product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
SirT3 (C73E3) Rabbit mAb
catalog :
2627
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
C73E3
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunoprecipitation, immunohistochemistry - paraffin section, western blot knockout validation
more info or order :
Cell Signaling Technology product webpage
citations: 15
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; human; 1:1000; loading ...; fig 1m
Wei Z, Song J, Wang G, Cui X, Zheng J, Tang Y, et al. Deacetylation of serine hydroxymethyl-transferase 2 by SIRT3 promotes colorectal carcinogenesis. Nat Commun. 2018;9:4468 pubmed publisher
  • immunohistochemistry - paraffin section; human
  • immunohistochemistry; human
Lin J, Izar B, Wang S, Yapp C, Mei S, Shah P, et al. Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes. elife. 2018;7: pubmed publisher
  • western blot; mouse; loading ...; fig 6a
Peterson B, Campbell J, Ilkayeva O, Grimsrud P, Hirschey M, Newgard C. Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or ? Cell Metabolism in the Absence of Overnutrition. Cell Rep. 2018;24:209-223.e6 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4a
Lee C, Hanna A, Wang H, Dagnino Acosta A, Joshi A, Knoblauch M, et al. A chemical chaperone improves muscle function in mice with a RyR1 mutation. Nat Commun. 2017;8:14659 pubmed publisher
  • western blot; human; fig 2a
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 9a
Li Y, Choi D, Lee E, Seo S, Lee S, Cho E. Sirtuin 3 (SIRT3) Regulates α-Smooth Muscle Actin (α-SMA) Production through the Succinate Dehydrogenase-G Protein-coupled Receptor 91 (GPR91) Pathway in Hepatic Stellate Cells. J Biol Chem. 2016;291:10277-92 pubmed publisher
  • western blot; human; fig 1a
  • western blot; mouse; fig 1a
Liu R, Fan M, Candas D, Qin L, Zhang X, Eldridge A, et al. CDK1-Mediated SIRT3 Activation Enhances Mitochondrial Function and Tumor Radioresistance. Mol Cancer Ther. 2015;14:2090-102 pubmed publisher
  • immunohistochemistry; human; 1:50; fig 1
McGlynn L, McCluney S, Jamieson N, Thomson J, MacDonald A, Oien K, et al. SIRT3 & SIRT7: Potential Novel Biomarkers for Determining Outcome in Pancreatic Cancer Patients. PLoS ONE. 2015;10:e0131344 pubmed publisher
  • western blot; human
Li Y, Wang W, Xu X, Sun S, Xu X, Qu X. {2-[1-(3-Methoxycarbonylmethyl-1H-indol-2-yl)-1-methyl-ethyl]-1H-indol-3-yl}-acetic Acid Methyl Ester Inhibited Hepatocellular Carcinoma Growth in Bel-7402 Cells and Its Resistant Variants by Activation of NOX4 and SIRT3. Biomed Res Int. 2015;2015:491205 pubmed publisher
  • western blot; human; fig s3
Polletta L, Vernucci E, Carnevale I, Arcangeli T, Rotili D, Palmerio S, et al. SIRT5 regulation of ammonia-induced autophagy and mitophagy. Autophagy. 2015;11:253-70 pubmed publisher
Garva R, Thepmalee C, Yasamut U, Sudsaward S, Guazzelli A, Rajendran R, et al. Sirtuin Family Members Selectively Regulate Autophagy in Osteosarcoma and Mesothelioma Cells in Response to Cellular Stress. Front Oncol. 2019;9:949 pubmed publisher
Kenny T, Craig A, Villanueva A, Germain D. Mitohormesis Primes Tumor Invasion and Metastasis. Cell Rep. 2019;27:2292-2303.e6 pubmed publisher
Lim R, Barker G, Menon R, Lappas M. A Novel Role for SIRT3 in Regulating Mediators Involved in the Terminal Pathways of Human Labor and Delivery. Biol Reprod. 2016;95:95 pubmed
Pantazi E, Folch Puy E, Bejaoui M, Panisello A, Varela A, Rolo A, et al. PPARα Agonist WY-14643 Induces SIRT1 Activity in Rat Fatty Liver Ischemia-Reperfusion Injury. Biomed Res Int. 2015;2015:894679 pubmed publisher
Wang X, Shao Y, Ma C, Chen W, Sun L, Liu W, et al. Decreased SIRT3 in aged human mesenchymal stromal/stem cells increases cellular susceptibility to oxidative stress. J Cell Mol Med. 2014;18:2298-310 pubmed publisher
Lutz M, Milenkovic I, Regelsberger G, Kovacs G. Distinct patterns of sirtuin expression during progression of Alzheimer's disease. Neuromolecular Med. 2014;16:405-14 pubmed publisher
product information
SKU :
2627S
Product-Name :
SirT3 (C73E3) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, R, Mk
Applications :
Immunohistochemistry (Paraffin)
Product-Category :
Chromatin Regulation / Nuclear Function
Shipping-Temp :
COLD
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
28
Host :
Rabbit
Target :
SirT3
Primary-Protein :
SIRT3
Alt-Names :
NAD-dependent deacetylase sirtuin-3, mitochondrial,SIR2-like protein 3,SIR2L3,SIRT3,hSIRT3,mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase,silent mating type information regulation 2, S.cerevisiae, homolog 3,sir2-like 3,sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae),sirtuin type 3
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.