Phospho-IKKα/β (Ser176/180) (16A6) Rabbit mAb | Cell Signaling Technology 2697 product information

product summary

company name :

Cell Signaling Technology

product type :

antibody

product name :

Phospho-IKKα/β (Ser176/180) (16A6) Rabbit mAb

catalog :

2697

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

clone name :

16A6

reactivity :

human, mouse, rat, bovine, pigs

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Cell Signaling Technology product webpage

citations: 107

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; fig 5i	Ma S, Xu H, Huang W, Gao Y, Zhou H, Li X, et al. Chrysophanol Relieves Cisplatin-Induced Nephrotoxicity via Concomitant Inhibition of Oxidative Stress, Apoptosis, and Inflammation. Front Physiol. 2021;12:706359 pubmed publisher
western blot; human; 1:1000; loading ...; fig 5a	Wang X, Yung M, Sharma R, Chen F, Poon Y, Lam W, et al. Epigenetic Silencing of miR-33b Promotes Peritoneal Metastases of Ovarian Cancer by Modulating the TAK1/FASN/CPT1A/NF-κB Axis. Cancers (Basel). 2021;13: pubmed publisher
western blot; mouse; loading ...; fig s8c	Cheng J, Dong Y, Ma J, Pan R, Liao Y, Kong X, et al. Microglial Calhm2 regulates neuroinflammation and contributes to Alzheimer's disease pathology. Sci Adv. 2021;7: pubmed publisher
flow cytometry; mouse	Hutton C, Heider F, Blanco Gómez A, Banyard A, Kononov A, Zhang X, et al. Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity. Cancer Cell. 2021;: pubmed publisher
western blot; mouse; fig 6a western blot; human; loading ...; fig 1a, 7f	Chen S, Liu H, Li Z, Tang J, Huang B, Zhi F, et al. Epithelial PBLD attenuates intestinal inflammatory response and improves intestinal barrier function by inhibiting NF-κB signaling. Cell Death Dis. 2021;12:563 pubmed publisher
western blot; mouse; fig 3d	Watahiki A, Hoshikawa S, Chiba M, Egusa H, Fukumoto S, Inuzuka H. Deficiency of Lipin2 Results in Enhanced NF-κB Signaling and Osteoclast Formation in RAW-D Murine Macrophages. Int J Mol Sci. 2021;22: pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 4b, s12b	von Roemeling C, Wang Y, Qie Y, Yuan H, Zhao H, Liu X, et al. Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity. Nat Commun. 2020;11:1508 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 2i, 5h	Yang H, Wang L, Zang C, Wang Y, Shang J, Zhang Z, et al. Src Inhibition Attenuates Neuroinflammation and Protects Dopaminergic Neurons in Parkinson's Disease Models. Front Neurosci. 2020;14:45 pubmed publisher
western blot; human; fig 1b	Chen M, Zhao Z, Meng Q, Liang P, Su Z, Wu Y, et al. TRIM14 Promotes Noncanonical NF-κB Activation by Modulating p100/p52 Stability via Selective Autophagy. Adv Sci (Weinh). 2020;7:1901261 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 7b	Yuan Z, Yang L, Zhang X, Ji P, Hua Y, Wei Y. Huang-Lian-Jie-Du Decoction Ameliorates Acute Ulcerative Colitis in Mice via Regulating NF-κB and Nrf2 Signaling Pathways and Enhancing Intestinal Barrier Function. Front Pharmacol. 2019;10:1354 pubmed publisher
western blot; rat; loading ...; fig 6i	Huang X, Ni B, Xi Y, Chu X, Zhang R, You H. Protease-activated receptor 2 (PAR-2) antagonist AZ3451 as a novel therapeutic agent for osteoarthritis. Aging (Albany NY). 2019;11:12532-12545 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 4c	Wu Y, Chen K, Xing G, Li L, Ma B, Hu Z, et al. Phospholipid remodeling is critical for stem cell pluripotency by facilitating mesenchymal-to-epithelial transition. Sci Adv. 2019;5:eaax7525 pubmed publisher
western blot; human; loading ...; fig 2d	Managò A, Audrito V, Mazzola F, Sorci L, Gaudino F, Gizzi K, et al. Extracellular nicotinate phosphoribosyltransferase binds Toll like receptor 4 and mediates inflammation. Nat Commun. 2019;10:4116 pubmed publisher
