| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot knockout validation; mouse; 1:1000; loading ...; fig 5G
- western blot; African green monkey; 1:1000; loading ...; fig S1L
| Herms A, Bosch M, Reddy B, Schieber N, Fajardo A, Rupérez C, et al. AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation. Nat Commun. 2015;6:7176 pubmed publisher |
- western blot; rat; loading ...; fig 4a
| Zhang N, Wei W, Liao H, Yang Z, Hu C, Wang S, et al. AdipoRon, an adiponectin receptor agonist, attenuates cardiac remodeling induced by pressure overload. J Mol Med (Berl). 2018;: pubmed publisher |
- western blot; mouse; 1:1000; fig 5a
| Yang L, Shen L, Gao P, Li G, He Y, Wang M, et al. Effect of AMPK signal pathway on pathogenesis of abdominal aortic aneurysms. Oncotarget. 2017;8:92827-92840 pubmed publisher |
- western blot; mouse; loading ...; fig 2b
- western blot; human; loading ...; fig 2a
| Hwangbo C, Wu J, Papangeli I, Adachi T, Sharma B, Park S, et al. Endothelial APLNR regulates tissue fatty acid uptake and is essential for apelin's glucose-lowering effects. Sci Transl Med. 2017;9: pubmed publisher |
- western blot; mouse; loading ...; fig 2d
| Vienken H, Mabrouki N, Grabau K, Claas R, Rudowski A, Schömel N, et al. Characterization of cholesterol homeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts reveals a Niemann-Pick disease type C-like phenotype with enhanced lysosomal Ca2+ storage. Sci Rep. 2017;7:43575 pubmed publisher |
- western blot; mouse; loading ...; fig 1b
| Qiao A, Jin X, Pang J, Moskophidis D, Mivechi N. The transcriptional regulator of the chaperone response HSF1 controls hepatic bioenergetics and protein homeostasis. J Cell Biol. 2017;216:723-741 pubmed publisher |
- western blot; mouse; 1:1000; fig 4g
| Cederquist C, Lentucci C, Martinez Calejman C, Hayashi V, Orofino J, GUERTIN D, et al. Systemic insulin sensitivity is regulated by GPS2 inhibition of AKT ubiquitination and activation in adipose tissue. Mol Metab. 2017;6:125-137 pubmed publisher |
- western blot; mouse; 1:1000; fig 2
| Möllmann J, Kahles F, Lebherz C, Kappel B, Baeck C, Tacke F, et al. The PDE4 inhibitor roflumilast reduces weight gain by increasing energy expenditure and leads to improved glucose metabolism. Diabetes Obes Metab. 2017;19:496-508 pubmed publisher |
- western blot; mouse; loading ...; fig 5c
| Park J, Kim S, Yoo J, Jang J, Lee A, Oh J, et al. Novel Neuroprotective Effects of Melanin-Concentrating Hormone in Parkinson's Disease. Mol Neurobiol. 2017;54:7706-7721 pubmed publisher |
- western blot; mouse; loading ...; fig 8a
| Gurley J, Ilkayeva O, Jackson R, Griesel B, White P, Matsuzaki S, et al. Enhanced GLUT4-Dependent Glucose Transport Relieves Nutrient Stress in Obese Mice Through Changes in Lipid and Amino Acid Metabolism. Diabetes. 2016;65:3585-3597 pubmed |
- western blot; human; 1:1000; loading ...; fig 6f
| Zhong W, Yi Q, Xu B, Li S, Wang T, Liu F, et al. ORP4L is essential for T-cell acute lymphoblastic leukemia cell survival. Nat Commun. 2016;7:12702 pubmed publisher |
| Koch F, Lamp O, Eslamizad M, Weitzel J, Kuhla B. Metabolic Response to Heat Stress in Late-Pregnant and Early Lactation Dairy Cows: Implications to Liver-Muscle Crosstalk. PLoS ONE. 2016;11:e0160912 pubmed publisher |
