product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Phospho-LRP6 (Ser1490) Antibody
catalog :
2568S
quantity :
100 ul
price :
274 USD
clonality :
polyclonal
host :
rabbit
antigen modification :
phosphorylated
reactivity :
human, mouse
application :
western blot, immunoprecipitation
citations: 12
Published Application/Species/DilutionReference
  • western blot; human; 1:200; fig st1
Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher
  • western blot; mouse; fig 2
Fagnocchi L, Cherubini A, Hatsuda H, Fasciani A, Mazzoleni S, Poli V, et al. A Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity. Nat Commun. 2016;7:11903 pubmed publisher
  • western blot; human; 1:1000; fig s1d
Chen Y, Statt S, Wu R, Chang H, Liao J, Wang C, et al. High mobility group box 1-induced epithelial mesenchymal transition in human airway epithelial cells. Sci Rep. 2016;6:18815 pubmed publisher
  • western blot; human
Yu J, Kong C, Zhang Z, Zhan B, Jiang Z. Aplasia Ras homolog member I expression induces apoptosis in renal cancer cells via the β-catenin signaling pathway. Mol Med Rep. 2015;11:475-81 pubmed publisher
  • western blot; mouse; fig s3
Etnyre D, Stone A, Fong J, Jacobs R, Uppada S, Botting G, et al. Targeting c-Met in melanoma: mechanism of resistance and efficacy of novel combinatorial inhibitor therapy. Cancer Biol Ther. 2014;15:1129-41 pubmed publisher
  • western blot; human
Kriz V, Pospichalova V, Masek J, Kilander M, Slavík J, Tanneberger K, et al. β-arrestin promotes Wnt-induced low density lipoprotein receptor-related protein 6 (Lrp6) phosphorylation via increased membrane recruitment of Amer1 protein. J Biol Chem. 2014;289:1128-41 pubmed publisher
  • western blot; mouse
Willis C, Klüppel M. Chondroitin sulfate-E is a negative regulator of a pro-tumorigenic Wnt/beta-catenin-Collagen 1 axis in breast cancer cells. PLoS ONE. 2014;9:e103966 pubmed publisher
  • western blot; human
Li S, Song W, Jiang M, Zeng L, Zhu X, Chen J. Phosphorylation of cyclin Y by CDK14 induces its ubiquitination and degradation. FEBS Lett. 2014;588:1989-96 pubmed publisher
Lee H, Bao J, Miller A, Zhang C, Wu J, Baday Y, et al. Structure-based Discovery of Novel Small Molecule Wnt Signaling Inhibitors by Targeting the Cysteine-rich Domain of Frizzled. J Biol Chem. 2015;290:30596-606 pubmed publisher
Liang J, Fu Y, Cruciat C, Jia S, Wang Y, Tong Z, et al. Transmembrane protein 198 promotes LRP6 phosphorylation and Wnt signaling activation. Mol Cell Biol. 2011;31:2577-90 pubmed publisher
Grumolato L, Liu G, Mong P, Mudbhary R, Biswas R, Arroyave R, et al. Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors. Genes Dev. 2010;24:2517-30 pubmed publisher
MacDonald B, Semenov M, Huang H, He X. Dissecting molecular differences between Wnt coreceptors LRP5 and LRP6. PLoS ONE. 2011;6:e23537 pubmed publisher
product information
SKU :
2568S
Product-Name :
Phospho-LRP6 (Ser1490) Antibody
Size :
100 ul
Price-(USD) :
274 USD
Species-x-Reactivity :
H, (M)
Applications :
Immunoprecipitation
Product-Category :
Developmental Biology
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Polyclonal Antibody
MW :
180, 210
Host :
Rabbit
Target :
LRP6 (Ser1490) phosphate
Primary-Protein :
LRP6
Alt-Names :
ADCAD2,FLJ90062,FLJ90421,LRP-6,LRP6,Low-density lipoprotein receptor-related protein 6,low density lipoprotein receptor-related protein 6
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.