western blot; human; loading ...; fig 4a	Barbero G, Castro M, Villanueva M, Quezada M, Fernández N, Demorrow S, et al. An Autocrine Wnt5a Loop Promotes NF-κB Pathway Activation and Cytokine/Chemokine Secretion in Melanoma. Cells. 2019;8: pubmed publisher
western blot; human; loading ...; fig 4a	Xu G, Xia Z, Deng F, Liu L, Wang Q, Yu Y, et al. Inducible LGALS3BP/90K activates antiviral innate immune responses by targeting TRAF6 and TRAF3 complex. PLoS Pathog. 2019;15:e1008002 pubmed publisher
western blot; human; loading ...; fig 2f	Xia Z, Xu G, Nie L, Liu L, Peng N, He Q, et al. NAC1 Potentiates Cellular Antiviral Signaling by Bridging MAVS and TBK1. J Immunol. 2019;: pubmed publisher
western blot; human; 1:1000; loading ...; fig 2h	Hari P, Millar F, Tarrats N, Birch J, Quintanilla A, Rink C, et al. The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype. Sci Adv. 2019;5:eaaw0254 pubmed publisher
western blot; mouse; loading ...; fig 4c	Loh J, Xu S, Huo J, Kim S, Wang Y, Lam K. Dok3-protein phosphatase 1 interaction attenuates Card9 signaling and neutrophil-dependent antifungal immunity. J Clin Invest. 2019;129:2717-2729 pubmed publisher
western blot; mouse; loading ...; fig s1c	Yang S, Harding A, Sweeney C, Miao D, Swan G, Zhou C, et al. Control of antiviral innate immune response by protein geranylgeranylation. Sci Adv. 2019;5:eaav7999 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 6c	Ben J, Jiang B, Wang D, Liu Q, Zhang Y, Qi Y, et al. Major vault protein suppresses obesity and atherosclerosis through inhibiting IKK-NF-κB signaling mediated inflammation. Nat Commun. 2019;10:1801 pubmed publisher
western blot; human; loading ...; fig 3a	Oda H, Beck D, Kuehn H, Sampaio Moura N, Hoffmann P, Ibarra M, et al. Second Case of HOIP Deficiency Expands Clinical Features and Defines Inflammatory Transcriptome Regulated by LUBAC. Front Immunol. 2019;10:479 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 5a	Herb M, Gluschko A, Wiegmann K, Farid A, Wolf A, Utermöhlen O, et al. Mitochondrial reactive oxygen species enable proinflammatory signaling through disulfide linkage of NEMO. Sci Signal. 2019;12: pubmed publisher
western blot; human; fig 7c	Fauster A, Rebsamen M, Willmann K, César Razquin A, Girardi E, Bigenzahn J, et al. Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking. Cell Death Differ. 2019;26:1138-1155 pubmed publisher
western blot; human; 1:800; loading ...; fig 1e	Sheng C, Yao C, Wang Z, Chen H, Zhao Y, Xu D, et al. Cyclophilin J limits inflammation through the blockage of ubiquitin chain sensing. Nat Commun. 2018;9:4381 pubmed publisher
flow cytometry; human; 1:100; loading ... western blot; human; 1:500; loading ...; fig 4f	Deng M, Gui X, Kim J, Xie L, Chen W, Li Z, et al. LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration. Nature. 2018;562:605-609 pubmed publisher
western blot; mouse; loading ...; fig 5a	Xu X, Xu J, Wu J, Hu Y, Han Y, Gu Y, et al. Phosphorylation-Mediated IFN-γR2 Membrane Translocation Is Required to Activate Macrophage Innate Response. Cell. 2018;175:1336-1351.e17 pubmed publisher
western blot; human; 1:1000; loading ...; fig s9a	Cuchet Lourenço D, Eletto D, Wu C, Plagnol V, Papapietro O, CURTIS J, et al. Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation. Science. 2018;361:810-813 pubmed publisher
western blot; mouse; fig 4d	Li F, Li Y, Liang H, Xu T, Kong Y, Huang M, et al. HECTD3 mediates TRAF3 polyubiquitination and type I interferon induction during bacterial infection. J Clin Invest. 2018;128:4148-4162 pubmed publisher
