| Published Application/Species/Dilution | Reference |
|---|
- western blot (knockdown validation); human; fig 1
- western blot; mouse; fig 1
| Yosef R, Pilpel N, Tokarsky-Amiel R, Biran A, Ovadya Y, Cohen S, et al. Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL. Nat Commun. 2016;7:11190 pubmed publisher |
- western blot; human; 1:1000; fig 3
| Li L, Liu H, Wang C, Liu X, Hu F, Xie N, et al. Overexpression of β-Catenin Induces Cisplatin Resistance in Oral Squamous Cell Carcinoma. Biomed Res Int. 2016;2016:5378567 pubmed publisher |
- western blot; mouse; fig 3
| Mollá B, Riveiro F, Bolinches-Amorós A, Muñoz-Lasso D, Palau F, Gonzalez-Cabo P. Two different pathogenic mechanisms, dying-back axonal neuropathy and pancreatic senescence, are present in the YG8R mouse model of Friedreich's ataxia. Dis Model Mech. 2016;9:647-57 pubmed publisher |
- western blot; human; fig 4
| Zhao F, Huang W, Zhang Z, Mao L, Han Y, Yan J, et al. Triptolide induces protective autophagy through activation of the CaMKKβ-AMPK signaling pathway in prostate cancer cells. Oncotarget. 2016;7:5366-82 pubmed publisher |
- western blot; human; fig 2
| Kim H, Oh J, Choi S, Nam Y, Jo A, Kwon A, et al. Down-regulation of p21-activated serine/threonine kinase 1 is involved in loss of mesencephalic dopamine neurons. Mol Brain. 2016;9:45 pubmed publisher |
- western blot; human; 1:1000; fig st1
| Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher |
- western blot; human; 1:1000; fig 5
| Bao H, Liu P, Jiang K, Zhang X, Xie L, Wang Z, et al. Huaier polysaccharide induces apoptosis in hepatocellular carcinoma cells through p38 MAPK. Oncol Lett. 2016;12:1058-1066 pubmed |
- western blot; human; fig 5
| Wang F, Feng Y, Li P, Wang K, Feng L, Liu Y, et al. RASSF10 is an epigenetically inactivated tumor suppressor and independent prognostic factor in hepatocellular carcinoma. Oncotarget. 2016;7:4279-97 pubmed publisher |
- western blot; human; fig 4
| Xia Z, Huang X, Chen K, Wang H, Xiao J, He K, et al. Proapoptotic Role of Potassium Ions in Liver Cells. Biomed Res Int. 2016;2016:1729135 pubmed publisher |
- western blot; human; 1:1000; fig 1
| Yu L, Wu W, Gu C, Zhong D, Zhao X, Kong Y, et al. Obatoclax impairs lysosomal function to block autophagy in cisplatin-sensitive and -resistant esophageal cancer cells. Oncotarget. 2016;7:14693-707 pubmed publisher |
| Bao M, Cai Z, Zhang X, Li L, Liu X, Wan N, et al. Dickkopf-3 protects against cardiac dysfunction and ventricular remodelling following myocardial infarction. Basic Res Cardiol. 2015;110:25 pubmed publisher |
| Zou J, Li W, Misra A, Yue F, Song K, Chen Q, et al. The viral restriction factor tetherin prevents leucine-rich pentatricopeptide repeat-containing protein (LRPPRC) from association with beclin 1 and B-cell CLL/lymphoma 2 (Bcl-2) and enhances autophagy and mitophagy. J Biol Chem. 2015;290:7269-79 pubmed publisher |
- western blot; human; 1:1000; tbl 1
| Vega-Naredo I, Cunha-Oliveira T, Serafim T, Sardao V, Oliveira P. Analysis of pro-apoptotic protein trafficking to and from mitochondria. Methods Mol Biol. 2015;1241:163-80 pubmed publisher |
| Liu H, Xie Q, Xin B, Liu J, Liu Y, Li Y, et al. Inhibition of autophagy recovers cardiac dysfunction and atrophy in response to tail-suspension. Life Sci. 2015;121:1-9 pubmed publisher |
- western blot; rat; 1:1000; fig 8
| Chen L, Tao Y, Feng J, Jiang Y. Apelin Protects Primary Rat Retinal Pericytes from Chemical Hypoxia-Induced Apoptosis. J Ophthalmol. 2015;2015:186946 pubmed publisher |
- western blot; human; fig 3
| Yang L, Li Y, Bhattacharya A, Zhang Y. Inhibition of ERBB2-overexpressing Tumors by Recombinant Human Prolidase and Its Enzymatically Inactive Mutant. EBioMedicine. 2015;2:396-405 pubmed |
- western blot; mouse; 1:1000
