product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
p53 (1C12) Mouse mAb
catalog :
2524
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
1C12
reactivity :
human, mouse, rat, cow, pig, Rhesus monkey
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, ChIP-Seq, RNA immunoprecipitation, western blot knockout validation, immunocytochemistry knockout validation
more info or order :
Cell Signaling Technology product webpage
citations: 218
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; mouse; loading ...; fig 4a
Burikhanov R, Hebbar N, Noothi S, Shukla N, Sledziona J, Araujo N, et al. Chloroquine-Inducible Par-4 Secretion Is Essential for Tumor Cell Apoptosis and Inhibition of Metastasis. Cell Rep. 2017;18:508-519 pubmed publisher
  • western blot; mouse; loading ...; fig 6d
  • western blot knockout validation; human; loading ...; fig 1d
  • RNA immunoprecipitation; human; loading ...; fig 3b
  • ChIP-Seq; human; loading ...; fig 1a
  • immunoprecipitation; human; loading ...; fig 3d
Schmitt A, Garcia J, Hung T, Flynn R, Shen Y, Qu K, et al. An inducible long noncoding RNA amplifies DNA damage signaling. Nat Genet. 2016;48:1370-1376 pubmed publisher
  • immunocytochemistry knockout validation; rat; 1:50; fig s1
Chen P, Qin L, Li G, Tellides G, Simons M. Fibroblast growth factor (FGF) signaling regulates transforming growth factor beta (TGF?)-dependent smooth muscle cell phenotype modulation. Sci Rep. 2016;6:33407 pubmed publisher
  • western blot knockout validation; mouse; 1:750; fig 3
  • immunoprecipitation; human; fig 6
  • western blot; human; fig 6
Fernández Majada V, Welz P, Ermolaeva M, Schell M, Adam A, Dietlein F, et al. The tumour suppressor CYLD regulates the p53 DNA damage response. Nat Commun. 2016;7:12508 pubmed publisher
  • western blot knockout validation; mouse; fig 1c
Llanos S, García Pedrero J, Morgado Palacin L, Rodrigo J, Serrano M. Stabilization of p21 by mTORC1/4E-BP1 predicts clinical outcome of head and neck cancers. Nat Commun. 2016;7:10438 pubmed publisher
  • immunocytochemistry knockout validation; rat; 1:50; fig s1
Chen F, Rosiene J, Che A, Becker A, LoTurco J. Tracking and transforming neocortical progenitors by CRISPR/Cas9 gene targeting and piggyBac transposase lineage labeling. Development. 2015;142:3601-11 pubmed publisher
  • western blot knockout validation; mouse; 1:2000; fig 2a
Ahronian L, Driscoll D, Klimstra D, Lewis B. The p53R172H mutant does not enhance hepatocellular carcinoma development and progression. PLoS ONE. 2015;10:e0123816 pubmed publisher
  • western blot knockout validation; rat; 1:500; fig 1
McCoy A, Besch Williford C, Franklin C, Weinstein E, Cui X. Creation and preliminary characterization of a Tp53 knockout rat. Dis Model Mech. 2013;6:269-78 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 7a
  • western blot; rat; 1:1000; loading ...; fig 6c
Xu T, Ding W, Ao X, Chu X, Wan Q, Wang Y, et al. ARC regulates programmed necrosis and myocardial ischemia/reperfusion injury through the inhibition of mPTP opening. Redox Biol. 2019;20:414-426 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig s8a
  • western blot; mouse; loading ...; fig s8b
  • western blot; human; fig s8c, s8d
Wang Y, Du L, Liang X, Meng P, Bi L, Wang Y, et al. SIRT4 Depletion Promotes HCC Tumorigenesis through Regulating AMPKα/mTOR Axis. Hepatology. 2018;: pubmed publisher
  • western blot; human; loading ...; fig 6d
Ghosh R, Roy S, Franco S. PARP1 depletion induces RIG-I-dependent signaling in human cancer cells. PLoS ONE. 2018;13:e0194611 pubmed publisher
  • western blot; mouse; fig 2d
Xiao G, Chan L, Klemm L, Braas D, Chen Z, Geng H, et al. B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies. Cell. 2018;173:470-484.e18 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5a
Fu X, Zhang C, Meng H, Zhang K, Shi L, Cao C, et al. Oncoprotein Tudor-SN is a key determinant providing survival advantage under DNA damaging stress. Cell Death Differ. 2018;25:1625-1637 pubmed publisher
  • flow cytometry; mouse; loading ...; fig e6a