western blot; human; 1:1000; loading ...; fig 2a	Padilla J, Carpenter A, Das N, Kandikattu H, López Ongil S, Martinez Lemus L, et al. TRAF3IP2 mediates high glucose-induced endothelin-1 production as well as endothelin-1-induced inflammation in endothelial cells. Am J Physiol Heart Circ Physiol. 2018;314:H52-H64 pubmed publisher
western blot; human; fig 2b	Wu G, Mu T, Gao Z, Wang J, Sy M, Li C. Prion protein is required for tumor necrosis factor α (TNFα)-triggered nuclear factor κB (NF-κB) signaling and cytokine production. J Biol Chem. 2017;292:18747-18759 pubmed publisher
western blot; human; loading ...; fig 3a	Franz S, Rennert P, Woznik M, GrÃ¼tzke J, LÃ¼dde A, Arriero Pais E, et al. Mumps Virus SH Protein Inhibits NF-ÎºB Activation by Interacting with Tumor Necrosis Factor Receptor 1, Interleukin-1 Receptor 1, and Toll-Like Receptor 3 Complexes. J Virol. 2017;91: pubmed publisher
western blot; human; loading ...; fig 5b	Zhang J, MacArtney T, Peggie M, Cohen P. Interleukin-1 and TRAF6-dependent activation of TAK1 in the absence of TAB2 and TAB3. Biochem J. 2017;474:2235-2248 pubmed publisher
western blot; human; loading ...; fig s1a western blot; mouse	Strickson S, Emmerich C, Goh E, Zhang J, Kelsall I, MacArtney T, et al. Roles of the TRAF6 and Pellino E3 ligases in MyD88 and RANKL signaling. Proc Natl Acad Sci U S A. 2017;114:E3481-E3489 pubmed publisher
western blot; human; loading ...; fig 2b	Wang X, Wang R, Luo M, Li C, Wang H, Huan C, et al. (DEAD)-box RNA helicase 3 modulates NF-ÎºB signal pathway by controlling the phosphorylation of PP2A-C subunit. Oncotarget. 2017;8:33197-33213 pubmed publisher
western blot; human; loading ...; fig 8a	Xia Z, Xu G, Yang X, Peng N, Zuo Q, Zhu S, et al. Inducible TAP1 Negatively Regulates the Antiviral Innate Immune Response by Targeting the TAK1 Complex. J Immunol. 2017;198:3690-3704 pubmed publisher
western blot; human; loading ...; fig 8a western blot; mouse; loading ...; fig EV3d	Lafont E, Kantari Mimoun C, Dráber P, De Miguel D, Hartwig T, Reichert M, et al. The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death. EMBO J. 2017;36:1147-1166 pubmed publisher
western blot; human; loading ...; fig 1b, 2b	Hsia H, Hutti J, Baldwin A. Cytosolic DNA Promotes Signal Transducer and Activator of Transcription 3 (STAT3) Phosphorylation by TANK-binding Kinase 1 (TBK1) to Restrain STAT3 Activity. J Biol Chem. 2017;292:5405-5417 pubmed publisher
western blot; mouse; loading ...; fig 5b	Zhang H, Qi Y, Yuan Y, Cai L, Xu H, Zhang L, et al. Paeoniflorin Ameliorates Experimental Autoimmune Encephalomyelitis via Inhibition of Dendritic Cell Function and Th17 Cell Differentiation. Sci Rep. 2017;7:41887 pubmed publisher
western blot; human; loading ...; fig 1a western blot; mouse; loading ...; fig 2a	Shibata Y, Tokunaga F, Goto E, Komatsu G, Gohda J, Saeki Y, et al. HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63- and Met1-Linked Hybrid Polyubiquitin Chains. PLoS Pathog. 2017;13:e1006162 pubmed publisher
western blot; human; loading ...; fig 1a	Dudhgaonkar S, Ranade S, Nagar J, Subramani S, Prasad D, Karunanithi P, et al. Selective IRAK4 Inhibition Attenuates Disease in Murine Lupus Models and Demonstrates Steroid Sparing Activity. J Immunol. 2017;198:1308-1319 pubmed publisher
western blot; mouse; loading ...; fig 2e	Huh H, Ra E, Lee T, Kang S, Park A, Lee E, et al. STRAP Acts as a Scaffolding Protein in Controlling the TLR2/4 Signaling Pathway. Sci Rep. 2016;6:38849 pubmed publisher
