| Published Application/Species/Dilution | Reference |
|---|
- western blot; human; fig 7
| Köhler C, Koalick D, Fabricius A, Parplys A, Borgmann K, Pospiech H, et al. Cdc45 is limiting for replication initiation in humans. Cell Cycle. 2016;15:974-85 pubmed publisher |
- immunocytochemistry; human; fig s7
| Saquilabon Cruz G, Kong X, Silva B, Khatibzadeh N, Thai R, Berns M, et al. Femtosecond near-infrared laser microirradiation reveals a crucial role for PARP signaling on factor assemblies at DNA damage sites. Nucleic Acids Res. 2016;44:e27 pubmed publisher |
- western blot; human; fig 1
| Park S, Shim J, Park H, Eum D, Park M, Mi Yi J, et al. MacroH2A1 downregulation enhances the stem-like properties of bladder cancer cells by transactivation of Lin28B. Oncogene. 2016;35:1292-301 pubmed publisher |
- western blot; human; fig 3
| Hoffmann S, Smedegaard S, Nakamura K, Mortuza G, Raschle M, Ibañez de Opakua A, et al. TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress. J Cell Biol. 2016;212:63-75 pubmed publisher |
- western blot; human; 1:1000; fig 3
| Ikeuchi M, Fukumoto Y, Honda T, Kuga T, Saito Y, Yamaguchi N, et al. v-Src Causes Chromosome Bridges in a Caffeine-Sensitive Manner by Generating DNA Damage. Int J Mol Sci. 2016;17: pubmed publisher |
- western blot; human; fig 8
| Yu Z, Huang Y, Shieh S. Requirement for human Mps1/TTK in oxidative DNA damage repair and cell survival through MDM2 phosphorylation. Nucleic Acids Res. 2016;44:1133-50 pubmed publisher |
- western blot; mouse; 1:1000; fig 1
| Rai R, Chen Y, Lei M, Chang S. TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions. Nat Commun. 2016;7:10881 pubmed publisher |
- western blot; chicken; fig s4
| Romanello M, Schiavone D, Frey A, Sale J. Histone H3.3 promotes IgV gene diversification by enhancing formation of AID-accessible single-stranded DNA. EMBO J. 2016;35:1452-64 pubmed publisher |
- immunocytochemistry; mouse; 1:200; fig 5
- western blot; mouse; 1:1000; fig 5
| Ma X, Lin F, Wang Z, Hu M, Huang L, Meng T, et al. Geminin deletion in mouse oocytes results in impaired embryo development and reduced fertility. Mol Biol Cell. 2016;27:768-75 pubmed publisher |
- western blot; human; fig 2
| Ribeyre C, Zellweger R, Chauvin M, Bec N, Larroque C, Lopes M, et al. Nascent DNA Proteomics Reveals a Chromatin Remodeler Required for Topoisomerase I Loading at Replication Forks. Cell Rep. 2016;15:300-9 pubmed publisher |
- western blot; mouse; 1:100; fig 6
| Parameswaran B, Chiang H, Lu Y, Coates J, Deng C, Baer R, et al. Damage-induced BRCA1 phosphorylation by Chk2 contributes to the timing of end resection. Cell Cycle. 2015;14:437-48 pubmed publisher |
- western blot; human; 1:1000; fig 2
| Tollenaere M, Villumsen B, Blasius M, Nielsen J, Wagner S, Bartek J, et al. p38- and MK2-dependent signalling promotes stress-induced centriolar satellite remodelling via 14-3-3-dependent sequestration of CEP131/AZI1. Nat Commun. 2015;6:10075 pubmed publisher |
- western blot; human; 1:1000; fig 4
| Tomás-Roca L, Tsaalbi-Shtylik A, Jansen J, Singh M, Epstein J, Altunoglu U, et al. De novo mutations in PLXND1 and REV3L cause Möbius syndrome. Nat Commun. 2015;6:7199 pubmed publisher |
| Xue L, Furusawa Y, Okayasu R, Miura M, Cui X, Liu C, et al. The complexity of DNA double strand break is a crucial factor for activating ATR signaling pathway for G2/M checkpoint regulation regardless of ATM function. DNA Repair (Amst). 2015;25:72-83 pubmed publisher |
| Nakahara T, Tanaka K, Ohno S, Egawa N, Yugawa T, Kiyono T. Activation of NF-κB by human papillomavirus 16 E1 limits E1-dependent viral replication through degradation of E1. J Virol. 2015;89:5040-59 pubmed publisher |
| Sokka M, Rilla K, Miinalainen I, Pospiech H, Syvaoja J. High levels of TopBP1 induce ATR-dependent shut-down of rRNA transcription and nucleolar segregation. Nucleic Acids Res. 2015;43:4975-89 pubmed publisher |
- western blot; human; fig 6
