product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
p27 Kip1 Antibody
catalog :
2552
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat, chicken
application :
western blot, immunohistochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, western blot knockout validation
citations: 27
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; human; fig s1a
Andrade J, Shi C, Costa A, Choi J, Kim J, Doddaballapur A, et al. Control of endothelial quiescence by FOXO-regulated metabolites. Nat Cell Biol. 2021;23:413-423 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3e
Zhang J, Huang J, Zhang Y, Zhang X, Zhao L, Li C, et al. Microtubule associated protein 9 inhibits liver tumorigenesis by suppressing ERCC3. EBioMedicine. 2020;53:102701 pubmed publisher
  • western blot; human; fig 1h
Xue J, Zhao Y, Aronowitz J, Mai T, Vides A, Qeriqi B, et al. Rapid non-uniform adaptation to conformation-specific KRAS(G12C) inhibition. Nature. 2020;577:421-425 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 6d
Guiley K, Stevenson J, Lou K, Barkovich K, Kumarasamy V, Wijeratne T, et al. p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition. Science. 2019;366: pubmed publisher
  • immunohistochemistry - frozen section; chicken; 1:500; loading ...; fig 2k
Pickering J, Chinnaiya K, Towers M. An autoregulatory cell cycle timer integrates growth and specification in chick wing digit development. elife. 2019;8: pubmed publisher
  • western blot; human; loading ...; fig 1e
Cornell L, Wander S, Visal T, Wagle N, Shapiro G. MicroRNA-Mediated Suppression of the TGF-β Pathway Confers Transmissible and Reversible CDK4/6 Inhibitor Resistance. Cell Rep. 2019;26:2667-2680.e7 pubmed publisher
  • western blot; human; loading ...; fig 2b
Xu B, Deng Y, Bi R, Guo H, Shu C, Shah N, et al. A first-in-class inhibitor, MLN4924 (pevonedistat), induces cell-cycle arrest, senescence, and apoptosis in human renal cell carcinoma by suppressing UBE2M-dependent neddylation modification. Cancer Chemother Pharmacol. 2018;81:1083-1093 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4a
  • immunohistochemistry; mouse; loading ...; fig 2a
Shen L, Qu X, Li H, Xu C, Wei M, Wang Q, et al. NDRG2 facilitates colorectal cancer differentiation through the regulation of Skp2-p21/p27 axis. Oncogene. 2018;37:1759-1774 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3b
Haricharan S, Punturi N, Singh P, Holloway K, Anurag M, Schmelz J, et al. Loss of MutL Disrupts CHK2-Dependent Cell-Cycle Control through CDK4/6 to Promote Intrinsic Endocrine Therapy Resistance in Primary Breast Cancer. Cancer Discov. 2017;7:1168-1183 pubmed publisher
  • western blot; human; loading ...; fig 2g
Zhou Y, Huang T, Zhang J, Wong C, Zhang B, Dong Y, et al. TEAD1/4 exerts oncogenic role and is negatively regulated by miR-4269 in gastric tumorigenesis. Oncogene. 2017;36:6518-6530 pubmed publisher
  • western blot; mouse; fig 4b
Wang Q, Yu Y, Zhang P, Chen Y, Li C, Chen J, et al. The crucial role of activin A/ALK4 pathway in the pathogenesis of Ang-II-induced atrial fibrosis and vulnerability to atrial fibrillation. Basic Res Cardiol. 2017;112:47 pubmed publisher
  • western blot; mouse; loading ...; fig 4b
Tormos A, Rius Pérez S, Jorques M, Rada P, Ramírez L, Valverde A, et al. p38α regulates actin cytoskeleton and cytokinesis in hepatocytes during development and aging. PLoS ONE. 2017;12:e0171738 pubmed publisher
  • western blot; human; loading ...; fig 6h
Jinesh G, Molina J, Huang L, Laing N, Mills G, Bar Eli M, et al. Mitochondrial oligomers boost glycolysis in cancer stem cells to facilitate blebbishield-mediated transformation after apoptosis. Cell Death Discov. 2016;2:16003 pubmed publisher