western blot; human; 1:1000; fig 6d	Lin C, Lin W, Cho R, Wang C, Hsiao L, Yang C. TNF-?-Induced cPLA2 Expression via NADPH Oxidase/Reactive Oxygen Species-Dependent NF-?B Cascade on Human Pulmonary Alveolar Epithelial Cells. Front Pharmacol. 2016;7:447 pubmed
western blot; mouse; fig 4G	Marichal T, Gaudenzio N, El Abbas S, Sibilano R, Zurek O, Starkl P, et al. Guanine nucleotide exchange factor RABGEF1 regulates keratinocyte-intrinsic signaling to maintain skin homeostasis. J Clin Invest. 2016;126:4497-4515 pubmed publisher
flow cytometry; human; loading ...; fig 1a	Chen D, Ireland S, Remington G, Alvarez E, Racke M, Greenberg B, et al. CD40-Mediated NF-?B Activation in B Cells Is Increased in Multiple Sclerosis and Modulated by Therapeutics. J Immunol. 2016;197:4257-4265 pubmed
western blot; pigs ; loading ...; fig 1a	Ismail H, Didangelos A, Vincent T, Saklatvala J. Rapid Activation of Transforming Growth Factor ?-Activated Kinase 1 in Chondrocytes by Phosphorylation and K63 -Linked Polyubiquitination Upon Injury to Animal Articular Cartilage. Arthritis Rheumatol. 2017;69:565-575 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 9a	He Y, Yan Y, Zhang H, Lin Y, Chen Y, Yan Y, et al. Methyl salicylate 2-O-?-d-lactoside alleviates the pathological progression of pristane-induced systemic lupus erythematosus-like disease in mice via suppression of inflammatory response and signal transduction. Drug Des Devel Ther. 2016;10:3183-3196 pubmed
western blot; mouse; 1:1000; loading ...; fig 2a	Bettaieb A, Cremonini E, Kang H, Kang J, Haj F, Oteiza P. Anti-inflammatory actions of (-)-epicatechin in the adipose tissue of obese mice. Int J Biochem Cell Biol. 2016;81:383-392 pubmed publisher
western blot; human; fig 1	Zhou Q, Yu X, Demirkaya E, Deuitch N, Stone D, Tsai W, et al. Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease. Proc Natl Acad Sci U S A. 2016;113:10127-32 pubmed publisher
western blot; human; 1:1000; fig s15	Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H, et al. Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis. Nat Commun. 2016;7:12547 pubmed publisher
western blot; mouse; loading ...; fig 5a	Cameron A, Morrison V, Levin D, Mohan M, Forteath C, Beall C, et al. Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status. Circ Res. 2016;119:652-65 pubmed publisher
western blot; human; loading ...; fig 3b	Taminiau A, Draime A, Tys J, Lambert B, Vandeputte J, Nguyen N, et al. HOXA1 binds RBCK1/HOIL-1 and TRAF2 and modulates the TNF/NF-?B pathway in a transcription-independent manner. Nucleic Acids Res. 2016;44:7331-49 pubmed publisher
western blot; mouse; fig 5	Wang T, Pan D, Zhou Z, You Y, Jiang C, Zhao X, et al. Dectin-3 Deficiency Promotes Colitis Development due to Impaired Antifungal Innate Immune Responses in the Gut. PLoS Pathog. 2016;12:e1005662 pubmed publisher
western blot; human; loading ...; fig 1a	Kwon H, Choi G, Ryu S, Kwon S, Kim S, Booth C, et al. Stepwise phosphorylation of p65 promotes NF-?B activation and NK cell responses during target cell recognition. Nat Commun. 2016;7:11686 pubmed publisher
western blot; human; loading ...; fig 3d	Park S, Yi H, Suh N, Park Y, Koh J, Jeong S, et al. Inhibition of EHMT2/G9a epigenetically increases the transcription of Beclin-1 via an increase in ROS and activation of NF-?B. Oncotarget. 2016;7:39796-39808 pubmed publisher
western blot; human; fig 4	Emmerich C, Bakshi S, Kelsall I, Ortiz Guerrero J, Shpiro N, Cohen P. Lys63/Met1-hybrid ubiquitin chains are commonly formed during the activation of innate immune signalling. Biochem Biophys Res Commun. 2016;474:452-461 pubmed publisher