Garaycoechea J, Crossan G, Langevin F, Mulderrig L, Louzada S, Yang F, et al. Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells. Nature. 2018;553:171-177 pubmed publisher
  • western blot; mouse; loading ...; fig 3n
Beker M, Çağlayan B, Yalcin E, Caglayan A, Turkseven S, Gurel B, et al. Time-of-Day Dependent Neuronal Injury After Ischemic Stroke: Implication of Circadian Clock Transcriptional Factor Bmal1 and Survival Kinase AKT. Mol Neurobiol. 2018;55:2565-2576 pubmed publisher
  • western blot; mouse; loading ...; fig 5a
Zhao L, Liu J, He C, Yan R, Zhou K, Cui Q, et al. Protein kinase A determines platelet life span and survival by regulating apoptosis. J Clin Invest. 2017;127:4338-4351 pubmed publisher
  • western blot; mouse; loading ...; fig s4c
Van T, Polykratis A, Straub B, Kondylis V, Papadopoulou N, Pasparakis M. Kinase-independent functions of RIPK1 regulate hepatocyte survival and liver carcinogenesis. J Clin Invest. 2017;127:2662-2677 pubmed publisher
  • western blot; mouse; fig 3i
Wassermann Dozorets R, Rubinstein M. C/EBPβ LIP augments cell death by inducing osteoglycin. Cell Death Dis. 2017;8:e2733 pubmed publisher
  • western blot; mouse; loading ...; fig 1d
Cong Q, Jia H, Li P, Qiu S, Yeh J, Wang Y, et al. p38α MAPK regulates proliferation and differentiation of osteoclast progenitors and bone remodeling in an aging-dependent manner. Sci Rep. 2017;7:45964 pubmed publisher
  • western blot; mouse; 1:1000; fig 2g
Coni S, Mancuso A, Di Magno L, Sdruscia G, Manni S, Serrao S, et al. Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma. Sci Rep. 2017;7:44079 pubmed publisher
  • western blot; human; loading ...; fig 3b
Li J, Yakushi T, Parlati F, MacKinnon A, Pérez C, Ma Y, et al. Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11. Nat Chem Biol. 2017;13:486-493 pubmed publisher
  • western blot; mouse; loading ...; fig s6b
Chan L, Chen Z, Braas D, Lee J, Xiao G, Geng H, et al. Metabolic gatekeeper function of B-lymphoid transcription factors. Nature. 2017;542:479-483 pubmed publisher
  • western blot; human; 1:2000; fig 1h
Xu W, Li B, Guan X, Chung S, Wang Y, Yip Y, et al. Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression. Nat Commun. 2017;8:14399 pubmed publisher
  • western blot; human; loading ...; fig 6a
Yuan H, Tan B, Gao S. Tenovin-6 impairs autophagy by inhibiting autophagic flux. Cell Death Dis. 2017;8:e2608 pubmed publisher
  • western blot; mouse; fig 5c
Corbineau S, Lassalle B, Givelet M, Souissi Sarahoui I, Firlej V, Romeo P, et al. Spermatogonial stem cells and progenitors are refractory to reprogramming to pluripotency by the transcription factors Oct3/4, c-Myc, Sox2 and Klf4. Oncotarget. 2017;8:10050-10063 pubmed publisher
  • western blot; human; 1:1500; fig 7i
  • western blot; mouse; 1:1500; loading ...; fig 3i
Benkafadar N, Menardo J, Bourien J, Nouvian R, François F, Decaudin D, et al. Reversible p53 inhibition prevents cisplatin ototoxicity without blocking chemotherapeutic efficacy. EMBO Mol Med. 2017;9:7-26 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1c
Liu G, Xiang T, Wu Q, Wang W. Curcumin suppresses the proliferation of gastric cancer cells by downregulating H19. Oncol Lett. 2016;12:5156-5162 pubmed publisher
  • western blot; human; 1:1200; loading ...; fig 2e
Gan J, Wang F, Mu D, Qu Y, Luo R, Wang Q. RNA interference targeting Aurora-A sensitizes glioblastoma cells to temozolomide chemotherapy. Oncol Lett. 2016;12:4515-4523 pubmed publisher
  • western blot; human; loading ...; fig 5
Ren Z, Aerts J, Vandenplas H, Wang J, Gorbenko O, Chen J, et al. Phosphorylated STAT5 regulates p53 expression via BRCA1/BARD1-NPM1 and MDM2. Cell Death Dis. 2016;7:e2560 pubmed publisher
  • western blot; human; loading ...; fig s6a
Narayanaswamy P, Tkachuk S, Haller H, Dumler I, Kiyan Y. CHK1 and RAD51 activation after DNA damage is regulated via urokinase receptor/TLR4 signaling. Cell Death Dis. 2016;7:e2383 pubmed publisher
  • western blot; human; fig 6i
Nip H, Dar A, Saini S, Colden M, Varahram S, Chowdhary H, et al. Oncogenic microRNA-4534 regulates PTEN pathway in prostate cancer. Oncotarget. 2016;7:68371-68384 pubmed publisher
  • western blot; human; 1:1000; loading ...
