product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
FoxO1 (C29H4) Rabbit mAb
catalog :
2880
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
C29H4
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, western blot knockout validation, immunohistochemistry knockout validation
more info or order :
Cell Signaling Technology product webpage
citations: 181
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry knockout validation; mouse; 1:100; loading ...; fig 3
  • western blot knockout validation; mouse; 1:1000; loading ...; fig 2a
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 3
Oh H, Paik J. Genetic Ablation of FOXO in Mice to Investigate Its Physiological Role. Methods Mol Biol. 2019;1890:239-248 pubmed publisher
  • immunohistochemistry knockout validation; mouse; fig 1
  • western blot knockout validation; mouse; fig 1
Kim Muller J, Zhao S, Srivastava S, Mugabo Y, Noh H, Kim Y, et al. Metabolic inflexibility impairs insulin secretion and results in MODY-like diabetes in triple FoxO-deficient mice. Cell Metab. 2014;20:593-602 pubmed publisher
  • western blot knockout validation; mouse; loading ...; fig s24
  • immunocytochemistry; human; loading ...; fig 3c
  • western blot; human; loading ...; fig 3a
Hwangbo C, Wu J, Papangeli I, Adachi T, Sharma B, Park S, et al. Endothelial APLNR regulates tissue fatty acid uptake and is essential for apelin's glucose-lowering effects. Sci Transl Med. 2017;9: pubmed publisher
  • western blot knockout validation; mouse; loading ...; fig 1b
Inoue T, Shinnakasu R, Ise W, Kawai C, Egawa T, Kurosaki T. The transcription factor Foxo1 controls germinal center B cell proliferation in response to T cell help. J Exp Med. 2017;214:1181-1198 pubmed publisher
  • immunohistochemistry knockout validation; mouse; 1:100; fig s1
  • immunohistochemistry - frozen section; mouse; 1:100; fig 1
  • western blot; human; 1:1000; fig s5
Wilhelm K, Happel K, Eelen G, Schoors S, Oellerich M, Lim R, et al. FOXO1 couples metabolic activity and growth state in the vascular endothelium. Nature. 2016;529:216-20 pubmed publisher
  • western blot knockout validation; mouse; 1:1000; fig 1
Milan G, Romanello V, Pescatore F, Armani A, Paik J, Frasson L, et al. Regulation of autophagy and the ubiquitin-proteasome system by the FoxO transcriptional network during muscle atrophy. Nat Commun. 2015;6:6670 pubmed publisher
  • western blot knockout validation; mouse; fig 1
Cook J, Matsumoto M, Banks A, Kitamura T, Tsuchiya K, Accili D. A mutant allele encoding DNA binding-deficient FoxO1 differentially regulates hepatic glucose and lipid metabolism. Diabetes. 2015;64:1951-65 pubmed publisher
  • western blot; mouse; loading ...; fig 3a
Zhu Y, Gu H, Yang L, Li N, Chen Q, Kang D, et al. Involvement of MST1/mTORC1/STAT1 activity in the regulation of B-cell receptor signalling by chemokine receptor 2. Clin Transl Med. 2022;12:e887 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1000; loading ...; fig 6b
Schoppa A, Chen X, Ramge J, Vikman A, Fischer V, Haffner Luntzer M, et al. Osteoblast lineage Sod2 deficiency leads to an osteoporosis-like phenotype in mice. Dis Model Mech. 2022;15: pubmed publisher
  • western blot; mouse; loading ...; fig 7c
Cao X, Shi T, Zhang C, Jin W, Song L, Zhang Y, et al. ACE2 pathway regulates thermogenesis and energy metabolism. elife. 2022;11: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:75; loading ...; fig 6a
Nahle A, Joseph Y, Pereira S, Mori Y, Poon F, Ghadieh H, et al. Nicotinamide Mononucleotide Prevents Free Fatty Acid-Induced Reduction in Glucose Tolerance by Decreasing Insulin Clearance. Int J Mol Sci. 2021;22: pubmed publisher
