| Published Application/Species/Dilution | Reference |
|---|
- immunocytochemistry (knockdown validation); human; fig 1
- proximity ligation assay; human; fig 1
- immunoprecipitation; human; fig 3
- western blot; human; fig 3
| Rassoolzadeh H, Coucoravas C, Farnebo M. The proximity ligation assay reveals that at DNA double-strand breaks WRAP53β associates with γH2AX and controls interactions between RNF8 and MDC1. Nucleus. 2015;6:417-24 pubmed publisher |
- immunocytochemistry; human; fig 2
| Ah-Koon L, Lesage D, Lemadre E, Souissi I, Fagard R, Varin-Blank N, et al. Cellular response to alkylating agent MNNG is impaired in STAT1-deficients cells. J Cell Mol Med. 2016;20:1956-65 pubmed publisher |
- immunocytochemistry; human; fig s1
- western blot; human; fig 1
| Hoffmann S, Smedegaard S, Nakamura K, Mortuza G, Raschle M, Ibañez de Opakua A, et al. TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress. J Cell Biol. 2016;212:63-75 pubmed publisher |
- immunohistochemistry; human; 1:100; fig 4a
| Gruosso T, Mieulet V, Cardon M, Bourachot B, Kieffer Y, Devun F, et al. Chronic oxidative stress promotes H2AX protein degradation and enhances chemosensitivity in breast cancer patients. EMBO Mol Med. 2016;: pubmed publisher |
- immunocytochemistry; human; 1:500; fig 4
| Feringa F, Krenning L, Koch A, van den Berg J, van den Broek B, Jalink K, et al. Hypersensitivity to DNA damage in antephase as a safeguard for genome stability. Nat Commun. 2016;7:12618 pubmed publisher |
- western blot; human; fig s3e
| Petroni M, Sardina F, Heil C, Sahún-Roncero M, Colicchia V, Veschi V, et al. The MRN complex is transcriptionally regulated by MYCN during neural cell proliferation to control replication stress. Cell Death Differ. 2016;23:197-206 pubmed publisher |
- immunocytochemistry; human; 1:400; fig 2
- western blot; human; 1:500; fig 2
| Ikeuchi M, Fukumoto Y, Honda T, Kuga T, Saito Y, Yamaguchi N, et al. v-Src Causes Chromosome Bridges in a Caffeine-Sensitive Manner by Generating DNA Damage. Int J Mol Sci. 2016;17: pubmed publisher |
- western blot; mouse; fig 3
| García-Prat L, Martinez-Vicente M, Perdiguero E, Ortet L, Rodriguez-Ubreva J, Rebollo E, et al. Autophagy maintains stemness by preventing senescence. Nature. 2016;529:37-42 pubmed publisher |
- immunocytochemistry; human; fig 5
| Alessio N, Del Gaudio S, Capasso S, Di Bernardo G, Cappabianca S, Cipollaro M, et al. Low dose radiation induced senescence of human mesenchymal stromal cells and impaired the autophagy process. Oncotarget. 2015;6:8155-66 pubmed |
- western blot; human; 1:1000
| Zanotto-Filho A, Braganhol E, Klafke K, Figueiró F, Terra S, Paludo F, et al. Autophagy inhibition improves the efficacy of curcumin/temozolomide combination therapy in glioblastomas. Cancer Lett. 2015;358:220-31 pubmed publisher |
| Kim B, Serebreni L, Fallica J, Hamdan O, Wang L, Johnston L, et al. Cyclin-dependent kinase five mediates activation of lung xanthine oxidoreductase in response to hypoxia. PLoS ONE. 2015;10:e0124189 pubmed publisher |
- immunocytochemistry; human; 1:200; fig 5
| Pérès E, Gérault A, Valable S, Roussel S, Toutain J, Divoux D, et al. Silencing erythropoietin receptor on glioma cells reinforces efficacy of temozolomide and X-rays through senescence and mitotic catastrophe. Oncotarget. 2015;6:2101-19 pubmed |
- western blot; human; fig 1d
| Zuazua-Villar P, Ganesh A, Phear G, Gagou M, Meuth M. Extensive RPA2 hyperphosphorylation promotes apoptosis in response to DNA replication stress in CHK1 inhibited cells. Nucleic Acids Res. 2015;43:9776-87 pubmed publisher |
- western blot; mouse
- immunocytochemistry; mouse; 1:100
| Xu H, Zhou Y, Coughlan K, Ding Y, Wang S, Wu Y, et al. AMPKα1 deficiency promotes cellular proliferation and DNA damage via p21 reduction in mouse embryonic fibroblasts. Biochim Biophys Acta. 2015;1853:65-73 pubmed publisher |