Jones R, Robinson T, Liu J, Shrestha M, Voisin V, Ju Y, et al. RB1 deficiency in triple-negative breast cancer induces mitochondrial protein translation. J Clin Invest. 2016;126:3739-3757 pubmed publisher
  • western blot; human; 1:1000; fig 5
Lee W, Jo S, Lee M, Won C, Lee M, Choi J, et al. The Effect of MCP-1/CCR2 on the Proliferation and Senescence of Epidermal Constituent Cells in Solar Lentigo. Int J Mol Sci. 2016;17: pubmed publisher
  • western blot; mouse; 1:1000; fig 4
Li X, Cheng K, Liu Z, Yang J, Wang B, Jiang X, et al. The MDM2-p53-pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β-cells. Nat Commun. 2016;7:11740 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3a
El Husseini N, Schlisser A, Hales B. Editor's Highlight: Hydroxyurea Exposure Activates the P53 Signaling Pathway in Murine Organogenesis-Stage Embryos. Toxicol Sci. 2016;152:297-308 pubmed publisher
  • western blot; human; loading ...; fig s4
  • western blot; mouse; loading ...; fig 3c
Avila A, Illing A, Becker F, Maerz L, Morita Y, Philipp M, et al. Xpg limits the expansion of haematopoietic stem and progenitor cells after ionising radiation. Nucleic Acids Res. 2016;44:6252-61 pubmed publisher
  • western blot; mouse; fig 6
He D, Xiang J, Li B, Liu H. The dynamic behavior of Ect2 in response to DNA damage. Sci Rep. 2016;6:24504 pubmed publisher
  • western blot; mouse; 1:2000; fig 1
Walia M, Ho P, Taylor S, Ng A, Gupte A, Chalk A, et al. Activation of PTHrP-cAMP-CREB1 signaling following p53 loss is essential for osteosarcoma initiation and maintenance. elife. 2016;5: pubmed publisher
  • western blot; rat; fig 3
Negis Y, Karabay A. Expression of cell cycle proteins in cortical neurons-Correlation with glutamate-induced neurotoxicity. Biofactors. 2016;42:358-67 pubmed publisher
  • western blot; mouse; fig 1
Vermeer D, Coppock J, Zeng E, Lee K, Spanos W, Onken M, et al. Metastatic model of HPV+ oropharyngeal squamous cell carcinoma demonstrates heterogeneity in tumor metastasis. Oncotarget. 2016;7:24194-207 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 8
Weeks R, Ludgate J, LeMée G, Morison I. TESTIN Induces Rapid Death and Suppresses Proliferation in Childhood B Acute Lymphoblastic Leukaemia Cells. PLoS ONE. 2016;11:e0151341 pubmed publisher
  • western blot; mouse; fig 1
Han X, Tai H, Wang X, Wang Z, Zhou J, Wei X, et al. AMPK activation protects cells from oxidative stress-induced senescence via autophagic flux restoration and intracellular NAD(+) elevation. Aging Cell. 2016;15:416-27 pubmed publisher
  • western blot; human; 1:1000; fig s1
Zheng F, Yue C, Li G, He B, Cheng W, Wang X, et al. Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype. Nat Commun. 2016;7:10180 pubmed publisher
  • western blot; human; loading ...; fig s7a
Olsen J, Cao X, Han B, Chen L, Horvath A, Richardson T, et al. Quantitative Profiling of the Activity of Protein Lysine Methyltransferase SMYD2 Using SILAC-Based Proteomics. Mol Cell Proteomics. 2016;15:892-905 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1a
Wu B, Yu L, Wang Y, Wang H, Li C, Yin Y, et al. Aldehyde dehydrogenase 2 activation in aged heart improves the autophagy by reducing the carbonyl modification on SIRT1. Oncotarget. 2016;7:2175-88 pubmed publisher
  • western blot; mouse; 1:200; fig 1d
Kondo H, Kim H, Wang L, Okada M, Paul C, Millard R, et al. Blockade of senescence-associated microRNA-195 in aged skeletal muscle cells facilitates reprogramming to produce induced pluripotent stem cells. Aging Cell. 2016;15:56-66 pubmed publisher
  • western blot; mouse; fig 4
