product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
SCD1 (C12H5) Rabbit mAb
catalog :
2794
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
C12H5
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 17
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 3j
Guo W, Liu J, Cheng L, Liu Z, Zheng X, Liang H, et al. Metformin Alleviates Steatohepatitis in Diet-Induced Obese Mice in a SIRT1-Dependent Way. Front Pharmacol. 2021;12:704112 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3f, 3j
Mu W, Qian S, Song Y, Yang L, Song S, Yang Q, et al. BMP4-mediated browning of perivascular adipose tissue governs an anti-inflammatory program and prevents atherosclerosis. Redox Biol. 2021;43:101979 pubmed publisher
  • western blot; human; loading ...; fig 5c
Feng Y, Mischler W, Gurung A, Kavanagh T, Androsov G, Sadow P, et al. Therapeutic Targeting of the Secreted Lysophospholipase D Autotaxin Suppresses Tuberous Sclerosis Complex-Associated Tumorigenesis. Cancer Res. 2020;80:2751-2763 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5b
Zhang X, Chen X, Qi T, Kong Q, Cheng H, Cao X, et al. HSPA12A is required for adipocyte differentiation and diet-induced obesity through a positive feedback regulation with PPARγ. Cell Death Differ. 2019;: pubmed publisher
  • western blot; mouse; loading ...; fig s2g, s4a
Grohmann M, Wiede F, Dodd G, Gurzov E, Ooi G, Butt T, et al. Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC. Cell. 2018;175:1289-1306.e20 pubmed publisher
  • western blot; human; loading ...; fig 6b
Guo J, Fang W, Chen X, Lin Y, Hu G, Wei J, et al. Upstream stimulating factor 1 suppresses autophagy and hepatic lipid droplet catabolism by activating mTOR. FEBS Lett. 2018;592:2725-2738 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s2b
Li T, Song L, Sun Y, Li J, Yi C, Lam S, et al. Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate. Nat Commun. 2018;9:1916 pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig e4i
Liakath Ali K, Mills E, Sequeira I, Lichtenberger B, Pisco A, Sipilä K, et al. An evolutionarily conserved ribosome-rescue pathway maintains epidermal homeostasis. Nature. 2018;556:376-380 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 8b
Bai X, Hong W, Cai P, Chen Y, Xu C, Cao D, et al. Valproate induced hepatic steatosis by enhanced fatty acid uptake and triglyceride synthesis. Toxicol Appl Pharmacol. 2017;324:12-25 pubmed publisher
  • western blot; mouse; loading ...; fig 3a
Kong Q, Zhang H, Zhao T, Zhang W, Yan M, Dong X, et al. Tangshen formula attenuates hepatic steatosis by inhibiting hepatic lipogenesis and augmenting fatty acid oxidation in db/db mice. Int J Mol Med. 2016;38:1715-1726 pubmed publisher
  • western blot; mouse; fig 3
Shinohara S, Gu Y, Yang Y, Furuta Y, Tanaka M, Yue X, et al. Ethanol extracts of chickpeas alter the total lipid content and expression levels of genes related to fatty acid metabolism in mouse 3T3-L1 adipocytes. Int J Mol Med. 2016;38:574-84 pubmed publisher
  • immunohistochemistry; mouse; fig st1
  • western blot; mouse; fig st1
Wang C, Che L, Hu J, Zhang S, Jiang L, Latte G, et al. Activated mutant forms of PIK3CA cooperate with RasV12 or c-Met to induce liver tumour formation in mice via AKT2/mTORC1 cascade. Liver Int. 2016;36:1176-86 pubmed publisher
  • western blot; mouse; 1:1000; fig 2
Zeng X, Wang H, Bai F, Zhou X, Li S, Ren L, et al. Identification of matrine as a promising novel drug for hepatic steatosis and glucose intolerance with HSP72 as an upstream target. Br J Pharmacol. 2015;172:4303-18 pubmed publisher
  • immunohistochemistry - paraffin section; mouse
  • western blot; mouse
Antony N, Weir J, McDougall A, Mantamadiotis T, Meikle P, Cole T, et al. cAMP response element binding protein1 is essential for activation of steroyl co-enzyme a desaturase 1 (Scd1) in mouse lung type II epithelial cells. PLoS ONE. 2013;8:e59763 pubmed publisher
Bricambert J, Alves Guerra M, Esteves P, Prip Buus C, Bertrand Michel J, Guillou H, et al. The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity. Nat Commun. 2018;9:2092 pubmed publisher
Lu H, Lei X, Zhang Q. Moderate activation of IKK2-NF-kB in unstressed adult mouse liver induces cytoprotective genes and lipogenesis without apparent signs of inflammation or fibrosis. BMC Gastroenterol. 2015;15:94 pubmed publisher
Matsui H, Yokoyama T, Sekiguchi K, Iijima D, Sunaga H, Maniwa M, et al. Stearoyl-CoA desaturase-1 (SCD1) augments saturated fatty acid-induced lipid accumulation and inhibits apoptosis in cardiac myocytes. PLoS ONE. 2012;7:e33283 pubmed publisher
product information
SKU :
2794S
Product-Name :
SCD1 (C12H5) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
M
Applications :
Immunofluorescence (Immunocytochemistry)
Product-Category :
Metabolism
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
37
Host :
Rabbit
Target :
SCD
Primary-Protein :
SCD
Alt-Names :
ACOD,Acyl-CoA desaturase,Delta(9)-desaturase,FADS5,Fatty acid desaturase,MSTP008,SCD,SCD1,SCDOS,Stearoyl-CoA desaturase,delta-9-desaturase,predicted protein of HQ0998,stearoyl-CoA desaturase (delta-9-desaturase),stearoyl-CoA desaturase opposite strand
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.