  • western blot; mouse; loading ...; fig 5c
Takaoka S, Yanagiya A, Mohamed H, Higa R, Abe T, Inoue K, et al. Neuronal XRN1 is required for maintenance of whole-body metabolic homeostasis. iScience. 2021;24:103151 pubmed publisher
  • western blot; mouse; 1:1000; fig s8
Kitakaze K, Oyadomari M, Zhang J, Hamada Y, Takenouchi Y, Tsuboi K, et al. ATF4-mediated transcriptional regulation protects against β-cell loss during endoplasmic reticulum stress in a mouse model. Mol Metab. 2021;54:101338 pubmed publisher
  • immunocytochemistry; mouse; 1:100; fig 7i
  • western blot; mouse; 1:1000; fig 7d
Coudert L, Osseni A, Gangloff Y, Schaeffer L, Leblanc P. The ESCRT-0 subcomplex component Hrs/Hgs is a master regulator of myogenesis via modulation of signaling and degradation pathways. BMC Biol. 2021;19:153 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1a
Al Zahrani K, Abou Hamad J, Pascoal J, Labrèche C, Garland B, Sabourin L. AKT-mediated phosphorylation of Sox9 induces Sox10 transcription in a murine model of HER2-positive breast cancer. Breast Cancer Res. 2021;23:55 pubmed publisher
  • western blot; human; fig s1f
Andrade J, Shi C, Costa A, Choi J, Kim J, Doddaballapur A, et al. Control of endothelial quiescence by FOXO-regulated metabolites. Nat Cell Biol. 2021;23:413-423 pubmed publisher
  • western blot; mouse; loading ...; fig 4b
Huang J, Li R, Yang J, Cai M, Lee Y, Wang A, et al. Bioadaptation of implants to In vitro and In vivo oxidative stress pathological conditions via nanotopography-induced FoxO1 signaling pathways to enhance Osteoimmunal regeneration. Bioact Mater. 2021;6:3164-3176 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5f
Wallace M, Aguirre N, Marcotte G, Marshall A, Baehr L, Hughes D, et al. The ketogenic diet preserves skeletal muscle with aging in mice. Aging Cell. 2021;20:e13322 pubmed publisher
  • western blot; mouse; loading ...; fig 6b
Wang X, Zhao Y, Zhou D, Tian Y, Feng G, Lu Z. Gab2 deficiency suppresses high-fat diet-induced obesity by reducing adipose tissue inflammation and increasing brown adipose function in mice. Cell Death Dis. 2021;12:212 pubmed publisher
  • flow cytometry; mouse; 1:100; fig 6c
Sun Z, Yao Y, You M, Liu J, Guo W, Qi Z, et al. The kinase PDK1 is critical for promoting T follicular helper cell differentiation. elife. 2021;10: pubmed publisher
  • western blot; mouse; loading ...; fig s8b
Wan X, Zhou M, Huang F, Zhao N, Chen X, Wu Y, et al. AKT1-CREB stimulation of PDGFRα expression is pivotal for PTEN deficient tumor development. Cell Death Dis. 2021;12:172 pubmed publisher
  • western blot; human; loading ...; fig 2f
Hu Q, Zhu L, Li Y, Zhou J, Xu J. ACTA1 is inhibited by PAX3-FOXO1 through RhoA-MKL1-SRF signaling pathway and impairs cell proliferation, migration and tumor growth in Alveolar Rhabdomyosarcoma. Cell Biosci. 2021;11:25 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4a
Singh S, Abu Zaid A, Lin W, Low J, Abdolvahabi A, Jin H, et al. 17-DMAG dually inhibits Hsp90 and histone lysine demethylases in alveolar rhabdomyosarcoma. iScience. 2021;24:101996 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3b
Xu K, Yin N, Peng M, Stamatiades E, Shyu A, Li P, et al. Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity. Science. 2021;371:405-410 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1m
Ow J, Cadez M, Zafer G, Foo J, Li H, Ghosh S, et al. Remodeling of whole-body lipid metabolism and a diabetic-like phenotype caused by loss of CDK1 and hepatocyte division. elife. 2020;9: pubmed publisher
  • immunohistochemistry; human; 1:1000; loading ...