Wang J, Chen S, Sun C, Chien T, Chern Y. A central role of TRAX in the ATM-mediated DNA repair. Oncogene. 2016;35:1657-70 pubmed publisher
  • western blot; human; fig 3a
Petroni M, Sardina F, Heil C, Sahún Roncero M, Colicchia V, Veschi V, et al. The MRN complex is transcriptionally regulated by MYCN during neural cell proliferation to control replication stress. Cell Death Differ. 2016;23:197-206 pubmed publisher
  • immunohistochemistry; mouse; 1:300; fig 4
  • western blot; mouse; 1:400; fig 5
Huang Y, Chen N, Miao D. Biological effects of pyrroloquinoline quinone on liver damage in Bmi-1 knockout mice. Exp Ther Med. 2015;10:451-458 pubmed
  • western blot; human; fig 5
Yang B, Zhang M, Gao J, Li J, Fan L, Xiang G, et al. Small molecule RL71 targets SERCA2 at a novel site in the treatment of human colorectal cancer. Oncotarget. 2015;6:37613-25 pubmed publisher
  • western blot; mouse; fig 6e
Wang J, De Veirman K, De Beule N, Maes K, De Bruyne E, Van Valckenborgh E, et al. The bone marrow microenvironment enhances multiple myeloma progression by exosome-mediated activation of myeloid-derived suppressor cells. Oncotarget. 2015;6:43992-4004 pubmed publisher
  • chromatin immunoprecipitation; human; fig 3
  • immunocytochemistry; human; fig 4
  • western blot; human; fig 4
Ahn H, Kim K, Shin K, Lim K, Kim J, Lee J, et al. Ell3 stabilizes p53 following CDDP treatment via its effects on ubiquitin-dependent and -independent proteasomal degradation pathways in breast cancer cells. Oncotarget. 2015;6:44523-37 pubmed publisher
  • western blot; mouse; fig s3
Antonucci L, Fagman J, Kim J, Todoric J, Gukovsky I, Mackey M, et al. Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress. Proc Natl Acad Sci U S A. 2015;112:E6166-74 pubmed publisher
  • western blot; human; 1:1000; fig 5b
Rastetter R, Blömacher M, Drebber U, Marko M, Behrens J, Solga R, et al. Coronin 2A (CRN5) expression is associated with colorectal adenoma-adenocarcinoma sequence and oncogenic signalling. BMC Cancer. 2015;15:638 pubmed publisher
  • western blot; human; fig 3e
Zhu J, Sammons M, Donahue G, Dou Z, Vedadi M, Getlik M, et al. Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth. Nature. 2015;525:206-11 pubmed publisher
  • western blot; human; fig 3
Xia H, Najafov A, Geng J, Galan Acosta L, Han X, Guo Y, et al. Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death. J Cell Biol. 2015;210:705-16 pubmed publisher
  • western blot; human; 1:1000; fig 5a
Mughal A, Grieg Z, Skjellegrind H, Fayzullin A, Lamkhannat M, Joel M, et al. Knockdown of NAT12/NAA30 reduces tumorigenic features of glioblastoma-initiating cells. Mol Cancer. 2015;14:160 pubmed publisher
  • western blot; human; 1:1000; fig 3
Cañeque T, Gomes F, Mai T, Maestri G, Malacria M, Rodriguez R. Synthesis of marmycin A and investigation into its cellular activity. Nat Chem. 2015;7:744-51 pubmed publisher
  • western blot; mouse; 1:1000; fig 2
Goh A, Xue Y, Leushacke M, Li L, Wong J, Chiam P, et al. Mutant p53 accumulates in cycling and proliferating cells in the normal tissues of p53 R172H mutant mice. Oncotarget. 2015;6:17968-80 pubmed
  • western blot; mouse; 1:500
González Loyola A, Fernández Miranda G, Trakala M, Partida D, Samejima K, Ogawa H, et al. Aurora B Overexpression Causes Aneuploidy and p21Cip1 Repression during Tumor Development. Mol Cell Biol. 2015;35:3566-78 pubmed publisher
  • western blot; mouse; 1:1000; fig 4b
Pencik J, Schlederer M, Gruber W, Unger C, Walker S, Chalaris A, et al. STAT3 regulated ARF expression suppresses prostate cancer metastasis. Nat Commun. 2015;6:7736 pubmed publisher
