product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
PCNA (PC10) Mouse mAb
catalog :
2586S
quantity :
100 ul
price :
235 USD
clonality :
monoclonal
host :
mouse
reactivity :
human, mouse, rat, cow
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 48
Published Application/Species/DilutionReference
  • western blot; human; fig s1
Hrecka K, Hao C, Shun M, Kaur S, Swanson S, Florens L, et al. HIV-1 and HIV-2 exhibit divergent interactions with HLTF and UNG2 DNA repair proteins. Proc Natl Acad Sci U S A. 2016;113:E3921-30 pubmed publisher
  • western blot; mouse; fig 3
de Jong P, Taniguchi K, Harris A, Bertin S, Takahashi N, Duong J, et al. ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation. Nat Commun. 2016;7:11551 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100
Kaku M, Rosales Rocabado J, Kitami M, Ida T, Akiba Y, Yamauchi M, et al. Mechanical Loading Stimulates Expression of Collagen Cross-Linking Associated Enzymes in Periodontal Ligament. J Cell Physiol. 2016;231:926-33 pubmed publisher
  • western blot; human
Xue H, Yuan G, Guo X, Liu Q, Zhang J, Gao X, et al. A novel tumor-promoting mechanism of IL6 and the therapeutic efficacy of tocilizumab: Hypoxia-induced IL6 is a potent autophagy initiator in glioblastoma via the p-STAT3-MIR155-3p-CREBRF pathway. Autophagy. 2016;12:1129-52 pubmed publisher
  • immunohistochemistry; mouse; 1:300; fig 2, 4, 5
Trasino S, Benoit Y, Gudas L. Vitamin A deficiency causes hyperglycemia and loss of pancreatic β-cell mass. J Biol Chem. 2015;290:1456-73 pubmed publisher
  • immunohistochemistry; rat
Chen W, Chen C, Chen N, Sung C, Wen Z. Neuroprotective Effects of Direct Intrathecal Administration of Granulocyte Colony-Stimulating Factor in Rats with Spinal Cord Injury. CNS Neurosci Ther. 2015;21:698-707 pubmed publisher
  • western blot; mouse; 1:1000
Olah G, Szczesny B, Brunyánszki A, López-García I, Gero D, Radak Z, et al. Differentiation-Associated Downregulation of Poly(ADP-Ribose) Polymerase-1 Expression in Myoblasts Serves to Increase Their Resistance to Oxidative Stress. PLoS ONE. 2015;10:e0134227 pubmed publisher
  • immunohistochemistry; human
Knoblich K, Wang H, Sharma C, Fletcher A, Turley S, Hemler M. Tetraspanin TSPAN12 regulates tumor growth and metastasis and inhibits β-catenin degradation. Cell Mol Life Sci. 2014;71:1305-14 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:3000
  • western blot; mouse; 1:3000
Xiao W, Feng Y, Holst J, Hartmann B, Yang H, Teitelbaum D. Glutamate prevents intestinal atrophy via luminal nutrient sensing in a mouse model of total parenteral nutrition. FASEB J. 2014;28:2073-87 pubmed publisher
  • western blot; mouse; fig 13
Edwards J, Bruno J, Key P, Cheng Y. Absence of chloride intracellular channel 4 (CLIC4) predisposes to acute kidney injury but has minimal impact on recovery. BMC Nephrol. 2014;15:54 pubmed publisher
Cao J, Huang W. Compensatory Increase of Transglutaminase 2 Is Responsible for Resistance to mTOR Inhibitor Treatment. PLoS ONE. 2016;11:e0149388 pubmed publisher
Aini H, Itaka K, Fujisawa A, Uchida H, Uchida S, Fukushima S, et al. Messenger RNA delivery of a cartilage-anabolic transcription factor as a disease-modifying strategy for osteoarthritis treatment. Sci Rep. 2016;6:18743 pubmed publisher
Yan G, Wang Q, Hu S, Wang D, Qiao Y, Ma G, et al. Digoxin inhibits PDGF-BB-induced VSMC proliferation and migration through an increase in ILK signaling and attenuates neointima formation following carotid injury. Int J Mol Med. 2015;36:1001-11 pubmed publisher
Senger S, Kollmar O, Menger M, Schilling M, Rupertus K. Darbepoetin-α accelerates neovascularization and engraftment of extrahepatic colorectal metastases. Eur Surg Res. 2014;53:25-36 pubmed publisher