Helker C, Eberlein J, Wilhelm K, Sugino T, Malchow J, Schuermann A, et al. Apelin signaling drives vascular endothelial cells toward a pro-angiogenic state. elife. 2020;9: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2a
Kumar A, Xie L, Ta C, Hinton A, Gunasekar S, Minerath R, et al. SWELL1 regulates skeletal muscle cell size, intracellular signaling, adiposity and glucose metabolism. elife. 2020;9: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 11c
Suzuki K, Matsumoto M, Katoh Y, Liu L, Ochiai K, Aizawa Y, et al. Bach1 promotes muscle regeneration through repressing Smad-mediated inhibition of myoblast differentiation. PLoS ONE. 2020;15:e0236781 pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig 5c
Kuroki S, Maeda R, Yano M, Kitano S, Miyachi H, Fukuda M, et al. H3K9 Demethylases JMJD1A and JMJD1B Control Prospermatogonia to Spermatogonia Transition in Mouse Germline. Stem Cell Reports. 2020;15:424-438 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig s3f
Fulgenzi G, Hong Z, Tomassoni Ardori F, Barella L, Becker J, Barrick C, et al. Novel metabolic role for BDNF in pancreatic β-cell insulin secretion. Nat Commun. 2020;11:1950 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3d
Wu W, Jing D, Meng Z, Hu B, Zhong B, Deng X, et al. FGD1 promotes tumor progression and regulates tumor immune response in osteosarcoma via inhibiting PTEN activity. Theranostics. 2020;10:2859-2871 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2e
Xu M, Ge C, Qin Y, Lou D, Li Q, Feng J, et al. Functional loss of inactive rhomboid-like protein 2 mitigates obesity by suppressing pro-inflammatory macrophage activation-triggered adipose inflammation. Mol Metab. 2020;34:112-123 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 6g
Wu Q, Yuan X, Bai J, Han R, Li Z, Zhang H, et al. MicroRNA-181a protects against pericyte apoptosis via directly targeting FOXO1: implication for ameliorated cognitive deficits in APP/PS1 mice. Aging (Albany NY). 2019;11:6120-6133 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 3c
Ghaffari R, Di Bona K, Riley C, Richburg J. Copper transporter 1 (CTR1) expression by mouse testicular germ cells, but not Sertoli cells, is essential for functional spermatogenesis. PLoS ONE. 2019;14:e0215522 pubmed publisher
  • western blot; mouse; loading ...; fig 4a
Wang S, Ni H, Chao X, Wang H, Bridges B, Kumer S, et al. Impaired TFEB-mediated lysosomal biogenesis promotes the development of pancreatitis in mice and is associated with human pancreatitis. Autophagy. 2019;15:1954-1969 pubmed publisher
  • western blot; mouse; 1:3000; loading ...; fig e7a
Ranek M, Kokkonen Simon K, Chen A, Dunkerly Eyring B, Vera M, Oeing C, et al. PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress. Nature. 2019;566:264-269 pubmed publisher
  • western blot; rat; loading ...; fig 2b
Bitar M, Nader J, Al Ali W, Al Madhoun A, Arefanian H, Al Mulla F. Hydrogen Sulfide Donor NaHS Improves Metabolism and Reduces Muscle Atrophy in Type 2 Diabetes: Implication for Understanding Sarcopenic Pathophysiology. Oxid Med Cell Longev. 2018;2018:6825452 pubmed publisher
  • western blot; mouse; loading ...; fig 4b
Du X, de Almeida P, Manieri N, de Almeida Nagata D, Wu T, Harden Bowles K, et al. CD226 regulates natural killer cell antitumor responses via phosphorylation-mediated inactivation of transcription factor FOXO1. Proc Natl Acad Sci U S A. 2018;115:E11731-E11740 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig 3a, 3b
Zhang J, Zhang Y, Zhao L, Guo J, Yu J, Ji S, et al. Mammalian nucleolar protein DCAF13 is essential for ovarian follicle maintenance and oocyte growth by mediating rRNA processing. Cell Death Differ. 2019;26:1251-1266 pubmed publisher
  • western blot; mouse; fig s3a
Xiao G, Chan L, Klemm L, Braas D, Chen Z, Geng H, et al. B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies. Cell. 2018;173:470-484.e18 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1g
