product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Bcl-xL Antibody
catalog :
2762
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat, dogs
application :
western blot, immunohistochemistry, immunoprecipitation, reverse phase protein lysate microarray, other
citations: 30
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; 1:150; loading ...; fig 5e
Mangold N, Pippin J, Unnersjoe Jess D, Koehler S, Shankland S, Brähler S, et al. The Atypical Cyclin-Dependent Kinase 5 (Cdk5) Guards Podocytes from Apoptosis in Glomerular Disease While Being Dispensable for Podocyte Development. Cells. 2021;10: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 8f
Gyamfi J, Yeo J, Kwon D, Min B, Cha Y, Koo J, et al. Interaction between CD36 and FABP4 modulates adipocyte-induced fatty acid import and metabolism in breast cancer. NPJ Breast Cancer. 2021;7:129 pubmed publisher
  • western blot; mouse; loading ...; fig 4a
Campbell K, Mason S, Winder M, Willemsen R, Cloix C, Lawson H, et al. Breast cancer dependence on MCL-1 is due to its canonical anti-apoptotic function. Cell Death Differ. 2021;: pubmed publisher
  • western blot; human; loading ...; fig 1b
Littler S, Sloss O, Geary B, Pierce A, Whetton A, Taylor S. Oncogenic MYC amplifies mitotic perturbations. Open Biol. 2019;9:190136 pubmed publisher
  • other; human; loading ...; fig 4c
Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed publisher
  • western blot; human; loading ...; fig 3a
Bogenberger J, Whatcott C, Hansen N, Delman D, Shi C, Kim W, et al. Combined venetoclax and alvocidib in acute myeloid leukemia. Oncotarget. 2017;8:107206-107222 pubmed publisher
  • reverse phase protein lysate microarray; human; loading ...; fig st6
Cherniack A, Shen H, Walter V, Stewart C, Murray B, Bowlby R, et al. Integrated Molecular Characterization of Uterine Carcinosarcoma. Cancer Cell. 2017;31:411-423 pubmed publisher
  • western blot; human; loading ...
Hill S, Nesser N, Johnson Camacho K, Jeffress M, Johnson A, Boniface C, et al. Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling. Cell Syst. 2017;4:73-83.e10 pubmed publisher
  • western blot; human; loading ...; fig 5
Ren Z, Aerts J, Vandenplas H, Wang J, Gorbenko O, Chen J, et al. Phosphorylated STAT5 regulates p53 expression via BRCA1/BARD1-NPM1 and MDM2. Cell Death Dis. 2016;7:e2560 pubmed publisher
  • western blot; human; loading ...; fig s3
Damas N, Marcatti M, Come C, Christensen L, Nielsen M, Baumgartner R, et al. SNHG5 promotes colorectal cancer cell survival by counteracting STAU1-mediated mRNA destabilization. Nat Commun. 2016;7:13875 pubmed publisher
  • western blot; dogs; loading ...; tbl 1
Bulldan A, Shihan M, Goericke Pesch S, Scheiner Bobis G. Signaling events associated with gonadotropin releasing hormone-agonist-induced hormonal castration and its reversal in canines. Mol Reprod Dev. 2016;83:1092-1101 pubmed publisher
  • western blot; human; fig 7
Duggan S, Behan F, Kirca M, Zaheer A, McGarrigle S, Reynolds J, et al. The characterization of an intestine-like genomic signature maintained during Barrett's-associated adenocarcinogenesis reveals an NR5A2-mediated promotion of cancer cell survival. Sci Rep. 2016;6:32638 pubmed publisher
  • western blot; human; fig s2
Franzese O, Palermo B, Di Donna C, Sperduti I, Ferraresi V, Stabile H, et al. Polyfunctional Melan-A-specific tumor-reactive CD8(+) T cells elicited by dacarbazine treatment before peptide-vaccination depends on AKT activation sustained by ICOS. Oncoimmunology. 2016;5:e1114203 pubmed publisher
  • western blot; human; 1:1000; fig 5
Bao H, Liu P, Jiang K, Zhang X, Xie L, Wang Z, et al. Huaier polysaccharide induces apoptosis in hepatocellular carcinoma cells through p38 MAPK. Oncol Lett. 2016;12:1058-1066 pubmed
  • western blot; human; fig 3
Hein A, Post C, Sheinin Y, Lakshmanan I, Natarajan A, Enke C, et al. RAC1 GTPase promotes the survival of breast cancer cells in response to hyper-fractionated radiation treatment. Oncogene. 2016;35:6319-6329 pubmed publisher
