product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
PPARγ (C26H12) Rabbit mAb
catalog :
2435
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
C26H12
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 46
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 4a
Han H, Kim S, Kim Y, Jang S, Kwon Y, Choi D, et al. A novel role of CRTC2 in promoting nonalcoholic fatty liver disease. Mol Metab. 2022;55:101402 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 6h
Gyamfi J, Yeo J, Kwon D, Min B, Cha Y, Koo J, et al. Interaction between CD36 and FABP4 modulates adipocyte-induced fatty acid import and metabolism in breast cancer. NPJ Breast Cancer. 2021;7:129 pubmed publisher
  • immunohistochemistry; mouse; fig 6c
  • western blot; mouse; fig 6a
Cheng C, Xue F, Sui W, Meng L, Xie L, Zhang C, et al. Deletion of natriuretic peptide receptor C alleviates adipose tissue inflammation in hypercholesterolemic Apolipoprotein E knockout mice. J Cell Mol Med. 2021;25:9837-9850 pubmed publisher
  • western blot; human; loading ...; fig 2e
Sun Z, Sun D, Feng Y, Zhang B, Sun P, Zhou B, et al. Exosomal linc-ROR mediates crosstalk between cancer cells and adipocytes to promote tumor growth in pancreatic cancer. Mol Ther Nucleic Acids. 2021;26:253-268 pubmed publisher
  • western blot; human; loading ...
Chen Q, Liu X, Wang D, Zheng J, Chen L, Xie Q, et al. Periodontal Inflammation-Triggered by Periodontal Ligament Stem Cell Pyroptosis Exacerbates Periodontitis. Front Cell Dev Biol. 2021;9:663037 pubmed publisher
  • western blot; mouse; loading ...; fig e7c
Lu Z, Zou J, Li S, Topper M, Tao Y, Zhang H, et al. Epigenetic therapy inhibits metastases by disrupting premetastatic niches. Nature. 2020;579:284-290 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 6a
  • western blot; human; loading ...; fig 1a
Kaur S, Nag A, Gangenahalli G, Sharma K. Peroxisome Proliferator Activated Receptor Gamma Sensitizes Non-small Cell Lung Carcinoma to Gamma Irradiation Induced Apoptosis. Front Genet. 2019;10:554 pubmed publisher
  • western blot; mouse; loading ...; fig 1d
Song T, Yang Y, Wei H, Xie X, Lu J, Zeng Q, et al. Zfp217 mediates m6A mRNA methylation to orchestrate transcriptional and post-transcriptional regulation to promote adipogenic differentiation. Nucleic Acids Res. 2019;: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4b
Zuo Z, Liu Z, Gao T, Yin Y, Wang Z, Hou Y, et al. Prolonged inorganic arsenic exposure via drinking water impairs brown adipose tissue function in mice. Sci Total Environ. 2019;668:310-317 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5b
Zhang X, Chen X, Qi T, Kong Q, Cheng H, Cao X, et al. HSPA12A is required for adipocyte differentiation and diet-induced obesity through a positive feedback regulation with PPARγ. Cell Death Differ. 2019;: pubmed publisher
  • western blot; mouse; loading ...; fig s2g, s4a
Grohmann M, Wiede F, Dodd G, Gurzov E, Ooi G, Butt T, et al. Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC. Cell. 2018;175:1289-1306.e20 pubmed publisher
  • western blot; mouse; loading ...; fig 1e
Macdougall C, Wood E, Loschko J, Scagliotti V, Cassidy F, Robinson M, et al. Visceral Adipose Tissue Immune Homeostasis Is Regulated by the Crosstalk between Adipocytes and Dendritic Cell Subsets. Cell Metab. 2018;27:588-601.e4 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 1f
  • immunohistochemistry - paraffin section; human; 1:100; loading ...; fig 1b
Ernszt D, Banfai K, Kellermayer Z, Pap A, Lord J, Pongracz J, et al. PPARgamma Deficiency Counteracts Thymic Senescence. Front Immunol. 2017;8:1515 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 1a
Al Khalaf H, Amir M, Al Mohanna F, Tulbah A, Al Sayed A, Aboussekhra A. Obesity and p16INK4A Downregulation Activate Breast Adipocytes and Promote Their Protumorigenicity. Mol Cell Biol. 2017;37: pubmed publisher
  • western blot; human; fig 1e
Lee R, Reese C, Carmen Lopez G, Perry B, Bonner M, Zemskova M, et al. Deficient Adipogenesis of Scleroderma Patient and Healthy African American Monocytes. Front Pharmacol. 2017;8:174 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:400; loading ...; fig st13
