product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
VE-Cadherin (D87F2) XP® Rabbit mAb
catalog :
2500
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
D87F2
reactivity :
human, mouse, rat, bovine, rhesus macaque
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section
citations: 29
Published Application/Species/Sample/DilutionReference
  • western blot; human; fig 4d
  • immunohistochemistry; mouse; 1:50; loading ...; fig 4a
Guo X, Zhang H, Huang J, Wang S, Lu Y, Cheng B, et al. PIEZO1 Ion Channel Mediates Ionizing Radiation-Induced Pulmonary Endothelial Cell Ferroptosis via Ca2+/Calpain/VE-Cadherin Signaling. Front Mol Biosci. 2021;8:725274 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:500; loading ...; fig 4g
  • immunocytochemistry; human; 1:500; loading ...; fig 5a
  • western blot; human; 1:500; loading ...; fig 5d
Hemanthakumar K, Fang S, Anisimov A, Mäyränpää M, Mervaala E, Kivela R. Cardiovascular disease risk factors induce mesenchymal features and senescence in mouse cardiac endothelial cells. elife. 2021;10: pubmed publisher
  • immunocytochemistry; human; 1:100; loading ...; fig s2-5
Bersini S, Schulte R, Huang L, Tsai H, Hetzer M. Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome. elife. 2020;9: pubmed publisher
  • immunocytochemistry; human; 1:1000; loading ...; fig 3c
Verrando P, Capovilla M, Rahmani R. Trans-nonachlor decreases miR-141-3p levels in human melanocytes in vitro promoting melanoma cell characteristics and shows a multigenerational impact on miR-8 levels in Drosophila. Toxicology. 2016;368-369:129-141 pubmed publisher
  • western blot; human; fig s1
Huang L, Stuart C, Takeda K, D Agnillo F, Golding B. Poly(I:C) Induces Human Lung Endothelial Barrier Dysfunction by Disrupting Tight Junction Expression of Claudin-5. PLoS ONE. 2016;11:e0160875 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; loading ...; fig 3a
Huang M, Liu T, Ma P, Mitteer R, Zhang Z, Kim H, et al. c-Met-mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma. J Clin Invest. 2016;126:1801-14 pubmed publisher
  • immunocytochemistry; human; 1:200; fig 2
Jin G, Zhao J, Yang Y, Liu K, Jiang Y, Zhang X, et al. JAK/STAT3 signaling pathway mediates endothelial-like differentiation of immature dendritic cells. Oncol Lett. 2015;10:3471-3477 pubmed
  • immunocytochemistry; rat; 1:200; fig 2
  • western blot; rat; 1:200; fig 2
Szulcek R, Happé C, Rol N, Fontijn R, Dickhoff C, Hartemink K, et al. Delayed Microvascular Shear Adaptation in Pulmonary Arterial Hypertension. Role of Platelet Endothelial Cell Adhesion Molecule-1 Cleavage. Am J Respir Crit Care Med. 2016;193:1410-20 pubmed publisher
  • western blot; human; 1:2000; fig 6g
Roth Flach R, Skoura A, Matevossian A, Danai L, Zheng W, Cortes C, et al. Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis. Nat Commun. 2015;6:8995 pubmed publisher
  • immunocytochemistry; human; 1:400; loading ...; fig 2c
  • western blot; human; 1:100
Leclercq A, Veillat V, Loriot S, Spuul P, Madonna F, Roques X, et al. A Methodology for Concomitant Isolation of Intimal and Adventitial Endothelial Cells from the Human Thoracic Aorta. PLoS ONE. 2015;10:e0143144 pubmed publisher
  • immunocytochemistry; human
  • western blot; human
Sivaraj K, Li R, Albarrán Juárez J, Wang S, Tischner D, Grimm M, et al. Endothelial Gαq/11 is required for VEGF-induced vascular permeability and angiogenesis. Cardiovasc Res. 2015;108:171-80 pubmed publisher
  • immunocytochemistry; rhesus macaque; fig 10
Kumar P, Thirkill T, Ji J, Monte L, Douglas G. Differential Effects of Sodium Butyrate and Lithium Chloride on Rhesus Monkey Trophoblast Differentiation. PLoS ONE. 2015;10:e0135089 pubmed publisher
  • western blot; human; 1:300-500
Sajja R, Green K, Cucullo L. Altered Nrf2 signaling mediates hypoglycemia-induced blood-brain barrier endothelial dysfunction in vitro. PLoS ONE. 2015;10:e0122358 pubmed publisher
  • immunocytochemistry; mouse; 1:400
  • western blot; mouse; 1:1000
Kalwa H, Storch U, Demleitner J, Fiedler S, Mayer T, Kannler M, et al. Phospholipase C epsilon (PLCε) induced TRPC6 activation: a common but redundant mechanism in primary podocytes. J Cell Physiol. 2015;230:1389-99 pubmed publisher
