product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Phospho-VEGF Receptor 2 (Tyr1175) (19A10) Rabbit mAb
catalog :
2478S
quantity :
100 ul
price :
274 USD
clonality :
monoclonal
host :
rabbit
antigen modification :
phosphorylated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - frozen section
more info or order :
Cell Signaling Technology product webpage
citations: 21
Published Application/Species/DilutionReference
  • western blot; mouse; fig 5
Nishida-Fukuda H, Araki R, Shudou M, Okazaki H, Tomono Y, Nakayama H, et al. Ectodomain Shedding of Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE-1) Is Induced by Vascular Endothelial Growth Factor A (VEGF-A). J Biol Chem. 2016;291:10490-500 pubmed publisher
  • western blot; human; fig 1
Fearnley G, Smith G, Abdul-Zani I, Yuldasheva N, Mughal N, Homer-Vanniasinkam S, et al. VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis. Biol Open. 2016;5:571-83 pubmed publisher
  • western blot; human; 1:1000; fig 5
Zhang Z, Zhang H, Peng T, Li D, Xu J. Melittin suppresses cathepsin S-induced invasion and angiogenesis via blocking of the VEGF-A/VEGFR-2/MEK1/ERK1/2 pathway in human hepatocellular carcinoma. Oncol Lett. 2016;11:610-618 pubmed
  • western blot; mouse
Suzuki Y, Nagai N, Yamakawa K, Muranaka Y, Hokamura K, Umemura K. Recombinant tissue-type plasminogen activator transiently enhances blood-brain barrier permeability during cerebral ischemia through vascular endothelial growth factor-mediated endothelial endocytosis in mice. J Cereb Blood Flow Metab. 2015;35:2021-31 pubmed publisher
  • western blot; human
Kim B, Lee J, Choi J, Park D, Song H, Park T, et al. Imidazole-based alkaloid derivative LCB54-0009 suppresses ocular angiogenesis and lymphangiogenesis in models of experimental retinopathy and corneal neovascularization. Br J Pharmacol. 2015;172:3875-89 pubmed publisher
  • western blot; mouse
Andersson L, Scharin Tang M, Lundqvist A, Lindbom M, Mardani I, Fogelstrand P, et al. Rip2 modifies VEGF-induced signalling and vascular permeability in myocardial ischaemia. Cardiovasc Res. 2015;107:478-86 pubmed publisher
  • western blot; human
Coon B, Baeyens N, Han J, Budatha M, Ross T, Fang J, et al. Intramembrane binding of VE-cadherin to VEGFR2 and VEGFR3 assembles the endothelial mechanosensory complex. J Cell Biol. 2015;208:975-86 pubmed publisher
  • western blot; mouse; fig 3
Zhao C, Su Y, Zhang J, Feng Q, Qu L, Wang L, et al. Fibrinogen-derived fibrinostatin inhibits tumor growth through anti-angiogenesis. Cancer Sci. 2015;106:1596-606 pubmed publisher
  • western blot; human
Chen P, Qin L, Zhuang Z, Tellides G, Lax I, Schlessinger J, et al. The docking protein FRS2α is a critical regulator of VEGF receptors signaling. Proc Natl Acad Sci U S A. 2014;111:5514-9 pubmed publisher
  • western blot; rat; 1:1000; fig 5
Scotti L, Abramovich D, Pascuali N, Irusta G, Meresman G, Tesone M, et al. Local VEGF inhibition prevents ovarian alterations associated with ovarian hyperstimulation syndrome. J Steroid Biochem Mol Biol. 2014;144:392-401 pubmed publisher
  • immunohistochemistry - frozen section; mouse
Chatterjee S, Wang Y, Duncan M, Naik U. Junctional adhesion molecule-A regulates vascular endothelial growth factor receptor-2 signaling-dependent mouse corneal wound healing. PLoS ONE. 2013;8:e63674 pubmed publisher
