product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb
catalog :
2710
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
antigen modification :
phosphorylated
clone name :
C87C1
reactivity :
human, mouse, rat, swine
application :
western blot, immunoprecipitation
citations: 25
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:1000; loading ...; fig 5a
Zewinger S, Reiser J, Jankowski V, Alansary D, Hahm E, Triem S, et al. Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation. Nat Immunol. 2020;21:30-41 pubmed publisher
  • western blot; mouse; loading ...; fig 3d
  • western blot; swine; fig 3a
Liu Y, Li R, Chen X, Zhi Y, Deng R, Zhou E, et al. Nonmuscle Myosin Heavy Chain IIA Recognizes Sialic Acids on Sialylated RNA Viruses To Suppress Proinflammatory Responses via the DAP12-Syk Pathway. MBio. 2019;10: pubmed publisher
  • western blot; human; loading ...; fig 4d
Pircher J, Czermak T, Ehrlich A, Eberle C, Gaitzsch E, Margraf A, et al. Cathelicidins prime platelets to mediate arterial thrombosis and tissue inflammation. Nat Commun. 2018;9:1523 pubmed publisher
  • western blot; human; 1:1000; fig 3a
Park G, Kim D. Cigarette smoke-induced EGFR activation promotes epithelial mesenchymal migration of human retinal pigment epithelial cells through regulation of the FAK-mediated Syk/Src pathway. Mol Med Rep. 2018;17:3563-3574 pubmed publisher
  • western blot; mouse; loading ...; fig 5a
Purvis H, Clarke F, Jordan C, Blanco C, Cornish G, Dai X, et al. Protein tyrosine phosphatase PTPN22 regulates IL-1β dependent Th17 responses by modulating dectin-1 signaling in mice. Eur J Immunol. 2018;48:306-315 pubmed publisher
  • western blot; mouse; loading ...; fig 6a
Schwartz S, Cleyrat C, Olah M, Relich P, Phillips G, Hlavacek W, et al. Differential mast cell outcomes are sensitive to FcεRI-Syk binding kinetics. Mol Biol Cell. 2017;28:3397-3414 pubmed publisher
  • western blot; rat; 1:500; loading ...; fig 3b
Honjoh C, Chihara K, Yoshiki H, Yamauchi S, Takeuchi K, Kato Y, et al. Association of C-Type Lectin Mincle with FcεRIβγ Subunits Leads to Functional Activation of RBL-2H3 Cells through Syk. Sci Rep. 2017;7:46064 pubmed publisher
  • western blot; human; loading ...; fig 5d
Burgess M, Mapp S, Mazzieri R, Cheung C, Chambers L, Mattarollo S, et al. Increased FcγRIIB dominance contributes to the emergence of resistance to therapeutic antibodies in chronic lymphocytic leukaemia patients. Oncogene. 2017;36:2366-2376 pubmed publisher
  • western blot; human; 1:500; fig 1
Wu J, Wu H, Tsai D, Chiang M, Chen Y, Gao S, et al. Temporal regulation of Lsp1 O-GlcNAcylation and phosphorylation during apoptosis of activated B cells. Nat Commun. 2016;7:12526 pubmed publisher
  • immunoprecipitation; mouse; loading ...; fig 3b
  • western blot; mouse; loading ...; fig 3e
Zhu L, Luo T, Xu X, Guo Y, Zhao X, Wang T, et al. E3 ubiquitin ligase Cbl-b negatively regulates C-type lectin receptor-mediated antifungal innate immunity. J Exp Med. 2016;213:1555-70 pubmed publisher
  • western blot; mouse; fig 4a
Wittmann A, Lamprinaki D, Bowles K, Katzenellenbogen E, Knirel Y, Whitfield C, et al. Dectin-2 Recognizes Mannosylated O-antigens of Human Opportunistic Pathogens and Augments Lipopolysaccharide Activation of Myeloid Cells. J Biol Chem. 2016;291:17629-38 pubmed publisher
  • western blot; human; fig s1
Elder M, Webster S, Williams D, Gaston J, Goodall J. TSLP production by dendritic cells is modulated by IL-1β and components of the endoplasmic reticulum stress response. Eur J Immunol. 2016;46:455-63 pubmed publisher
