product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
HSP27 (G31) Mouse mAb
catalog :
2402
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
G31
reactivity :
human, rat
application :
western blot, immunohistochemistry, immunocytochemistry, other
citations: 29
Published Application/Species/Sample/DilutionReference
  • western blot; rat; loading ...; fig 5a
Rafikova O, James J, Eccles C, Kurdyukov S, Niihori M, Varghese M, et al. Early progression of pulmonary hypertension in the monocrotaline model in males is associated with increased lung permeability. Biol Sex Differ. 2020;11:11 pubmed publisher
  • other; human; loading ...; fig 4c
Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 7b
Booth L, Roberts J, Poklepovic A, Gordon S, Dent P. PDE5 inhibitors enhance the lethality of pemetrexed through inhibition of multiple chaperone proteins and via the actions of cyclic GMP and nitric oxide. Oncotarget. 2017;8:1449-1468 pubmed publisher
  • western blot; human; fig 6
Adam A, Lowery A, Martino N, Alsaffar H, Vincent P. Src Family Kinases Modulate the Loss of Endothelial Barrier Function in Response to TNF-α: Crosstalk with p38 Signaling. PLoS ONE. 2016;11:e0161975 pubmed publisher
  • immunocytochemistry; human; fig 8
Tavallai M, Booth L, Roberts J, Poklepovic A, Dent P. Rationally Repurposing Ruxolitinib (Jakafi (®)) as a Solid Tumor Therapeutic. Front Oncol. 2016;6:142 pubmed publisher
  • western blot; human; loading ...; fig 4c
Li J, Tang C, Li L, Li R, Fan Y. Quercetin sensitizes glioblastoma to t-AUCB by dual inhibition of Hsp27 and COX-2 in vitro and in vivo. J Exp Clin Cancer Res. 2016;35:61 pubmed publisher
  • immunocytochemistry; human; fig 3d
Booth L, Shuch B, Albers T, Roberts J, Tavallai M, Proniuk S, et al. Multi-kinase inhibitors can associate with heat shock proteins through their NH2-termini by which they suppress chaperone function. Oncotarget. 2016;7:12975-96 pubmed publisher
  • western blot; human; fig 8
Wu S, Guo Z, Hopkins C, Wei N, Chu E, Wipf P, et al. Bis-cyclopropane analog of disorazole C1 is a microtubule-destabilizing agent active in ABCB1-overexpressing human colon cancer cells. Oncotarget. 2015;6:40866-79 pubmed publisher
  • western blot; human; loading ...; fig 4b
Li K, Gao B, Li J, Chen H, Li Y, Wei Y, et al. ZNF32 protects against oxidative stress-induced apoptosis by modulating C1QBP transcription. Oncotarget. 2015;6:38107-26 pubmed publisher
  • western blot; human; 1:1000; fig 5b
Rastetter R, Blömacher M, Drebber U, Marko M, Behrens J, Solga R, et al. Coronin 2A (CRN5) expression is associated with colorectal adenoma-adenocarcinoma sequence and oncogenic signalling. BMC Cancer. 2015;15:638 pubmed publisher
  • western blot; human; fig 7
Artero Castro A, Perez Alea M, Feliciano A, Leal J, Genestar M, Castellvi J, et al. Disruption of the ribosomal P complex leads to stress-induced autophagy. Autophagy. 2015;11:1499-519 pubmed publisher
  • western blot; human; loading ...; fig 8a
Nishi H, Maeda N, Izumi S, Higa Nakamine S, Toku S, Kakinohana M, et al. Differential regulation of epidermal growth factor receptor by hydrogen peroxide and flagellin in cultured lung alveolar epithelial cells. Eur J Pharmacol. 2015;748:133-42 pubmed publisher
Sevin M, Kubovcakova L, Pernet N, Causse S, Vitte F, Villeval J, et al. HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis. Nat Commun. 2018;9:1431 pubmed publisher
Chen X, Tzekov R, Su M, Hong H, Min W, Han A, et al. Auranofin Inhibits Retinal Pigment Epithelium Cell Survival through Reactive Oxygen Species-Dependent Epidermal Growth Factor Receptor/ Mitogen-Activated Protein Kinase Signaling Pathway. PLoS ONE. 2016;11:e0166386 pubmed publisher
Booth L, Albers T, Roberts J, Tavallai M, Poklepovic A, Lebedyeva I, et al. Multi-kinase inhibitors interact with sildenafil and ERBB1/2/4 inhibitors to kill tumor cells in vitro and in vivo. Oncotarget. 2016;7:40398-40417 pubmed publisher
