product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Phospho-IκBα (Ser32) (14D4) Rabbit mAb
catalog :
2859L
quantity :
300 ul
price :
658 USD
clonality :
monoclonal
host :
rabbit
antigen modification :
phosphorylated
clone name :
14D4
reactivity :
human, mouse, rat, dog, cow
application :
western blot, immunocytochemistry, immunoprecipitation, flow cytometry
citations: 36
Published Application/Species/DilutionReference
  • western blot; mouse; fig 4
Yang Y, Andersson P, Hosaka K, Zhang Y, Cao R, Iwamoto H, et al. The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages. Nat Commun. 2016;7:11385 pubmed publisher
  • western blot; human; fig 5
Zeng W, Liu Q, Chen Z, Wu X, Zhong Y, Wu J. Silencing of hERG1 Gene Inhibits Proliferation and Invasion, and Induces Apoptosis in Human Osteosarcoma Cells by Targeting the NF-κB Pathway. J Cancer. 2016;7:746-57 pubmed publisher
  • western blot; rat; 1:1000; fig 5
Li X, Chen Y, Wang L, Shang G, Zhang C, Zhao Z, et al. Quercetin alleviates pulmonary angiogenesis in a rat model of hepatopulmonary syndrome. Braz J Med Biol Res. 2016;49: pubmed publisher
  • western blot; rat; 1:1000
Maurya S, Mishra J, Abbas S, Bandyopadhyay S. Cypermethrin Stimulates GSK3β-Dependent Aβ and p-tau Proteins and Cognitive Loss in Young Rats: Reduced HB-EGF Signaling and Downstream Neuroinflammation as Critical Regulators. Mol Neurobiol. 2016;53:968-82 pubmed publisher
  • western blot; mouse; 1:200
Zarpelon A, Rodrigues F, Lopes A, Souza G, Carvalho T, Pinto L, et al. Spinal cord oligodendrocyte-derived alarmin IL-33 mediates neuropathic pain. FASEB J. 2016;30:54-65 pubmed publisher
  • western blot; mouse; 1:500; fig 8
Ogura Y, Hindi S, Sato S, Xiong G, Akira S, Kumar A. TAK1 modulates satellite stem cell homeostasis and skeletal muscle repair. Nat Commun. 2015;6:10123 pubmed publisher
  • western blot; human
Wu N, Huang D, Tsou H, Lin Y, Lin W. Syk mediates IL-17-induced CCL20 expression by targeting Act1-dependent K63-linked ubiquitination of TRAF6. J Invest Dermatol. 2015;135:490-8 pubmed publisher
  • western blot; mouse; 1:1000
Hung Y, Hung S, Wu Y, Wong L, Lai M, Shih Y, et al. Soluble epoxide hydrolase activity regulates inflammatory responses and seizure generation in two mouse models of temporal lobe epilepsy. Brain Behav Immun. 2015;43:118-29 pubmed publisher
  • western blot; mouse; fig 9a
Xie C, Wei D, Zhao L, Marchetto S, Mei L, Borg J, et al. Erbin is a novel substrate of the Sag-βTrCP E3 ligase that regulates KrasG12D-induced skin tumorigenesis. J Cell Biol. 2015;209:721-37 pubmed publisher
  • western blot; human; 1:1000
Contreras T, Ricciardi E, Cremonini E, Oteiza P. (-)-Epicatechin in the prevention of tumor necrosis alpha-induced loss of Caco-2 cell barrier integrity. Arch Biochem Biophys. 2015;573:84-91 pubmed publisher
  • western blot; mouse; 1:2000; fig s16c
Aschar-Sobbi R, Izaddoustdar F, Korogyi A, Wang Q, Farman G, Yang F, et al. Increased atrial arrhythmia susceptibility induced by intense endurance exercise in mice requires TNFα. Nat Commun. 2015;6:6018 pubmed publisher
  • western blot; mouse
Yang S, Deng P, Zhu Z, Zhu J, Wang G, Zhang L, et al. Adenosine deaminase acting on RNA 1 limits RIG-I RNA detection and suppresses IFN production responding to viral and endogenous RNAs. J Immunol. 2014;193:3436-45 pubmed publisher
