| Published Application/Species/Dilution | Reference |
|---|
- western blot; mouse; fig 4
| Shinohara S, Gu Y, Yang Y, Furuta Y, Tanaka M, Yue X, et al. Ethanol extracts of chickpeas alter the total lipid content and expression levels of genes related to fatty acid metabolism in mouse 3T3-L1 adipocytes. Int J Mol Med. 2016;38:574-84 pubmed publisher |
- western blot; mouse; 1:1000; fig 4a
| Lee K, Hsieh Y, Yang Y, Chan C, Huang Y, Lin H. Aliskiren Reduces Hepatic steatosis and Epididymal Fat Mass and Increases Skeletal Muscle Insulin Sensitivity in High-Fat Diet-Fed Mice. Sci Rep. 2016;6:18899 pubmed publisher |
- western blot; mouse; 1:1000; fig 2
| Wang K, Cao P, Wang H, Tang Z, Wang N, Wang J, et al. Chronic administration of Angelica sinensis polysaccharide effectively improves fatty liver and glucose homeostasis in high-fat diet-fed mice. Sci Rep. 2016;6:26229 pubmed publisher |
| Koch F, Lamp O, Eslamizad M, Weitzel J, Kuhla B. Metabolic Response to Heat Stress in Late-Pregnant and Early Lactation Dairy Cows: Implications to Liver-Muscle Crosstalk. PLoS ONE. 2016;11:e0160912 pubmed publisher |
- western blot; human; fig 1
| Taniguchi T, Iizumi Y, Watanabe M, Masuda M, Morita M, Aono Y, et al. Resveratrol directly targets DDX5 resulting in suppression of the mTORC1 pathway in prostate cancer. Cell Death Dis. 2016;7:e2211 pubmed publisher |
- western blot; human; fig 3
| Pandiri I, Chen Y, Joe Y, Kim H, Park J, Chung H, et al. Tristetraprolin mediates the anti-proliferative effects of metformin in breast cancer cells. Breast Cancer Res Treat. 2016;156:57-64 pubmed publisher |
- immunocytochemistry; human; 1:100; fig s3
| Schmitt D, Cheng Y, Park J, An S. Sequestration-Mediated Downregulation of de Novo Purine Biosynthesis by AMPK. ACS Chem Biol. 2016;: pubmed |
| Kim J, Hong S, Park C, Park J, Choi S, Woo S, et al. Intramyocardial Adipose-Derived Stem Cell Transplantation Increases Pericardial Fat with Recovery of Myocardial Function after Acute Myocardial Infarction. PLoS ONE. 2016;11:e0158067 pubmed publisher |
- western blot; mouse; 1:1000; fig s3
| Thomas A, Belaidi E, Aron-Wisnewsky J, van der Zon G, Levy P, Clement K, et al. Hypoxia-inducible factor prolyl hydroxylase 1 (PHD1) deficiency promotes hepatic steatosis and liver-specific insulin resistance in mice. Sci Rep. 2016;6:24618 pubmed publisher |
- western blot; rat; 1:1000; fig 5
| Liu L, Wang C, Lin Y, Xi Y, Li H, Shi S, et al. Suppression of calcium‑sensing receptor ameliorates cardiac hypertrophy through inhibition of autophagy. Mol Med Rep. 2016;14:111-20 pubmed publisher |
- western blot; mouse; 1:1000; fig 4
| Walter C, Clemens L, Müller A, Fallier-Becker P, Proikas-Cezanne T, Riess O, et al. Activation of AMPK-induced autophagy ameliorates Huntington disease pathology in vitro. Neuropharmacology. 2016;108:24-38 pubmed publisher |
- western blot; mouse; fig 5
| Peteranderl C, Morales-Nebreda L, Selvakumar B, Lecuona E, Vadász I, Morty R, et al. Macrophage-epithelial paracrine crosstalk inhibits lung edema clearance during influenza infection. J Clin Invest. 2016;126:1566-80 pubmed publisher |
- western blot; mouse; fig 4a