  • western blot; Rhesus monkey; fig 2
  • western blot; pig; fig 2
Simões M, Martins C, Ferreira F. Early intranuclear replication of African swine fever virus genome modifies the landscape of the host cell nucleus. Virus Res. 2015;210:1-7 pubmed publisher
  • immunocytochemistry; human; 1:2000; fig st1
Jones A, Gokhale P, Allison T, Sampson B, Athwal S, Grant S, et al. Evidence for bystander signalling between human trophoblast cells and human embryonic stem cells. Sci Rep. 2015;5:11694 pubmed publisher
  • western blot; mouse; 1:1000; fig 8b
Szlachcic W, Switonski P, Krzyzosiak W, Figlerowicz M, Figiel M. Huntington disease iPSCs show early molecular changes in intracellular signaling, the expression of oxidative stress proteins and the p53 pathway. Dis Model Mech. 2015;8:1047-57 pubmed publisher
  • western blot; mouse; loading ...; fig 4b
Slatter T, Hung N, Bowie S, Campbell H, Rubio C, Speidel D, et al. Δ122p53, a mouse model of Δ133p53α, enhances the tumor-suppressor activities of an attenuated p53 mutant. Cell Death Dis. 2015;6:e1783 pubmed publisher
  • western blot; mouse; fig s3
Xie C, Wei D, Zhao L, Marchetto S, Mei L, Borg J, et al. Erbin is a novel substrate of the Sag-βTrCP E3 ligase that regulates KrasG12D-induced skin tumorigenesis. J Cell Biol. 2015;209:721-37 pubmed publisher
  • western blot; mouse; 1:1000; fig 1b
Yoshida Y, Shimizu I, Katsuumi G, Jiao S, Suda M, Hayashi Y, et al. p53-Induced inflammation exacerbates cardiac dysfunction during pressure overload. J Mol Cell Cardiol. 2015;85:183-98 pubmed publisher
  • immunocytochemistry; human; 1:100; loading ...; fig 4c
Kotipatruni R, Ren X, Thotala D, Jaboin J. NDRG4 is a novel oncogenic protein and p53 associated regulator of apoptosis in malignant meningioma cells. Oncotarget. 2015;6:17594-604 pubmed
  • immunocytochemistry; human; 1:1000
  • western blot; human
Waters A, Stewart J, Atigadda V, Mroczek Musulman E, Muccio D, Grubbs C, et al. Preclinical Evaluation of a Novel RXR Agonist for the Treatment of Neuroblastoma. Mol Cancer Ther. 2015;14:1559-69 pubmed publisher
  • western blot; human; loading ...; fig 1c,1e
Zhao J, Molitor T, Langston J, Nichols R. LRRK2 dephosphorylation increases its ubiquitination. Biochem J. 2015;469:107-20 pubmed publisher
  • western blot; human
Sechler M, Borowicz S, Van Scoyk M, Avasarala S, Zerayesus S, Edwards M, et al. Novel Role for γ-Catenin in the Regulation of Cancer Cell Migration via the Induction of Hepatocyte Growth Factor Activator Inhibitor Type 1 (HAI-1). J Biol Chem. 2015;290:15610-20 pubmed publisher
  • western blot; mouse; fig s5
Cattoglio C, Zhang E, Grubisic I, Chiba K, Fong Y, Tjian R. Functional and mechanistic studies of XPC DNA-repair complex as transcriptional coactivator in embryonic stem cells. Proc Natl Acad Sci U S A. 2015;112:E2317-26 pubmed publisher
  • western blot; human; fig 8
Zhang M, Xu E, Zhang J, Chen X. PPM1D phosphatase, a target of p53 and RBM38 RNA-binding protein, inhibits p53 mRNA translation via dephosphorylation of RBM38. Oncogene. 2015;34:5900-11 pubmed publisher
  • western blot; human; fig s4g
Chen Z, Shojaee S, Buchner M, Geng H, Lee J, Klemm L, et al. Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia. Nature. 2015;521:357-61 pubmed publisher
  • immunocytochemistry; human; fig s3
Zhou Q, Derti A, Ruddy D, Rakiec D, Kao I, Lira M, et al. A chemical genetics approach for the functional assessment of novel cancer genes. Cancer Res. 2015;75:1949-58 pubmed publisher
  • western blot; human; 1:2000; fig 1