  • western blot; human; 1:1000
  • western blot; mouse; 1:1000
Dou W, Zhang J, Ren G, Ding L, Sun A, Deng C, et al. Mangiferin attenuates the symptoms of dextran sulfate sodium-induced colitis in mice via NF-κB and MAPK signaling inactivation. Int Immunopharmacol. 2014;23:170-8 pubmed publisher
  • western blot; mouse
Baek J, Kim J, Cheon Y, Park S, Ahn S, Yoon K, et al. Aconitum pseudo-laeve var. erectum inhibits receptor activator of nuclear factor kappa-B ligand-induced osteoclastogenesis via the c-Fos/nuclear factor of activated T-cells, cytoplasmic 1 signaling pathway and prevents lipopolysaccharide-induced bone loss. Molecules. 2014;19:11628-44 pubmed publisher
  • western blot; mouse; 1:1000
Watatani H, Maeshima Y, Hinamoto N, Yamasaki H, Ujike H, Tanabe K, et al. Vasohibin-1 deficiency enhances renal fibrosis and inflammation after unilateral ureteral obstruction. Physiol Rep. 2014;2: pubmed publisher
  • immunocytochemistry; rat; 1:400
Cavaretta J, Sherer K, Lee K, Kim E, Issema R, Chung H. Polarized axonal surface expression of neuronal KCNQ potassium channels is regulated by calmodulin interaction with KCNQ2 subunit. PLoS ONE. 2014;9:e103655 pubmed publisher
  • western blot; human
Ramello M, Tosello Boari J, Canale F, Mena H, Negrotto S, Gastman B, et al. Tumor-induced senescent T cells promote the secretion of pro-inflammatory cytokines and angiogenic factors by human monocytes/macrophages through a mechanism that involves Tim-3 and CD40L. Cell Death Dis. 2014;5:e1507 pubmed publisher
  • western blot; human; fig 2
Bist P, Dikshit N, Koh T, Mortellaro A, Tan T, Sukumaran B. The Nod1, Nod2, and Rip2 axis contributes to host immune defense against intracellular Acinetobacter baumannii infection. Infect Immun. 2014;82:1112-22 pubmed publisher
  • western blot; human; 1:1000; fig 5
Lei Q, Qiang F, Chao D, Di W, Guoqian Z, Bo Y, et al. Amelioration of hypoxia and LPS-induced intestinal epithelial barrier dysfunction by emodin through the suppression of the NF-κB and HIF-1α signaling pathways. Int J Mol Med. 2014;34:1629-39 pubmed publisher
Burcham G, Cresswell G, Snyder P, Chen L, Liu X, Crist S, et al. Impact of prostate inflammation on lesion development in the POET3(+)Pten(+/-) mouse model of prostate carcinogenesis. Am J Pathol. 2014;184:3176-91 pubmed publisher
Li X, Jiang J, Shi S, Bligh S, Li Y, Jiang Y, et al. A RG-II type polysaccharide purified from Aconitum coreanum alleviates lipopolysaccharide-induced inflammation by inhibiting the NF-κB signal pathway. PLoS ONE. 2014;9:e99697 pubmed publisher
GAO P, Tao N, Ma Q, Fan W, Ni C, Wang H, et al. DH332, a synthetic β-carboline alkaloid, inhibits B cell lymphoma growth by activation of the caspase family. Asian Pac J Cancer Prev. 2014;15:3901-6 pubmed
Wong S, Chan S, Wong W, Wong P, Lai M. Andrographolide attenuates interleukin-1β-stimulated upregulation of chemokine CCL5 and glial fibrillary acidic protein in astrocytes. Neuroreport. 2014;25:881-6 pubmed publisher
Shembade N, Harhaj N, Yamamoto M, Akira S, Harhaj E. The human T-cell leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-kappaB activation. J Virol. 2007;81:13735-42 pubmed