western blot; human; 1:1000; loading ...; fig 2a	Mendel I, Yacov N, Shoham A, Ishai E, Breitbart E. Treatment with Oxidized Phospholipids Directly Inhibits Nonalcoholic Steatohepatitis and Liver Fibrosis Without Affecting Steatosis. Dig Dis Sci. 2016;61:2545-53 pubmed publisher
immunocytochemistry; mouse; loading ...; fig 5c western blot; mouse; loading ...; fig 5d	Dang Y, Mu Y, Wang K, Xu K, Yang J, Zhu Y, et al. Papaverine inhibits lipopolysaccharide-induced microglial activation by suppressing NF-ÎºB signaling pathway. Drug Des Devel Ther. 2016;10:851-9 pubmed publisher
western blot; mouse; 1:1000; fig 5	Acharya M, Sokolovska A, Tam J, Conway K, Stefani C, Raso F, et al. αv Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells. Nat Commun. 2016;7:10917 pubmed publisher
western blot; mouse; fig 3	Barroso GonzÃ¡lez J, Auclair S, Luan S, Thomas L, Atkins K, Aslan J, et al. PACS-2 mediates the ATM and NF-ÎºB-dependent induction of anti-apoptotic Bcl-xL in response to DNA damage. Cell Death Differ. 2016;23:1448-57 pubmed publisher
western blot; human; loading ...; fig 2b, 2c	Zhou Q, Wang H, Schwartz D, Stoffels M, Park Y, Zhang Y, et al. Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease. Nat Genet. 2016;48:67-73 pubmed publisher
western blot; human; loading ...; fig 5d	Varney M, Niederkorn M, Konno H, Matsumura T, Gohda J, Yoshida N, et al. Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor-TRAF6 signaling. J Exp Med. 2015;212:1967-85 pubmed publisher
western blot; human; fig 1, 5, 6 western blot; mouse; fig 1, 5, 6	Hwang B, McCool K, Wan J, Wuerzberger Davis S, Young E, Choi E, et al. IPO3-mediated Nonclassical Nuclear Import of NF-ÎºB Essential Modulator (NEMO) Drives DNA Damage-dependent NF-ÎºB Activation. J Biol Chem. 2015;290:17967-84 pubmed publisher
western blot; human; fig 3	Boisson B, Laplantine E, Dobbs K, Cobat A, Tarantino N, Hazen M, et al. Human HOIP and LUBAC deficiency underlies autoinflammation, immunodeficiency, amylopectinosis, and lymphangiectasia. J Exp Med. 2015;212:939-51 pubmed publisher
western blot; human; fig 8.a,b,c,d	Sahu G, Farley K, El Hage N, Aiamkitsumrit B, Fassnacht R, Kashanchi F, et al. Cocaine promotes both initiation and elongation phase of HIV-1 transcription by activating NF-κB and MSK1 and inducing selective epigenetic modifications at HIV-1 LTR. Virology. 2015;483:185-202 pubmed publisher
western blot; human; fig 1d	Wang W, Huang X, Xin H, Fu M, Xue A, Wu Z. TRAF Family Member-associated NF-κB Activator (TANK) Inhibits Genotoxic Nuclear Factor κB Activation by Facilitating Deubiquitinase USP10-dependent Deubiquitination of TRAF6 Ligase. J Biol Chem. 2015;290:13372-85 pubmed publisher
western blot; human; 1:1000; loading ...; fig 6e	Dong T, Li C, Wang X, Dian L, Zhang X, Li L, et al. Ainsliadimer A selectively inhibits IKKα/β by covalently binding a conserved cysteine. Nat Commun. 2015;6:6522 pubmed publisher
western blot; human; 1:1000	Contreras T, Ricciardi E, Cremonini E, Oteiza P. (-)-Epicatechin in the prevention of tumor necrosis alpha-induced loss of Caco-2 cell barrier integrity. Arch Biochem Biophys. 2015;573:84-91 pubmed publisher
western blot; human; 1:1000	Cañeda Guzmán I, Salaiza Suazo N, Fernández Figueroa E, Carrada Figueroa G, Aguirre García M, Becker I. NK cell activity differs between patients with localized and diffuse cutaneous leishmaniasis infected with Leishmania mexicana: a comparative study of TLRs and cytokines. PLoS ONE. 2014;9:e112410 pubmed publisher
western blot; human	Zhuang C, Sheng C, Shin W, Wu Y, Li J, Yao J, et al. A novel drug discovery strategy: mechanistic investigation of an enantiomeric antitumor agent targeting dual p53 and NF-ÎºB pathways. Oncotarget. 2014;5:10830-9 pubmed