- western blot; mouse; loading ...; fig 1b
| Cameron A, Morrison V, Levin D, Mohan M, Forteath C, Beall C, et al. Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status. Circ Res. 2016;119:652-65 pubmed publisher |
- western blot; human; fig 3
| Oliveira A, Gomes Marcondes M. Metformin treatment modulates the tumour-induced wasting effects in muscle protein metabolism minimising the cachexia in tumour-bearing rats. BMC Cancer. 2016;16:418 pubmed publisher |
- western blot; mouse; fig 4
| Shinohara S, Gu Y, Yang Y, Furuta Y, Tanaka M, Yue X, et al. Ethanol extracts of chickpeas alter the total lipid content and expression levels of genes related to fatty acid metabolism in mouse 3T3-L1 adipocytes. Int J Mol Med. 2016;38:574-84 pubmed publisher |
| Kim J, Hong S, Park C, Park J, Choi S, Woo S, et al. Intramyocardial Adipose-Derived Stem Cell Transplantation Increases Pericardial Fat with Recovery of Myocardial Function after Acute Myocardial Infarction. PLoS ONE. 2016;11:e0158067 pubmed publisher |
- western blot; human; fig 1
| Taniguchi T, Iizumi Y, Watanabe M, Masuda M, Morita M, Aono Y, et al. Resveratrol directly targets DDX5 resulting in suppression of the mTORC1 pathway in prostate cancer. Cell Death Dis. 2016;7:e2211 pubmed publisher |
- western blot; mouse; 1:1000; fig 4
| Walter C, Clemens L, Müller A, Fallier Becker P, Proikas Cezanne T, Riess O, et al. Activation of AMPK-induced autophagy ameliorates Huntington disease pathology in vitro. Neuropharmacology. 2016;108:24-38 pubmed publisher |
- western blot; mouse; 1:1000; fig 6
| Dokas J, Chadt A, Joost H, Al Hasani H. Tbc1d1 deletion suppresses obesity in leptin-deficient mice. Int J Obes (Lond). 2016;40:1242-9 pubmed publisher |
- western blot; mouse; 1:3000; fig 4
| Dinger K, Kasper P, Hucklenbruch Rother E, Vohlen C, Jobst E, Janoschek R, et al. Early-onset obesity dysregulates pulmonary adipocytokine/insulin signaling and induces asthma-like disease in mice. Sci Rep. 2016;6:24168 pubmed publisher |
- western blot; human; loading ...; fig 3e
| Su K, Cao J, Tang Z, Dai S, He Y, Sampson S, et al. HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth. Nat Cell Biol. 2016;18:527-39 pubmed publisher |
- western blot; human; fig 3
| Pandiri I, Chen Y, Joe Y, Kim H, Park J, Chung H, et al. Tristetraprolin mediates the anti-proliferative effects of metformin in breast cancer cells. Breast Cancer Res Treat. 2016;156:57-64 pubmed publisher |
- western blot; mouse; fig 5
| Ost M, Coleman V, Voigt A, van Schothorst E, Keipert S, van der Stelt I, et al. Muscle mitochondrial stress adaptation operates independently of endogenous FGF21 action. Mol Metab. 2016;5:79-90 pubmed publisher |
- western blot; mouse; 1:500; fig 4
| Ruiz A, Rockfield S, Taran N, Haller E, Engelman R, Flores I, et al. Effect of hydroxychloroquine and characterization of autophagy in a mouse model of endometriosis. Cell Death Dis. 2016;7:e2059 pubmed publisher |
- western blot; human; 1:1000; fig 8
| E L, Swerdlow R. Lactate's effect on human neuroblastoma cell bioenergetic fluxes. Biochem Pharmacol. 2016;99:88-100 pubmed publisher |
- western blot; mouse; fig 4a