Omilusik K, Nadjsombati M, Shaw L, Yu B, Milner J, Goldrath A. Sustained Id2 regulation of E proteins is required for terminal differentiation of effector CD8+ T cells. J Exp Med. 2018;215:773-783 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 4d
Souma T, Thomson B, Heinen S, Carota I, Yamaguchi S, Onay T, et al. Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP. Proc Natl Acad Sci U S A. 2018;115:1298-1303 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1a
Ling A, Gearing M, Semova I, Shin D, Clements R, Lai Z, et al. FoxO1 Is Required for Most of the Metabolic and Hormonal Perturbations Produced by Hepatic Insulin Receptor Deletion in Male Mice. Endocrinology. 2018;159:1253-1263 pubmed publisher
  • western blot; human; loading ...; fig 1a
Zhang F, Virshup D, Cheong J. Oncogenic RAS-induced CK1α drives nuclear FOXO proteolysis. Oncogene. 2018;37:363-376 pubmed publisher
  • western blot; mouse; fig 1f
Cai X, Yuan Y, Liao Z, Xing K, Zhu C, Xu Y, et al. α-Ketoglutarate prevents skeletal muscle protein degradation and muscle atrophy through PHD3/ADRB2 pathway. FASEB J. 2018;32:488-499 pubmed publisher
  • western blot; mouse; loading ...; fig 5f
Lingel H, Wissing J, Arra A, Schanze D, Lienenklaus S, Klawonn F, et al. CTLA-4-mediated posttranslational modifications direct cytotoxic T-lymphocyte differentiation. Cell Death Differ. 2017;24:1739-1749 pubmed publisher
  • western blot; human; loading ...; fig 6f
Mandl M, Zhang S, Ulrich M, Schmoeckel E, Mayr D, Vollmar A, et al. Inhibition of Cdk5 induces cell death of tumor-initiating cells. Br J Cancer. 2017;116:912-922 pubmed publisher
  • western blot; mouse; fig s3d
Chan L, Chen Z, Braas D, Lee J, Xiao G, Geng H, et al. Metabolic gatekeeper function of B-lymphoid transcription factors. Nature. 2017;542:479-483 pubmed publisher
  • immunocytochemistry; mouse; 1:500; fig 7a
  • western blot; mouse; 1:2000; fig 7e
Yue F, Bi P, Wang C, Shan T, Nie Y, Ratliff T, et al. Pten is necessary for the quiescence and maintenance of adult muscle stem cells. Nat Commun. 2017;8:14328 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3g
Xu J, Zhou W, Yang F, Chen G, Li H, Zhao Y, et al. The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor. Nat Commun. 2017;8:14002 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2c
Zangari J, Ilie M, Rouaud F, Signetti L, Ohanna M, Didier R, et al. Rapid decay of engulfed extracellular miRNA by XRN1 exonuclease promotes transient epithelial-mesenchymal transition. Nucleic Acids Res. 2017;45:4131-4141 pubmed publisher
  • western blot; mouse; loading ...; fig 1h
Pal M, Gupta S. Testosterone supplementation improves glucose homeostasis despite increasing hepatic insulin resistance in male mouse model of type 2 diabetes mellitus. Nutr Diabetes. 2016;6:e236 pubmed publisher
  • western blot; human; 1:3000; loading ...; fig 5a
He X, Liu Z, Xia Y, Xu J, Lv G, Wang L, et al. HOXB7 overexpression promotes cell proliferation and correlates with poor prognosis in gastric cancer patients by inducing expression of both AKT and MARKs. Oncotarget. 2017;8:1247-1261 pubmed publisher
  • immunoprecipitation; mouse; loading ...; fig 5f
  • western blot; mouse; loading ...; fig 5c
  • immunocytochemistry; rat; 1:200; loading ...; fig 6a
  • western blot; rat; loading ...; fig 6b
Li J, Chen T, Xiao M, Li N, Wang S, Su H, et al. Mouse Sirt3 promotes autophagy in AngII-induced myocardial hypertrophy through the deacetylation of FoxO1. Oncotarget. 2016;7:86648-86659 pubmed publisher
  • western blot; mouse; 1:2000; fig 1c
Doan K, Kinyua A, Yang D, Ko C, Moh S, Shong K, et al. FoxO1 in dopaminergic neurons regulates energy homeostasis and targets tyrosine hydroxylase. Nat Commun. 2016;7:12733 pubmed publisher
  • flow cytometry; mouse; loading ...