Huang T, Tsai Y, Chiang S, Wang G, Kuo Y, Chang Y, et al. Anti-viral effect of a compound isolated from Liriope platyphylla against hepatitis B virus in vitro. Virus Res. 2014;192:16-24 pubmed publisher
Kitajima M, Dolmans M, Donnez O, Masuzaki H, Soares M, Donnez J. Enhanced follicular recruitment and atresia in cortex derived from ovaries with endometriomas. Fertil Steril. 2014;101:1031-7 pubmed publisher
Kato S, Hayakawa Y, Sakurai H, Saiki I, Yokoyama S. Mesenchymal-transitioned cancer cells instigate the invasion of epithelial cancer cells through secretion of WNT3 and WNT5B. Cancer Sci. 2014;105:281-9 pubmed publisher
Inoue A, Kikuchi S, Hishiki A, Shao Y, Heath R, Evison B, et al. A small molecule inhibitor of monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin. J Biol Chem. 2014;289:7109-20 pubmed publisher
Bonacci T, Audebert S, Camoin L, Baudelet E, Bidaut G, Garcia M, et al. Identification of new mechanisms of cellular response to chemotherapy by tracking changes in post-translational modifications by ubiquitin and ubiquitin-like proteins. J Proteome Res. 2014;13:2478-94 pubmed publisher
Tsuneki M, Madri J. CD44 regulation of endothelial cell proliferation and apoptosis via modulation of CD31 and VE-cadherin expression. J Biol Chem. 2014;289:5357-70 pubmed publisher
Tsuneki M, Madri J. Adhesion molecule-mediated hippo pathway modulates hemangioendothelioma cell behavior. Mol Cell Biol. 2014;34:4485-99 pubmed publisher
Kushwaha D, Ramakrishnan V, Ng K, Steed T, Nguyen T, Futalan D, et al. A genome-wide miRNA screen revealed miR-603 as a MGMT-regulating miRNA in glioblastomas. Oncotarget. 2014;5:4026-39 pubmed
Meeker S, Seamons A, Paik J, Treuting P, Brabb T, Grady W, et al. Increased dietary vitamin D suppresses MAPK signaling, colitis, and colon cancer. Cancer Res. 2014;74:4398-408 pubmed publisher
Cazzalini O, Sommatis S, Tillhon M, Dutto I, Bachi A, Rapp A, et al. CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis. Nucleic Acids Res. 2014;42:8433-48 pubmed publisher
Akane H, Shiraki A, Imatanaka N, Akahori Y, Itahashi M, Abe H, et al. Glycidol induces axonopathy and aberrations of hippocampal neurogenesis affecting late-stage differentiation by exposure to rats in a framework of 28-day toxicity study. Toxicol Lett. 2014;224:424-32 pubmed publisher
Lin X, Yi Z, Diao J, Shao M, Zhao L, Cai H, et al. ShaoYao decoction ameliorates colitis-associated colorectal cancer by downregulating proinflammatory cytokines and promoting epithelial-mesenchymal transition. J Transl Med. 2014;12:105 pubmed publisher
Yamada J, Jinno S. Novel objective classification of reactive microglia following hypoglossal axotomy using hierarchical cluster analysis. J Comp Neurol. 2013;521:1184-201 pubmed publisher
Currais A, Kato K, Canuet L, Ishii R, Tanaka T, Takeda M, et al. Caffeine modulates tau phosphorylation and affects Akt signaling in postmitotic neurons. J Mol Neurosci. 2011;43:326-32 pubmed publisher
Terai K, Shibata E, Abbas T, Dutta A. Degradation of p12 subunit by CRL4Cdt2 E3 ligase inhibits fork progression after DNA damage. J Biol Chem. 2013;288:30509-14 pubmed publisher
Kurose H, Shibata M, Iinuma M, Otsuki Y. Alterations in cell cycle and induction of apoptotic cell death in breast cancer cells treated with α-mangostin extracted from mangosteen pericarp. J Biomed Biotechnol. 2012;2012:672428 pubmed publisher
Ramasamy R, Tong C, Yip W, Vellasamy S, Tan B, Seow H. Basic fibroblast growth factor modulates cell cycle of human umbilical cord-derived mesenchymal stem cells. Cell Prolif. 2012;45:132-9 pubmed publisher
Fujisawa H, Zhang Z, Sun W, Huang M, Kobayashi J, Yasuda H, et al. Histopathological changes in the pancreas from a spontaneous hyperglycemic cynomolgus monkey. J Toxicol Pathol. 2012;25:215-9 pubmed