Rauert H, Stühmer T, Bargou R, Wajant H, Siegmund D. TNFR1 and TNFR2 regulate the extrinsic apoptotic pathway in myeloma cells by multiple mechanisms. Cell Death Dis. 2011;2:e194 pubmed publisher
Salzmann S, Lang I, Rosenthal A, Schäfer V, Weisenberger D, Carmona Arana J, et al. TWEAK inhibits TRAF2-mediated CD40 signaling by destabilization of CD40 signaling complexes. J Immunol. 2013;191:2308-18 pubmed publisher
Taura M, Suico M, Koyama K, Komatsu K, Miyakita R, Matsumoto C, et al. Rb/E2F1 regulates the innate immune receptor Toll-like receptor 3 in epithelial cells. Mol Cell Biol. 2012;32:1581-90 pubmed publisher
Chattopadhyay M, Kodela R, Nath N, Barsegian A, Boring D, Kashfi K. Hydrogen sulfide-releasing aspirin suppresses NF-κB signaling in estrogen receptor negative breast cancer cells in vitro and in vivo. Biochem Pharmacol. 2012;83:723-32 pubmed publisher
Wang H, Syrovets T, Kess D, Büchele B, Hainzl H, Lunov O, et al. Targeting NF-kappa B with a natural triterpenoid alleviates skin inflammation in a mouse model of psoriasis. J Immunol. 2009;183:4755-63 pubmed publisher
Antoon J, White M, Burow M, Beckman B. Dual inhibition of sphingosine kinase isoforms ablates TNF-induced drug resistance. Oncol Rep. 2012;27:1779-86 pubmed publisher
Wu H, Tao N, Liu X, Li X, Tang J, Ma C, et al. Polysaccharide from Lentinus edodes inhibits the immunosuppressive function of myeloid-derived suppressor cells. PLoS ONE. 2012;7:e51751 pubmed publisher
Antognelli C, Mezzasoma L, Fettucciari K, Mearini E, Talesa V. Role of glyoxalase I in the proliferation and apoptosis control of human LNCaP and PC3 prostate cancer cells. Prostate. 2013;73:121-32 pubmed publisher
Hosokawa J, Suzuki K, Nakagomi D, Tamachi T, Takatori H, Suto A, et al. Role of calcium ionophore A23187-induced activation of IkappaB kinase 2 in mast cells. Int Arch Allergy Immunol. 2013;161:37-43 pubmed publisher
Yang Y, Chen W, Carrigan S, Chen W, Roth K, Akiyama T, et al. TRAF6 specifically contributes to FcepsilonRI-mediated cytokine production but not mast cell degranulation. J Biol Chem. 2008;283:32110-8 pubmed publisher
Xie S, Li J, Wang J, Wu Q, Yang P, Hsu H, et al. IL-17 activates the canonical NF-kappaB signaling pathway in autoimmune B cells of BXD2 mice to upregulate the expression of regulators of G-protein signaling 16. J Immunol. 2010;184:2289-96 pubmed publisher
Taura M, Eguma A, Suico M, Shuto T, Koga T, Komatsu K, et al. p53 regulates Toll-like receptor 3 expression and function in human epithelial cell lines. Mol Cell Biol. 2008;28:6557-67 pubmed publisher
product information
SKU :
2859L
Product-Name :
Phospho-IκBα (Ser32) (14D4) Rabbit mAb
Size :
300 ul
Price-(USD) :
658 USD
Species-x-Reactivity :
H, M, R, Mk, (B, Dg, Pg, GP)
Applications :
Immunoprecipitation
Product-Category :
Immunology and Inflammation
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
40
Host :
Rabbit
Target :
IkB-a (Ser32) phosphate
Primary-Protein :
IkB-alpha
Alt-Names :
I-kappa-B-alpha,IKBA,IkB-alpha,IkappaBalpha,MAD-3,MAD3,Major histocompatibility complex enhancer-binding protein MAD3,NF-kappa-B inhibitor alpha,NFKBI,NFKBIA,nuclear factor of kappa light chain gene enhancer in B-cells,nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.