western blot; mouse	Zhao X, Zhu L, Chang Q, Jiang C, You Y, Luo T, et al. C-type lectin receptor dectin-3 mediates trehalose 6,6'-dimycolate (TDM)-induced Mincle expression through CARD9/Bcl10/MALT1-dependent nuclear factor (NF)-ÎºB activation. J Biol Chem. 2014;289:30052-62 pubmed publisher
western blot; mouse; 1:250	Nteeba J, Ganesan S, Keating A. Progressive obesity alters ovarian folliculogenesis with impacts on pro-inflammatory and steroidogenic signaling in female mice. Biol Reprod. 2014;91:86 pubmed publisher
western blot; mouse; fig 6	Tang S, Chen T, Yu Z, Zhu X, Yang M, Xie B, et al. RasGRP3 limits Toll-like receptor-triggered inflammatory response in macrophages by activating Rap1 small GTPase. Nat Commun. 2014;5:4657 pubmed publisher
immunohistochemistry - paraffin section; mouse; 1:150; fig 5	Stodden G, Lindberg M, King M, Paquet M, MacLean J, Mann J, et al. Loss of Cdh1 and Trp53 in the uterus induces chronic inflammation with modification of tumor microenvironment. Oncogene. 2015;34:2471-82 pubmed publisher
western blot; rat	Qian H, Shi J, Fan T, Lv J, Chen S, Song C, et al. Sophocarpine attenuates liver fibrosis by inhibiting the TLR4 signaling pathway in rats. World J Gastroenterol. 2014;20:1822-32 pubmed publisher
western blot; human	Olesen J, Gliemann L, Biensø R, Schmidt J, Hellsten Y, Pilegaard H. Exercise training, but not resveratrol, improves metabolic and inflammatory status in skeletal muscle of aged men. J Physiol. 2014;592:1873-86 pubmed publisher
western blot; human; 1:1000; loading ...; fig s2	Piao H, Yuan Y, Wang M, Sun Y, Liang H, Ma L. ?-catenin acts as a tumour suppressor in E-cadherin-negative basal-like breast cancer by inhibiting NF-?B signalling. Nat Cell Biol. 2014;16:245-54 pubmed publisher
western blot; rat; 1:1000	Zhang Q, Pan Y, Wang R, Kang L, Xue Q, Wang X, et al. Quercetin inhibits AMPK/TXNIP activation and reduces inflammatory lesions to improve insulin signaling defect in the hypothalamus of high fructose-fed rats. J Nutr Biochem. 2014;25:420-8 pubmed publisher
western blot; mouse; 1:1000	Bhaskar K, Maphis N, Xu G, Varvel N, Kokiko Cochran O, Weick J, et al. Microglial derived tumor necrosis factor-? drives Alzheimer's disease-related neuronal cell cycle events. Neurobiol Dis. 2014;62:273-85 pubmed publisher
immunohistochemistry - paraffin section; mouse	Aoshiba K, Tsuji T, Kameyama S, Itoh M, Semba S, Yamaguchi K, et al. Senescence-associated secretory phenotype in a mouse model of bleomycin-induced lung injury. Exp Toxicol Pathol. 2013;65:1053-62 pubmed publisher
western blot; human	Lau R, Niu M, Pratt M. cIAP2 represses IKK?/?-mediated activation of MDM2 to prevent p53 degradation. Cell Cycle. 2012;11:4009-19 pubmed publisher
western blot; human; fig 5	Wan F, Weaver A, Gao X, Bern M, Hardwidge P, Lenardo M. IKK? phosphorylation regulates RPS3 nuclear translocation and NF-?B function during infection with Escherichia coli strain O157:H7. Nat Immunol. 2011;12:335-43 pubmed publisher
	Sui Y, Liu Z, Park S, Thatcher S, Zhu B, Fernandez J, et al. IKKβ is a β-catenin kinase that regulates mesenchymal stem cell differentiation. JCI Insight. 2018;3: pubmed publisher
	Schlechter N, Glanzmann B, Hoal E, Schoeman M, Petersen B, Franke A, et al. Exome Sequencing Identifies a Novel MAP3K14 Mutation in Recessive Atypical Combined Immunodeficiency. Front Immunol. 2017;8:1624 pubmed publisher
	Xu J, Xu X, Wang B, Ma Y, Zhang L, Xu H, et al. Nuclear carbonic anhydrase 6B associates with PRMT5 to epigenetically promote IL-12 expression in innate response. Proc Natl Acad Sci U S A. 2017;114:8620-8625 pubmed publisher