  • western blot; human
Rapraeger A, Ell B, Roy M, Li X, Morrison O, Thomas G, et al. Vascular endothelial-cadherin stimulates syndecan-1-coupled insulin-like growth factor-1 receptor and cross-talk between αVβ3 integrin and vascular endothelial growth factor receptor 2 at the onset of endothelial cell dissemination during angiogenesis. FEBS J. 2013;280:2194-206 pubmed publisher
Kondo S, Bottos A, Allegood J, Masson R, Maurer F, Genoud C, et al. Memo has a novel role in S1P signaling and is [corrected] crucial for vascular development. PLoS ONE. 2014;9:e94114 pubmed publisher
Sun Q, Zhou J, Zhang Z, Guo M, Liang J, Zhou F, et al. Discovery of fruquintinib, a potent and highly selective small molecule inhibitor of VEGFR 1, 2, 3 tyrosine kinases for cancer therapy. Cancer Biol Ther. 2014;15:1635-45 pubmed publisher
Ding X, Xiang L, Wang N, Zhao Z, Jin X, Sun Y, et al. Vandetanib-induced inhibition of neuroblastoma cell migration and invasion is associated with downregulation of the SDF-1/CXCR4 axis and matrix metalloproteinase 14. Oncol Rep. 2014;31:1165-74 pubmed publisher
Antonescu C, Yoshida A, Guo T, Chang N, Zhang L, Agaram N, et al. KDR activating mutations in human angiosarcomas are sensitive to specific kinase inhibitors. Cancer Res. 2009;69:7175-9 pubmed publisher
Dellinger M, Brekken R. Phosphorylation of Akt and ERK1/2 is required for VEGF-A/VEGFR2-induced proliferation and migration of lymphatic endothelium. PLoS ONE. 2011;6:e28947 pubmed publisher
Takeuchi S, Wang W, Li Q, Yamada T, Kita K, Donev I, et al. Dual inhibition of Met kinase and angiogenesis to overcome HGF-induced EGFR-TKI resistance in EGFR mutant lung cancer. Am J Pathol. 2012;181:1034-43 pubmed publisher
Curradi G, Walters M, Ding B, Rafii S, Hackett N, Crystal R. Airway basal cell vascular endothelial growth factor-mediated cross-talk regulates endothelial cell-dependent growth support of human airway basal cells. Cell Mol Life Sci. 2012;69:2217-31 pubmed publisher
Kappas N, Zeng G, Chappell J, Kearney J, Hazarika S, Kallianos K, et al. The VEGF receptor Flt-1 spatially modulates Flk-1 signaling and blood vessel branching. J Cell Biol. 2008;181:847-58 pubmed publisher
Narayanan A, Popova T, Turell M, Kidd J, Chertow J, Popov S, et al. Alteration in superoxide dismutase 1 causes oxidative stress and p38 MAPK activation following RVFV infection. PLoS ONE. 2011;6:e20354 pubmed publisher
product information
SKU :
2478S
Product-Name :
Phospho-VEGF Receptor 2 (Tyr1175) (19A10) Rabbit mAb
Size :
100 ul
Price-(USD) :
274 USD
Species-x-Reactivity :
H, M
Applications :
Immunofluorescence (Immunocytochemistry)
Product-Category :
RTK
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
230
Host :
Rabbit
Target :
VEGFR2 (Tyr1175) phosphate
Primary-Protein :
VEGFR-2
Alt-Names :
CD309,FLK-1,FLK1,Fetal liver kinase 1,KDR,Kinase insert domain receptor,Protein-tyrosine kinase receptor flk-1,VEGFR,VEGFR-2,VEGFR2,VGFR2,Vascular endothelial growth factor receptor 2,fetal liver kinase-1,kinase insert domain receptor (a type III receptor tyrosine kinase),soluble VEGFR2,tyrosine kinase growth factor receptor
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.