| Lee Y, Yun M, Kim H, Jeon B, Park B, Lee B, et al. Exogenous administration of DLK1 ameliorates hepatic steatosis and regulates gluconeogenesis via activation of AMPK. Int J Obes (Lond). 2016;40:356-65 pubmed publisher |
- western blot; rat; 1:500; fig 6
| Tang S, Su H, Zhang Q, Tang H, Wang C, Zhou Q, et al. Sitagliptin inhibits endothelin-1 expression in the aortic endothelium of rats with streptozotocin-induced diabetes by suppressing the nuclear factor-κB/IκBα system through the activation of AMP-activated protein kinase. Int J Mol Med. 2016;37:1558-66 pubmed publisher |
- western blot; mouse; fig s2
| Song J, Sun Y, Peluso I, Zeng Y, Yu X, Lu J, et al. A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition. Autophagy. 2016;: pubmed |
- western blot; human; fig 1
| Sato N, Takasaka N, Yoshida M, Tsubouchi K, Minagawa S, Araya J, et al. Metformin attenuates lung fibrosis development via NOX4 suppression. Respir Res. 2016;17:107 pubmed publisher |
- western blot; human; fig 3
| Oliveira A, Gomes-Marcondes M. Metformin treatment modulates the tumour-induced wasting effects in muscle protein metabolism minimising the cachexia in tumour-bearing rats. BMC Cancer. 2016;16:418 pubmed publisher |
- western blot; mouse; 1:1000; fig 4
| Dinger K, Kasper P, Hucklenbruch-Rother E, Vohlen C, Jobst E, Janoschek R, et al. Early-onset obesity dysregulates pulmonary adipocytokine/insulin signaling and induces asthma-like disease in mice. Sci Rep. 2016;6:24168 pubmed publisher |
- western blot; mouse; 1:1000; fig 6
| Dokas J, Chadt A, Joost H, Al-Hasani H. Tbc1d1 deletion suppresses obesity in leptin-deficient mice. Int J Obes (Lond). 2016;: pubmed publisher |
- western blot; mouse; 1:1000; fig 8
| Lee B, Koo J, Yun Jun J, Gavrilova O, Lee Y, Seo A, et al. A mouse model for a partially inactive obesity-associated human MC3R variant. Nat Commun. 2016;7:10522 pubmed publisher |
- western blot; human; 1:1000; fig s5
| Wilhelm K, Happel K, Eelen G, Schoors S, Oellerich M, Lim R, et al. FOXO1 couples metabolic activity and growth state in the vascular endothelium. Nature. 2016;529:216-20 pubmed publisher |
- western blot; mouse; fig 2
| Møller C, Kjøbsted R, Enriori P, Jensen T, Garcia-Rudaz C, Litwak S, et al. α-MSH Stimulates Glucose Uptake in Mouse Muscle and Phosphorylates Rab-GTPase-Activating Protein TBC1D1 Independently of AMPK. PLoS ONE. 2016;11:e0157027 pubmed publisher |
- western blot; human; fig 1
| Sundararaman A, Amirtham U, Rangarajan A. Calcium-Oxidant Signaling Network Regulates AMP-activated Protein Kinase (AMPK) Activation upon Matrix Deprivation. J Biol Chem. 2016;291:14410-29 pubmed publisher |
- western blot; human; 1:200; fig st1
| Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher |
- western blot; mouse; 1:1000
| Parodi B, Rossi S, Morando S, Cordano C, Bragoni A, Motta C, et al. Fumarates modulate microglia activation through a novel HCAR2 signaling pathway and rescue synaptic dysregulation in inflamed CNS. Acta Neuropathol. 2015;130:279-95 pubmed publisher |
- western blot; human; fig s21