Ladle B, Li K, Phillips M, Pucsek A, Haile A, Powell J, et al. De novo DNA methylation by DNA methyltransferase 3a controls early effector CD8+ T-cell fate decisions following activation. Proc Natl Acad Sci U S A. 2016;113:10631-6 pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig 4a
Kim M, Allen B, Korhonen E, Nitschké M, Yang H, Baluk P, et al. Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation. J Clin Invest. 2016;126:3511-25 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 5
Liu M, Shan J, Li J, Zhang Y, Lin X. Resveratrol inhibits doxorubicin-induced cardiotoxicity via sirtuin 1 activation in H9c2 cardiomyocytes. Exp Ther Med. 2016;12:1113-1118 pubmed
  • western blot; mouse; 1:1000; fig 4
Jang H, Lee G, Selby C, Lee G, Jeon Y, Lee J, et al. SREBP1c-CRY1 signalling represses hepatic glucose production by promoting FOXO1 degradation during refeeding. Nat Commun. 2016;7:12180 pubmed publisher
  • western blot; human; fig 5a
Chan W, Ismail H, Mayaki D, Sanchez V, Tiedemann K, Davis E, et al. Fibulin-5 Regulates Angiopoietin-1/Tie-2 Receptor Signaling in Endothelial Cells. PLoS ONE. 2016;11:e0156994 pubmed publisher
  • western blot; mouse; fig 2
Nwadozi E, Roudier E, Rullman E, Tharmalingam S, Liu H, Gustafsson T, et al. Endothelial FoxO proteins impair insulin sensitivity and restrain muscle angiogenesis in response to a high-fat diet. FASEB J. 2016;30:3039-52 pubmed publisher
  • western blot; human; loading ...; fig 1d
Yang Y, Lu Y, Wang L, Mizokami A, Keller E, Zhang J, et al. Skp2 is associated with paclitaxel resistance in prostate cancer cells. Oncol Rep. 2016;36:559-66 pubmed publisher
  • western blot; human; 1:500; fig 2
Rhee M, Lee S, Kim J, Ham D, Park H, Yang H, et al. Preadipocyte factor 1 induces pancreatic ductal cell differentiation into insulin-producing cells. Sci Rep. 2016;6:23960 pubmed publisher
  • western blot; human; 1:1000; fig 4
Cheng C, Jiao J, Qian Y, Guo X, Huang J, Dai M, et al. Curcumin induces G2/M arrest and triggers apoptosis via FoxO1 signaling in U87 human glioma cells. Mol Med Rep. 2016;13:3763-70 pubmed publisher
  • western blot; mouse; fig s8
Winnay J, Solheim M, Dirice E, Sakaguchi M, Noh H, Kang H, et al. PI3-kinase mutation linked to insulin and growth factor resistance in vivo. J Clin Invest. 2016;126:1401-12 pubmed publisher
  • western blot; mouse; 1:1000; tbl 1
Guillot F, Kemppainen S, Lavasseur G, Miettinen P, Laroche S, Tanila H, et al. Brain-Specific Basal and Novelty-Induced Alternations in PI3K-Akt and MAPK/ERK Signaling in a Middle-Aged AβPP/PS1 Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2016;51:1157-73 pubmed publisher
  • western blot; mouse; 1:1000; fig 6
Wang P, Zhang X, Luo P, Jiang X, Zhang P, Guo J, et al. Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling. Nat Commun. 2016;7:10592 pubmed publisher
  • western blot; mouse; fig 2
Malanga D, Belmonte S, Colelli F, Scarfò M, De Marco C, Oliveira D, et al. AKT1E¹⁷K Is Oncogenic in Mouse Lung and Cooperates with Chemical Carcinogens in Inducing Lung Cancer. PLoS ONE. 2016;11:e0147334 pubmed publisher
  • western blot; human; fig 1
Kavlashvili T, Jia Y, Dai D, Meng X, Thiel K, Leslie K, et al. Inverse Relationship between Progesterone Receptor and Myc in Endometrial Cancer. PLoS ONE. 2016;11:e0148912 pubmed publisher
  • western blot; mouse; loading ...; fig 2c
Chen C, Lee T, Kwok C, Hsu Y, Shih K, Lin Y, et al. Cannabinoid receptor type 1 mediates high-fat diet-induced insulin resistance by increasing forkhead box O1 activity in a mouse model of obesity. Int J Mol Med. 2016;37:743-54 pubmed publisher
  • western blot; mouse; 1:1000; fig 5a