	Brady G, Haas D, Farrell P, Pichlmair A, Bowie A. Molluscum Contagiosum Virus Protein MC005 Inhibits NF-ÎºB Activation by Targeting NEMO-Regulated IÎºB Kinase Activation. J Virol. 2017;91: pubmed publisher
	Chen B, Liu J, Ho T, Ding X, Mo Y. ERK-mediated NF-?B activation through ASIC1 in response to acidosis. Oncogenesis. 2016;5:e279 pubmed publisher
	Henry W, Laszewski T, Tsang T, Beca F, Beck A, McAllister S, et al. Aspirin Suppresses Growth in PI3K-Mutant Breast Cancer by Activating AMPK and Inhibiting mTORC1 Signaling. Cancer Res. 2017;77:790-801 pubmed publisher
	Adams A, Bolanos L, Dexheimer P, Karns R, Aronow B, Komurov K, et al. IRAK1 is a novel DEK transcriptional target and is essential for head and neck cancer cell survival. Oncotarget. 2015;6:43395-407 pubmed publisher
	Price L, Shao D, Meng C, Perros F, Garfield B, Zhu J, et al. Dexamethasone induces apoptosis in pulmonary arterial smooth muscle cells. Respir Res. 2015;16:114 pubmed publisher
	Wu J, Xu X, Li Y, Kou J, Huang F, Liu B, et al. Quercetin, luteolin and epigallocatechin gallate alleviate TXNIP and NLRP3-mediated inflammation and apoptosis with regulation of AMPK in endothelial cells. Eur J Pharmacol. 2014;745:59-68 pubmed publisher
	Lavorgna A, Matsuoka M, Harhaj E. A critical role for IL-17RB signaling in HTLV-1 tax-induced NF-ÎºB activation and T-cell transformation. PLoS Pathog. 2014;10:e1004418 pubmed publisher
	Wang Q, Chu C, Qian L, Chen S, Wilson B, Oyarzabal E, et al. Substance P exacerbates dopaminergic neurodegeneration through neurokinin-1 receptor-independent activation of microglial NADPH oxidase. J Neurosci. 2014;34:12490-503 pubmed publisher
	Dang Y, Xu Y, Wu W, Li W, Sun Y, Yang J, et al. Tetrandrine suppresses lipopolysaccharide-induced microglial activation by inhibiting NF-ÎºB and ERK signaling pathways in BV2 cells. PLoS ONE. 2014;9:e102522 pubmed publisher
	König H, Coughlan K, Kinsella S, Breen B, Prehn J. The BCL-2 family protein Bid is critical for pro-inflammatory signaling in astrocytes. Neurobiol Dis. 2014;70:99-107 pubmed publisher
	Zhang J, Clark K, Lawrence T, Peggie M, Cohen P. An unexpected twist to the activation of IKKÎ²: TAK1 primes IKKÎ² for activation by autophosphorylation. Biochem J. 2014;461:531-7 pubmed publisher
	Li H, Wang D. Streptococcus mutans wall-associated protein A promotes TLR4-induced dendritic cell maturation. Scand J Immunol. 2014;80:121-6 pubmed publisher
	Li Y, Xu Z, Yu Y, Yuan H, Xu H, Zhu Q, et al. The vagus nerve attenuates fulminant hepatitis by activating the Src kinase in Kuppfer cells. Scand J Immunol. 2014;79:105-12 pubmed publisher
	Li Y, Zhang P, Wang C, Han C, Meng J, Liu X, et al. Immune responsive gene 1 (IRG1) promotes endotoxin tolerance by increasing A20 expression in macrophages through reactive oxygen species. J Biol Chem. 2013;288:16225-34 pubmed publisher
	Zhao X, Rong L, Zhao X, Li X, Liu X, Deng J, et al. TNF signaling drives myeloid-derived suppressor cell accumulation. J Clin Invest. 2012;122:4094-104 pubmed publisher
	Yao J, Hu R, Sun J, Lin B, Zhao L, Sha Y, et al. Oroxylin A prevents inflammation-related tumor through down-regulation of inflammatory gene expression by inhibiting NF-?B signaling. Mol Carcinog. 2014;53:145-58 pubmed publisher
	Antoon J, White M, Burow M, Beckman B. Dual inhibition of sphingosine kinase isoforms ablates TNF-induced drug resistance. Oncol Rep. 2012;27:1779-86 pubmed publisher
	Wang Z, Sokolovska A, Seymour R, Sundberg J, HogenEsch H. SHARPIN is essential for cytokine production, NF-?B signaling, and induction of Th1 differentiation by dendritic cells. PLoS ONE. 2012;7:e31809 pubmed publisher
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product information

