product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Phospho-Paxillin (Tyr118) Antibody
catalog :
2541
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
antigen modification :
phosphorylated
reactivity :
human, mouse, rat
application :
western blot, immunocytochemistry
citations: 25
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:1000; fig 1n
Yin H, Wang J, Li H, Yu Y, Wang X, Lu L, et al. Extracellular matrix protein-1 secretory isoform promotes ovarian cancer through increasing alternative mRNA splicing and stemness. Nat Commun. 2021;12:4230 pubmed publisher
  • immunocytochemistry; mouse; 1:50; loading ...; fig 1s2b
  • immunocytochemistry; human; 1:50; loading ...; fig 1s2b
Lehtimäki J, Rajakylä E, Tojkander S, Lappalainen P. Generation of stress fibers through myosin-driven reorganization of the actin cortex. elife. 2021;10: pubmed publisher
  • immunocytochemistry; human; loading ...; fig 6a, 6b
Dilshat R, Fock V, Kenny C, Gerritsen I, Lasseur R, Travnickova J, et al. MITF reprograms the extracellular matrix and focal adhesion in melanoma. elife. 2021;10: pubmed publisher
  • western blot; human; 1:250; fig 3b
Sato T, Verma S, Andrade C, Omeara M, Campbell N, Wang J, et al. A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction. Nat Commun. 2020;11:3282 pubmed publisher
  • immunocytochemistry; rat; 1:50; loading ...; fig 3f
Torres Mejía E, Trumbach D, Kleeberger C, Dornseifer U, Orschmann T, Bäcker T, et al. Sox2 controls Schwann cell self-organization through fibronectin fibrillogenesis. Sci Rep. 2020;10:1984 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 6a
Fearnley G, Young K, Edgar J, Antrobus R, Hay I, Liang W, et al. The homophilic receptor PTPRK selectively dephosphorylates multiple junctional regulators to promote cell-cell adhesion. elife. 2019;8: pubmed publisher
  • western blot; human; 1:1000; fig 3c
DeLalio L, Billaud M, Ruddiman C, Johnstone S, Butcher J, Wolpe A, et al. Constitutive SRC-mediated phosphorylation of pannexin 1 at tyrosine 198 occurs at the plasma membrane. J Biol Chem. 2019;294:6940-6956 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4b
Baghdadi M, Firmino J, Soni K, Evano B, Di Girolamo D, Mourikis P, et al. Notch-Induced miR-708 Antagonizes Satellite Cell Migration and Maintains Quiescence. Cell Stem Cell. 2018;23:859-868.e5 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 6c
Kim H, Mun Y, Lee K, Park Y, Park J, Park J, et al. T cell microvilli constitute immunological synaptosomes that carry messages to antigen-presenting cells. Nat Commun. 2018;9:3630 pubmed publisher
  • western blot; human; loading ...; fig 7a
Wang Z, Kim M, Martinez Ferrando I, Koleske A, Pandey A, Cole P. Analysis of Cellular Tyrosine Phosphorylation via Chemical Rescue of Conditionally Active Abl Kinase. Biochemistry. 2018;57:1390-1398 pubmed publisher
  • western blot; human; loading ...; fig 4a
Jeong S, Lim S, Schevzov G, Gunning P, Helfman D. Loss of Tpm4.1 leads to disruption of cell-cell adhesions and invasive behavior in breast epithelial cells via increased Rac1 signaling. Oncotarget. 2017;8:33544-33559 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3f
Gerarduzzi C, Kumar R, Trivedi P, Ajay A, Iyer A, Boswell S, et al. Silencing SMOC2 ameliorates kidney fibrosis by inhibiting fibroblast to myofibroblast transformation. JCI Insight. 2017;2: pubmed publisher
  • western blot; human; loading ...; fig s8a
Mekhdjian A, Kai F, Rubashkin M, Prahl L, Przybyla L, McGregor A, et al. Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix. Mol Biol Cell. 2017;28:1467-1488 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 8f
