product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
TCF4 (C48H11) Rabbit mAb
catalog :
2569
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
C48H11
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunoprecipitation, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 33
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; 1:500; loading ...; fig 3e
Talley M, Nardini D, Shabbir N, Ehrman L, Prada C, Waclaw R. Generation of a Mouse Model to Study the Noonan Syndrome Gene Lztr1 in the Telencephalon. Front Cell Dev Biol. 2021;9:673995 pubmed publisher
  • western blot; human; loading ...; fig 2e
Low J, Du W, Gocha T, Oguz G, Zhang X, Chen M, et al. Molecular docking-aided identification of small molecule inhibitors targeting β-catenin-TCF4 interaction. iScience. 2021;24:102544 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s7-1e
Zewdu R, Mehrabad E, Ingram K, Fang P, Gillis K, Camolotto S, et al. An NKX2-1/ERK/WNT feedback loop modulates gastric identity and response to targeted therapy in lung adenocarcinoma. elife. 2021;10: pubmed publisher
  • chromatin immunoprecipitation; mouse; 1:400; loading ...; fig 6g
Chen M, Lu P, Ma Q, Cao Y, Chen N, Li W, et al. CTNNB1/β-catenin dysfunction contributes to adiposity by regulating the cross-talk of mature adipocytes and preadipocytes. Sci Adv. 2020;6:eaax9605 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2i
van de Vlekkert D, Demmers J, Nguyen X, Campos Y, Machado E, Annunziata I, et al. Excessive exosome release is the pathogenic pathway linking a lysosomal deficiency to generalized fibrosis. Sci Adv. 2019;5:eaav3270 pubmed publisher
  • immunoprecipitation; human; 1:100; loading ...; fig 1k
  • western blot; human; 1:1000; loading ...; fig 1k
Ji L, Lu B, Wang Z, Yang Z, Reece Hoyes J, Russ C, et al. Identification of ICAT as an APC Inhibitor, Revealing Wnt-Dependent Inhibition of APC-Axin Interaction. Mol Cell. 2018;72:37-47.e4 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5b
Wanet A, Caruso M, Domelevo Entfellner J, Najar M, Fattaccioli A, Demazy C, et al. The Transcription Factor 7-Like 2-Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Axis Connects Mitochondrial Biogenesis and Metabolic Shift with Stem Cell Commitment to Hepatic Differentiation. Stem Cells. 2017;35:2184-2197 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; fig 3e
  • immunohistochemistry; human; 1:100; fig 3e
  • western blot; human; 1:1000; fig 3c
Ku A, Shaver T, Rao A, Howard J, Rodriguez C, Miao Q, et al. TCF7L1 promotes skin tumorigenesis independently of β-catenin through induction of LCN2. elife. 2017;6: pubmed publisher
  • immunohistochemistry - frozen section; human; loading ...; fig 1
Mackey A, Magnan M, Chazaud B, Kjaer M. Human skeletal muscle fibroblasts stimulate in vitro myogenesis and in vivo muscle regeneration. J Physiol. 2017;595:5115-5127 pubmed publisher
  • immunohistochemistry - frozen section; human; loading ...; fig 1a
Fry C, Johnson D, Ireland M, Noehren B. ACL injury reduces satellite cell abundance and promotes fibrogenic cell expansion within skeletal muscle. J Orthop Res. 2017;35:1876-1885 pubmed publisher
  • chromatin immunoprecipitation; mouse; fig 5
  • western blot; mouse; 1:1000; fig 2
  • western blot; human; 1:1000; fig 2
Liu Y, Xu Y, Guo S, Chen H. T cell factor-4 functions as a co-activator to promote NF-?B-dependent MMP-15 expression in lung carcinoma cells. Sci Rep. 2016;6:24025 pubmed publisher
  • western blot; human; fig 4
Rockel J, Yu C, Whetstone H, Craft A, Reilly K, Ma H, et al. Hedgehog inhibits ?-catenin activity in synovial joint development and osteoarthritis. J Clin Invest. 2016;126:1649-63 pubmed publisher
  • western blot; mouse; loading ...; fig 4c
Cironi L, Petricevic T, Fernandes Vieira V, Provero P, Fusco C, Cornaz S, et al. The fusion protein SS18-SSX1 employs core Wnt pathway transcription factors to induce a partial Wnt signature in synovial sarcoma. Sci Rep. 2016;6:22113 pubmed publisher
  • immunoprecipitation; mouse; fig 7
  • western blot; mouse; 1:500; fig 7
Eisses J, Criscimanna A, Dionise Z, Orabi A, Javed T, Sarwar S, et al. Valproic Acid Limits Pancreatic Recovery after Pancreatitis by Inhibiting Histone Deacetylases and Preventing Acinar Redifferentiation Programs. Am J Pathol. 2015;185:3304-15 pubmed publisher
  • chromatin immunoprecipitation; human
  • western blot; human; fig 4