| Pedersen R, Kruse T, Nilsson J, Oestergaard V, Lisby M. TopBP1 is required at mitosis to reduce transmission of DNA damage to G1 daughter cells. J Cell Biol. 2015;210:565-82 pubmed publisher |
| Simões M, Martins C, Ferreira F. Early intranuclear replication of African swine fever virus genome modifies the landscape of the host cell nucleus. Virus Res. 2015;210:1-7 pubmed publisher |
- western blot; human; fig 3
| Smith-Roe S, Nakamura J, Holley D, Chastain P, Rosson G, Simpson D, et al. SWI/SNF complexes are required for full activation of the DNA-damage response. Oncotarget. 2015;6:732-45 pubmed |
- western blot; human; fig 5
| Neumann J, Yang Y, Kohler R, Giaisi M, Witzens-Harig M, Liu D, et al. Mangrove dolabrane-type of diterpenes tagalsins suppresses tumor growth via ROS-mediated apoptosis and ATM/ATR-Chk1/Chk2-regulated cell cycle arrest. Int J Cancer. 2015;137:2739-48 pubmed publisher |
- western blot; human; fig 2
| Teasley D, Parajuli S, Nguyen M, Moore H, Alspach E, Lock Y, et al. Flap Endonuclease 1 Limits Telomere Fragility on the Leading Strand. J Biol Chem. 2015;290:15133-45 pubmed publisher |
- western blot; human; 1:1000
| Zanotto-Filho A, Braganhol E, Klafke K, Figueiró F, Terra S, Paludo F, et al. Autophagy inhibition improves the efficacy of curcumin/temozolomide combination therapy in glioblastomas. Cancer Lett. 2015;358:220-31 pubmed publisher |
| Xu H, Zhou Y, Coughlan K, Ding Y, Wang S, Wu Y, et al. AMPKα1 deficiency promotes cellular proliferation and DNA damage via p21 reduction in mouse embryonic fibroblasts. Biochim Biophys Acta. 2015;1853:65-73 pubmed publisher |
| Kiyonari S, Iimori M, Matsuoka K, Watanabe S, Morikawa-Ichinose T, Miura D, et al. The 1,2-Diaminocyclohexane Carrier Ligand in Oxaliplatin Induces p53-Dependent Transcriptional Repression of Factors Involved in Thymidylate Biosynthesis. Mol Cancer Ther. 2015;14:2332-42 pubmed publisher |
- western blot; human; fig 4
| Zellweger R, Dalcher D, Mutreja K, Berti M, Schmid J, Herrador R, et al. Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells. J Cell Biol. 2015;208:563-79 pubmed publisher |
- immunocytochemistry; mouse; 1:1000; fig s6
- western blot; mouse; fig 7
| Hartlerode A, Morgan M, Wu Y, Buis J, Ferguson D. Recruitment and activation of the ATM kinase in the absence of DNA-damage sensors. Nat Struct Mol Biol. 2015;22:736-43 pubmed publisher |
- western blot; human; fig 1
| Chou W, Hu L, Hsiung C, Shen C. Initiation of the ATM-Chk2 DNA damage response through the base excision repair pathway. Carcinogenesis. 2015;36:832-40 pubmed publisher |
- western blot; human; fig 5
| Ceccon M, Merlo M, Mologni L, Poggio T, Varesio L, Menotti M, et al. Excess of NPM-ALK oncogenic signaling promotes cellular apoptosis and drug dependency. Oncogene. 2015;: pubmed publisher |
- western blot; mouse; fig 1
| Liu E, Xu N, O'Prey J, Lao L, Joshi S, Long J, et al. Loss of autophagy causes a synthetic lethal deficiency in DNA repair. Proc Natl Acad Sci U S A. 2015;112:773-8 pubmed publisher |
- western blot; human; fig 5
| Xu Y, Wu X, Her C. hMSH5 Facilitates the Repair of Camptothecin-induced Double-strand Breaks through an Interaction with FANCJ. J Biol Chem. 2015;290:18545-58 pubmed publisher |
- western blot; human; 1:1000; fig 4
| Thangavel S, Berti M, Levikova M, Pinto C, Gomathinayagam S, Vujanovic M, et al. DNA2 drives processing and restart of reversed replication forks in human cells. J Cell Biol. 2015;208:545-62 pubmed publisher |
- western blot; mouse; 1:1000; fig 3
- immunocytochemistry; mouse; fig s4
| Boersma V, Moatti N, Segura-Bayona S, Peuscher M, van der Torre J, Wevers B, et al. MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5' end resection. Nature. 2015;521:537-40 pubmed publisher |
- western blot; human; fig 6
| Lindsey-Boltz L, Kemp M, Capp C, Sancar A. RHINO forms a stoichiometric complex with the 9-1-1 checkpoint clamp and mediates ATR-Chk1 signaling. Cell Cycle. 2015;14:99-108 pubmed publisher |
- western blot; human; fig 3
| Zuazua-Villar P, Ganesh A, Phear G, Gagou M, Meuth M. Extensive RPA2 hyperphosphorylation promotes apoptosis in response to DNA replication stress in CHK1 inhibited cells. Nucleic Acids Res. 2015;43:9776-87 pubmed publisher |