| Kawada M, Inoue H, Ohba S, Yoshida J, Masuda T, Yamasaki M, et al. Stromal cells positively and negatively modulate the growth of cancer cells: stimulation via the PGE2-TNFα-IL-6 pathway and inhibition via secreted GAPDH-E-cadherin interaction. PLoS ONE. 2015;10:e0119415 pubmed publisher |
| Kim S, Ka S, Lee Y, Park B, Fei X, Jung J, et al. The new 4-O-methylhonokiol analog GS12021 inhibits inflammation and macrophage chemotaxis: role of AMP-activated protein kinase α activation. PLoS ONE. 2015;10:e0117120 pubmed publisher |
- western blot; mouse; 1:1000; fig 4a
| Zheng T, Yang X, Wu D, Xing S, Bian F, Li W, et al. Salidroside ameliorates insulin resistance through activation of a mitochondria-associated AMPK/PI3K/Akt/GSK3β pathway. Br J Pharmacol. 2015;172:3284-301 pubmed publisher |
- western blot; mouse; fig 2
| McMurray F, Demetriades M, Aik W, Merkestein M, Kramer H, Andrew D, et al. Pharmacological inhibition of FTO. PLoS ONE. 2015;10:e0121829 pubmed publisher |
- western blot; human; fig 5
| Wong T, Lin S, Leung L. The flavone apigenin blocks nuclear translocation of sterol regulatory element-binding protein-2 in the hepatic cells WRL-68. Br J Nutr. 2015;113:1844-52 pubmed publisher |
- western blot; mouse; 1:1000; fig 5
| Shi S, Lu S, Sivasubramaniyam T, Revelo X, Cai E, Luk C, et al. DJ-1 links muscle ROS production with metabolic reprogramming and systemic energy homeostasis in mice. Nat Commun. 2015;6:7415 pubmed publisher |
- western blot; human; fig 2c
| Nezich C, Wang C, Fogel A, Youle R. MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5. J Cell Biol. 2015;210:435-50 pubmed publisher |
| Tian W, Li W, Chen Y, Yan Z, Huang X, Zhuang H, et al. Phosphorylation of ULK1 by AMPK regulates translocation of ULK1 to mitochondria and mitophagy. FEBS Lett. 2015;589:1847-54 pubmed publisher |
- western blot; mouse; 1:2000; fig 7
| Dijk W, Heine M, Vergnes L, Boon M, Schaart G, Hesselink M, et al. ANGPTL4 mediates shuttling of lipid fuel to brown adipose tissue during sustained cold exposure. elife. 2015;4: pubmed publisher |
- western blot; human; fig 4a
| Drießen S, Berleth N, Friesen O, Löffler A, Böhler P, Hieke N, et al. Deubiquitinase inhibition by WP1130 leads to ULK1 aggregation and blockade of autophagy. Autophagy. 2015;11:1458-70 pubmed publisher |
| Wong T, Lin S, Leung L. The Flavone Luteolin Suppresses SREBP-2 Expression and Post-Translational Activation in Hepatic Cells. PLoS ONE. 2015;10:e0135637 pubmed publisher |
- western blot; mouse
- western blot; rat
| Jaishy B, Zhang Q, Chung H, Riehle C, Soto J, Jenkins S, et al. Lipid-induced NOX2 activation inhibits autophagic flux by impairing lysosomal enzyme activity. J Lipid Res. 2015;56:546-61 pubmed publisher |
| Xu H, Zhou Y, Coughlan K, Ding Y, Wang S, Wu Y, et al. AMPKα1 deficiency promotes cellular proliferation and DNA damage via p21 reduction in mouse embryonic fibroblasts. Biochim Biophys Acta. 2015;1853:65-73 pubmed publisher |
- western blot; mouse; 1:1000; fig 8
| Shimizu N, Maruyama T, Yoshikawa N, Matsumiya R, Ma Y, Ito N, et al. A muscle-liver-fat signalling axis is essential for central control of adaptive adipose remodelling. Nat Commun. 2015;6:6693 pubmed publisher |
- western blot; mouse; 1:1000
