This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Bcl-2 Antibody
catalog :
2876
quantity :
100 ul
price :
235 USD
clonality :
polyclonal
host :
rabbit
reactivity :
human, mouse, rat
application :
western blot, immunocytochemistry
citations: 46
Published Application/Species/DilutionReference
  • western blot; human; fig s6
Kline C, van den Heuvel A, Allen J, Prabhu V, Dicker D, El-Deiry W. ONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2α kinases. Sci Signal. 2016;9:ra18 pubmed publisher
  • western blot; mouse; fig 3d
Jiang Y, Du M, Wu M, Zhu Y, Zhao X, Cao X, et al. Phosphatidic Acid Improves Reprogramming to Pluripotency by Reducing Apoptosis. Stem Cells Dev. 2016;25:43-54 pubmed publisher
  • western blot; rat; 1:1000; fig 4
Zhang H, Xiong Z, Wang J, Zhang S, Lei L, Yang L, et al. Glucagon-like peptide-1 protects cardiomyocytes from advanced oxidation protein product-induced apoptosis via the PI3K/Akt/Bad signaling pathway. Mol Med Rep. 2016;13:1593-601 pubmed publisher
  • western blot; rat
Asano S, Arvapalli R, Manne N, Maheshwari M, Ma B, Rice K, et al. Cerium oxide nanoparticle treatment ameliorates peritonitis-induced diaphragm dysfunction. Int J Nanomedicine. 2015;10:6215-25 pubmed publisher
  • western blot; mouse; fig 4A
Wang Z, Liu N, Liu K, Zhou G, Gan J, Wang Z, et al. Autophagy mediated CoCrMo particle-induced peri-implant osteolysis by promoting osteoblast apoptosis. Autophagy. 2015;11:2358-69 pubmed publisher
  • western blot; mouse; 1:1000
Lee Y, Liu C, Liao M, Sukhova G, Shirakawa J, Abdennour M, et al. Deficiency of FcϵR1 Increases Body Weight Gain but Improves Glucose Tolerance in Diet-Induced Obese Mice. Endocrinology. 2015;156:4047-58 pubmed publisher
  • immunocytochemistry; human
  • western blot; rat
Zhang L, Wang H, Ding K, Xu J. FTY720 induces autophagy-related apoptosis and necroptosis in human glioblastoma cells. Toxicol Lett. 2015;236:43-59 pubmed publisher
  • western blot; human; 1:1000; fig 5, 6
Zhou J, Lin J, Liu L, Zheng Y, Hong Z. Qianliening capsules influence the apoptosis of benign prostatic hyperplasia epithelial-1 cells by regulating the extracellular matrix. Mol Med Rep. 2015;11:3734-40 pubmed publisher
  • western blot; human; 1:500; fig s3
Lu T, Aron L, Zullo J, Pan Y, Kim H, Chen Y, et al. REST and stress resistance in ageing and Alzheimer's disease. Nature. 2014;507:448-54 pubmed publisher
  • western blot; human
Liu W, Han F, Du X, Jiang X, Li Y, Liu Y, et al. Epigenetic silencing of Aristaless-like homeobox-4, a potential tumor suppressor gene associated with lung cancer. Int J Cancer. 2014;134:1311-22 pubmed publisher
  • western blot; rat; 1:1000
Ding Y, Xu Y, Shuai X, Shi X, Chen X, Huang W, et al. Reg3α Overexpression Protects Pancreatic Beta-Cells From Cytokine-Induced Damage and Improves Islet Transplant Outcome. Mol Med. 2014;: pubmed publisher
Liu T, Shi Y, Wang E, Zhu T, Zhao Q. AT1R blocker losartan attenuates intestinal epithelial cell apoptosis in a mouse model of Crohn's disease. Mol Med Rep. 2016;13:1156-62 pubmed publisher
Liu X, Ward K, Xavier C, Jann J, Clark A, Pang I, et al. The novel triterpenoid RTA 408 protects human retinal pigment epithelial cells against H2O2-induced cell injury via NF-E2-related factor 2 (Nrf2) activation. Redox Biol. 2016;8:98-109 pubmed publisher
Zhang C, Fu J, Xue F, Ryu B, Zhang T, Zhang S, et al. Knockdown of ribosomal protein S15A induces human glioblastoma cell apoptosis. World J Surg Oncol. 2016;14:129 pubmed publisher
Su H, Waldron R, Gong R, Ramanujan V, Pandol S, Lugea A. The Unfolded Protein Response Plays a Predominant Homeostatic Role in Response to Mitochondrial Stress in Pancreatic Stellate Cells. PLoS ONE. 2016;11:e0148999 pubmed publisher
