product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Oct-4A (C30A3) Rabbit mAb
catalog :
2840
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
C30A3
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section
citations: 40
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; human; 1:200; loading ...; fig s5d
Marin Navarro A, Pronk R, van der Geest A, Oliynyk G, Nordgren A, Arsenian Henriksson M, et al. p53 controls genomic stability and temporal differentiation of human neural stem cells and affects neural organization in human brain organoids. Cell Death Dis. 2020;11:52 pubmed publisher
  • immunocytochemistry; human; 1:200; loading ...; fig 4a
Farhy C, Hariharan S, Ylanko J, Orozco L, Zeng F, Pass I, et al. Improving drug discovery using image-based multiparametric analysis of the epigenetic landscape. elife. 2019;8: pubmed publisher
  • western blot; human; fig 5a
Toosi B, El Zawily A, Truitt L, Shannon M, Allonby O, Babu M, et al. EPHB6 augments both development and drug sensitivity of triple-negative breast cancer tumours. Oncogene. 2018;37:4073-4093 pubmed publisher
  • immunocytochemistry; human; 1:400; loading ...; fig 1b
Hsieh W, Ramadesikan S, FEKETE D, Aguilar R. Kidney-differentiated cells derived from Lowe Syndrome patient's iPSCs show ciliogenesis defects and Six2 retention at the Golgi complex. PLoS ONE. 2018;13:e0192635 pubmed publisher
  • immunohistochemistry; human; loading ...; fig 3a6
Spitzhorn L, Rahman M, Schwindt L, Ho H, Wruck W, Bohndorf M, et al. Isolation and Molecular Characterization of Amniotic Fluid-Derived Mesenchymal Stem Cells Obtained from Caesarean Sections. Stem Cells Int. 2017;2017:5932706 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 1e
Hazim R, Karumbayaram S, Jiang M, Dimashkie A, Lopes V, Li D, et al. Differentiation of RPE cells from integration-free iPS cells and their cell biological characterization. Stem Cell Res Ther. 2017;8:217 pubmed publisher
  • western blot; human; loading ...; fig 3a
Jin L, Vu T, Yuan G, Datta P. STRAP Promotes Stemness of Human Colorectal Cancer via Epigenetic Regulation of the NOTCH Pathway. Cancer Res. 2017;77:5464-5478 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:50; loading ...; fig 1c
Iglesia R, Prado M, Cruz L, Martins V, Santos T, Lopes M. Engagement of cellular prion protein with the co-chaperone Hsp70/90 organizing protein regulates the proliferation of glioblastoma stem-like cells. Stem Cell Res Ther. 2017;8:76 pubmed publisher
  • immunocytochemistry; human; 1:200; loading ...; fig 1g
Uhlin E, Rönnholm H, Day K, Kele M, Tammimies K, Bölte S, et al. Derivation of human iPS cell lines from monozygotic twins in defined and xeno free conditions. Stem Cell Res. 2017;18:22-25 pubmed publisher
  • immunocytochemistry; human; fig 3b
Bharathan S, Manian K, Aalam S, Palani D, Deshpande P, Pratheesh M, et al. Systematic evaluation of markers used for the identification of human induced pluripotent stem cells. Biol Open. 2017;6:100-108 pubmed publisher
  • immunocytochemistry; mouse; 1:500; loading ...; fig s1c
Achuta V, Grym H, Putkonen N, Louhivuori V, Kärkkäinen V, Koistinaho J, et al. Metabotropic glutamate receptor 5 responses dictate differentiation of neural progenitors to NMDA-responsive cells in fragile X syndrome. Dev Neurobiol. 2017;77:438-453 pubmed publisher
  • immunohistochemistry; human; 1:200; loading ...; fig 1g
Kele M, Day K, Rönnholm H, Schuster J, Dahl N, Falk A. Generation of human iPS cell line CTL07-II from human fibroblasts, under defined and xeno-free conditions. Stem Cell Res. 2016;17:474-478 pubmed publisher
  • immunohistochemistry; mouse; 1:100; fig 2a