| Huang Z, Han Z, Ye B, Dai Z, Shan P, Lu Z, et al. Berberine alleviates cardiac ischemia/reperfusion injury by inhibiting excessive autophagy in cardiomyocytes. Eur J Pharmacol. 2015;762:1-10 pubmed publisher |
- western blot; mouse; 1:1000; fig 3
| Shimoda Y, Matsuo K, Kitamura Y, Ono K, Ueyama T, Matoba S, et al. Diabetes-Related Ankyrin Repeat Protein (DARP/Ankrd23) Modifies Glucose Homeostasis by Modulating AMPK Activity in Skeletal Muscle. PLoS ONE. 2015;10:e0138624 pubmed publisher |
| Bejaoui M, Pantazi E, De Luca V, Panisello A, Folch-Puy E, Hotter G, et al. Carbonic Anhydrase Protects Fatty Liver Grafts against Ischemic Reperfusion Damage. PLoS ONE. 2015;10:e0134499 pubmed publisher |
- western blot; mouse; fig 1
| Roe N, Xu X, Kandadi M, Hu N, Pang J, Weiser-Evans M, et al. Targeted deletion of PTEN in cardiomyocytes renders cardiac contractile dysfunction through interruption of Pink1-AMPK signaling and autophagy. Biochim Biophys Acta. 2015;1852:290-8 pubmed publisher |
- western blot; human; 1:2000; fig 3
| Mahboubi H, Barisé R, Stochaj U. 5'-AMP-activated protein kinase alpha regulates stress granule biogenesis. Biochim Biophys Acta. 2015;1853:1725-37 pubmed publisher |
| De Zio D, Molinari F, Rizza S, Gatta L, Ciotti M, Salvatore A, et al. Apaf1-deficient cortical neurons exhibit defects in axonal outgrowth. Cell Mol Life Sci. 2015;72:4173-91 pubmed publisher |
| Ducommun S, Deak M, Sumpton D, Ford R, Núñez Galindo A, Kussmann M, et al. Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: identification of mitochondrial fission factor as a new AMPK substrate. Cell Signal. 2015;27:978-88 pubmed publisher |
- western blot; human; fig 1
| Murata Y, Uehara Y, Hosoi Y. Activation of mTORC1 under nutrient starvation conditions increases cellular radiosensitivity in human liver cancer cell lines, HepG2 and HuH6. Biochem Biophys Res Commun. 2015;468:684-90 pubmed publisher |
- western blot; human; fig 4
| Zagani R, El-Assaad W, Gamache I, Teodoro J. Inhibition of adipose triglyceride lipase (ATGL) by the putative tumor suppressor G0S2 or a small molecule inhibitor attenuates the growth of cancer cells. Oncotarget. 2015;6:28282-95 pubmed publisher |
| Irimia J, Tagliabracci V, Meyer C, Segvich D, Depaoli-Roach A, Roach P. Muscle glycogen remodeling and glycogen phosphate metabolism following exhaustive exercise of wild type and laforin knockout mice. J Biol Chem. 2015;290:22686-98 pubmed publisher |
- western blot; mouse; fig 5
| Antonucci L, Fagman J, Kim J, Todoric J, Gukovsky I, Mackey M, et al. Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress. Proc Natl Acad Sci U S A. 2015;112:E6166-74 pubmed publisher |
- western blot; human; fig s13
| Kao Y, Chang B, Liang J, Tsai H, Lee Y, Lin R, et al. Japanese encephalitis virus nonstructural protein NS5 interacts with mitochondrial trifunctional protein and impairs fatty acid β-oxidation. PLoS Pathog. 2015;11:e1004750 pubmed publisher |
- western blot; human; 1:1000; fig 1
| Mo J, Meng Z, Kim Y, Park H, Hansen C, Kim S, et al. Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway. Nat Cell Biol. 2015;17:500-10 pubmed publisher |
- western blot; mouse; 1:1000; fig 2
