product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
LRP6 (C5C7) Rabbit mAb
catalog :
2560
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
C5C7
reactivity :
human, mouse, rat
application :
western blot, immunoprecipitation, immunohistochemistry - paraffin section
citations: 21
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 7d
Pothuraju R, Rachagani S, Krishn S, Chaudhary S, Nimmakayala R, Siddiqui J, et al. Molecular implications of MUC5AC-CD44 axis in colorectal cancer progression and chemoresistance. Mol Cancer. 2020;19:37 pubmed publisher
  • western blot; rat; loading ...; fig 4a
Chen Z, Li Y, Jiang G, Yang C, Wang Y, Wang X, et al. Knockdown of LRP6 activates Drp1 to inhibit survival of cardiomyocytes during glucose deprivation. Biomed Pharmacother. 2018;103:1408-1414 pubmed publisher
  • western blot; human; loading ...; fig 1b
Glaeser K, Urban M, Fenech E, Voloshanenko O, Kranz D, Lari F, et al. ERAD-dependent control of the Wnt secretory factor Evi. EMBO J. 2018;37: pubmed publisher
  • western blot; human; loading ...; fig 2a
Nag J, Kancharla A, Maoz M, Turm H, Agranovich D, Gupta C, et al. Low-density lipoprotein receptor-related protein 6 is a novel coreceptor of protease-activated receptor-2 in the dynamics of cancer-associated ?-catenin stabilization. Oncotarget. 2017;8:38650-38667 pubmed publisher
  • western blot; human; loading ...; fig 1b
JENKINS L, Singh P, Varadaraj A, Lee N, Shah S, Flores H, et al. Altering the Proteoglycan State of Transforming Growth Factor ? Type III Receptor (T?RIII)/Betaglycan Modulates Canonical Wnt/?-Catenin Signaling. J Biol Chem. 2016;291:25716-25728 pubmed
  • western blot; human; loading ...; fig s9b
Tao L, Zhang J, Meraner P, Tovaglieri A, Wu X, Gerhard R, et al. Frizzled proteins are colonic epithelial receptors for C. difficile toxin B. Nature. 2016;538:350-355 pubmed publisher
  • western blot; human; 1:1000; fig 6
Yang E, Tacchelly Benites O, Wang Z, Randall M, Tian A, Benchabane H, et al. Wnt pathway activation by ADP-ribosylation. Nat Commun. 2016;7:11430 pubmed publisher
  • western blot; rat; loading ...; fig 3
Bañón Maneus E, Rovira J, Ramírez Bajo M, Moya Rull D, Hierro Garcia N, Takenaka S, et al. Wnt pathway activation in long term remnant rat model. Biomed Res Int. 2014;2014:324713 pubmed publisher
  • western blot; human; fig 6
McEwen A, Maher M, Mo R, Gottardi C. E-cadherin phosphorylation occurs during its biosynthesis to promote its cell surface stability and adhesion. Mol Biol Cell. 2014;25:2365-74 pubmed publisher
  • western blot; human
Li S, Song W, Jiang M, Zeng L, Zhu X, Chen J. Phosphorylation of cyclin Y by CDK14 induces its ubiquitination and degradation. FEBS Lett. 2014;588:1989-96 pubmed publisher
  • western blot; human; 1:1000
Sakane H, Horii Y, Nogami S, Kawano Y, Kaneko Kawano T, Shirataki H. ?-Taxilin interacts with sorting nexin 4 and participates in the recycling pathway of transferrin receptor. PLoS ONE. 2014;9:e93509 pubmed publisher
  • western blot; human; 1:1000
Ogunkolade B, Jones T, Aarum J, Szary J, Owen N, Ottaviani D, et al. BORIS/CTCFL is an RNA-binding protein that associates with polysomes. BMC Cell Biol. 2013;14:52 pubmed publisher
  • western blot; human
Knoblich K, Wang H, Sharma C, Fletcher A, Turley S, Hemler M. Tetraspanin TSPAN12 regulates tumor growth and metastasis and inhibits ?-catenin degradation. Cell Mol Life Sci. 2014;71:1305-14 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200
Parviainen H, Schrade A, Kiiveri S, Prunskaite Hyyryläinen R, Haglund C, Vainio S, et al. Expression of Wnt and TGF-? pathway components and key adrenal transcription factors in adrenocortical tumors: association to carcinoma aggressiveness. Pathol Res Pract. 2013;209:503-9 pubmed publisher
  • western blot; mouse; fig 3
Baljinnyam B, Klauzinska M, Saffo S, Callahan R, Rubin J. Recombinant R-spondin2 and Wnt3a up- and down-regulate novel target genes in C57MG mouse mammary epithelial cells. PLoS ONE. 2012;7:e29455 pubmed publisher
Lu Y, Zhao X, Liu Q, Li C, Graves Deal R, Cao Z, et al. lncRNA MIR100HG-derived miR-100 and miR-125b mediate cetuximab resistance via Wnt/β-catenin signaling. Nat Med. 2017;23:1331-1341 pubmed publisher
Maubant S, Tesson B, Maire V, Ye M, Rigaill G, Gentien D, et al. Transcriptome analysis of Wnt3a-treated triple-negative breast cancer cells. PLoS ONE. 2015;10:e0122333 pubmed publisher
Fei C, Li Z, Li C, Chen Y, Chen Z, He X, et al. Smurf1-mediated Lys29-linked nonproteolytic polyubiquitination of axin negatively regulates Wnt/?-catenin signaling. Mol Cell Biol. 2013;33:4095-105 pubmed publisher
Liang J, Fu Y, Cruciat C, Jia S, Wang Y, Tong Z, et al. Transmembrane protein 198 promotes LRP6 phosphorylation and Wnt signaling activation. Mol Cell Biol. 2011;31:2577-90 pubmed publisher
Tanneberger K, Pfister A, Kriz V, Bryja V, Schambony A, Behrens J. Structural and functional characterization of the Wnt inhibitor APC membrane recruitment 1 (Amer1). J Biol Chem. 2011;286:19204-14 pubmed publisher
Konigshoff M, Balsara N, Pfaff E, Kramer M, Chrobak I, Seeger W, et al. Functional Wnt signaling is increased in idiopathic pulmonary fibrosis. PLoS ONE. 2008;3:e2142 pubmed publisher
product information
SKU :
2560S
Product-Name :
LRP6 (C5C7) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, R
Applications :
Immunoprecipitation
Product-Category :
Developmental Biology
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
180, 210 kDa
Host :
Rabbit
Target :
LRP6
Primary-Protein :
LRP6
Alt-Names :
ADCAD2,FLJ90062,FLJ90421,LRP-6,LRP6,Low-density lipoprotein receptor-related protein 6,low density lipoprotein receptor-related protein 6
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.