| Lee Y, Yun M, Kim H, Jeon B, Park B, Lee B, et al. Exogenous administration of DLK1 ameliorates hepatic steatosis and regulates gluconeogenesis via activation of AMPK. Int J Obes (Lond). 2016;40:356-65 pubmed publisher |
- western blot; human; fig 1
| Murata Y, Uehara Y, Hosoi Y. Activation of mTORC1 under nutrient starvation conditions increases cellular radiosensitivity in human liver cancer cell lines, HepG2 and HuH6. Biochem Biophys Res Commun. 2015;468:684-90 pubmed publisher |
- western blot; human; fig 4
| Zucal C, D Agostino V, Casini A, Mantelli B, Thongon N, Soncini D, et al. EIF2A-dependent translational arrest protects leukemia cells from the energetic stress induced by NAMPT inhibition. BMC Cancer. 2015;15:855 pubmed publisher |
- western blot; human; loading ...; fig 3c
| Jeon J, Kim S, Park K, Yun M. The bifunctional autophagic flux by 2-deoxyglucose to control survival or growth of prostate cancer cells. BMC Cancer. 2015;15:623 pubmed publisher |
| Bejaoui M, Pantazi E, De Luca V, Panisello A, Folch Puy E, Hotter G, et al. Carbonic Anhydrase Protects Fatty Liver Grafts against Ischemic Reperfusion Damage. PLoS ONE. 2015;10:e0134499 pubmed publisher |
| Perera R, Stoykova S, Nicolay B, Ross K, Fitamant J, Boukhali M, et al. Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism. Nature. 2015;524:361-5 pubmed publisher |
- western blot; mouse; 1:1000; fig 5
| Shi S, Lu S, Sivasubramaniyam T, Revelo X, Cai E, Luk C, et al. DJ-1 links muscle ROS production with metabolic reprogramming and systemic energy homeostasis in mice. Nat Commun. 2015;6:7415 pubmed publisher |
- western blot; human; fig 3
| Yen C, Chiang W, Liu S, Lin C, Liao K, Lin C, et al. Impacts of autophagy-inducing ingredient of areca nut on tumor cells. PLoS ONE. 2015;10:e0128011 pubmed publisher |
| De Zio D, Molinari F, Rizza S, Gatta L, Ciotti M, Salvatore A, et al. Apaf1-deficient cortical neurons exhibit defects in axonal outgrowth. Cell Mol Life Sci. 2015;72:4173-91 pubmed publisher |
- western blot; human; 1:1000
| Mendonsa A, Chalfant M, Gorden L, VanSaun M. Modulation of the leptin receptor mediates tumor growth and migration of pancreatic cancer cells. PLoS ONE. 2015;10:e0126686 pubmed publisher |
- western blot; mouse; 1:2000; fig 1
| Yan Y, Tsukamoto O, Nakano A, Kato H, Kioka H, Ito N, et al. Augmented AMPK activity inhibits cell migration by phosphorylating the novel substrate Pdlim5. Nat Commun. 2015;6:6137 pubmed publisher |
- western blot; mouse; fig s3
| Xu R, Hu Q, Ma Q, Liu C, Wang G. The protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathway. Cell Death Dis. 2014;5:e1373 pubmed publisher |
| Abdul Wahed A, Gautier Stein A, Casteras S, Soty M, Roussel D, Romestaing C, et al. A link between hepatic glucose production and peripheral energy metabolism via hepatokines. Mol Metab. 2014;3:531-43 pubmed publisher |
- western blot; human; fig 1a
- western blot; mouse; fig 1b
| Lau A, Liu P, Inuzuka H, Gao D. SIRT1 phosphorylation by AMP-activated protein kinase regulates p53 acetylation. Am J Cancer Res. 2014;4:245-55 pubmed |
- western blot; human; loading ...; fig 6a
- western blot; mouse; loading ...; fig 1c