- western blot; mouse
- immunocytochemistry; mouse
| Xiong J, Todorova D, Su N, Kim J, Lee P, Shen Z, et al. Stemness factor Sall4 is required for DNA damage response in embryonic stem cells. J Cell Biol. 2015;208:513-20 pubmed publisher |
- western blot; human; fig 4
| Huhn D, Kousholt A, Sørensen C, Sartori A. miR-19, a component of the oncogenic miR-17∼92 cluster, targets the DNA-end resection factor CtIP. Oncogene. 2015;34:3977-84 pubmed publisher |
- western blot; human; 1:1000; fig s8
| Ohashi A, Ohori M, Iwai K, Nakayama Y, Nambu T, Morishita D, et al. Aneuploidy generates proteotoxic stress and DNA damage concurrently with p53-mediated post-mitotic apoptosis in SAC-impaired cells. Nat Commun. 2015;6:7668 pubmed publisher |
- immunocytochemistry; common tobacco; 1:200; fig 5
| Mursalimov S, Permyakova N, Deineko E, Houben A, Demidov D. Cytomixis doesn't induce obvious changes in chromatin modifications and programmed cell death in tobacco male meiocytes. Front Plant Sci. 2015;6:846 pubmed publisher |
- immunocytochemistry; human; fig s6c
| Munson M, Allen G, Toth R, Campbell D, Lucocq J, Ganley I. mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival. EMBO J. 2015;34:2272-90 pubmed publisher |
- western blot; mouse; 1:1000
| Li P, Ma X, Adams I, Yuan P. A tight control of Rif1 by Oct4 and Smad3 is critical for mouse embryonic stem cell stability. Cell Death Dis. 2015;6:e1588 pubmed publisher |
- western blot; human; fig s7
| Tonsing-Carter E, Bailey B, Saadatzadeh M, Ding J, Wang H, Sinn A, et al. Potentiation of Carboplatin-Mediated DNA Damage by the Mdm2 Modulator Nutlin-3a in a Humanized Orthotopic Breast-to-Lung Metastatic Model. Mol Cancer Ther. 2015;14:2850-63 pubmed publisher |
- western blot; human; fig 4
- immunocytochemistry; human; fig 3
| Hedstrom E, Pederiva C, Farnebo J, Nodin B, Jirstrom K, Brennan D, et al. Downregulation of the cancer susceptibility protein WRAP53β in epithelial ovarian cancer leads to defective DNA repair and poor clinical outcome. Cell Death Dis. 2015;6:e1892 pubmed publisher |
- western blot; human; 1:1000; fig 3
| Cañeque T, Gomes F, Mai T, Maestri G, Malacria M, Rodriguez R. Synthesis of marmycin A and investigation into its cellular activity. Nat Chem. 2015;7:744-51 pubmed publisher |
- immunocytochemistry; mouse
| Meng X, Yang S, Zhang Y, Wang X, Goodfellow R, Jia Y, et al. Genetic Deficiency of Mtdh Gene in Mice Causes Male Infertility via Impaired Spermatogenesis and Alterations in the Expression of Small Non-coding RNAs. J Biol Chem. 2015;290:11853-64 pubmed publisher |
- immunocytochemistry; human; 1:50
- western blot; human; 1:1000
| Nikitin P, Price A, McFadden K, Yan C, Luftig M. Mitogen-induced B-cell proliferation activates Chk2-dependent G1/S cell cycle arrest. PLoS ONE. 2014;9:e87299 pubmed publisher |
| Kemp M, Gaddameedhi S, Choi J, Hu J, Sancar A. DNA repair synthesis and ligation affect the processing of excised oligonucleotides generated by human nucleotide excision repair. J Biol Chem. 2014;289:26574-83 pubmed publisher |
- western blot; human; 1:1000; fig 2c
| Zhang P, Wei Y, Wang L, Debeb B, Yuan Y, Zhang J, et al. ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1. Nat Cell Biol. 2014;16:864-75 pubmed publisher |
- immunohistochemistry - frozen section; mouse
| Sousa-Victor P, Gutarra S, García-Prat L, Rodriguez-Ubreva J, Ortet L, Ruiz-Bonilla V, et al. Geriatric muscle stem cells switch reversible quiescence into senescence. Nature. 2014;506:316-21 pubmed publisher |
- western blot; human
- immunocytochemistry; human
| Manguan-García C, Pintado-Berninches L, Carrillo J, Machado-Pinilla R, Sastre L, Perez-Quilis C, et al. Expression of the genetic suppressor element 24.2 (GSE24.2) decreases DNA damage and oxidative stress in X-linked dyskeratosis congenita cells. PLoS ONE. 2014;9:e101424 pubmed publisher |