Bothur E, Raifer H, Haftmann C, Stittrich A, Brüstle A, Brenner D, et al. Antigen receptor-mediated depletion of FOXP3 in induced regulatory T-lymphocytes via PTPN2 and FOXO1. Nat Commun. 2015;6:8576 pubmed publisher
  • immunocytochemistry; mouse; 1:150; fig 2
Luo C, Liao W, Dadi S, Toure A, Li M. Graded Foxo1 activity in Treg cells differentiates tumour immunity from spontaneous autoimmunity. Nature. 2016;529:532-6 pubmed publisher
  • western blot; mouse; 1:1000; fig 4
Ruiz A, Rockfield S, Taran N, Haller E, Engelman R, Flores I, et al. Effect of hydroxychloroquine and characterization of autophagy in a mouse model of endometriosis. Cell Death Dis. 2016;7:e2059 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 6c, 9b
Wu B, Yu L, Wang Y, Wang H, Li C, Yin Y, et al. Aldehyde dehydrogenase 2 activation in aged heart improves the autophagy by reducing the carbonyl modification on SIRT1. Oncotarget. 2016;7:2175-88 pubmed publisher
  • immunocytochemistry; human; fig 7
  • western blot; human; fig 7
Yasuda K, Takahashi M, Mori N. Mdm20 Modulates Actin Remodeling through the mTORC2 Pathway via Its Effect on Rictor Expression. PLoS ONE. 2015;10:e0142943 pubmed publisher
  • western blot; human; 1:500; fig 9
E L, Swerdlow R. Lactate's effect on human neuroblastoma cell bioenergetic fluxes. Biochem Pharmacol. 2016;99:88-100 pubmed publisher
  • western blot; rat; 1:1000; fig 3
de Andrade P, Neff L, Strosova M, Arsenijevic D, Patthey Vuadens O, Scapozza L, et al. Caloric restriction induces energy-sparing alterations in skeletal muscle contraction, fiber composition and local thyroid hormone metabolism that persist during catch-up fat upon refeeding. Front Physiol. 2015;6:254 pubmed publisher
  • immunocytochemistry; mouse; fig 6
  • western blot; mouse; 1:1000; fig 4
Nemazanyy I, Montagnac G, Russell R, Morzyglod L, Burnol A, Guan K, et al. Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling. Nat Commun. 2015;6:8283 pubmed publisher
  • western blot; human; fig 4
Agarwal S, Bell C, Taylor S, Moran R. p53 Deletion or Hotspot Mutations Enhance mTORC1 Activity by Altering Lysosomal Dynamics of TSC2 and Rheb. Mol Cancer Res. 2016;14:66-77 pubmed publisher
  • immunohistochemistry - frozen section; mouse; fig 2
  • western blot; mouse; fig 3
Yang L, McKnight G. Hypothalamic PKA regulates leptin sensitivity and adiposity. Nat Commun. 2015;6:8237 pubmed publisher
  • western blot; mouse; fig 1c
Krishnan N, Krishnan K, Connors C, Choy M, Page R, Peti W, et al. PTP1B inhibition suggests a therapeutic strategy for Rett syndrome. J Clin Invest. 2015;125:3163-77 pubmed publisher
  • western blot; mouse; 1:200; fig 2
Lee I, Hüttemann M, Kruger A, Bollig Fischer A, Malek M. (-)-Epicatechin combined with 8 weeks of treadmill exercise is associated with increased angiogenic and mitochondrial signaling in mice. Front Pharmacol. 2015;6:43 pubmed publisher
  • western blot; mouse; 1:1000; fig 7
Tontonoz P, Cortez Toledo O, Wroblewski K, Hong C, Lim L, Carranza R, et al. The orphan nuclear receptor Nur77 is a determinant of myofiber size and muscle mass in mice. Mol Cell Biol. 2015;35:1125-38 pubmed publisher
  • western blot; mouse
  • western blot; rat
Jaishy B, Zhang Q, Chung H, Riehle C, Soto J, Jenkins S, et al. Lipid-induced NOX2 activation inhibits autophagic flux by impairing lysosomal enzyme activity. J Lipid Res. 2015;56:546-61 pubmed publisher
  • western blot; human; fig 6
Huertas Martínez J, Rello Varona S, Herrero Martín D, Barrau I, García Monclús S, Sáinz Jaspeado M, et al. Caveolin-1 is down-regulated in alveolar rhabdomyosarcomas and negatively regulates tumor growth. Oncotarget. 2014;5:9744-55 pubmed