| Milan G, Romanello V, Pescatore F, Armani A, Paik J, Frasson L, et al. Regulation of autophagy and the ubiquitin-proteasome system by the FoxO transcriptional network during muscle atrophy. Nat Commun. 2015;6:6670 pubmed publisher |
| Perera R, Stoykova S, Nicolay B, Ross K, Fitamant J, Boukhali M, et al. Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism. Nature. 2015;524:361-5 pubmed publisher |
- immunohistochemistry - paraffin section; human; fig 5
- western blot; human; fig 4
| Tsutsumi Y, Nomiyama T, Kawanami T, Hamaguchi Y, Terawaki Y, Tanaka T, et al. Combined Treatment with Exendin-4 and Metformin Attenuates Prostate Cancer Growth. PLoS ONE. 2015;10:e0139709 pubmed publisher |
- western blot; mouse; fig 4
| Wang H, Wan H, Li X, Liu W, Chen Q, Wang Y, et al. Atg7 is required for acrosome biogenesis during spermatogenesis in mice. Cell Res. 2014;24:852-69 pubmed publisher |
- western blot; rat; 1:5000
| Hardman S, Hall D, Cabrera A, Hancock C, Thomson D. The effects of age and muscle contraction on AMPK activity and heterotrimer composition. Exp Gerontol. 2014;55:120-8 pubmed publisher |
- western blot; human; fig 1c
| Lau A, Liu P, Inuzuka H, Gao D. SIRT1 phosphorylation by AMP-activated protein kinase regulates p53 acetylation. Am J Cancer Res. 2014;4:245-55 pubmed |
- western blot; mouse; 1:1000
- immunocytochemistry; mouse; 1:1000
| Langone F, Cannata S, Fuoco C, Lettieri Barbato D, Testa S, Nardozza A, et al. Metformin protects skeletal muscle from cardiotoxin induced degeneration. PLoS ONE. 2014;9:e114018 pubmed publisher |
| Abdul-Wahed A, Gautier-Stein A, Casteras S, Soty M, Roussel D, Romestaing C, et al. A link between hepatic glucose production and peripheral energy metabolism via hepatokines. Mol Metab. 2014;3:531-43 pubmed publisher |
| Mackeh R, Lorin S, Ratier A, Mejdoubi-Charef N, Baillet A, Bruneel A, et al. Reactive oxygen species, AMP-activated protein kinase, and the transcription cofactor p300 regulate α-tubulin acetyltransferase-1 (αTAT-1/MEC-17)-dependent microtubule hyperacetylation during cell stress. J Biol Chem. 2014;289:11816-28 pubmed publisher |
| Yi X, Pashaj A, Xia M, Moreau R. Reversal of obesity-induced hypertriglyceridemia by (R)-α-lipoic acid in ZDF (fa/fa) rats. Biochem Biophys Res Commun. 2013;439:390-5 pubmed publisher |
| Ivanina A, Nesmelova I, Leamy L, Sokolov E, Sokolova I. Intermittent hypoxia leads to functional reorganization of mitochondria and affects cellular bioenergetics in marine molluscs. J Exp Biol. 2016;219:1659-74 pubmed publisher |
| Montesano A, Senesi P, Luzi L, Benedini S, Terruzzi I. Potential therapeutic role of L-carnitine in skeletal muscle oxidative stress and atrophy conditions. Oxid Med Cell Longev. 2015;2015:646171 pubmed publisher |
| Guo C, Hao C, Shao R, Fang B, Correa A, Hofstetter W, et al. RNA-dependent protein kinase (PKR) depletes nutrients, inducing phosphorylation of AMP-activated kinase in lung cancer. Oncotarget. 2015;6:11114-24 pubmed |
| Sarr O, Thompson J, Zhao L, Lee T, Regnault T. Low birth weight male guinea pig offspring display increased visceral adiposity in early adulthood. PLoS ONE. 2014;9:e98433 pubmed publisher |