- immunohistochemistry - frozen section; mouse; 1:200; fig 5a
| Katyal S, Lee Y, Nitiss K, Downing S, Li Y, Shimada M, et al. Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes. Nat Neurosci. 2014;17:813-21 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:100
- western blot; human; 1:1000
| Cook G, Caudell D, Elford H, Pardee T. The efficacy of the ribonucleotide reductase inhibitor Didox in preclinical models of AML. PLoS ONE. 2014;9:e112619 pubmed publisher |
| Hori T, Gardner L, Hata T, Chen F, Baine A, Uemoto S, et al. Pretreatment of liver grafts in vivo by γ-aminobutyric acid receptor regulation reduces cold ischemia/warm reperfusion injury in rat. Ann Transplant. 2013;18:299-313 pubmed publisher |
| Ma T, Galimberti F, Erkmen C, Memoli V, Chinyengetere F, SEMPERE L, et al. Comparing histone deacetylase inhibitor responses in genetically engineered mouse lung cancer models and a window of opportunity trial in patients with lung cancer. Mol Cancer Ther. 2013;12:1545-55 pubmed publisher |
- western blot; mouse; 1:1000
| Licandro G, Ling Khor H, Beretta O, Lai J, Derks H, Laudisi F, et al. The NLRP3 inflammasome affects DNA damage responses after oxidative and genotoxic stress in dendritic cells. Eur J Immunol. 2013;43:2126-37 pubmed publisher |
| Ding G, Liu H, Liang H, Ni R, Ding Z, Ni G, et al. HIF1-regulated ATRIP expression is required for hypoxia induced ATR activation. FEBS Lett. 2013;587:930-5 pubmed publisher |
- immunocytochemistry; mouse
- western blot; mouse
| Luebben S, Kawabata T, Akre M, Lee W, Johnson C, O'Sullivan M, et al. Helq acts in parallel to Fancc to suppress replication-associated genome instability. Nucleic Acids Res. 2013;41:10283-97 pubmed publisher |
| Gardner L, Hori T, Chen F, Baine A, Hata T, Uemoto S, et al. Effect of specific activation of γ-aminobutyric acid receptor in vivo on oxidative stress-induced damage after extended hepatectomy. Hepatol Res. 2012;42:1131-40 pubmed publisher |
| Zhang C, Spektor A, Cornils H, FRANCIS J, Jackson E, Liu S, et al. Chromothripsis from DNA damage in micronuclei. Nature. 2015;522:179-84 pubmed publisher |
| Iacobucci I, Di Rorà A, Falzacappa M, Agostinelli C, Derenzini E, Ferrari A, et al. In vitro and in vivo single-agent efficacy of checkpoint kinase inhibition in acute lymphoblastic leukemia. J Hematol Oncol. 2015;8:125 pubmed publisher |
| Boersma V, Moatti N, Segura-Bayona S, Peuscher M, van der Torre J, Wevers B, et al. MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5' end resection. Nature. 2015;521:537-40 pubmed publisher |
| Maya-Mendoza A, Merchut-Maya J, Bartkova J, Bartek J, Streuli C, Jackson D. Immortalised breast epithelia survive prolonged DNA replication stress and return to cycle from a senescent-like state. Cell Death Dis. 2014;5:e1351 pubmed publisher |
| Beuzer P, Quivy J, Almouzni G. Establishment of a replication fork barrier following induction of DNA binding in mammalian cells. Cell Cycle. 2014;13:1607-16 pubmed publisher |
| Aymard F, Bugler B, Schmidt C, Guillou E, Caron P, Briois S, et al. Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks. Nat Struct Mol Biol. 2014;21:366-74 pubmed publisher |
| Wu Y, Lu J, Antony S, Juhasz A, Liu H, Jiang G, et al. Activation of TLR4 is required for the synergistic induction of dual oxidase 2 and dual oxidase A2 by IFN-γ and lipopolysaccharide in human pancreatic cancer cell lines. J Immunol. 2013;190:1859-72 pubmed publisher |
| Tran J, Zamdborg L, Ahlf D, Lee J, Catherman A, Durbin K, et al. Mapping intact protein isoforms in discovery mode using top-down proteomics. Nature. 2011;480:254-8 pubmed publisher |
| Wang G, He J, Zhao J, Yun W, Xie C, Taub J, et al. Class I and class II histone deacetylases are potential therapeutic targets for treating pancreatic cancer. PLoS ONE. 2012;7:e52095 pubmed publisher |
