| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot knockout validation; mouse; 1:1000; loading ...; fig 3c
- immunohistochemistry - paraffin section; mouse; 1:100; fig 4d
| Coni S, Mancuso A, Di Magno L, Sdruscia G, Manni S, Serrao S, et al. Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma. Sci Rep. 2017;7:44079 pubmed publisher |
- western blot knockout validation; mouse; loading ...; fig 2a
| Xu T, Zhang H, Park S, Venneti S, Kuick R, Ha K, et al. Loss of Pin1 Suppresses Hedgehog-Driven Medulloblastoma Tumorigenesis. Neoplasia. 2017;19:216-225 pubmed publisher |
- western blot; mouse; 1:500; loading ...; fig 4s1a
| Kinnebrew M, Iverson E, Patel B, Pusapati G, Kong J, Johnson K, et al. Cholesterol accessibility at the ciliary membrane controls hedgehog signaling. elife. 2019;8: pubmed publisher |
- western blot; human; loading ...; fig 3c
| Das S, Jackson W, Prasain J, Hanna A, Bailey S, Tucker J, et al. Loss of Merlin induces metabolomic adaptation that engages dependence on Hedgehog signaling. Sci Rep. 2017;7:40773 pubmed publisher |
- western blot; human; loading ...; fig 4a
| Zhao Z, Lee R, Pusapati G, Iyu A, Rohatgi R, Ingham P. An essential role for Grk2 in Hedgehog signalling downstream of Smoothened. EMBO Rep. 2016;17:739-52 pubmed publisher |
- western blot; human; 1:1000; fig 4
| Vukićević T, Schulz M, Faust D, Klussmann E. The Trafficking of the Water Channel Aquaporin-2 in Renal Principal Cells-a Potential Target for Pharmacological Intervention in Cardiovascular Diseases. Front Pharmacol. 2016;7:23 pubmed publisher |
- western blot; mouse; fig 6
| Bhattacharyya S, Rainey M, Arya P, Mohapatra B, Mushtaq I, Dutta S, et al. Endocytic recycling protein EHD1 regulates primary cilia morphogenesis and SHH signaling during neural tube development. Sci Rep. 2016;6:20727 pubmed publisher |
- western blot; mouse; fig 3
| Shi X, Zhan X, Wu J. A positive feedback loop between Gli1 and tyrosine kinase Hck amplifies shh signaling activities in medulloblastoma. Oncogenesis. 2015;4:e176 pubmed publisher |
- western blot; mouse; loading ...; fig 5d
| Singh J, Wen X, Scales S. The Orphan G Protein-coupled Receptor Gpr175 (Tpra40) Enhances Hedgehog Signaling by Modulating cAMP Levels. J Biol Chem. 2015;290:29663-75 pubmed publisher |
- western blot; human; fig 4a
| Inaguma S, Ito H, Riku M, Ikeda H, Kasai K. Addiction of pancreatic cancer cells to zinc-finger transcription factor ZIC2. Oncotarget. 2015;6:28257-68 pubmed publisher |
- western blot; human; fig 4b
- western blot; mouse; loading ...; fig 1a
| Bora Singhal N, Perumal D, Nguyen J, Chellappan S. Gli1-Mediated Regulation of Sox2 Facilitates Self-Renewal of Stem-Like Cells and Confers Resistance to EGFR Inhibitors in Non-Small Cell Lung Cancer. Neoplasia. 2015;17:538-51 pubmed publisher |
- western blot; human; fig 4
| Lee S, Litan A, Li Z, Graves B, Lindsey S, Barwe S, et al. Na,K-ATPase β1-subunit is a target of sonic hedgehog signaling and enhances medulloblastoma tumorigenicity. Mol Cancer. 2015;14:159 pubmed publisher |
- western blot; mouse; fig 3
| Chong Y, Mann R, Zhao C, Kato M, Beachy P. Bifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5. Genes Dev. 2015;29:262-76 pubmed publisher |
- western blot; mouse; fig 6
| Shi X, Zhang Z, Zhan X, Cao M, Satoh T, Akira S, et al. An epigenetic switch induced by Shh signalling regulates gene activation during development and medulloblastoma growth. Nat Commun. 2014;5:5425 pubmed publisher |
| Matsumoto T, Tabata K, Suzuki T. The GANT61, a GLI inhibitor, induces caspase-independent apoptosis of SK-N-LO cells. Biol Pharm Bull. 2014;37:633-41 pubmed |
- western blot; mouse; fig 3
| Barakat M, Humke E, Scott M. Kif3a is necessary for initiation and maintenance of medulloblastoma. Carcinogenesis. 2013;34:1382-92 pubmed publisher |
| Pusapati G, Kong J, Patel B, Krishnan A, Sagner A, Kinnebrew M, et al. CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog. Dev Cell. 2018;44:113-129.e8 pubmed publisher |
| Zhao Z, Jia Q, Wu M, Xie X, Wang Y, Song G, et al. Degalactotigonin, a Natural Compound from Solanum nigrum L., Inhibits Growth and Metastasis of Osteosarcoma through GSK3β Inactivation-Mediated Repression of the Hedgehog/Gli1 Pathway. Clin Cancer Res. 2018;24:130-144 pubmed publisher |
| Po A, Silvano M, Miele E, Capalbo C, Eramo A, Salvati V, et al. Noncanonical GLI1 signaling promotes stemness features and in vivo growth in lung adenocarcinoma. Oncogene. 2017;36:4641-4652 pubmed publisher |
| Luchetti G, Sircar R, Kong J, Nachtergaele S, Sagner A, Byrne E, et al. Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling. elife. 2016;5: pubmed publisher |
| Byrne E, Sircar R, Miller P, Hedger G, Luchetti G, Nachtergaele S, et al. Structural basis of Smoothened regulation by its extracellular domains. Nature. 2016;535:517-522 pubmed publisher |
| Carbe C, Cheng L, Addya S, Gold J, Gao E, Koch W, et al. Gi proteins mediate activation of the canonical hedgehog pathway in the myocardium. Am J Physiol Heart Circ Physiol. 2014;307:H66-72 pubmed publisher |
| Beauchamp E, Ringer L, Bulut G, Sajwan K, Hall M, Lee Y, et al. Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway. J Clin Invest. 2011;121:148-60 pubmed publisher |