  • western blot; human; loading ...; fig 5a
Viganò E, Diamond C, Spreafico R, Balachander A, Sobota R, Mortellaro A. Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes. Nat Commun. 2015;6:8761 pubmed publisher
  • western blot; mouse; fig 3a
Bugajev V, Hálová I, Dráberová L, Bambousková M, Potůčková L, Draberova H, et al. Negative regulatory roles of ORMDL3 in the FcεRI-triggered expression of proinflammatory mediators and chemotactic response in murine mast cells. Cell Mol Life Sci. 2016;73:1265-85 pubmed publisher
  • western blot; human; 1:1000; fig 3
Zucha M, Wu A, Lee W, Wang L, Lin W, Yuan C, et al. Bruton's tyrosine kinase (Btk) inhibitor ibrutinib suppresses stem-like traits in ovarian cancer. Oncotarget. 2015;6:13255-68 pubmed
  • western blot; human
Cohen Kedar S, Baram L, Elad H, Brazowski E, Guzner Gur H, Dotan I. Human intestinal epithelial cells respond to β-glucans via Dectin-1 and Syk. Eur J Immunol. 2014;44:3729-40 pubmed publisher
  • western blot; human
Abbonante V, Gruppi C, Rubel D, Gross O, Moratti R, Balduini A. Discoidin domain receptor 1 protein is a novel modulator of megakaryocyte-collagen interactions. J Biol Chem. 2013;288:16738-46 pubmed publisher
Pandori W, Lima T, Mallya S, Kao T, Gov L, Lodoen M. Toxoplasma gondii activates a Syk-CARD9-NF-κB signaling axis and gasdermin D-independent release of IL-1β during infection of primary human monocytes. PLoS Pathog. 2019;15:e1007923 pubmed publisher
Roders N, Herr F, Ambroise G, Thaunat O, Portier A, Vazquez A, et al. SYK Inhibition Induces Apoptosis in Germinal Center-Like B Cells by Modulating the Antiapoptotic Protein Myeloid Cell Leukemia-1, Affecting B-Cell Activation and Antibody Production. Front Immunol. 2018;9:787 pubmed publisher
Lim J, Coates C, Seoane P, Garelnabi M, Taylor Smith L, Monteith P, et al. Characterizing the Mechanisms of Nonopsonic Uptake of Cryptococci by Macrophages. J Immunol. 2018;200:3539-3546 pubmed publisher
Mohr S, Doebele C, Comoglio F, Berg T, Beck J, Bohnenberger H, et al. Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia. Cancer Cell. 2017;31:549-562.e11 pubmed publisher
Totsuka N, Kim Y, Kanemaru K, Niizuma K, Umemoto E, Nagai K, et al. Toll-like receptor 4 and MAIR-II/CLM-4/LMIR2 immunoreceptor regulate VLA-4-mediated inflammatory monocyte migration. Nat Commun. 2014;5:4710 pubmed publisher
Uhde M, Kuehl S, Richardt U, Fleischer B, Osterloh A. Differential regulation of marginal zone and follicular B cell responses by CD83. Int Immunol. 2013;25:507-20 pubmed publisher
Carnevale J, Ross L, Puissant A, Banerji V, Stone R, DeAngelo D, et al. SYK regulates mTOR signaling in AML. Leukemia. 2013;27:2118-28 pubmed publisher
Yamauchi S, Kawauchi K, Sawada Y. Myosin II-dependent exclusion of CD45 from the site of Fc? receptor activation during phagocytosis. FEBS Lett. 2012;586:3229-35 pubmed publisher
product information
SKU :
2710S
Product-Name :
Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb
Size :
100 ul
Price-(USD) :
274 USD
Species-x-Reactivity :
H, (M, R)
Applications :
Immunoprecipitation
Product-Category :
Immunology and Inflammation
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
72 kDa
Host :
Rabbit
Target :
Syk (Tyr525/Tyr526) phosphate
Primary-Protein :
Syk
Alt-Names :
DKFZp313N1010,FLJ25043,FLJ37489,KSYK,SYK,Spleen tyrosine kinase,Tyrosine-protein kinase SYK
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.