Li N, Xue W, Yuan H, Dong B, Ding Y, Liu Y, et al. AKT-mediated stabilization of histone methyltransferase WHSC1 promotes prostate cancer metastasis. J Clin Invest. 2017;127:1284-1302 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s9b
Grasso S, Chapelle J, Salemme V, Aramu S, Russo I, Vitale N, et al. The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries. Nat Commun. 2017;8:14797 pubmed publisher
  • western blot; human; loading ...; fig 10a
Lemler D, Lynch M, Tesfay L, Deng Z, Paul B, Wang X, et al. DCYTB is a predictor of outcome in breast cancer that functions via iron-independent mechanisms. Breast Cancer Res. 2017;19:25 pubmed publisher
  • western blot; rat; 1:1000; fig 2C
Wang N, Yao F, Li K, Zhang L, Yin G, Du M, et al. Fisetin regulates astrocyte migration and proliferation in vitro. Int J Mol Med. 2017;39:783-790 pubmed publisher
  • western blot; human; 1:2000; loading ...; fig 5d
Yoo S, Latifkar A, Cerione R, Antonyak M. Cool-associated Tyrosine-phosphorylated Protein 1 Is Required for the Anchorage-independent Growth of Cervical Carcinoma Cells by Binding Paxillin and Promoting AKT Activation. J Biol Chem. 2017;292:3947-3957 pubmed publisher
  • western blot; human; loading ...; fig 5c
Piasecka D, Kitowska K, Czaplinska D, Mieczkowski K, Mieszkowska M, Turczyk L, et al. Fibroblast growth factor signalling induces loss of progesterone receptor in breast cancer cells. Oncotarget. 2016;7:86011-86025 pubmed publisher
  • western blot; human; 1:1000; loading ...
Harrington K, Clevenger C. Identification of NEK3 Kinase Threonine 165 as a Novel Regulatory Phosphorylation Site That Modulates Focal Adhesion Remodeling Necessary for Breast Cancer Cell Migration. J Biol Chem. 2016;291:21388-21406 pubmed
  • western blot; mouse; fig 1
Jadav R, Kumar D, Buwa N, Ganguli S, Thampatty S, Balasubramanian N, et al. Deletion of inositol hexakisphosphate kinase 1 (IP6K1) reduces cell migration and invasion, conferring protection from aerodigestive tract carcinoma in mice. Cell Signal. 2016;28:1124-36 pubmed publisher
  • western blot; human; fig 5
Hayashi K, Michiue H, Yamada H, Takata K, Nakayama H, Wei F, et al. Fluvoxamine, an anti-depressant, inhibits human glioblastoma invasion by disrupting actin polymerization. Sci Rep. 2016;6:23372 pubmed publisher
  • western blot; human; 1:1000; fig 6
Kraft Sheleg O, Zaffryar Eilot S, Genin O, Yaseen W, Soueid Baumgarten S, Kessler O, et al. Localized LoxL3-Dependent Fibronectin Oxidation Regulates Myofiber Stretch and Integrin-Mediated Adhesion. Dev Cell. 2016;36:550-61 pubmed publisher
  • western blot; human; fig 7
Kim D, Helfman D. Loss of MLCK leads to disruption of cell-cell adhesion and invasive behavior of breast epithelial cells via increased expression of EGFR and ERK/JNK signaling. Oncogene. 2016;35:4495-508 pubmed publisher
Bergert M, Lendenmann T, Zündel M, Ehret A, Panozzo D, Richner P, et al. Confocal reference free traction force microscopy. Nat Commun. 2016;7:12814 pubmed publisher
product information
SKU :
2541S
Product-Name :
Phospho-Paxillin (Tyr118) Antibody
Size :
100 ul
Price-(USD) :
274 USD
Species-x-Reactivity :
H, M, R, Mk, Pg
Applications :
Immunofluorescence (Immunocytochemistry)
Product-Category :
Adhesion/ECM
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Polyclonal Antibody
MW :
68
Host :
Rabbit
Target :
Paxillin (Tyr118) phosphate
Primary-Protein :
PXN iso2
Alt-Names :
FLJ16691,PAXI,PXN,Paxillin
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.