  • western blot; human; loading ...; fig 1d
Yang Y, Lu Y, Wang L, Mizokami A, Keller E, Zhang J, et al. Skp2 is associated with paclitaxel resistance in prostate cancer cells. Oncol Rep. 2016;36:559-66 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; fig s1
Koussounadis A, Langdon S, Um I, Kay C, Francis K, Harrison D, et al. Dynamic modulation of phosphoprotein expression in ovarian cancer xenograft models. BMC Cancer. 2016;16:205 pubmed publisher
  • western blot; human; fig 3b
Singh A, Joshi S, Zulcic M, Alcaraz M, GARLICH J, Morales G, et al. PI-3K Inhibitors Preferentially Target CD15+ Cancer Stem Cell Population in SHH Driven Medulloblastoma. PLoS ONE. 2016;11:e0150836 pubmed publisher
  • western blot; human; fig 7a
Cho C, Lee K, Chen W, Wang C, Chang Y, Huang H, et al. MST3 promotes proliferation and tumorigenicity through the VAV2/Rac1 signal axis in breast cancer. Oncotarget. 2016;7:14586-604 pubmed publisher
  • western blot; human
Couderc C, Boin A, Fuhrmann L, Vincent Salomon A, Mandati V, Kieffer Y, et al. AMOTL1 Promotes Breast Cancer Progression and Is Antagonized by Merlin. Neoplasia. 2016;18:10-24 pubmed publisher
  • western blot; human; loading ...; fig 4f
Kapoor I, Kanaujiya J, Kumar Y, Thota J, Bhatt M, Chattopadhyay N, et al. Proteomic discovery of MNT as a novel interacting partner of E3 ubiquitin ligase E6AP and a key mediator of myeloid differentiation. Oncotarget. 2016;7:7640-56 pubmed publisher
Oldrini B, Hsieh W, Erdjument Bromage H, Codega P, Carro M, Curiel García A, et al. EGFR feedback-inhibition by Ran-binding protein 6 is disrupted in cancer. Nat Commun. 2017;8:2035 pubmed publisher
Zhou Y, Huang T, Siu H, Wong C, Dong Y, Wu F, et al. IGF2BP3 functions as a potential oncogene and is a crucial target of miR-34a in gastric carcinogenesis. Mol Cancer. 2017;16:77 pubmed publisher
Smn Mydin R, Sreekantan S, Hazan R, Farid Wajidi M, Mat I. Cellular Homeostasis and Antioxidant Response in Epithelial HT29 Cells on Titania Nanotube Arrays Surface. Oxid Med Cell Longev. 2017;2017:3708048 pubmed publisher
Shiina M, Hashimoto Y, Kato T, Yamamura S, Tanaka Y, Majid S, et al. Differential expression of miR-34b and androgen receptor pathway regulate prostate cancer aggressiveness between African-Americans and Caucasians. Oncotarget. 2017;8:8356-8368 pubmed publisher
Wang X, Sehgal L, Jain N, Khashab T, Mathur R, Samaniego F. LncRNA MALAT1 promotes development of mantle cell lymphoma by associating with EZH2. J Transl Med. 2016;14:346 pubmed publisher
Cieniewicz A, Kirchner T, Hinke S, Nanjunda R, D AQUINO K, Boayke K, et al. Novel Monoclonal Antibody Is an Allosteric Insulin Receptor Antagonist That Induces Insulin Resistance. Diabetes. 2017;66:206-217 pubmed publisher
Zhang Y, Shi C, Zhang H, Li G, Li S. MLN4924 suppresses neddylation and induces cell cycle arrest, senescence, and apoptosis in human osteosarcoma. Oncotarget. 2016;7:45263-45274 pubmed publisher
Huang T, Kang W, Zhang B, Wu F, Dong Y, Tong J, et al. miR-508-3p concordantly silences NFKB1 and RELA to inactivate canonical NF-κB signaling in gastric carcinogenesis. Mol Cancer. 2016;15:9 pubmed publisher
product information
SKU :
2552S
Product-Name :
p27 Kip1 Antibody
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R
Applications :
Immunoprecipitation
Product-Category :
Cell Cycle / Checkpoint Control
Shipping-Temp :
COLD
Storage-Temp :
-20°C
Product-Type :
Polyclonal Antibody
MW :
27
Host :
Rabbit
Target :
p27 Kip1
Primary-Protein :
p27Kip1
Alt-Names :
CDKN1B,CDKN4,CDN1B,Cyclin-dependent kinase inhibitor 1B,Cyclin-dependent kinase inhibitor p27,KIP1,MEN1B,MEN4,cyclin-dependent kinase inhibitor 1B (p27, Kip1),p27Kip1
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.