Mitkin N, Hook C, Schwartz A, Biswas S, Kochetkov D, Muratova A, et al. p53-dependent expression of CXCR5 chemokine receptor in MCF-7 breast cancer cells. Sci Rep. 2015;5:9330 pubmed publisher
  • western blot; human; loading ...; fig 2b
Ruan X, Zuo Q, Jia H, Chau J, Lin J, Ao J, et al. P53 deficiency-induced Smad1 upregulation suppresses tumorigenesis and causes chemoresistance in colorectal cancers. J Mol Cell Biol. 2015;7:105-18 pubmed publisher
  • immunoprecipitation; human; loading ...; fig 2b
  • immunoprecipitation; mouse; loading ...; fig 2a
Keskin N, Deniz E, Eryilmaz J, Un M, Batur T, Ersahin T, et al. PATZ1 Is a DNA Damage-Responsive Transcription Factor That Inhibits p53 Function. Mol Cell Biol. 2015;35:1741-53 pubmed publisher
  • immunocytochemistry; mouse
  • western blot; mouse
Yan H, Solozobova V, Zhang P, Armant O, Kuehl B, Brenner Weiss G, et al. p53 is active in murine stem cells and alters the transcriptome in a manner that is reminiscent of mutant p53. Cell Death Dis. 2015;6:e1662 pubmed publisher
  • western blot; mouse; fig 1c
Tomasovic A, Kurrle N, Sürün D, Heidler J, Husnjak K, Poser I, et al. Sestrin 2 protein regulates platelet-derived growth factor receptor β (Pdgfrβ) expression by modulating proteasomal and Nrf2 transcription factor functions. J Biol Chem. 2015;290:9738-52 pubmed publisher
  • western blot; mouse
Kitajima S, Kohno S, Kondoh A, Sasaki N, Nishimoto Y, Li F, et al. Undifferentiated State Induced by Rb-p53 Double Inactivation in Mouse Thyroid Neuroendocrine Cells and Embryonic Fibroblasts. Stem Cells. 2015;33:1657-69 pubmed publisher
  • western blot; mouse; 1:2500; loading ...; fig 3a
Li X, Gu S, Ling Y, Shen C, Cao X, Xie R. p53 inhibition provides a pivotal protective effect against ischemia-reperfusion injury in vitro via mTOR signaling. Brain Res. 2015;1605:31-8 pubmed publisher
  • western blot; human; fig 6
Yang Z, Broz D, Noderer W, Ferreira J, Overton K, Spencer S, et al. p53 suppresses muscle differentiation at the myogenin step in response to genotoxic stress. Cell Death Differ. 2015;22:560-73 pubmed publisher
  • western blot; human; 1:1000; tbl 1
Vega Naredo I, Cunha Oliveira T, Serafim T, Sardao V, Oliveira P. Analysis of pro-apoptotic protein trafficking to and from mitochondria. Methods Mol Biol. 2015;1241:163-80 pubmed publisher
  • western blot; mouse
Xu H, Zhou Y, Coughlan K, Ding Y, Wang S, Wu Y, et al. AMPKα1 deficiency promotes cellular proliferation and DNA damage via p21 reduction in mouse embryonic fibroblasts. Biochim Biophys Acta. 2015;1853:65-73 pubmed publisher
  • western blot; human
Huang E, Wang F, Chen Y, Chen Y, Wang C, Lin I, et al. Amifostine alleviates radiation-induced lethal small bowel damage via promotion of 14-3-3σ-mediated nuclear p53 accumulation. Oncotarget. 2014;5:9756-69 pubmed
  • western blot; rat; 1:1000
Jebelli J, Hooper C, Pocock J. Microglial p53 activation is detrimental to neuronal synapses during activation-induced inflammation: Implications for neurodegeneration. Neurosci Lett. 2014;583:92-7 pubmed publisher
  • western blot; mouse
Kim C, Pasparakis M. Epidermal p65/NF-?B signalling is essential for skin carcinogenesis. EMBO Mol Med. 2014;6:970-83 pubmed publisher
  • western blot; mouse; fig 1
Ying Y, Kim J, Westphal S, Long K, Padanilam B. Targeted deletion of p53 in the proximal tubule prevents ischemic renal injury. J Am Soc Nephrol. 2014;25:2707-16 pubmed publisher
  • immunocytochemistry; cow; 1:100