  • immunocytochemistry; human; 1:200
  • western blot; human; 1:500
Sajja R, Prasad S, Cucullo L. Impact of altered glycaemia on blood-brain barrier endothelium: an in vitro study using the hCMEC/D3 cell line. Fluids Barriers CNS. 2014;11:8 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:20
Larson A, Lee C, Lezcano C, Zhan Q, Huang J, Fischer A, et al. Melanoma spheroid formation involves laminin-associated vasculogenic mimicry. Am J Pathol. 2014;184:71-8 pubmed publisher
  • immunocytochemistry; human; 1:300
  • western blot; human; 1:500
Lopez Ramirez M, Fischer R, Torres Badillo C, Davies H, Logan K, Pfizenmaier K, et al. Role of caspases in cytokine-induced barrier breakdown in human brain endothelial cells. J Immunol. 2012;189:3130-9 pubmed publisher
Koo C, Harrison N, Noy P, Szyroka J, Matthews A, Hsia H, et al. The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex. J Biol Chem. 2020;: pubmed publisher
Klotz B, Oosterhoff L, Utomo L, Lim K, Vallmajo Martin Q, Clevers H, et al. A Versatile Biosynthetic Hydrogel Platform for Engineering of Tissue Analogues. Adv Healthc Mater. 2019;8:e1900979 pubmed publisher
Meegan J, Yang X, Beard R, Jannaway M, Chatterjee V, Taylor Clark T, et al. Citrullinated histone 3 causes endothelial barrier dysfunction. Biochem Biophys Res Commun. 2018;503:1498-1502 pubmed publisher
Rey Gallardo A, Tomlins H, Joachim J, Rahman I, Kitscha P, Frudd K, et al. Sequential binding of ezrin and moesin to L-selectin regulates monocyte protrusive behaviour during transendothelial migration. J Cell Sci. 2018;131: pubmed publisher
Zhao H, Zhang L, Zhang Y, Zhao L, Wan Q, Wang B, et al. Calmodulin promotes matrix metalloproteinase 9 production and cell migration by inhibiting the ubiquitination and degradation of TBC1D3 oncoprotein in human breast cancer cells. Oncotarget. 2017;8:36383-36398 pubmed publisher
Weyemi U, Redon C, Choudhuri R, Aziz T, Maeda D, Boufraqech M, et al. The histone variant H2A.X is a regulator of the epithelial-mesenchymal transition. Nat Commun. 2016;7:10711 pubmed publisher
Chaki S, Barhoumi R, Rivera G. Actin remodeling by Nck regulates endothelial lumen formation. Mol Biol Cell. 2015;26:3047-60 pubmed publisher
Krishnan S, Szabo E, Burghardt I, Frei K, Tabatabai G, Weller M. Modulation of cerebral endothelial cell function by TGF-β in glioblastoma: VEGF-dependent angiogenesis versus endothelial mesenchymal transition. Oncotarget. 2015;6:22480-95 pubmed
Mikelis C, Simaan M, Ando K, Fukuhara S, Sakurai A, Amornphimoltham P, et al. RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock. Nat Commun. 2015;6:6725 pubmed publisher
Smith J, Leslie M, Robinson S, Korasick D, Zhang T, Backues S, et al. Loss of Arabidopsis thaliana Dynamin-Related Protein 2B reveals separation of innate immune signaling pathways. PLoS Pathog. 2014;10:e1004578 pubmed publisher
Osborne L, Li G, How T, O Brien E, Blobe G, Superfine R, et al. TGF-β regulates LARG and GEF-H1 during EMT to affect stiffening response to force and cell invasion. Mol Biol Cell. 2014;25:3528-40 pubmed publisher
Naik P, Fofaria N, Prasad S, Sajja R, Weksler B, Couraud P, et al. Oxidative and pro-inflammatory impact of regular and denicotinized cigarettes on blood brain barrier endothelial cells: is smoking reduced or nicotine-free products really safe?. BMC Neurosci. 2014;15:51 pubmed publisher
product information
SKU :
2500S
Product-Name :
VE-Cadherin (D87F2) XP® Rabbit mAb
Size :
100 ul
Price-(USD) :
260 USD
Species-x-Reactivity :
H, Dm, B, Pg, (Mk)
Applications :
Flow cytometry
Product-Category :
Adhesion/ECM
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
130-140
Host :
Rabbit
Target :
VE-Cadherin
Primary-Protein :
CDH5
Alt-Names :
7B4,7B4 antigen,CADH5,CD144,CDH5,Cadherin-5,FLJ17376,VE-cadherin,Vascular endothelial cadherin,cadherin 5, type 2 (vascular endothelium),cadherin 5, type 2, VE-cadherin (vascular epithelium),cd144 antigen,endothelial-specific cadherin
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.