| Sarbajna S, Davies D, West S. Roles of SLX1-SLX4, MUS81-EME1, and GEN1 in avoiding genome instability and mitotic catastrophe. Genes Dev. 2014;28:1124-36 pubmed publisher |
- flow cytometry; human; 1:100
- western blot; human
- immunocytochemistry; human; 1:150
| Kawasumi M, Bradner J, Tolliday N, Thibodeau R, Sloan H, Brummond K, et al. Identification of ATR-Chk1 pathway inhibitors that selectively target p53-deficient cells without directly suppressing ATR catalytic activity. Cancer Res. 2014;74:7534-45 pubmed publisher |
- western blot; human; fig 2d
| Fukumoto Y, Morii M, Miura T, Kubota S, Ishibashi K, Honda T, et al. Src family kinases promote silencing of ATR-Chk1 signaling in termination of DNA damage checkpoint. J Biol Chem. 2014;289:12313-29 pubmed publisher |
- immunocytochemistry; mouse; fig 3
| Flach J, Bakker S, Mohrin M, Conroy P, Pietras E, Reynaud D, et al. Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells. Nature. 2014;512:198-202 pubmed publisher |
- western blot; human; 1:1000; fig 2a
| Martino-Echarri E, Henderson B, Brocardo M. Targeting the DNA replication checkpoint by pharmacologic inhibition of Chk1 kinase: a strategy to sensitize APC mutant colon cancer cells to 5-fluorouracil chemotherapy. Oncotarget. 2014;5:9889-900 pubmed |
- western blot; human; fig 1b
| Zhu M, Zhao H, Liao J, Xu X. HERC2/USP20 coordinates CHK1 activation by modulating CLASPIN stability. Nucleic Acids Res. 2014;42:13074-81 pubmed publisher |
- western blot; mouse; 1:10000; fig 2b
| Lindsey-Boltz L, Kemp M, Reardon J, DEROCCO V, Iyer R, Modrich P, et al. Coupling of human DNA excision repair and the DNA damage checkpoint in a defined in vitro system. J Biol Chem. 2014;289:5074-82 pubmed publisher |
- western blot; human; 1:1000; fig s2
| Fernandez-Vidal A, Guitton-Sert L, Cadoret J, Drac M, Schwob E, Baldacci G, et al. A role for DNA polymerase θ in the timing of DNA replication. Nat Commun. 2014;5:4285 pubmed publisher |
| Kubota S, Fukumoto Y, Ishibashi K, Soeda S, Kubota S, Yuki R, et al. Activation of the prereplication complex is blocked by mimosine through reactive oxygen species-activated ataxia telangiectasia mutated (ATM) protein without DNA damage. J Biol Chem. 2014;289:5730-46 pubmed publisher |
| Oike T, Komachi M, Ogiwara H, Amornwichet N, Saitoh Y, Torikai K, et al. C646, a selective small molecule inhibitor of histone acetyltransferase p300, radiosensitizes lung cancer cells by enhancing mitotic catastrophe. Radiother Oncol. 2014;111:222-7 pubmed publisher |
| Neumann J, Boerries M, Kohler R, Giaisi M, Krammer P, Busch H, et al. The natural anticancer compound rocaglamide selectively inhibits the G1-S-phase transition in cancer cells through the ATM/ATR-mediated Chk1/2 cell cycle checkpoints. Int J Cancer. 2014;134:1991-2002 pubmed publisher |
| Cai B, Lyu H, Huang J, Wang S, Lee C, Gao C, et al. Combination of bendamustine and entinostat synergistically inhibits proliferation of multiple myeloma cells via induction of apoptosis and DNA damage response. Cancer Lett. 2013;335:343-50 pubmed publisher |
| Cai B, Wang S, Huang J, Lee C, Gao C, Liu B. Cladribine and bendamustine exhibit inhibitory activity in dexamethasone-sensitive and -resistant multiple myeloma cells. Am J Transl Res. 2013;5:36-46 pubmed |
| Oike T, Ogiwara H, Torikai K, Nakano T, Yokota J, Kohno T. Garcinol, a histone acetyltransferase inhibitor, radiosensitizes cancer cells by inhibiting non-homologous end joining. Int J Radiat Oncol Biol Phys. 2012;84:815-21 pubmed publisher |
| Okita N, Minato S, Ohmi E, Tanuma S, Higami Y. DNA damage-induced CHK1 autophosphorylation at Ser296 is regulated by an intramolecular mechanism. FEBS Lett. 2012;586:3974-9 pubmed publisher |
| Gotoh T, Kishimoto T, Sible J. Phosphorylation of Claspin is triggered by the nucleocytoplasmic ratio at the Xenopus laevis midblastula transition. Dev Biol. 2011;353:302-8 pubmed publisher |