| Cicerchi C, Li N, Kratzer J, Garcia G, Roncal Jimenez C, Tanabe K, et al. Uric acid-dependent inhibition of AMP kinase induces hepatic glucose production in diabetes and starvation: evolutionary implications of the uricase loss in hominids. FASEB J. 2014;28:3339-50 pubmed publisher |
- western blot; mouse; 1:1000
| Bejarano E, Yuste A, Patel B, Stout R, Spray D, Cuervo A. Connexins modulate autophagosome biogenesis. Nat Cell Biol. 2014;16:401-14 pubmed publisher |
| Yi X, Pashaj A, Xia M, Moreau R. Reversal of obesity-induced hypertriglyceridemia by (R)-?-lipoic acid in ZDF (fa/fa) rats. Biochem Biophys Res Commun. 2013;439:390-5 pubmed publisher |
| Kim J, Hu Z, Cai L, Li K, Choi E, Faubert B, et al. CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells. Nature. 2017;546:168-172 pubmed publisher |
| Leidgens V, Proske J, Rauer L, Moeckel S, Renner K, Bogdahn U, et al. Stattic and metformin inhibit brain tumor initiating cells by reducing STAT3-phosphorylation. Oncotarget. 2017;8:8250-8263 pubmed publisher |
| Anders P, Zhang Z, Bhende P, Giffin L, Damania B. The KSHV K1 Protein Modulates AMPK Function to Enhance Cell Survival. PLoS Pathog. 2016;12:e1005985 pubmed publisher |
| Yamamoto H, Morino K, Mengistu L, Ishibashi T, Kiriyama K, Ikami T, et al. Amla Enhances Mitochondrial Spare Respiratory Capacity by Increasing Mitochondrial Biogenesis and Antioxidant Systems in a Murine Skeletal Muscle Cell Line. Oxid Med Cell Longev. 2016;2016:1735841 pubmed publisher |
| Ideta T, Shirakami Y, Miyazaki T, Kochi T, Sakai H, Moriwaki H, et al. The Dipeptidyl Peptidase-4 Inhibitor Teneligliptin Attenuates Hepatic Lipogenesis via AMPK Activation in Non-Alcoholic Fatty Liver Disease Model Mice. Int J Mol Sci. 2015;16:29207-18 pubmed publisher |
| Tavecchio M, Lisanti S, Bennett M, Languino L, Altieri D. Deletion of Cyclophilin D Impairs β-Oxidation and Promotes Glucose Metabolism. Sci Rep. 2015;5:15981 pubmed publisher |
| Ge R, Wang Z, Wu S, Zhuo Y, Otsetov A, Cai C, et al. Metformin represses cancer cells via alternate pathways in N-cadherin expressing vs. N-cadherin deficient cells. Oncotarget. 2015;6:28973-87 pubmed publisher |
| Combes A, Dekerle J, Webborn N, Watt P, Bougault V, Daussin F. Exercise-induced metabolic fluctuations influence AMPK, p38-MAPK and CaMKII phosphorylation in human skeletal muscle. Physiol Rep. 2015;3: pubmed publisher |
| Hrynyk M, Ellis J, Haxho F, Allison S, Steele J, Abdulkhalek S, et al. Therapeutic designed poly (lactic-co-glycolic acid) cylindrical oseltamivir phosphate-loaded implants impede tumor neovascularization, growth and metastasis in mouse model of human pancreatic carcinoma. Drug Des Devel Ther. 2015;9:4573-86 pubmed publisher |
| Parodi B, Rossi S, Morando S, Cordano C, Bragoni A, Motta C, et al. Fumarates modulate microglia activation through a novel HCAR2 signaling pathway and rescue synaptic dysregulation in inflamed CNS. Acta Neuropathol. 2015;130:279-95 pubmed publisher |
| Zhang X, Zhang T, Song D, Zhou J, Han R, Qin Z, et al. Endoplasmic reticulum chaperone GRP78 is involved in autophagy activation induced by ischemic preconditioning in neural cells. Mol Brain. 2015;8:20 pubmed publisher |