  • western blot; mouse; fig 2a
Chu Y, Gómez Rosso L, Huang P, Wang Z, Xu Y, Yao X, et al. Liver Med23 ablation improves glucose and lipid metabolism through modulating FOXO1 activity. Cell Res. 2014;24:1250-65 pubmed publisher
  • western blot; human; 1:500
Stefanetti R, Lamon S, Wallace M, Vendelbo M, Russell A, Vissing K. Regulation of ubiquitin proteasome pathway molecular markers in response to endurance and resistance exercise and training. Pflugers Arch. 2015;467:1523-1537 pubmed publisher
  • western blot; mouse; 1:500
E L, Burns J, Swerdlow R. Effect of high-intensity exercise on aged mouse brain mitochondria, neurogenesis, and inflammation. Neurobiol Aging. 2014;35:2574-2583 pubmed publisher
  • western blot; mouse; fig 3a
  • western blot; human; fig 4a
Zheng X, Zhai B, Koivunen P, Shin S, Lu G, Liu J, et al. Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase. Genes Dev. 2014;28:1429-44 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100
Harman J, Richburg J. Cisplatin-induced alterations in the functional spermatogonial stem cell pool and niche in C57/BL/6J mice following a clinically relevant multi-cycle exposure. Toxicol Lett. 2014;227:99-112 pubmed publisher
  • western blot; human; 1:500; fig 10c
Lu T, Aron L, Zullo J, Pan Y, Kim H, Chen Y, et al. REST and stress resistance in ageing and Alzheimer's disease. Nature. 2014;507:448-54 pubmed publisher
  • western blot; human; 1:500
Stefanetti R, Zacharewicz E, Della Gatta P, Garnham A, Russell A, Lamon S. Ageing has no effect on the regulation of the ubiquitin proteasome-related genes and proteins following resistance exercise. Front Physiol. 2014;5:30 pubmed publisher
  • immunoprecipitation; human
  • western blot; human
Tanaka T, Iino M. Knockdown of Sec8 promotes cell-cycle arrest at G1/S phase by inducing p21 via control of FOXO proteins. FEBS J. 2014;281:1068-84 pubmed publisher
  • western blot; mouse; fig 5
Tan S, Shui G, Zhou J, Shi Y, Huang J, Xia D, et al. Critical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled AKT-FOXO1 signaling pathway. Autophagy. 2014;10:226-42 pubmed publisher
  • western blot; mouse; 1:1000
Zhang Y, Zhang X, Gao L, Liu Y, Jiang D, Chen K, et al. Growth/differentiation factor 1 alleviates pressure overload-induced cardiac hypertrophy and dysfunction. Biochim Biophys Acta. 2014;1842:232-44 pubmed publisher
  • western blot; human
  • western blot; mouse
Ravnskjaer K, Hogan M, Lackey D, Tora L, Dent S, Olefsky J, et al. Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects. J Clin Invest. 2013;123:4318-28 pubmed publisher
  • western blot; human; fig 4
Shats I, Gatza M, Liu B, Angus S, You L, Nevins J. FOXO transcription factors control E2F1 transcriptional specificity and apoptotic function. Cancer Res. 2013;73:6056-67 pubmed publisher
  • western blot; mouse
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  • western blot; mouse; fig 1b
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product information
SKU :
2880S
Product-Name :
FoxO1 (C29H4) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R, Mk
Applications :
Immunofluorescence (Immunocytochemistry)
Product-Category :
PI3K / Akt Signaling
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
78 to 82
Host :
Rabbit
Target :
Foxo1a
Primary-Protein :
FOXO1A
Alt-Names :
FKH1,FKHR,FOXO1,FOXO1A,Forkhead box protein O1,Forkhead box protein O1A,Forkhead in rhabdomyosarcoma,forkhead box O1,forkhead box O1A (rhabdomyosarcoma),forkhead homolog in rhabdomyosarcoma,forkhead, Drosophila, homolog of, in rhabdomyosarcoma
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.