product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Numb (C29G11) Rabbit mAb
catalog :
2756
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
C29G11
reactivity :
human, mouse, rat
application :
western blot, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section, western blot knockout validation
more info or order :
Cell Signaling Technology product webpage
citations: 9
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; mouse; loading ...; fig 2c
  • immunohistochemistry - frozen section; mouse; loading ...; fig 2e
  • immunoprecipitation; mouse; loading ...; fig 4d
Ianni A, Hofmann M, Kumari P, Tarighi S, Al tamari H, Görgens A, et al. Depletion of Numb and Numblike in Murine Lung Epithelial Cells Ameliorates Bleomycin-Induced Lung Fibrosis by Inhibiting the β-Catenin Signaling Pathway. Front Cell Dev Biol. 2021;9:639162 pubmed publisher
  • western blot; human; loading ...; fig 3e
Jin L, Vu T, Yuan G, Datta P. STRAP Promotes Stemness of Human Colorectal Cancer via Epigenetic Regulation of the NOTCH Pathway. Cancer Res. 2017;77:5464-5478 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig s1b
  • western blot; mouse; 1:250; loading ...; fig 3c
Hirai M, Arita Y, McGlade C, Lee K, Chen J, Evans S. Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation. J Clin Invest. 2017;127:569-582 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:400; loading ...
Kuzmanov U, Guo H, Buchsbaum D, Cosme J, Abbasi C, Isserlin R, et al. Global phosphoproteomic profiling reveals perturbed signaling in a mouse model of dilated cardiomyopathy. Proc Natl Acad Sci U S A. 2016;113:12592-12597 pubmed
  • western blot; mouse; loading ...; fig 1f
Fujiwara T, Zhou J, Ye S, Zhao H. RNA-binding protein Musashi2 induced by RANKL is critical for osteoclast survival. Cell Death Dis. 2016;7:e2300 pubmed publisher
  • western blot; human
Camps J, Pitt J, Emons G, Hummon A, Case C, Grade M, et al. Genetic amplification of the NOTCH modulator LNX2 upregulates the WNT/β-catenin pathway in colorectal cancer. Cancer Res. 2013;73:2003-13 pubmed publisher
King J, Ung N, Paing M, Contreras J, Alberti M, Fernando T, et al. Regulation of Marginal Zone B-Cell Differentiation by MicroRNA-146a. Front Immunol. 2016;7:670 pubmed publisher
Tosoni D, Zecchini S, Coazzoli M, Colaluca I, Mazzarol G, Rubio A, et al. The Numb/p53 circuitry couples replicative self-renewal and tumor suppression in mammary epithelial cells. J Cell Biol. 2015;211:845-62 pubmed publisher
Ito T, Kwon H, Zimdahl B, Congdon K, Blum J, Lento W, et al. Regulation of myeloid leukaemia by the cell-fate determinant Musashi. Nature. 2010;466:765-8 pubmed publisher
product information
SKU :
2756S
Product-Name :
Numb (C29G11) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R, Mk
Applications :
Flow cytometry
Product-Category :
Developmental Biology
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
72, 74
Host :
Rabbit
Target :
Numb
Primary-Protein :
NUMB
Alt-Names :
NUMB,Protein S171,Protein numb homolog,S171,h-Numb,numb homolog (Drosophila)
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.