| Shibuya K, Okada M, Suzuki S, Seino M, Seino S, Takeda H, et al. Targeting the facilitative glucose transporter GLUT1 inhibits the self-renewal and tumor-initiating capacity of cancer stem cells. Oncotarget. 2015;6:651-61 pubmed |
| Abdulkhalek S, Geen O, Brodhagen L, Haxho F, Alghamdi F, Allison S, et al. Transcriptional factor snail controls tumor neovascularization, growth and metastasis in mouse model of human ovarian carcinoma. Clin Transl Med. 2014;3:28 pubmed publisher |
| Lin L, Lee J, Bongmba O, Ma X, Zhu X, Sheikh Hamad D, et al. The suppression of ghrelin signaling mitigates ageâ€associated thermogenic impairment. Aging (Albany NY). 2014;6:1019-32 pubmed |
| Langone F, Cannata S, Fuoco C, Lettieri Barbato D, Testa S, Nardozza A, et al. Metformin protects skeletal muscle from cardiotoxin induced degeneration. PLoS ONE. 2014;9:e114018 pubmed publisher |
| Cattaneo F, Guerra G, Parisi M, De Marinis M, Tafuri D, Cinelli M, et al. Cell-surface receptors transactivation mediated by g protein-coupled receptors. Int J Mol Sci. 2014;15:19700-28 pubmed publisher |
| Moak S, Dougan G, MarElia C, Danse W, Fernandez A, Kuehl M, et al. Enhanced glucose tolerance in pancreatic-derived factor (PANDER) knockout C57BL/6 mice. Dis Model Mech. 2014;7:1307-15 pubmed publisher |
| Chalkiadaki A, Igarashi M, Nasamu A, Knezevic J, Guarente L. Muscle-specific SIRT1 gain-of-function increases slow-twitch fibers and ameliorates pathophysiology in a mouse model of duchenne muscular dystrophy. PLoS Genet. 2014;10:e1004490 pubmed publisher |
| Chen C, Lin J, Cheng Y, Kuo C, Huang C, Kao S, et al. Amelioration of LPS-induced inflammation response in microglia by AMPK activation. Biomed Res Int. 2014;2014:692061 pubmed publisher |
| Ost M, Werner F, Dokas J, Klaus S, Voigt A. Activation of AMPK?2 is not crucial for mitochondrial uncoupling-induced metabolic effects but required to maintain skeletal muscle integrity. PLoS ONE. 2014;9:e94689 pubmed publisher |
| Ritchie I, Macdonald T, Wright D, Dyck D. Adiponectin is sufficient, but not required, for exercise-induced increases in the expression of skeletal muscle mitochondrial enzymes. J Physiol. 2014;592:2653-65 pubmed publisher |
| Tang C, Yang L, Jiang X, Xu C, Wang M, Wang Q, et al. Antibiotic drug tigecycline inhibited cell proliferation and induced autophagy in gastric cancer cells. Biochem Biophys Res Commun. 2014;446:105-12 pubmed publisher |
| O Shea L, Abdulkhalek S, Allison S, Neufeld R, Szewczuk M. Therapeutic targeting of Neu1 sialidase with oseltamivir phosphate (Tamiflu®) disables cancer cell survival in human pancreatic cancer with acquired chemoresistance. Onco Targets Ther. 2014;7:117-34 pubmed publisher |
| Shen M, Zhang Z, Ratnam M, Dou Q. The interplay of AMP-activated protein kinase and androgen receptor in prostate cancer cells. J Cell Physiol. 2014;229:688-95 pubmed publisher |
| Mazurais D, Ferraresso S, Gatta P, Desbruyeres E, Sévère A, Corporeau C, et al. Identification of hypoxia-regulated genes in the liver of common sole (Solea solea) fed different dietary lipid contents. Mar Biotechnol (NY). 2014;16:277-88 pubmed publisher |
| Pucer A, Brglez V, Payre C, Pungercar J, Lambeau G, Petan T. Group X secreted phospholipase A(2) induces lipid droplet formation and prolongs breast cancer cell survival. Mol Cancer. 2013;12:111 pubmed publisher |