Furukawa S, Nagaike M, Ozaki K. Databases for technical aspects of immunohistochemistry. J Toxicol Pathol. 2017;30:79-107 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 4a
Chruvattil R, Banerjee S, Nath S, Machhi J, Kharkwal G, Yadav M, et al. Dexamethasone Alters the Appetite Regulation via Induction of Hypothalamic Insulin Resistance in Rat Brain. Mol Neurobiol. 2017;54:7483-7496 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 4b
  • western blot; human; loading ...; fig s1b
Friedrich T, Söhn M, Gutting T, Janssen K, Behrens H, Rocken C, et al. Subcellular compartmentalization of docking protein-1 contributes to progression in colorectal cancer. EBioMedicine. 2016;8:159-172 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:500; loading ...; fig 7g
  • immunohistochemistry - paraffin section; mouse; 1:500; fig 6b
  • western blot; mouse; 1:1000; fig 7f
Lombardi R, Chen S, Ruggiero A, Gurha P, Czernuszewicz G, Willerson J, et al. Cardiac Fibro-Adipocyte Progenitors Express Desmosome Proteins and Preferentially Differentiate to Adipocytes Upon Deletion of the Desmoplakin Gene. Circ Res. 2016;119:41-54 pubmed publisher
  • immunohistochemistry; mouse; 1:400; fig 3b
  • western blot; mouse; 1:1000; fig 3b
Lee K, Hsieh Y, Yang Y, Chan C, Huang Y, Lin H. Aliskiren Reduces Hepatic steatosis and Epididymal Fat Mass and Increases Skeletal Muscle Insulin Sensitivity in High-Fat Diet-Fed Mice. Sci Rep. 2016;6:18899 pubmed publisher
  • western blot; human; 1:500; fig 6
Lauková J, Kozubík A, Hofmanová J, Nekvindová J, Sova P, Moyer M, et al. Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells. PLoS ONE. 2015;10:e0141020 pubmed publisher
  • western blot; mouse; 1:1000; fig s14
Nemazanyy I, Montagnac G, Russell R, Morzyglod L, Burnol A, Guan K, et al. Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling. Nat Commun. 2015;6:8283 pubmed publisher
  • western blot; human; fig 6
Kim J, Sato M, Choi J, Kim H, Yeh B, Larsen J, et al. Nuclear Receptor Expression and Function in Human Lung Cancer Pathogenesis. PLoS ONE. 2015;10:e0134842 pubmed publisher
  • western blot; human; 1:1000
Zhang H, Jing X, Wu X, Hu J, Zhang X, Wang X, et al. Suppression of multidrug resistance by rosiglitazone treatment in human ovarian cancer cells through downregulation of FZD1 and MDR1 genes. Anticancer Drugs. 2015;26:706-15 pubmed publisher
  • immunohistochemistry; human; fig 4
Eriksson P, Aine M, Veerla S, Liedberg F, Sjödahl G, Höglund M. Molecular subtypes of urothelial carcinoma are defined by specific gene regulatory systems. BMC Med Genomics. 2015;8:25 pubmed publisher
  • western blot; human; fig 2
Shi C, Zhang M, Tong M, Yang L, Pang L, Chen L, et al. miR-148a is Associated with Obesity and Modulates Adipocyte Differentiation of Mesenchymal Stem Cells through Wnt Signaling. Sci Rep. 2015;5:9930 pubmed publisher
  • immunohistochemistry - frozen section; rat
Ke X, Xing B, Yu B, Yu X, Majnik A, Cohen S, et al. IUGR disrupts the PPAR?-Setd8-H4K20me(1) and Wnt signaling pathways in the juvenile rat hippocampus. Int J Dev Neurosci. 2014;38:59-67 pubmed publisher
  • western blot; mouse
Sharma A, Huard C, Vernochet C, Ziemek D, Knowlton K, Tyminski E, et al. Brown fat determination and development from muscle precursor cells by novel action of bone morphogenetic protein 6. PLoS ONE. 2014;9:e92608 pubmed publisher
  • western blot; human; 1:500
Yoshida G, Saya H, Zouboulis C. Three-dimensional culture of sebaceous gland cells revealing the role of prostaglandin E2-induced activation of canonical Wnt signaling. Biochem Biophys Res Commun. 2013;438:640-6 pubmed publisher
  • western blot; mouse
Rippo M, Babini L, Prattichizzo F, Graciotti L, Fulgenzi G, Tomassoni Ardori F, et al. Low FasL levels promote proliferation of human bone marrow-derived mesenchymal stem cells, higher levels inhibit their differentiation into adipocytes. Cell Death Dis. 2013;4:e594 pubmed publisher
  • western blot; mouse; 1:1000
