product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
ATM (D2E2) Rabbit mAb
catalog :
2873S
quantity :
100 ul
price :
235 USD
clonality :
monoclonal
host :
rabbit
reactivity :
human, mouse
application :
western blot, immunoprecipitation
citations: 22
Published Application/Species/DilutionReference
  • western blot (knockdown validation); human; fig 2g
Guo Y, Feng W, Sy S, Huen M. ATM-dependent Phosphorylation of the Fanconi Anemia Protein PALB2 Promotes the DNA Damage Response. J Biol Chem. 2015;290:27545-56 pubmed publisher
  • western blot; human; 1:100; fig st1
Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher
  • western blot; human; fig 2
Kralovicova J, Knut M, Cross N, Vorechovsky I. Exon-centric regulation of ATM expression is population-dependent and amenable to antisense modification by pseudoexon targeting. Sci Rep. 2016;6:18741 pubmed publisher
  • western blot; human; 1:1000; fig 8
Yang H, Wu L, Ke S, Wang W, Yang L, Gao X, et al. Downregulation of Ubiquitin-conjugating Enzyme UBE2D3 Promotes Telomere Maintenance and Radioresistance of Eca-109 Human Esophageal Carcinoma Cells. J Cancer. 2016;7:1152-62 pubmed publisher
  • western blot; human; fig 4d
Chavoshi S, Egorova O, Lacdao I, Farhadi S, Sheng Y, Saridakis V. Identification of Kaposi Sarcoma Herpesvirus (KSHV) vIRF1 Protein as a Novel Interaction Partner of Human Deubiquitinase USP7. J Biol Chem. 2016;291:6281-91 pubmed publisher
  • western blot; human; fig S4
Sears C, Cooney S, Chin-Sinex H, Mendonca M, Turchi J. DNA damage response (DDR) pathway engagement in cisplatin radiosensitization of non-small cell lung cancer. DNA Repair (Amst). 2016;40:35-46 pubmed publisher
  • western blot; human; 1:1000; fig 1,2,3,4,5,6,7
Desantis A, Bruno T, Catena V, De Nicola F, Goeman F, Iezzi S, et al. Che-1-induced inhibition of mTOR pathway enables stress-induced autophagy. EMBO J. 2015;34:1214-30 pubmed publisher
  • western blot; mouse; fig 8f
Martin B, Chadwick W, Janssens J, Premont R, Schmalzigaug R, Becker K, et al. GIT2 Acts as a Systems-Level Coordinator of Neurometabolic Activity and Pathophysiological Aging. Front Endocrinol (Lausanne). 2015;6:191 pubmed publisher
  • western blot; human; 1:1000; fig 1g
Masuda Y, Takahashi H, Sato S, Tomomori-Sato C, Saraf A, Washburn M, et al. TRIM29 regulates the assembly of DNA repair proteins into damaged chromatin. Nat Commun. 2015;6:7299 pubmed publisher
  • western blot; human; fig S11
Wang L, Liu R, Ye P, Wong C, Chen G, Zhou P, et al. Intracellular CD24 disrupts the ARF-NPM interaction and enables mutational and viral oncogene-mediated p53 inactivation. Nat Commun. 2015;6:5909 pubmed publisher
  • western blot; mouse; fig s3
Hartlerode A, Morgan M, Wu Y, Buis J, Ferguson D. Recruitment and activation of the ATM kinase in the absence of DNA-damage sensors. Nat Struct Mol Biol. 2015;22:736-43 pubmed publisher
  • western blot; human; fig 5
Neumann J, Yang Y, Kohler R, Giaisi M, Witzens-Harig M, Liu D, et al. Mangrove dolabrane-type of diterpenes tagalsins suppresses tumor growth via ROS-mediated apoptosis and ATM/ATR-Chk1/Chk2-regulated cell cycle arrest. Int J Cancer. 2015;137:2739-48 pubmed publisher
  • western blot; human; fig 3h
Torres M, Pandita R, Kulak O, Kumar R, Formstecher E, Horikoshi N, et al. Role of the Exocyst Complex Component Sec6/8 in Genomic Stability. Mol Cell Biol. 2015;35:3633-45 pubmed publisher
  • western blot; human
Lin B, Gupta D, Heinen C. Human pluripotent stem cells have a novel mismatch repair-dependent damage response. J Biol Chem. 2014;289:24314-24 pubmed publisher
  • western blot; mouse
Schweikl H, Petzel C, Bolay C, Hiller K, Buchalla W, Krifka S. 2-Hydroxyethyl methacrylate-induced apoptosis through the ATM- and p53-dependent intrinsic mitochondrial pathway. Biomaterials. 2014;35:2890-904 pubmed publisher
  • western blot; human
Hu R, Wang E, Peng G, Dai H, Lin S. Zinc finger protein 668 interacts with Tip60 to promote H2AX acetylation after DNA damage. Cell Cycle. 2013;12:2033-41 pubmed publisher
  • western blot; human; 1:1000
Chen Y, Kamili A, Hardy J, Groblewski G, Khanna K, Byrne J. Tumor protein D52 represents a negative regulator of ATM protein levels. Cell Cycle. 2013;12:3083-97 pubmed publisher
Krześniak M, Zajkowicz A, Matuszczyk I, Rusin M. Rapamycin prevents strong phosphorylation of p53 on serine 46 and attenuates activation of the p53 pathway in A549 lung cancer cells exposed to actinomycin D. Mech Ageing Dev. 2014;139:11-21 pubmed publisher
Rizos H, Menzies A, Pupo G, Carlino M, Fung C, Hyman J, et al. BRAF inhibitor resistance mechanisms in metastatic melanoma: spectrum and clinical impact. Clin Cancer Res. 2014;20:1965-77 pubmed publisher
Tang H, Sampath P, Yan X, Thorne S. Potential for enhanced therapeutic activity of biological cancer therapies with doxycycline combination. Gene Ther. 2013;20:770-8 pubmed publisher
Hawkes W, Printsev I, Alkan Z. Selenoprotein W depletion induces a p53- and p21-dependent delay in cell cycle progression in RWPE-1 prostate epithelial cells. J Cell Biochem. 2012;113:61-9 pubmed publisher
Zhu H, Yue J, Pan Z, Wu H, Cheng Y, Lu H, et al. Involvement of Caveolin-1 in repair of DNA damage through both homologous recombination and non-homologous end joining. PLoS ONE. 2010;5:e12055 pubmed publisher
product information
SKU :
2873S
Product-Name :
ATM (D2E2) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M
Applications :
Western blot
Product-Category :
Cell Cycle / Checkpoint Control
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
350
Host :
Rabbit
Target :
ATM
Primary-Protein :
ATM
Alt-Names :
A-T mutated,AT mutated,AT1,ATA,ATC,ATD,ATDC,ATE,ATM,Ataxia telangiectasia mutated,DKFZp781A0353,MGC74674,Serine-protein kinase ATM,TEL1,TEL1, telomere maintenance 1, homolog,TELO1,ataxia telangiectasia mutated (includes complementation groups A, C and D),human phosphatidylinositol 3-kinase homolog
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.