| Kitada M, Koya D. The use of calorie restriction mimetics to study aging. Methods Mol Biol. 2013;1048:95-107 pubmed publisher |
| Tsunekawa Imai N, Miwa H, Shikami M, Suganuma K, Goto M, Mizuno S, et al. Growth of xenotransplanted leukemia cells is influenced by diet nutrients and is attenuated with 2-deoxyglucose. Leuk Res. 2013;37:1132-6 pubmed publisher |
| Fong J, Le Nihouannen D, Tiedemann K, Sadvakassova G, Barralet J, Komarova S. Moderate excess of pyruvate augments osteoclastogenesis. Biol Open. 2013;2:387-95 pubmed publisher |
| Bian S, Sun X, Bai A, Zhang C, Li L, Enjyoji K, et al. P2X7 integrates PI3K/AKT and AMPK-PRAS40-mTOR signaling pathways to mediate tumor cell death. PLoS ONE. 2013;8:e60184 pubmed publisher |
| Chen H, Luo Z, Dong L, Tan Y, Yang J, Feng G, et al. CD133/prominin-1-mediated autophagy and glucose uptake beneficial for hepatoma cell survival. PLoS ONE. 2013;8:e56878 pubmed publisher |
| Hernández Vázquez A, Ochoa Ruiz E, Ibarra Gonzalez I, Ortega Cuellar D, Salvador Adriano A, Velazquez Arellano A. Temporal development of genetic and metabolic effects of biotin deprivation. A search for the optimum time to study a vitamin deficiency. Mol Genet Metab. 2012;107:345-51 pubmed publisher |
| Magnaudeix A, Wilson C, Page G, Bauvy C, Codogno P, Leveque P, et al. PP2A blockade inhibits autophagy and causes intraneuronal accumulation of ubiquitinated proteins. Neurobiol Aging. 2013;34:770-90 pubmed publisher |
| Hofmann S, Cherkasova V, Bankhead P, Bukau B, Stoecklin G. Translation suppression promotes stress granule formation and cell survival in response to cold shock. Mol Biol Cell. 2012;23:3786-800 pubmed publisher |
| Osawa Y, Kanamori H, Seki E, Hoshi M, Ohtaki H, Yasuda Y, et al. L-tryptophan-mediated enhancement of susceptibility to nonalcoholic fatty liver disease is dependent on the mammalian target of rapamycin. J Biol Chem. 2011;286:34800-8 pubmed publisher |
| Bevan H, Slater S, Clarke H, Cahill P, Mathieson P, Welsh G, et al. Acute laminar shear stress reversibly increases human glomerular endothelial cell permeability via activation of endothelial nitric oxide synthase. Am J Physiol Renal Physiol. 2011;301:F733-42 pubmed publisher |
| Wen H, Gris D, Lei Y, JHA S, Zhang L, Huang M, et al. Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nat Immunol. 2011;12:408-15 pubmed publisher |
| Osawa Y, Seki E, Kodama Y, Suetsugu A, Miura K, Adachi M, et al. Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression. FASEB J. 2011;25:1133-44 pubmed publisher |
| Jiang S, Inada T, Tanaka M, Furuta R, Shingu K, Fujisawa J. Involvement of TORC2, a CREB co-activator, in the in vivo-specific transcriptional control of HTLV-1. Retrovirology. 2009;6:73 pubmed publisher |
| Krimi R, Letteron P, Chedid P, Nazaret C, Ducroc R, Marie J. Resistin-like molecule-beta inhibits SGLT-1 activity and enhances GLUT2-dependent jejunal glucose transport. Diabetes. 2009;58:2032-8 pubmed publisher |
| Boily G, Seifert E, Bevilacqua L, He X, Sabourin G, Estey C, et al. SirT1 regulates energy metabolism and response to caloric restriction in mice. PLoS ONE. 2008;3:e1759 pubmed publisher |