| Xu L, Ouyang Y, Xiong X, Stary C, Giffard R. Post-stroke treatment with miR-181 antagomir reduces injury and improves long-term behavioral recovery in mice after focal cerebral ischemia. Exp Neurol. 2015;264:1-7 pubmed publisher |
- western blot; rat; 1:1000; fig 4
| Liu K, Chuang S, Long C, Lee Y, Wang C, Lu M, et al. Ketamine-induced ulcerative cystitis and bladder apoptosis involve oxidative stress mediated by mitochondria and the endoplasmic reticulum. Am J Physiol Renal Physiol. 2015;309:F318-31 pubmed publisher |
- western blot; human; 1:1000
| Hsu H, Liu Y, Tseng K, Tan B, Chen S, Chen H. LGR5 regulates survival through mitochondria-mediated apoptosis and by targeting the Wnt/β-catenin signaling pathway in colorectal cancer cells. Cell Signal. 2014;26:2333-42 pubmed publisher |
| Fan Y, Meley D, Pizer B, See V. Mir-34a mimics are potential therapeutic agents for p53-mutated and chemo-resistant brain tumour cells. PLoS ONE. 2014;9:e108514 pubmed publisher |
- western blot; mouse
- immunoprecipitation; mouse
| Bai L, Chen J, McEachern D, Liu L, Zhou H, Aguilar A, et al. BM-1197: a novel and specific Bcl-2/Bcl-xL inhibitor inducing complete and long-lasting tumor regression in vivo. PLoS ONE. 2014;9:e99404 pubmed publisher |
- western blot; human; 1:1000
- western blot; rat; 1:1000
| Borkham-Kamphorst E, Schaffrath C, Van De Leur E, Haas U, Tihaa L, Meurer S, et al. The anti-fibrotic effects of CCN1/CYR61 in primary portal myofibroblasts are mediated through induction of reactive oxygen species resulting in cellular senescence, apoptosis and attenuated TGF-β signaling. Biochim Biophys Acta. 2014;1843:902-14 pubmed publisher |
| Dai J, Shen D, Bian Z, Zhou H, Gan H, Zong J, et al. IKKi deficiency promotes pressure overload-induced cardiac hypertrophy and fibrosis. PLoS ONE. 2013;8:e53412 pubmed publisher |
| Huang M, Sivagurunathan S, Ting S, Jansson P, Austin C, Kelly M, et al. Molecular and functional alterations in a mouse cardiac model of Friedreich ataxia: activation of the integrated stress response, eIF2α phosphorylation, and the induction of downstream targets. Am J Pathol. 2013;183:745-57 pubmed publisher |
| Nakamura K, Aizawa K, Nakabayashi K, Kato N, Yamauchi J, Hata K, et al. DNA methyltransferase inhibitor zebularine inhibits human hepatic carcinoma cells proliferation and induces apoptosis. PLoS ONE. 2013;8:e54036 pubmed publisher |
| Li W, Zhong S, Wu Y, Xu W, Xu J, Tang J, et al. Systematic expression analysis of genes related to multidrug-resistance in isogenic docetaxel- and adriamycin-resistant breast cancer cell lines. Mol Biol Rep. 2013;40:6143-50 pubmed |
| Sanders Y, Liu H, Zhang X, Hecker L, Bernard K, Desai L, et al. Histone modifications in senescence-associated resistance to apoptosis by oxidative stress. Redox Biol. 2013;1:8-16 pubmed publisher |
- western blot; human; 1:1000
| Zhang C, Zhao Y, Zeng B. Enhanced chemosensitivity by simultaneously inhibiting cell cycle progression and promoting apoptosis of drug-resistant osteosarcoma MG63/DXR cells by targeting Cyclin D1 and Bcl-2. Cancer Biomark. 2012;12:155-67 pubmed publisher |
| Li D, Wang J, Hou J, Fu J, Chang D, Bensoussan A, et al. Ginsenoside Rg1 protects starving H9c2 cells by dissociation of Bcl-2-Beclin1 complex. BMC Complement Altern Med. 2016;16:146 pubmed publisher |
| Zhou J, Xu Z, Li N, Zhao Y, Wang Z, Xiao W. Identification of cardioprotective agents from traditional Chinese medicine against oxidative damage. Mol Med Rep. 2016;14:77-88 pubmed publisher |
| Wang L, Liu X, Chen H, Chen Z, Weng X, Qiu T, et al. Effect of picroside II on apoptosis induced by renal ischemia/reperfusion injury in rats. Exp Ther Med. 2015;9:817-822 pubmed |
