product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
APP/β-Amyloid (NAB228) Mouse mAb
catalog :
2450
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
NAB228
reactivity :
human, dog, cow
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
more info or order :
Cell Signaling Technology product webpage
citations: 6
Reference
Rao C, Farooqui M, Zhang Y, Asch A, Yamada H. Spontaneous development of Alzheimer's disease-associated brain pathology in a Shugoshin-1 mouse cohesinopathy model. Aging Cell. 2018;:e12797 pubmed publisher
Stock A, Kasus Jacobi A, Wren J, Sjoelund V, Prestwich G, Pereira H. The Role of Neutrophil Proteins on the Amyloid Beta-RAGE Axis. PLoS ONE. 2016;11:e0163330 pubmed publisher
Hurtado D, Molina Porcel L, Carroll J, Macdonald C, Aboagye A, Trojanowski J, et al. Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer's disease. J Neurosci. 2012;32:7392-402 pubmed publisher
Strang F, Scheichl A, Chen Y, Wang X, Htun N, Bassler N, et al. Amyloid plaques dissociate pentameric to monomeric C-reactive protein: a novel pathomechanism driving cortical inflammation in Alzheimer's disease?. Brain Pathol. 2012;22:337-46 pubmed publisher
Lee E, Leng L, Zhang B, Kwong L, Trojanowski J, Abel T, et al. Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic mice. J Biol Chem. 2006;281:4292-9 pubmed
Lee E, Zhang B, Liu K, Greenbaum E, Doms R, Trojanowski J, et al. BACE overexpression alters the subcellular processing of APP and inhibits Abeta deposition in vivo. J Cell Biol. 2005;168:291-302 pubmed
product information
SKU :
2450P
Product-Name :
APP/β-Amyloid (NAB228) Mouse mAb
Size :
40 ul
Price-(USD) :
123 USD
Species-x-Reactivity :
H, Mk, B, (Dg, Pg)
Applications :
Immunofluorescence (Paraffin)
Product-Category :
Neuroscience
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
100 to 140
Host :
Mouse
Target :
APP
Primary-Protein :
APP
Alt-Names :
A4,AAA,ABETA,ABPP,AD1,AICD-50,AICD-57,AICD-59,AID(50),AID(57),AID(59),APP,APPI,Alzheimer disease amyloid protein,Amyloid beta A4 protein,Amyloid intracellular domain 50,Amyloid intracellular domain 57,Amyloid intracellular domain 59,Beta-APP40,Beta-APP42,Beta-amyloid protein 40,Beta-amyloid protein 42,C31,C80,C83,C99,CTFgamma,CVAP,Cerebral vascular amyloid peptide,Gamma-CTF(50),Gamma-CTF(57),Gamma-CTF(59),Gamma-secretase C-terminal fragment 50,Gamma-secretase C-terminal fragment 57,Gamma-secretase C-terminal fragment 59,N-APP,P3(40),P3(42),PN-II,PN2,PreA4,Protease nexin-II,S-APP-alpha,S-APP-beta,Soluble APP-alpha,Soluble APP-beta,amyloid beta (A4) precursor protein,beta-amyloid peptide,peptidase nexin-II
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.