Hou Y, Xue P, Woods C, Wang X, Fu J, Yarborough K, et al. Association between arsenic suppression of adipogenesis and induction of CHOP10 via the endoplasmic reticulum stress response. Environ Health Perspect. 2013;121:237-43 pubmed publisher
Chen P, Qin L, Li G, Malagon Lopez J, Wang Z, Bergaya S, et al. Smooth Muscle Cell Reprogramming in Aortic Aneurysms. Cell Stem Cell. 2020;26:542-557.e11 pubmed publisher
Aprile M, Cataldi S, Ambrosio M, D Esposito V, Lim K, Dietrich A, et al. PPARγΔ5, a Naturally Occurring Dominant-Negative Splice Isoform, Impairs PPARγ Function and Adipocyte Differentiation. Cell Rep. 2018;25:1577-1592.e6 pubmed publisher
Arnett E, Weaver A, Woodyard K, Montoya M, Li M, Hoang K, et al. PPARγ is critical for Mycobacterium tuberculosis induction of Mcl-1 and limitation of human macrophage apoptosis. PLoS Pathog. 2018;14:e1007100 pubmed publisher
Heming M, Gran S, Jauch S, Fischer Riepe L, Russo A, Klotz L, et al. Peroxisome Proliferator-Activated Receptor-γ Modulates the Response of Macrophages to Lipopolysaccharide and Glucocorticoids. Front Immunol. 2018;9:893 pubmed publisher
Olona A, Terra X, Ko J, Grau Bové C, Pinent M, Ardevol A, et al. Epoxygenase inactivation exacerbates diet and aging-associated metabolic dysfunction resulting from impaired adipogenesis. Mol Metab. 2018;11:18-32 pubmed publisher
Xiao Z, Baudry J, Cao L, Huang J, Chen H, Yates C, et al. Polycystin-1 interacts with TAZ to stimulate osteoblastogenesis and inhibit adipogenesis. J Clin Invest. 2018;128:157-174 pubmed publisher
Goldstein J, Berger A, Shih J, Duke F, Furst L, Kwiatkowski D, et al. Genomic Activation of PPARG Reveals a Candidate Therapeutic Axis in Bladder Cancer. Cancer Res. 2017;77:6987-6998 pubmed publisher
Nadal X, Del Rio C, Casano S, Palomares B, Ferreiro Vera C, Navarrete C, et al. Tetrahydrocannabinolic acid is a potent PPAR? agonist with neuroprotective activity. Br J Pharmacol. 2017;174:4263-4276 pubmed publisher
Reneker L, Wang L, Irlmeier R, Huang A. Fibroblast Growth Factor Receptor 2 (FGFR2) Is Required for Meibomian Gland Homeostasis in the Adult Mouse. Invest Ophthalmol Vis Sci. 2017;58:2638-2646 pubmed publisher
Meng Z, Ma X, Du J, Wang X, He M, Gu Y, et al. CAMK2γ antagonizes mTORC1 activation during hepatocarcinogenesis. Oncogene. 2017;36:2446-2456 pubmed publisher
Ahmad I, Mui E, Galbraith L, Patel R, Tan E, Salji M, et al. Sleeping Beauty screen reveals Pparg activation in metastatic prostate cancer. Proc Natl Acad Sci U S A. 2016;113:8290-5 pubmed publisher
Liu Y, Huang Y, Lee S, Bookout A, Castorena C, Wu H, et al. PPARγ mRNA in the adult mouse hypothalamus: distribution and regulation in response to dietary challenges. Front Neuroanat. 2015;9:120 pubmed publisher
Long J, Svensson K, Tsai L, Zeng X, Roh H, Kong X, et al. A smooth muscle-like origin for beige adipocytes. Cell Metab. 2014;19:810-20 pubmed publisher
Komatsu Y, Yoshino T, Yamazaki K, Yuki S, Machida N, Sasaki T, et al. Phase 1 study of efatutazone, a novel oral peroxisome proliferator-activated receptor gamma agonist, in combination with FOLFIRI as second-line therapy in patients with metastatic colorectal cancer. Invest New Drugs. 2014;32:473-80 pubmed publisher
Zhan L, Zhang H, Zhang Q, Woods C, Chen Y, Xue P, et al. Regulatory role of KEAP1 and NRF2 in PPAR? expression and chemoresistance in human non-small-cell lung carcinoma cells. Free Radic Biol Med. 2012;53:758-68 pubmed publisher
product information
SKU :
2435S
Product-Name :
PPARγ (C26H12) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, (R)
Applications :
Immunofluorescence (Immunocytochemistry)
Product-Category :
Nuclear Receptor Signaling
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
53, 57
Host :
Rabbit
Target :
PPAR-gamma
Primary-Protein :
PPAR-gamma
Alt-Names :
CIMT1,GLM1,NR1C3,Nuclear receptor subfamily 1 group C member 3,PPAR gamma,PPAR-gamma,PPARG,PPARG1,PPARG2,PPARgamma,Peroxisome proliferator-activated receptor gamma,peroxisome proliferative activated receptor gamma,peroxisome proliferator-activated receptor gamma 1
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.