Magown P, Brownstone R, Rafuse V. Tumor prevention facilitates delayed transplant of stem cell-derived motoneurons. Ann Clin Transl Neurol. 2016;3:637-49 pubmed publisher
  • western blot; human; loading ...; fig 1d, 2a
Li H, Mai R, Huang H, Chou C, Chang Y, Chang Y, et al. DDX3 Represses Stemness by Epigenetically Modulating Tumor-suppressive miRNAs in Hepatocellular Carcinoma. Sci Rep. 2016;6:28637 pubmed publisher
  • immunocytochemistry; human; 1:400; fig 1
  • western blot; human; 1:400; fig 5
Francis K, Ton A, Xin Y, O Halloran P, Wassif C, Malik N, et al. Modeling Smith-Lemli-Opitz syndrome with induced pluripotent stem cells reveals a causal role for Wnt/β-catenin defects in neuronal cholesterol synthesis phenotypes. Nat Med. 2016;22:388-96 pubmed publisher
  • western blot; human; loading ...; fig 1c
Xu M, Bian S, Li J, He J, Chen H, Ge L, et al. MeCP2 suppresses LIN28A expression via binding to its methylated-CpG islands in pancreatic cancer cells. Oncotarget. 2016;7:14476-85 pubmed publisher
  • immunocytochemistry; human; 1:500; loading ...; fig 1e
Balboa D, Weltner J, Eurola S, Trokovic R, Wartiovaara K, Otonkoski T. Conditionally Stabilized dCas9 Activator for Controlling Gene Expression in Human Cell Reprogramming and Differentiation. Stem Cell Reports. 2015;5:448-59 pubmed publisher
  • immunocytochemistry; human; 1:500
Trokovic R, Weltner J, Noisa P, Raivio T, Otonkoski T. Combined negative effect of donor age and time in culture on the reprogramming efficiency into induced pluripotent stem cells. Stem Cell Res. 2015;15:254-62 pubmed publisher
  • immunocytochemistry; human; 1:500; fig 1
Trokovic R, Weltner J, Otonkoski T. Generation of iPSC line HEL47.2 from healthy human adult fibroblasts. Stem Cell Res. 2015;15:263-5 pubmed publisher
  • immunocytochemistry; human; 1:500; fig 1a
Trokovic R, Weltner J, Otonkoski T. Generation of iPSC line HEL24.3 from human neonatal foreskin fibroblasts. Stem Cell Res. 2015;15:266-8 pubmed publisher
  • immunocytochemistry; human; 1:200; tbl s1
Tsai P, Chang Y, Lee Y, Ko Y, Yang Y, Lin C, et al. Differentiation of blood T cells: Reprogramming human induced pluripotent stem cells into neuronal cells. J Chin Med Assoc. 2015;78:353-9 pubmed publisher
  • immunocytochemistry; human; 1:100
Costabile V, Duraturo F, Delrio P, Rega D, Pace U, Liccardo R, et al. Lithium chloride induces mesenchymal‑to‑epithelial reverting transition in primary colon cancer cell cultures. Int J Oncol. 2015;46:1913-23 pubmed publisher
  • immunocytochemistry; mouse; fig 1
Su M, Song Y, He Z, Hu R, Rood D, Lai L. Administration of embryonic stem cell-derived thymic epithelial progenitors expressing MOG induces antigen-specific tolerance and ameliorates experimental autoimmune encephalomyelitis. J Autoimmun. 2015;58:36-47 pubmed publisher
  • immunocytochemistry; human
Fathi A, Rasouli H, Yeganeh M, Salekdeh G, Baharvand H. Efficient differentiation of human embryonic stem cells toward dopaminergic neurons using recombinant LMX1A factor. Mol Biotechnol. 2015;57:184-94 pubmed publisher
  • immunocytochemistry; human; 1:200
Chang Y, Chang W, Hung K, Yang D, Cheng Y, Liao Y, et al. The generation of induced pluripotent stem cells for macular degeneration as a drug screening platform: identification of curcumin as a protective agent for retinal pigment epithelial cells against oxidative stress. Front Aging Neurosci. 2014;6:191 pubmed publisher
  • immunocytochemistry; human; 1:50
Xie Y, Lu W, Liu S, Yang Q, Carver B, Li E, et al. Crosstalk between nuclear MET and SOX9/?-catenin correlates with castration-resistant prostate cancer. Mol Endocrinol. 2014;28:1629-39 pubmed publisher
  • immunocytochemistry; human; 1:500; fig 1