Walker M, Stopford C, Cederlund M, Fang F, Jahn C, Rabinowitz A, et al. FOXP1 potentiates Wnt/β-catenin signaling in diffuse large B cell lymphoma. Sci Signal. 2015;8:ra12 pubmed publisher
  • immunoprecipitation; human
Norton L, Chen X, Fourcaudot M, Acharya N, DeFronzo R, Heikkinen S. The mechanisms of genome-wide target gene regulation by TCF7L2 in liver cells. Nucleic Acids Res. 2014;42:13646-61 pubmed publisher
  • western blot; human; fig 1
Zhu Z, Liu Y, Li K, Liu J, Wang H, Sun B, et al. Protein tyrosine phosphatase receptor U (PTPRU) is required for glioma growth and motility. Carcinogenesis. 2014;35:1901-10 pubmed publisher
  • western blot; human; 1:1000
Ogunkolade B, Jones T, Aarum J, Szary J, Owen N, Ottaviani D, et al. BORIS/CTCFL is an RNA-binding protein that associates with polysomes. BMC Cell Biol. 2013;14:52 pubmed publisher
  • chromatin immunoprecipitation; mouse
Nakamura I, Fernández Barrena M, Ortiz Ruiz M, Almada L, Hu C, Elsawa S, et al. Activation of the transcription factor GLI1 by WNT signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration. J Biol Chem. 2013;288:21389-98 pubmed publisher
Estell C, Davidson L, Steketee P, Monier A, West S. ZC3H4 restricts non-coding transcription in human cells. elife. 2021;10: pubmed publisher
Aono S, Hatanaka A, Hatanaka A, Gao Y, Hippo Y, Taketo M, et al. β-Catenin/TCF4 Complex-Mediated Induction of the NRF3 (NFE2L3) Gene in Cancer Cells. Int J Mol Sci. 2019;20: pubmed publisher
Davidsen J, Larsen S, Coskun M, Gogenur I, Dahlgaard K, Bennett E, et al. The VTI1A-TCF4 colon cancer fusion protein is a dominant negative regulator of Wnt signaling and is transcriptionally regulated by intestinal homeodomain factor CDX2. PLoS ONE. 2018;13:e0200215 pubmed publisher
Papaspyropoulos A, Bradley L, Thapa A, Leung C, Toskas K, Koennig D, et al. RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73. Nat Commun. 2018;9:424 pubmed publisher
Huang S, Fantini D, Merrill B, Bagchi S, Guzman G, Raychaudhuri P. DDB2 Is a Novel Regulator of Wnt Signaling in Colon Cancer. Cancer Res. 2017;77:6562-6575 pubmed publisher
Hu S, Zheng Q, Wu H, Wang C, Liu T, Zhou W. miR-532 promoted gastric cancer migration and invasion by targeting NKD1. Life Sci. 2017;177:15-19 pubmed publisher
Taniguchi K, Moroishi T, de Jong P, Krawczyk M, Grebbin B, Luo H, et al. YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis. Proc Natl Acad Sci U S A. 2017;114:1643-1648 pubmed publisher
Alldredge A, Fuhrmann S. Loss of Axin2 Causes Ocular Defects During Mouse Eye Development. Invest Ophthalmol Vis Sci. 2016;57:5253-5262 pubmed publisher
Corbett L, Mann J, Mann D. Non-Canonical Wnt Predominates in Activated Rat Hepatic Stellate Cells, Influencing HSC Survival and Paracrine Stimulation of Kupffer Cells. PLoS ONE. 2015;10:e0142794 pubmed publisher
Merhi A, De Mees C, Abdo R, Victoria Alberola J, Marini A. Wnt/β-Catenin Signaling Regulates the Expression of the Ammonium Permease Gene RHBG in Human Cancer Cells. PLoS ONE. 2015;10:e0128683 pubmed publisher
Hazelett D, Rhie S, Gaddis M, Yan C, Lakeland D, Coetzee S, et al. Comprehensive functional annotation of 77 prostate cancer risk loci. PLoS Genet. 2014;10:e1004102 pubmed publisher
Wang R, Hsu H, Blattler A, Wang Y, Lan X, Wang Y, et al. LOcating non-unique matched tags (LONUT) to improve the detection of the enriched regions for ChIP-seq data. PLoS ONE. 2013;8:e67788 pubmed publisher
Frietze S, Wang R, Yao L, Tak Y, Ye Z, Gaddis M, et al. Cell type-specific binding patterns reveal that TCF7L2 can be tethered to the genome by association with GATA3. Genome Biol. 2012;13:R52 pubmed publisher
Zhang Z, Wlodarczyk B, Niederreither K, Venugopalan S, Florez S, Finnell R, et al. Fuz regulates craniofacial development through tissue specific responses to signaling factors. PLoS ONE. 2011;6:e24608 pubmed publisher
product information
SKU :
2569S
Product-Name :
TCF4 (C48H11) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, (M, C)
Applications :
Chromatin Immunoprecipitation
Product-Category :
Developmental Biology
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
58, 79
Host :
Rabbit
Target :
TCF4
Primary-Protein :
TCF7L2
Alt-Names :
HMG box transcription factor 4,T-cell factor 4,T-cell-specific transcription factor 4,TCF-4,TCF4,TCF7L2,TF7L2,Transcription factor 7-like 2,hTCF-4,transcription factor 7-like 2 (T-cell specific, HMG-box)
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.