| Estañ M, Calviño E, Calvo S, Guillén-Guío B, Boyano-Adánez M, de Blas E, et al. Apoptotic efficacy of etomoxir in human acute myeloid leukemia cells. Cooperation with arsenic trioxide and glycolytic inhibitors, and regulation by oxidative stress and protein kinase activities. PLoS ONE. 2014;9:e115250 pubmed publisher |
| Medina E, Oberheu K, Polusani S, Ortega V, Velagaleti G, Oyajobi B. PKA/AMPK signaling in relation to adiponectin's antiproliferative effect on multiple myeloma cells. Leukemia. 2014;28:2080-9 pubmed publisher |
| Xu R, Hu Q, Ma Q, Liu C, Wang G. The protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathway. Cell Death Dis. 2014;5:e1373 pubmed publisher |
| Shen M, Zhang Z, Ratnam M, Dou Q. The interplay of AMP-activated protein kinase and androgen receptor in prostate cancer cells. J Cell Physiol. 2014;229:688-95 pubmed publisher |
| Magnaudeix A, Wilson C, Page G, Bauvy C, Codogno P, Leveque P, et al. PP2A blockade inhibits autophagy and causes intraneuronal accumulation of ubiquitinated proteins. Neurobiol Aging. 2013;34:770-90 pubmed publisher |
| Tsunekawa-Imai N, Miwa H, Shikami M, Suganuma K, Goto M, Mizuno S, et al. Growth of xenotransplanted leukemia cells is influenced by diet nutrients and is attenuated with 2-deoxyglucose. Leuk Res. 2013;37:1132-6 pubmed publisher |
| Montesano A, Luzi L, Senesi P, Mazzocchi N, Terruzzi I. Resveratrol promotes myogenesis and hypertrophy in murine myoblasts. J Transl Med. 2013;11:310 pubmed publisher |
| da Rocha J, Trapani L, Segatto M, La Rosa P, Nogueira C, Zeni G, et al. Molecular effects of diphenyl diselenide on cholesterol and glucose cell metabolism. Curr Med Chem. 2013;20:4426-34 pubmed |
| Vidal A, Andrade B, Vaisman F, Cazarin J, Pinto L, Breitenbach M, et al. AMP-activated protein kinase signaling is upregulated in papillary thyroid cancer. Eur J Endocrinol. 2013;169:521-8 pubmed publisher |
| Tzatsos A, Kandror K. Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation. Mol Cell Biol. 2006;26:63-76 pubmed |
| Nelson L, Valentine R, Cacicedo J, Gauthier M, Ido Y, Ruderman N. A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells. Am J Physiol Cell Physiol. 2012;303:C4-C13 pubmed publisher |
| Pintér K, Jefferson A, Czibik G, Watkins H, Redwood C. Subunit composition of AMPK trimers present in the cytokinetic apparatus: Implications for drug target identification. Cell Cycle. 2012;11:917-21 pubmed publisher |
| Kazgan N, Williams T, Forsberg L, Brenman J. Identification of a nuclear export signal in the catalytic subunit of AMP-activated protein kinase. Mol Biol Cell. 2010;21:3433-42 pubmed publisher |
| Roca H, Varsos Z, Pienta K. CCL2 is a negative regulator of AMP-activated protein kinase to sustain mTOR complex-1 activation, survivin expression, and cell survival in human prostate cancer PC3 cells. Neoplasia. 2009;11:1309-17 pubmed |
| Göransson O, McBride A, Hawley S, Ross F, Shpiro N, Foretz M, et al. Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase. J Biol Chem. 2007;282:32549-60 pubmed |
| Lützner N, De-Castro Arce J, Rösl F. Gene expression of the tumour suppressor LKB1 is mediated by Sp1, NF-Y and FOXO transcription factors. PLoS ONE. 2012;7:e32590 pubmed publisher |