Booth L, Roberts J, Tavallai M, Chuckalovcak J, Stringer D, Koromilas A, et al. [Pemetrexed + Sorafenib] lethality is increased by inhibition of ERBB1/2/3-PI3K-NFκB compensatory survival signaling. Oncotarget. 2016;7:23608-32 pubmed publisher
Hargrave B, Varghese F, Barabutis N, CATRAVAS J, Zemlin C. Nanosecond pulsed platelet-rich plasma (nsPRP) improves mechanical and electrical cardiac function following myocardial reperfusion injury. Physiol Rep. 2016;4: pubmed publisher
Dyve Lingelem A, Hjelseth I, Simm R, Torgersen M, Sandvig K. Geldanamycin Enhances Retrograde Transport of Shiga Toxin in HEp-2 Cells. PLoS ONE. 2015;10:e0129214 pubmed publisher
Wei N, Chu E, Wu S, Wipf P, Schmitz J. The cytotoxic effects of regorafenib in combination with protein kinase D inhibition in human colorectal cancer cells. Oncotarget. 2015;6:4745-56 pubmed
Altmann P, Mildner M, Haider T, Traxler D, Beer L, Ristl R, et al. Secretomes of apoptotic mononuclear cells ameliorate neurological damage in rats with focal ischemia. F1000Res. 2014;3:131 pubmed publisher
Pavese J, Ogden I, Voll E, Huang X, Xu L, Jovanovic B, et al. Mitogen-activated protein kinase kinase 4 (MAP2K4) promotes human prostate cancer metastasis. PLoS ONE. 2014;9:e102289 pubmed publisher
Sang D, Li R, Lan Q. Quercetin sensitizes human glioblastoma cells to temozolomide in vitro via inhibition of Hsp27. Acta Pharmacol Sin. 2014;35:832-8 pubmed publisher
Slotta Huspenina J, Wolff C, Drecoll E, Feith M, Bettstetter M, Malinowsky K, et al. A specific expression profile of heat-shock proteins and glucose-regulated proteins is associated with response to neoadjuvant chemotherapy in oesophageal adenocarcinomas. Br J Cancer. 2013;109:370-8 pubmed publisher
Slotta Huspenina J, Berg D, Bauer K, Wolff C, Malinowsky K, Bauer L, et al. Evidence of prognostic relevant expression profiles of heat-shock proteins and glucose-regulated proteins in oesophageal adenocarcinomas. PLoS ONE. 2012;7:e41420 pubmed publisher
Ishii T, Seike T, Nakashima T, Jüliger S, Maharaj L, Soga S, et al. Anti-tumor activity against multiple myeloma by combination of KW-2478, an Hsp90 inhibitor, with bortezomib. Blood Cancer J. 2012;2:e68 pubmed publisher
Berg D, Wolff C, Langer R, Schuster T, Feith M, Slotta Huspenina J, et al. Discovery of new molecular subtypes in oesophageal adenocarcinoma. PLoS ONE. 2011;6:e23985 pubmed publisher
Narayanan A, Popova T, Turell M, Kidd J, Chertow J, Popov S, et al. Alteration in superoxide dismutase 1 causes oxidative stress and p38 MAPK activation following RVFV infection. PLoS ONE. 2011;6:e20354 pubmed publisher
Turner N, Warburton P, O Regan D, Ball S, Porter K. Modulatory effect of interleukin-1? on expression of structural matrix proteins, MMPs and TIMPs in human cardiac myofibroblasts: role of p38 MAP kinase. Matrix Biol. 2010;29:613-20 pubmed publisher
Shen G, Liang S, Xu Z, Zhou L, Xiao S, Xia X, et al. Downregulated expression of HSP27 in human low-grade glioma tissues discovered by a quantitative proteomic analysis. Proteome Sci. 2010;8:17 pubmed publisher
product information
SKU :
2402S
Product-Name :
HSP27 (G31) Mouse mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, Mk
Applications :
Immunofluorescence (Immunocytochemistry)
Product-Category :
Protein Folding and Trafficking
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
27
Host :
Mouse
Target :
HSP27
Primary-Protein :
HSP27
Alt-Names :
28 kDa heat shock protein,CMT2F,DKFZp586P1322,Estrogen-regulated 24 kDa protein,HMN2B,HS.76067,HSP 27,HSP27,HSP28,HSPB1,Heat shock 27 kDa protein,Heat shock protein beta-1,Hsp25,SRP27,Stress-responsive protein 27,heat shock 27kD protein 1,heat shock 27kDa protein 1
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.