MEK1 (61B12) Mouse mAb | Cell Signaling Technology 2352 product information

product summary

company name :

Cell Signaling Technology

product type :

antibody

product name :

MEK1 (61B12) Mouse mAb

catalog :

2352

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

61B12

reactivity :

human, mouse, rat

application :

western blot, immunoprecipitation, flow cytometry, western blot knockout validation

more info or order :

Cell Signaling Technology product webpage

citations: 17

Published Application/Species/Sample/Dilution	Reference
western blot knockout validation; human; fig 1 western blot knockout validation; mouse; fig 6	Nowacka J, Baumgartner C, Pelorosso C, Roth M, Zuber J, Baccarini M. MEK1 is required for the development of NRAS-driven leukemia. Oncotarget. 2016;7:80113-80130 pubmed publisher
western blot; human; loading ...; fig s6b	Yoon I, Nam M, Kim H, Moon H, Kim S, Jang J, et al. Glucose-dependent control of leucine metabolism by leucyl-tRNA synthetase 1. Science. 2019;: pubmed publisher
western blot; human; 1:2000; loading ...; fig 8a western blot; mouse; 1:2000; loading ...; fig 8b	Zhang S, Liu W, Yang Y, Sun K, Li S, Xu H, et al. Tmem30a Deficiency in endothelial cells impairs cell proliferation and angiogenesis. J Cell Sci. 2019;: pubmed publisher
flow cytometry; mouse; loading ...; fig s1a	Baumgartner C, Toifl S, Farlik M, Halbritter F, Scheicher R, Fischer I, et al. An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion. Cell Stem Cell. 2018;22:879-892.e6 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 6b	Tsutsumi R, Harizanova J, Stockert R, Schröder K, Bastiaens P, Neel B. Assay to visualize specific protein oxidation reveals spatio-temporal regulation of SHP2. Nat Commun. 2017;8:466 pubmed publisher
western blot; human; loading ...; fig 3b	Yurugi H, Marini F, Weber C, David K, Zhao Q, Binder H, et al. Targeting prohibitins with chemical ligands inhibits KRAS-mediated lung tumours. Oncogene. 2017;36:4778-4789 pubmed publisher
western blot; human; loading ...; fig 5b	Wang T, Yu H, Hughes N, Liu B, Kendirli A, Klein K, et al. Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras. Cell. 2017;168:890-903.e15 pubmed publisher
western blot; human	Tang X, Chen X, Xu Y, Qiao Y, Zhang X, Wang Y, et al. CD166 positively regulates MCAM via inhibition to ubiquitin E3 ligases Smurf1 and Î²TrCP through PI3K/AKT and c-Raf/MEK/ERK signaling in Bel-7402 hepatocellular carcinoma cells. Cell Signal. 2015;27:1694-702 pubmed publisher
western blot; human	Chapnick D, Liu X. Leader cell positioning drives wound-directed collective migration in TGF?-stimulated epithelial sheets. Mol Biol Cell. 2014;25:1586-93 pubmed publisher
	Tsutsumi R, Ran H, Neel B. Off-target inhibition by active site-targeting SHP2 inhibitors. FEBS Open Bio. 2018;8:1405-1411 pubmed publisher
	Steven A, Leisz S, Sychra K, Hiebl B, Wickenhauser C, Mougiakakos D, et al. Hypoxia-mediated alterations and their role in the HER-2/neuregulated CREB status and localization. Oncotarget. 2016;7:52061-52084 pubmed publisher
	Obitsu S, Sakata K, Teshima R, Kondo K. Eleostearic acid induces RIP1-mediated atypical apoptosis in a kinase-independent manner via ERK phosphorylation, ROS generation and mitochondrial dysfunction. Cell Death Dis. 2013;4:e674 pubmed publisher
	Tzeng T, Liou S, Chang C, Liu I. The Ethanol Extract of Zingiber zerumbet Attenuates Streptozotocin-Induced Diabetic Nephropathy in Rats. Evid Based Complement Alternat Med. 2013;2013:340645 pubmed publisher
	Deng Z, Yan H, Hu J, Zhang S, Peng P, Liu Q, et al. Hepatitis C virus sensitizes host cells to TRAIL-induced apoptosis by up-regulating DR4 and DR5 via a MEK1-dependent pathway. PLoS ONE. 2012;7:e37700 pubmed publisher
	Tzeng T, Lu H, Liou S, Chang C, Liu I. Emodin, a Naturally Occurring Anthraquinone Derivative, Ameliorates Dyslipidemia by Activating AMP-Activated Protein Kinase in High-Fat-Diet-Fed Rats. Evid Based Complement Alternat Med. 2012;2012:781812 pubmed publisher
	Ishii K, Kanatsu Shinohara M, Toyokuni S, Shinohara T. FGF2 mediates mouse spermatogonial stem cell self-renewal via upregulation of Etv5 and Bcl6b through MAP2K1 activation. Development. 2012;139:1734-43 pubmed publisher
	Cai T, Nishida K, Hirano T, Khavari P. Gab1 and SHP-2 promote Ras/MAPK regulation of epidermal growth and differentiation. J Cell Biol. 2002;159:103-12 pubmed

product information

SKU :

2352S

Product-Name :

MEK1 (61B12) Mouse mAb

Size :

100 ul

Price-(USD) :

235 USD

Species-x-Reactivity :

H, M, R, Mk

Applications :

Immunoprecipitation

Product-Category :

MAP Kinase Signaling

Shipping-Temp :

COLD

Storage-Temp :

-20°C

Product-Type :

Monoclonal Antibody

MW :

45 kDa

Host :

Mouse

Target :

MEK1

Primary-Protein :

MEK1

Alt-Names :

Dual specificity mitogen-activated protein kinase kinase 1,ERK activator kinase 1,MAP kinase kinase 1,MAP2K1,MAPK/ERK kinase 1,MAPKK 1,MAPKK1,MEK 1,MEK1,MKK1,MP2K1,PRKMK1,mitogen-activated protein kinase kinase 1,protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1)

more info or order :

Cell Signaling Technology product webpage