PAX3-FKHR cooperation enforces myogenic differentiation blockade in alveolar rhabdomyosarcoma cell. Cell Cycle. 2012;11:895-908 pubmed publisher |
| Roudier E, Forn P, Perry M, Birot O. Murine double minute-2 expression is required for capillary maintenance and exercise-induced angiogenesis in skeletal muscle. FASEB J. 2012;26:4530-9 pubmed publisher |
| Quinci A, Vitale S, Parretta E, Soriani A, Iannitto M, Cippitelli M, et al. IL-15 inhibits IL-7Rα expression by memory-phenotype CD8⁺ T cells in the bone marrow. Eur J Immunol. 2012;42:1129-39 pubmed publisher |
| Inaba W, Mizukami H, Kamata K, Takahashi K, Tsuboi K, Yagihashi S. Effects of long-term treatment with the dipeptidyl peptidase-4 inhibitor vildagliptin on islet endocrine cells in non-obese type 2 diabetic Goto-Kakizaki rats. Eur J Pharmacol. 2012;691:297-306 pubmed publisher |
| Shi J, Wang A, Sen S, Wang Y, Kim H, Mitts T, et al. Insulin induces production of new elastin in cultures of human aortic smooth muscle cells. Am J Pathol. 2012;180:715-26 pubmed publisher |
| Ochi E, Hirose T, Hiranuma K, Min S, Ishii N, Nakazato K. Elevation of myostatin and FOXOs in prolonged muscular impairment induced by eccentric contractions in rat medial gastrocnemius muscle. J Appl Physiol (1985). 2010;108:306-13 pubmed publisher |
| Wang H, Geng Q, Wang L, Lu Y. Curcumin potentiates antitumor activity of L-asparaginase via inhibition of the AKT signaling pathway in acute lymphoblastic leukemia. Leuk Lymphoma. 2012;53:1376-82 pubmed publisher |
| Matsuyama H, Suzuki H, Nishimori H, Noguchi M, Yao T, Komatsu N, et al. miR-135b mediates NPM-ALK-driven oncogenicity and renders IL-17-producing immunophenotype to anaplastic large cell lymphoma. Blood. 2011;118:6881-92 pubmed publisher |