| Wei Z, Yu D, Bi Y, Cao Y. A disintegrin and metalloprotease 17 promotes microglial cell survival via epidermal growth factor receptor signalling following spinal cord injury. Mol Med Rep. 2015;12:63-70 pubmed publisher |
| Lu K, Fang X, Feng L, Jiang Y, Zhou X, Liu X, et al. The STAT3 inhibitor WP1066 reverses the resistance of chronic lymphocytic leukemia cells to histone deacetylase inhibitors induced by interleukin-6. Cancer Lett. 2015;359:250-8 pubmed publisher |
| Zang X, An S, Feng Z, Xia Y, Song Y, Yu Q. In vivo mechanism study of NGAL in rat renal ischemia-reperfusion injury. Genet Mol Res. 2014;13:8740-8 pubmed publisher |
| Gao Y, Trivedi S, Ferris R, Koide K. Regulation of HPV16 E6 and MCL1 by SF3B1 inhibitor in head and neck cancer cells. Sci Rep. 2014;4:6098 pubmed publisher |
| Keitel U, Scheel A, Thomale J, Halpape R, Kaulfuß S, Scheel C, et al. Bcl-xL mediates therapeutic resistance of a mesenchymal breast cancer cell subpopulation. Oncotarget. 2014;5:11778-91 pubmed |
| Tseng C, Hong Y, Chang H, Yu T, Hung T, Hou M, et al. Brefeldin A reduces anchorage-independent survival, cancer stem cell potential and migration of MDA-MB-231 human breast cancer cells. Molecules. 2014;19:17464-77 pubmed publisher |
| Shu Q, Li W, Li H, Sun G. Vasostatin inhibits VEGF-induced endothelial cell proliferation, tube formation and induces cell apoptosis under oxygen deprivation. Int J Mol Sci. 2014;15:6019-30 pubmed publisher |
| Umeshappa C, Xie Y, Xu S, Nanjundappa R, Freywald A, Deng Y, et al. Th cells promote CTL survival and memory via acquired pMHC-I and endogenous IL-2 and CD40L signaling and by modulating apoptosis-controlling pathways. PLoS ONE. 2013;8:e64787 pubmed publisher |
| Li S, Wu C, Chen J, Lu P, Chen C, Fu M, et al. An effective solution to discover synergistic drugs for anti-cerebral ischemia from traditional Chinese medicinal formulae. PLoS ONE. 2013;8:e78902 pubmed publisher |
| Dzieran J, Fabian J, Feng T, Coulouarn C, Ilkavets I, Kyselova A, et al. Comparative analysis of TGF-β/Smad signaling dependent cytostasis in human hepatocellular carcinoma cell lines. PLoS ONE. 2013;8:e72252 pubmed publisher |
| Schulman J, Wright F, Kaufmann T, Wojcikiewicz R. The Bcl-2 protein family member Bok binds to the coupling domain of inositol 1,4,5-trisphosphate receptors and protects them from proteolytic cleavage. J Biol Chem. 2013;288:25340-9 pubmed publisher |
| Guo X, Dong Y, Yin S, Zhao C, Huo Y, Fan L, et al. Patulin induces pro-survival functions via autophagy inhibition and p62 accumulation. Cell Death Dis. 2013;4:e822 pubmed publisher |
| Peng Z, Liu M, Fang Z, Chen L, Wu J, Zhang Q. In vitro antiproliferative effect of a water-soluble Laminaria japonica polysaccharide on human melanoma cell line A375. Food Chem Toxicol. 2013;58:56-60 pubmed publisher |
| Simões V, Alves M, Martins A, Dias T, Rato L, Socorro S, et al. Regulation of apoptotic signaling pathways by 5α-dihydrotestosterone and 17β-estradiol in immature rat Sertoli cells. J Steroid Biochem Mol Biol. 2013;135:15-23 pubmed publisher |
| Gong L, Yu H, Zhuge Y, Yu Q. Neutrophil gelatinase-associated lipocalin protects renal tubular epithelial cell in ischemic/reperfusion injury rats via apoptosis-regulating proteins. Ren Fail. 2012;34:777-83 pubmed publisher |
| Xiang X, Phung Y, Feng M, Nagashima K, Zhang J, Broaddus V, et al. The development and characterization of a human mesothelioma in vitro 3D model to investigate immunotoxin therapy. PLoS ONE. 2011;6:e14640 pubmed publisher |
| van Oosterwijk J, Herpers B, Meijer D, Briaire-de Bruijn I, Cleton-Jansen A, Gelderblom H, et al. Restoration of chemosensitivity for doxorubicin and cisplatin in chondrosarcoma in vitro: BCL-2 family members cause chemoresistance. Ann Oncol. 2012;23:1617-26 pubmed publisher |