Yu D, Swaroop M, Wang M, Baxa U, Yang R, Yan Y, et al. Niemann-Pick Disease Type C: Induced Pluripotent Stem Cell-Derived Neuronal Cells for Modeling Neural Disease and Evaluating Drug Efficacy. J Biomol Screen. 2014;19:1164-73 pubmed publisher
  • immunocytochemistry; human; 1:400
Ferrer M, Corneo B, Davis J, Wan Q, Miyagishima K, King R, et al. A multiplex high-throughput gene expression assay to simultaneously detect disease and functional markers in induced pluripotent stem cell-derived retinal pigment epithelium. Stem Cells Transl Med. 2014;3:911-22 pubmed publisher
  • immunocytochemistry; mouse; 1:100
Pertek A, Meier F, Irmler M, Beckers J, Skylaki S, Endele M, et al. Simple derivation of transgene-free iPS cells by a dual recombinase approach. Mol Biotechnol. 2014;56:697-713 pubmed publisher
  • western blot; mouse
Smith G, Kumar A, Saba J. Sphingosine Phosphate Lyase Regulates Murine Embryonic Stem Cell Proliferation and Pluripotency through an S1P2/STAT3 Signaling Pathway. Biomolecules. 2013;3:351-368 pubmed
  • immunocytochemistry; mouse; 1:200
Franck D, Gil E, Adam R, Kaplan D, Chung Y, Estrada C, et al. Evaluation of silk biomaterials in combination with extracellular matrix coatings for bladder tissue engineering with primary and pluripotent cells. PLoS ONE. 2013;8:e56237 pubmed publisher
Zambelli F, Mertens J, Dziedzicka D, Sterckx J, Markouli C, Keller A, et al. Random Mutagenesis, Clonal Events, and Embryonic or Somatic Origin Determine the mtDNA Variant Type and Load in Human Pluripotent Stem Cells. Stem Cell Reports. 2018;11:102-114 pubmed publisher
Ihry R, Worringer K, Salick M, Frias E, Ho D, Theriault K, et al. p53 inhibits CRISPR-Cas9 engineering in human pluripotent stem cells. Nat Med. 2018;24:939-946 pubmed publisher
Memon B, Karam M, Al Khawaga S, Abdelalim E. Enhanced differentiation of human pluripotent stem cells into pancreatic progenitors co-expressing PDX1 and NKX6.1. Stem Cell Res Ther. 2018;9:15 pubmed publisher
Cheng C, Villani V, Buono R, Wei M, Kumar S, Yilmaz O, et al. Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes. Cell. 2017;168:775-788.e12 pubmed publisher
Liu M, Cao G, Zhang Y, Qu J, Li W, Wan X, et al. Changes in the morphology and protein expression of germ cells and Sertoli cells in plateau pikas testes during non-breeding season. Sci Rep. 2016;6:22697 pubmed publisher
Bamodu O, Huang W, Lee W, Wu A, Wang L, Hsiao M, et al. Aberrant KDM5B expression promotes aggressive breast cancer through MALAT1 overexpression and downregulation of hsa-miR-448. BMC Cancer. 2016;16:160 pubmed publisher
Manukyan M, Singh P. Epigenome rejuvenation: HP1? mobility as a measure of pluripotent and senescent chromatin ground states. Sci Rep. 2014;4:4789 pubmed publisher
Kregel S, Kiriluk K, Rosen A, Cai Y, Reyes E, Otto K, et al. Sox2 is an androgen receptor-repressed gene that promotes castration-resistant prostate cancer. PLoS ONE. 2013;8:e53701 pubmed publisher
Western P, Ralli R, Wakeling S, Lo C, Van Den Bergen J, Miles D, et al. Mitotic arrest in teratoma susceptible fetal male germ cells. PLoS ONE. 2011;6:e20736 pubmed publisher
product information
SKU :
2840S
Product-Name :
Oct-4A (C30A3) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M
Applications :
Flow cytometry
Product-Category :
Developmental Biology
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
45
Host :
Rabbit
Target :
Oct4
Primary-Protein :
Oct4
Alt-Names :
MGC22487,OCT3,OCT4,OTF-3,OTF3,OTF4,Oct-3,Oct-4,Octamer-binding protein 3,Octamer-binding protein 4,Octamer-binding transcription factor 3,PO5F1,POU class 5 homeobox 1,POU domain, class 5, transcription factor 1,POU-type homeodomain-containing DNA-binding protein,POU5F1,octamer-binding transcription factor-3
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.