  • western blot; human; fig 5
Afsar T, Trembley J, Salomon C, Razak S, Khan M, Ahmed K. Growth inhibition and apoptosis in cancer cells induced by polyphenolic compounds of Acacia hydaspica: Involvement of multiple signal transduction pathways. Sci Rep. 2016;6:23077 pubmed publisher
  • western blot; human; fig 1
Gilormini M, Malesys C, Armandy E, Manas P, Guy J, Magne N, et al. Preferential targeting of cancer stem cells in the radiosensitizing effect of ABT-737 on HNSCC. Oncotarget. 2016;7:16731-44 pubmed publisher
Lee H, Kim M, Baek M, Morales L, Jang I, Slaga T, et al. Targeted disruption of TC-PTP in the proliferative compartment augments STAT3 and AKT signaling and skin tumor development. Sci Rep. 2017;7:45077 pubmed publisher
Li K, Guo Y, Yang X, Zhang Z, Zhang C, Xu Y. ELF5-Mediated AR Activation Regulates Prostate Cancer Progression. Sci Rep. 2017;7:42759 pubmed publisher
Feng T, Dzieran J, Yuan X, Dropmann A, Maass T, Teufel A, et al. Hepatocyte-specific Smad7 deletion accelerates DEN-induced HCC via activation of STAT3 signaling in mice. Oncogenesis. 2017;6:e294 pubmed publisher
Gong Y, Schumacher S, Wu W, Tang F, Beroukhim R, Chan T. Pan-Cancer Analysis Links PARK2 to BCL-XL-Dependent Control of Apoptosis. Neoplasia. 2017;19:75-83 pubmed publisher
Yin C, Kim Y, Argintaru D, Heit B. Rab17 mediates differential antigen sorting following efferocytosis and phagocytosis. Cell Death Dis. 2016;7:e2529 pubmed publisher
Pomeroy E, Lee L, Lee R, Schirm D, Temiz N, Ma J, et al. Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia. Oncogene. 2017;36:3263-3273 pubmed publisher
Kueh H, Zhu Y, Shi J. A simplified Bcl-2 network model reveals quantitative determinants of cell-to-cell variation in sensitivity to anti-mitotic chemotherapeutics. Sci Rep. 2016;6:36585 pubmed publisher
Bahr J, Robey R, Luchenko V, Basseville A, Chakraborty A, Kozlowski H, et al. Blocking downstream signaling pathways in the context of HDAC inhibition promotes apoptosis preferentially in cells harboring mutant Ras. Oncotarget. 2016;7:69804-69815 pubmed publisher
Fu B, Meng W, Zhao H, Zhang B, Tang H, Zou Y, et al. GRAM domain-containing protein 1A (GRAMD1A) promotes the expansion of hepatocellular carcinoma stem cell and hepatocellular carcinoma growth through STAT5. Sci Rep. 2016;6:31963 pubmed publisher
Ahmed K, Kren B, Abedin M, Vogel R, Shaughnessy D, Nacusi L, et al. CK2 targeted RNAi therapeutic delivered via malignant cell-directed tenfibgen nanocapsule: dose and molecular mechanisms of response in xenograft prostate tumors. Oncotarget. 2016;7:61789-61805 pubmed publisher
Wu J, Guo W, Lin S, Wang Z, Kan J, Chen S, et al. Gp130-mediated STAT3 activation by S-propargyl-cysteine, an endogenous hydrogen sulfide initiator, prevents doxorubicin-induced cardiotoxicity. Cell Death Dis. 2016;7:e2339 pubmed publisher
He L, Gao S, Zhu Z, Chen S, Gu H. Ikaros expression sensitizes leukemic cells to the chemotherapeutic drug doxorubicin. Oncol Lett. 2016;12:1178-1182 pubmed
Cheng C, Tang N, Kao S, Hsieh C. Ferulic Acid Administered at Various Time Points Protects against Cerebral Infarction by Activating p38 MAPK/p90RSK/CREB/Bcl-2 Anti-Apoptotic Signaling in the Subacute Phase of Cerebral Ischemia-Reperfusion Injury in Rats. PLoS ONE. 2016;11:e0155748 pubmed publisher
product information
SKU :
2762S
Product-Name :
Bcl-xL Antibody
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R, Mk
Applications :
Immunoprecipitation
Product-Category :
Apoptosis
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Polyclonal Antibody
MW :
30
Host :
Rabbit
Target :
BCL-xL
Primary-Protein :
Bcl-xL
Alt-Names :
Apoptosis regulator Bcl-X,B2CL1,BCL-XL/S,BCL2-like 1,BCL2L,BCL2L1,BCLX,BCLXL,BCLXS,Bcl-2-like protein 1,Bcl-X,Bcl2-L-1,DKFZp781P2092,bcl-xL,bcl-xS
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.