Lv L, Wang F, Ma X, Yang Y, Wang Z, Liu H, et al. Mismatch repair protein MSH2 regulates translesion DNA synthesis following exposure of cells to UV radiation. Nucleic Acids Res. 2013;41:10312-22 pubmed publisher
Rupertus K, Senger S, Menger M, Schilling M, Kollmar O. Darbepoetin-α promotes neovascularization and cell proliferation in established colorectal liver metastases. J Surg Res. 2012;176:517-23 pubmed publisher
Forrester M, Eyler C, Rich J. Bacterial flavohemoglobin: a molecular tool to probe mammalian nitric oxide biology. Biotechniques. 2011;50:41-5 pubmed publisher
Desai S, Maurin M, Smith M, Bolick S, Dessureault S, Tao J, et al. PRDM1 is required for mantle cell lymphoma response to bortezomib. Mol Cancer Res. 2010;8:907-18 pubmed publisher
Ng G, Yeh L, Zhang Y, Liu H, Feng G, Kao W, et al. Role of SH2-containing tyrosine phosphatase Shp2 in mouse corneal epithelial stratification. Invest Ophthalmol Vis Sci. 2013;54:7933-42 pubmed publisher
Gasnereau I, Boissan M, Margall-Ducos G, Couchy G, Wendum D, Bourgain-Guglielmetti F, et al. KIF20A mRNA and its product MKlp2 are increased during hepatocyte proliferation and hepatocarcinogenesis. Am J Pathol. 2012;180:131-40 pubmed publisher
Yoshimi K, Hashimoto T, Niwa Y, Hata K, Serikawa T, Tanaka T, et al. Use of a chemically induced-colon carcinogenesis-prone Apc-mutant rat in a chemotherapeutic bioassay. BMC Cancer. 2012;12:448 pubmed publisher
Tan Z, Wortman M, Dillehay K, Seibel W, EVELYN C, Smith S, et al. Small-molecule targeting of proliferating cell nuclear antigen chromatin association inhibits tumor cell growth. Mol Pharmacol. 2012;81:811-9 pubmed publisher
Zhang X, Wang W, Mize G, Takayama T, True L, Vessella R. Protease-activated receptor 2 signaling upregulates angiogenic growth factors in renal cell carcinoma. Exp Mol Pathol. 2013;94:91-7 pubmed publisher
Dias M, Furtado K, Rodrigues M, Barbisan L. Effects of Ginkgo biloba on chemically-induced mammary tumors in rats receiving tamoxifen. BMC Complement Altern Med. 2013;13:93 pubmed publisher
Han B, Qi S, Hu B, Luo H, Wu J. TGF-beta i promotes islet beta-cell function and regeneration. J Immunol. 2011;186:5833-44 pubmed publisher
Syed F, Sherris D, Paus R, Varmeh S, Singh S, Pandolfi P, et al. Keloid disease can be inhibited by antagonizing excessive mTOR signaling with a novel dual TORC1/2 inhibitor. Am J Pathol. 2012;181:1642-58 pubmed publisher
Chen C, Sloane J, Li H, Aytan N, Giannaris E, Zeldich E, et al. The antiaging protein Klotho enhances oligodendrocyte maturation and myelination of the CNS. J Neurosci. 2013;33:1927-39 pubmed publisher
Niimi A, Chambers A, Downs J, Lehmann A. A role for chromatin remodellers in replication of damaged DNA. Nucleic Acids Res. 2012;40:7393-403 pubmed publisher
Akane H, Shiraki A, Imatanaka N, Akahori Y, Itahashi M, Ohishi T, et al. Glycidol induces axonopathy by adult-stage exposure and aberration of hippocampal neurogenesis affecting late-stage differentiation by developmental exposure in rats. Toxicol Sci. 2013;134:140-54 pubmed publisher
Leake K, Singhal J, Nagaprashantha L, Awasthi S, Singhal S. RLIP76 regulates PI3K/Akt signaling and chemo-radiotherapy resistance in pancreatic cancer. PLoS ONE. 2012;7:e34582 pubmed publisher
product information
SKU :
2586S
Product-Name :
PCNA (PC10) Mouse mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R, Mk, B, Pg
Applications :
Flow cytometry
Product-Category :
Cell Cycle / Checkpoint Control
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
36
Host :
Mouse
Target :
PCNA
Primary-Protein :
PCNA
Alt-Names :
Cyclin,DNA polymerase delta auxiliary protein,MGC8367,PCNA,Proliferating cell nuclear antigen
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.