Ma M, Baumgartner M. Intracellular Theileria annulata promote invasive cell motility through kinase regulation of the host actin cytoskeleton. PLoS Pathog. 2014;10:e1004003 pubmed publisher
  • western blot; human
Sabò A, Doni M, Amati B. SUMOylation of Myc-family proteins. PLoS ONE. 2014;9:e91072 pubmed publisher
  • western blot; human; 1:1000; fig 3c
Okada N, Lin C, Ribeiro M, Biton A, Lai G, He X, et al. A positive feedback between p53 and miR-34 miRNAs mediates tumor suppression. Genes Dev. 2014;28:438-50 pubmed publisher
  • western blot; mouse; fig 6a
Berkenkamp B, Susnik N, Baisantry A, Kuznetsova I, Jacobi C, Sörensen Zender I, et al. In vivo and in vitro analysis of age-associated changes and somatic cellular senescence in renal epithelial cells. PLoS ONE. 2014;9:e88071 pubmed publisher
  • western blot; mouse; fig 4
Furuya N, Ikeda S, Sato S, Soma S, Ezaki J, Oliva Trejo J, et al. PARK2/Parkin-mediated mitochondrial clearance contributes to proteasome activation during slow-twitch muscle atrophy via NFE2L1 nuclear translocation. Autophagy. 2014;10:631-41 pubmed publisher
  • western blot; mouse
Schweikl H, Petzel C, Bolay C, Hiller K, Buchalla W, Krifka S. 2-Hydroxyethyl methacrylate-induced apoptosis through the ATM- and p53-dependent intrinsic mitochondrial pathway. Biomaterials. 2014;35:2890-904 pubmed publisher
  • western blot; mouse
Guo M, Cao Y, Wang T, Song X, Liu Z, Zhou E, et al. Baicalin inhibits Staphylococcus aureus-induced apoptosis by regulating TLR2 and TLR2-related apoptotic factors in the mouse mammary glands. Eur J Pharmacol. 2014;723:481-8 pubmed publisher
  • western blot; human; 1:1000; fig 6a
Kusama K, Yoshie M, Tamura K, Nakayama T, Nishi H, Isaka K, et al. The role of exchange protein directly activated by cyclic AMP 2-mediated calreticulin expression in the decidualization of human endometrial stromal cells. Endocrinology. 2014;155:240-8 pubmed publisher
  • western blot; mouse; fig 3
Fernandez S, Genis L, Torres Aleman I. A phosphatase-independent gain-of-function mutation in PTEN triggers aberrant cell growth in astrocytes through an autocrine IGF-1 loop. Oncogene. 2014;33:4114-22 pubmed publisher
  • western blot; human; 1:1000
Chen Y, Kamili A, Hardy J, Groblewski G, Khanna K, Byrne J. Tumor protein D52 represents a negative regulator of ATM protein levels. Cell Cycle. 2013;12:3083-97 pubmed publisher
  • western blot; mouse; fig 3
Xu Y, Swartz K, Siu K, Bhattacharyya M, Minella A. Fbw7-dependent cyclin E regulation ensures terminal maturation of bone marrow erythroid cells by restraining oxidative metabolism. Oncogene. 2014;33:3161-71 pubmed publisher
  • immunohistochemistry - frozen section; mouse
  • western blot; mouse
  • western blot; human; fig 5
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  • immunohistochemistry - frozen section; mouse
  • western blot; mouse
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product information
SKU :
2524S
Product-Name :
p53 (1C12) Mouse mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R, Mk
Applications :
Chromatin Immunoprecipitation
Product-Category :
Cell Cycle / Checkpoint Control
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
53
Host :
Mouse
Target :
p53
Primary-Protein :
p53
Alt-Names :
Antigen NY-CO-13,Cellular tumor antigen p53,FLJ92943,LFS1,P53,Phosphoprotein p53,TP53,TRP53,Tumor suppressor p53,p53 antigen,p53 transformation suppressor,p53 tumor suppressor,transformation-related protein 53,tumor protein p53
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
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Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.