product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
β-Amyloid Antibody
catalog :
2454
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry - free floating section
more info or order :
Cell Signaling Technology product webpage
citations: 18
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; human; 1:300; loading ...; fig 1c
Zhang P, Kishimoto Y, Grammatikakis I, Gottimukkala K, Cutler R, Zhang S, et al. Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer's disease model. Nat Neurosci. 2019;22:719-728 pubmed publisher
  • immunohistochemistry - frozen section; rat; 1:500; loading ...; fig 3e
  • western blot; rat; loading ...; fig 3a
Gasparotto J, Girardi C, Somensi N, Ribeiro C, Moreira J, Michels M, et al. Receptor for advanced glycation end products mediates sepsis-triggered amyloid-β accumulation, Tau phosphorylation, and cognitive impairment. J Biol Chem. 2018;293:226-244 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:250; loading ...; fig 2a
Salazar S, Gallardo C, Kaufman A, Herber C, Haas L, Robinson S, et al. Conditional Deletion of Prnp Rescues Behavioral and Synaptic Deficits after Disease Onset in Transgenic Alzheimer's Disease. J Neurosci. 2017;37:9207-9221 pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig 2a
Takahashi H, Klein Z, Bhagat S, Kaufman A, Kostylev M, Ikezu T, et al. Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network. Acta Neuropathol. 2017;133:785-807 pubmed publisher
  • immunohistochemistry; mouse; fig 1
Yuan P, Grutzendler J. Attenuation of β-Amyloid Deposition and Neurotoxicity by Chemogenetic Modulation of Neural Activity. J Neurosci. 2016;36:632-41 pubmed publisher
  • immunohistochemistry; mouse; 1:250; fig s9
Haas L, Salazar S, Kostylev M, Um J, Kaufman A, Strittmatter S. Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signalling in Alzheimer's disease. Brain. 2016;139:526-46 pubmed publisher
  • immunohistochemistry; mouse; 1:250
Nygaard H, Kaufman A, Sekine Konno T, Huh L, Going H, Feldman S, et al. Brivaracetam, but not ethosuximide, reverses memory impairments in an Alzheimer's disease mouse model. Alzheimers Res Ther. 2015;7:25 pubmed publisher
  • immunohistochemistry; mouse; fig 2
  • western blot; mouse; fig s2
Sykora P, Misiak M, Wang Y, Ghosh S, Leandro G, Liu D, et al. DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes. Nucleic Acids Res. 2015;43:943-59 pubmed publisher
Misiak M, Vergara Greeno R, Baptiste B, Sykora P, Liu D, Cordonnier S, et al. DNA polymerase ? decrement triggers death of olfactory bulb cells and impairs olfaction in a mouse model of Alzheimer's disease. Aging Cell. 2017;16:162-172 pubmed publisher
de la Rosa Prieto C, Saiz Sanchez D, Ubeda Bañon I, Flores Cuadrado A, Martinez Marcos A. Neurogenesis, Neurodegeneration, Interneuron Vulnerability, and Amyloid-? in the Olfactory Bulb of APP/PS1 Mouse Model of Alzheimer's Disease. Front Neurosci. 2016;10:227 pubmed publisher
O Neal Moffitt G, Delić V, Bradshaw P, Olcese J. Prophylactic melatonin significantly reduces Alzheimer's neuropathology and associated cognitive deficits independent of antioxidant pathways in AβPP(swe)/PS1 mice. Mol Neurodegener. 2015;10:27 pubmed publisher
Kostylev M, Kaufman A, Nygaard H, Patel P, Haas L, Gunther E, et al. Prion-Protein-interacting Amyloid-β Oligomers of High Molecular Weight Are Tightly Correlated with Memory Impairment in Multiple Alzheimer Mouse Models. J Biol Chem. 2015;290:17415-38 pubmed publisher
Hayasaka H, Kobayashi D, Yoshimura H, Nakayama E, Shioda T, Miyasaka M. The HIV-1 Gp120/CXCR4 axis promotes CCR7 ligand-dependent CD4 T cell migration: CCR7 homo- and CCR7/CXCR4 hetero-oligomer formation as a possible mechanism for up-regulation of functional CCR7. PLoS ONE. 2015;10:e0117454 pubmed publisher
Berth S, Caicedo H, Sarma T, Morfini G, Brady S. Internalization and axonal transport of the HIV glycoprotein gp120. ASN Neuro. 2015;7: pubmed publisher
Li H, Guo Q, Inoue T, Polito V, Tabuchi K, Hammer R, et al. Vascular and parenchymal amyloid pathology in an Alzheimer disease knock-in mouse model: interplay with cerebral blood flow. Mol Neurodegener. 2014;9:28 pubmed publisher
Guo Q, Li H, Cole A, Hur J, Li Y, Zheng H. Modeling Alzheimer's disease in mouse without mutant protein overexpression: cooperative and independent effects of A? and tau. PLoS ONE. 2013;8:e80706 pubmed publisher
Um J, Nygaard H, Heiss J, Kostylev M, Stagi M, Vortmeyer A, et al. Alzheimer amyloid-? oligomer bound to postsynaptic prion protein activates Fyn to impair neurons. Nat Neurosci. 2012;15:1227-35 pubmed publisher
Saiz Sanchez D, Ubeda Banon I, de la Rosa Prieto C, Argandoña Palacios L, Garcia Muñozguren S, Insausti R, et al. Somatostatin, tau, and beta-amyloid within the anterior olfactory nucleus in Alzheimer disease. Exp Neurol. 2010;223:347-50 pubmed publisher
product information
SKU :
2454S
Product-Name :
β-Amyloid Antibody
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H
Applications :
Immunofluorescence (Paraffin)
Product-Category :
Neuroscience
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Polyclonal Antibody
MW :
5
Host :
Rabbit
Target :
APP
Primary-Protein :
APP
Alt-Names :
A4,AAA,ABETA,ABPP,AD1,AICD-50,AICD-57,AICD-59,AID(50),AID(57),AID(59),APP,APPI,Alzheimer disease amyloid protein,Amyloid beta A4 protein,Amyloid intracellular domain 50,Amyloid intracellular domain 57,Amyloid intracellular domain 59,Beta-APP40,Beta-APP42,Beta-amyloid protein 40,Beta-amyloid protein 42,C31,C80,C83,C99,CTFgamma,CVAP,Cerebral vascular amyloid peptide,Gamma-CTF(50),Gamma-CTF(57),Gamma-CTF(59),Gamma-secretase C-terminal fragment 50,Gamma-secretase C-terminal fragment 57,Gamma-secretase C-terminal fragment 59,N-APP,P3(40),P3(42),PN-II,PN2,PreA4,Protease nexin-II,S-APP-alpha,S-APP-beta,Soluble APP-alpha,Soluble APP-beta,amyloid beta (A4) precursor protein,beta-amyloid peptide,peptidase nexin-II
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.