Cheng C, Tang N, Kao S, Hsieh C. Ferulic Acid Administered at Various Time Points Protects against Cerebral Infarction by Activating p38 MAPK/p90RSK/CREB/Bcl-2 Anti-Apoptotic Signaling in the Subacute Phase of Cerebral Ischemia-Reperfusion Injury in Rats. PLoS ONE. 2016;11:e0155748 pubmed publisher
Zhang F, Cui J, Lv B, Yu B. Nicorandil protects mesenchymal stem cells against hypoxia and serum deprivation-induced apoptosis. Int J Mol Med. 2015;36:415-23 pubmed publisher
Jiang J, Zhou C, Gao S, Tian Y, Wang C, Wang L, et al. BDNF-TrkB pathway mediates neuroprotection of hydrogen sulfide against formaldehyde-induced toxicity to PC12 cells. PLoS ONE. 2015;10:e0119478 pubmed publisher
Wang H, Li J, Chi H, Zhang F, Zhu X, Cai J, et al. MicroRNA-181c targets Bcl-2 and regulates mitochondrial morphology in myocardial cells. J Cell Mol Med. 2015;19:2084-97 pubmed publisher
Cheng C, Lin J, Tang N, Kao S, Hsieh C. Electroacupuncture at different frequencies (5Hz and 25Hz) ameliorates cerebral ischemia-reperfusion injury in rats: possible involvement of p38 MAPK-mediated anti-apoptotic signaling pathways. BMC Complement Altern Med. 2015;15:241 pubmed publisher
Wang X, Parrish A. Loss of α(E)-catenin promotes Fas mediated apoptosis in tubular epithelial cells. Apoptosis. 2015;20:921-9 pubmed publisher
Huang K, Dong B, Wang Y, Tian T, Zhang B. MicroRNA-519 enhances HL60 human acute myeloid leukemia cell line proliferation by reducing the expression level of RNA-binding protein human antigen R. Mol Med Rep. 2015;12:7830-6 pubmed publisher
Reddy N, Shoja M, Jayashree B, Nayak P, Kumar N, Prasad V, et al. In vitro and in vivo evaluation of novel cinnamyl sulfonamide hydroxamate derivative against colon adenocarcinoma. Chem Biol Interact. 2015;233:81-94 pubmed publisher
Kong L, Hao Q, Wang Y, Zhou P, Zou B, Zhang Y. Regulation of p53 expression and apoptosis by vault RNA2-1-5p in cervical cancer cells. Oncotarget. 2015;6:28371-88 pubmed publisher
Arabian M, Aboutaleb N, Soleimani M, Mehrjerdi F, Ajami M, Pazoki-Toroudi H. Role of morphine preconditioning and nitric oxide following brain ischemia reperfusion injury in mice. Iran J Basic Med Sci. 2015;18:14-21 pubmed
Zanardelli M, Micheli L, Nicolai R, Failli P, Ghelardini C, Di Cesare Mannelli L. Different apoptotic pathways activated by oxaliplatin in primary astrocytes vs. colo-rectal cancer cells. Int J Mol Sci. 2015;16:5386-99 pubmed publisher
Ran X, Diao J, Sun X, Wang M, An H, Huang G, et al. Huangzhi Oral Liquid Prevents Arrhythmias by Upregulating Caspase-3 and Apoptosis Network Proteins in Myocardial Ischemia-Reperfusion Injury in Rats. Evid Based Complement Alternat Med. 2015;2015:518926 pubmed publisher
Zhang T, Yang S, Du J. Protective Effects of Berberine on Isoproterenol-Induced Acute Myocardial Ischemia in Rats through Regulating HMGB1-TLR4 Axis. Evid Based Complement Alternat Med. 2014;2014:849783 pubmed publisher
Zekavati A, Nasir A, Alcaraz A, Aldrovandi M, Marsh P, Norton J, et al. Post-transcriptional regulation of BCL2 mRNA by the RNA-binding protein ZFP36L1 in malignant B cells. PLoS ONE. 2014;9:e102625 pubmed publisher
Widenmaier S, Ao Z, Kim S, Warnock G, McIntosh C. Suppression of p38 MAPK and JNK via Akt-mediated inhibition of apoptosis signal-regulating kinase 1 constitutes a core component of the beta-cell pro-survival effects of glucose-dependent insulinotropic polypeptide. J Biol Chem. 2009;284:30372-82 pubmed publisher