SKU :

2697S

Product-Name :

Phospho-IKKα/β (Ser176/180) (16A6) Rabbit mAb

Size :

100 ul

Price-(USD) :

274 USD

Species-x-Reactivity :

H, M, R, Mk, (B)

Applications :

Immunohistochemistry (Frozen)

Product-Category :

Immunology and Inflammation

Shipping-Temp :

AMBIENT

Storage-Temp :

-20°C

Product-Type :

Monoclonal Antibody

MW :

85 IKK-alpha 87 IKK-beta

Host :

Rabbit

Target :

IKK-alpha (Ser176/Ser180) phosphate

Primary-Protein :

IKK-alpha

Alt-Names :

CHUK,Conserved helix-loop-helix ubiquitous kinase,I-kappa-B kinase 1,I-kappa-B kinase alpha,I-kappa-B kinase-alpha,IKK-A,IKK-a kinase,IKK-alpha,IKK1,IKKA,IkB kinase alpha subunit,IkBKA,IkappaB kinase,Inhibitor of nuclear factor kappa-B kinase subunit alpha,NFKBIKA,Nuclear factor NF-kappa-B inhibitor kinase alpha,Nuclear factor NFkappaB inhibitor kinase alpha,TCF-16,TCF16,Transcription factor 16,conserved helix-loop ubiquitous kinase

more info or order :

Cell Signaling Technology product webpage