product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Cleaved Notch1 (Val1744) Antibody
catalog :
2421L
quantity :
300 ul
price :
658 USD
clonality :
polyclonal
host :
rabbit
reactivity :
human, mouse, rat
application :
western blot, immunoprecipitation, chromatin immunoprecipitation, ChIP-Seq
more info or order :
Cell Signaling Technology product webpage
citations: 15
Published Application/Species/DilutionReference
  • western blot; mouse; 1:1000
Marathe S, Liu S, Brai E, Kaczarowski M, Alberi L. Notch signaling in response to excitotoxicity induces neurodegeneration via erroneous cell cycle reentry. Cell Death Differ. 2015;22:1775-84 pubmed publisher
  • western blot; human
Nagahara T, Shiraha H, Sawahara H, Uchida D, Takeuchi Y, Iwamuro M, et al. Hepatic stellate cells promote upregulation of epithelial cell adhesion molecule and epithelial-mesenchymal transition in hepatic cancer cells. Oncol Rep. 2015;34:1169-77 pubmed publisher
  • western blot; mouse; fig 4e
Kim S, Kim T, Lee H, Kong Y, Kaang B. Mind Bomb-2 Regulates Hippocampus-dependent Memory Formation and Synaptic Plasticity. Korean J Physiol Pharmacol. 2015;19:515-22 pubmed publisher
  • western blot; mouse; 1:500; fig 3
Brai E, Marathe S, Astori S, Fredj N, Perry E, Lamy C, et al. Notch1 Regulates Hippocampal Plasticity Through Interaction with the Reelin Pathway, Glutamatergic Transmission and CREB Signaling. Front Cell Neurosci. 2015;9:447 pubmed publisher
  • western blot; human; fig 4
Wang J, Lu R, Yang J, Li H, He Z, Jing N, et al. TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production. Nat Commun. 2015;6:8876 pubmed publisher
  • western blot; human
Pattabiraman C, Hong S, Gunasekharan V, Pranatharthi A, Bajaj J, Srivastava S, et al. CD66+ cells in cervical precancers are partially differentiated progenitors with neoplastic traits. Cancer Res. 2014;74:6682-92 pubmed publisher
  • ChIP-Seq; human; fig 1
  • chromatin immunoprecipitation; human; fig 1
Herranz D, Ambesi-Impiombato A, Palomero T, Schnell S, Belver L, Wendorff A, et al. A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia. Nat Med. 2014;20:1130-7 pubmed publisher
  • western blot; mouse; 1:500-1:1000; fig 4c
Li N, Fassl A, Chick J, Inuzuka H, Li X, Mansour M, et al. Cyclin C is a haploinsufficient tumour suppressor. Nat Cell Biol. 2014;16:1080-91 pubmed publisher
  • western blot; human
Baumann T, Bergmann S, Schmidt-Rose T, Max H, Martin A, Enthaler B, et al. Glutathione-conjugated sulfanylalkanols are substrates for ABCC11 and γ-glutamyl transferase 1: a potential new pathway for the formation of odorant precursors in the apocrine sweat gland. Exp Dermatol. 2014;23:247-52 pubmed publisher
  • western blot; mouse; 1:500
Hale A, Tian H, Anih E, Recio F, Shatat M, Johnson T, et al. Endothelial Kruppel-like factor 4 regulates angiogenesis and the Notch signaling pathway. J Biol Chem. 2014;289:12016-28 pubmed publisher
Ishikura N, Clever J, Bouzamondo-Bernstein E, Samayoa E, Prusiner S, Huang E, et al. Notch-1 activation and dendritic atrophy in prion disease. Proc Natl Acad Sci U S A. 2005;102:886-91 pubmed
Palomero T, Barnes K, Real P, Glade Bender J, Sulis M, Murty V, et al. CUTLL1, a novel human T-cell lymphoma cell line with t(7;9) rearrangement, aberrant NOTCH1 activation and high sensitivity to gamma-secretase inhibitors. Leukemia. 2006;20:1279-87 pubmed
O'Neil J, Grim J, Strack P, Rao S, Tibbitts D, Winter C, et al. FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors. J Exp Med. 2007;204:1813-24 pubmed
Köchert K, Ullrich K, Kreher S, Aster J, Kitagawa M, Johrens K, et al. High-level expression of Mastermind-like 2 contributes to aberrant activation of the NOTCH signaling pathway in human lymphomas. Oncogene. 2011;30:1831-40 pubmed publisher
Huppert S, Ilagan M, De Strooper B, Kopan R. Analysis of Notch function in presomitic mesoderm suggests a gamma-secretase-independent role for presenilins in somite differentiation. Dev Cell. 2005;8:677-88 pubmed
product information
SKU :
2421L
Product-Name :
Cleaved Notch1 (Val1744) Antibody
Size :
300 ul
Price-(USD) :
658 USD
Species-x-Reactivity :
H, M, R, Mk
Applications :
Immunoprecipitation
Product-Category :
Developmental Biology
Shipping-Temp :
COLD
Storage-Temp :
-20°C
Product-Type :
Polyclonal Antibody
MW :
110
Host :
Rabbit
Target :
Notch1 (Val1744, small subunit) cleaved
Primary-Protein :
Notch 1
Alt-Names :
NOTC1,NOTCH1,Neurogenic locus notch homolog protein 1,Notch 1,Notch 1 extracellular truncation,Notch 1 intracellular domain,Notch homolog 1, translocation-associated (Drosophila),TAN1,Translocation-associated notch protein TAN-1,hN1
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.