Choi H, Shin J, Lee H, Kim J, Huh C, Youn S, et al. Potential redox-sensitive Akt activation by dopamine activates Bad and promotes cell death in melanocytes. Oxid Med Cell Longev. 2010;3:219-24 pubmed publisher
Li J, Li Y, Jin W, Yang Q, Shao Z, Tian X. ABT-737 reverses the acquired radioresistance of breast cancer cells by targeting Bcl-2 and Bcl-xL. J Exp Clin Cancer Res. 2012;31:102 pubmed publisher
Kannan S, Sutphin R, Hall M, Golfman L, Fang W, Nolo R, et al. Notch activation inhibits AML growth and survival: a potential therapeutic approach. J Exp Med. 2013;210:321-37 pubmed publisher
Concepcion C, Han Y, Mu P, Bonetti C, Yao E, D'Andrea A, et al. Intact p53-dependent responses in miR-34-deficient mice. PLoS Genet. 2012;8:e1002797 pubmed publisher
Yan W, Fang Z, Yang Q, Dong H, Lu Y, Lei C, et al. SirT1 mediates hyperbaric oxygen preconditioning-induced ischemic tolerance in rat brain. J Cereb Blood Flow Metab. 2013;33:396-406 pubmed publisher
Ho J, Asagiri M, Hoffmann A, Ghosh G. NF-κB potentiates caspase independent hydrogen peroxide induced cell death. PLoS ONE. 2011;6:e16815 pubmed publisher
Bhargavan B, Fatma N, Chhunchha B, Singh V, Kubo E, Singh D. LEDGF gene silencing impairs the tumorigenicity of prostate cancer DU145 cells by abating the expression of Hsp27 and activation of the Akt/ERK signaling pathway. Cell Death Dis. 2012;3:e316 pubmed publisher
Li X, Chen W, Zhang L, Liu W, Fei Z. Inhibition of store-operated calcium entry attenuates MPP(+)-induced oxidative stress via preservation of mitochondrial function in PC12 cells: involvement of Homer1a. PLoS ONE. 2013;8:e83638 pubmed publisher
Hong X, Bu L, Wang Y, Xu J, Wu J, Huang Y, et al. Increases in the risk of cognitive impairment and alterations of cerebral β-amyloid metabolism in mouse model of heart failure. PLoS ONE. 2013;8:e63829 pubmed publisher
Qiu R, Cai A, Dong Y, Zhou Y, Yu D, Huang Y, et al. SDF-1α upregulation by atorvastatin in rats with acute myocardial infarction via nitric oxide production confers anti-inflammatory and anti-apoptotic effects. J Biomed Sci. 2012;19:99 pubmed publisher
Bennett B, Mohamed J, Alway S. Effects of resveratrol on the recovery of muscle mass following disuse in the plantaris muscle of aged rats. PLoS ONE. 2013;8:e83518 pubmed publisher
Ulasov I, Sonabend A, Nandi S, Khramtsov A, Han Y, Lesniak M. Combination of adenoviral virotherapy and temozolomide chemotherapy eradicates malignant glioma through autophagic and apoptotic cell death in vivo. Br J Cancer. 2009;100:1154-64 pubmed publisher
Szepeshazi K, Schally A, Keller G, Block N, Benten D, Halmos G, et al. Receptor-targeted therapy of human experimental urinary bladder cancers with cytotoxic LH-RH analog AN-152 [AEZS- 108]. Oncotarget. 2012;3:686-99 pubmed
Gao L, Jiang T, Guo J, Liu Y, Cui G, Gu L, et al. Inhibition of autophagy contributes to ischemic postconditioning-induced neuroprotection against focal cerebral ischemia in rats. PLoS ONE. 2012;7:e46092 pubmed publisher
Liu N, Du X, Lu J, He B. Diva reduces cell death in response to oxidative stress and cytotoxicity. PLoS ONE. 2012;7:e43180 pubmed publisher
Woo T, Li S, Lai W, Wong D, Lo A. Neuroprotective effects of lutein in a rat model of retinal detachment. Graefes Arch Clin Exp Ophthalmol. 2013;251:41-51 pubmed publisher
product information
SKU :
2876S
Product-Name :
Bcl-2 Antibody
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R
Applications :
Western blot
Product-Category :
Apoptosis
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Polyclonal Antibody
MW :
28
Host :
Rabbit
Target :
Bcl-2
Primary-Protein :
Bcl-2
Alt-Names :
Apoptosis regulator Bcl-2,B-cell CLL/lymphoma 2,BCL2,Bcl-2
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.