product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Phospho-Chk1 (Ser317) Antibody
catalog :
2344P
quantity :
40 ul
price :
123 USD
clonality :
polyclonal
host :
rabbit
antigen modification :
phosphorylated
reactivity :
human, rat
application :
western blot
more info or order :
Cell Signaling Technology product webpage
citations: 16
Published Application/Species/DilutionReference
  • western blot; human; fig 2d
Baude A, Aaes T, Zhai B, Al-Nakouzi N, Oo H, Daugaard M, et al. Hepatoma-derived growth factor-related protein 2 promotes DNA repair by homologous recombination. Nucleic Acids Res. 2016;44:2214-26 pubmed publisher
  • western blot; human; 1:1000; fig 2
Ortega-Atienza S, Wong V, Deloughery Z, Luczak M, Zhitkovich A. ATM and KAT5 safeguard replicating chromatin against formaldehyde damage. Nucleic Acids Res. 2016;44:198-209 pubmed publisher
  • western blot; human; fig 1
Moudry P, Watanabe K, Wolanin K, Bartkova J, Wassing I, Watanabe S, et al. TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity. J Cell Biol. 2016;212:281-8 pubmed publisher
  • western blot; human; fig 4
Morales J, Richard P, Patidar P, Motea E, Dang T, Manley J, et al. XRN2 Links Transcription Termination to DNA Damage and Replication Stress. PLoS Genet. 2016;12:e1006107 pubmed publisher
  • western blot; human; fig 5
Huang C, Cheng J, BAWA-KHALFE T, Yao X, Chin Y, Yeh E. SUMOylated ORC2 Recruits a Histone Demethylase to Regulate Centromeric Histone Modification and Genomic Stability. Cell Rep. 2016;15:147-57 pubmed publisher
  • western blot; human; fig s4
Zuazua-Villar P, Ganesh A, Phear G, Gagou M, Meuth M. Extensive RPA2 hyperphosphorylation promotes apoptosis in response to DNA replication stress in CHK1 inhibited cells. Nucleic Acids Res. 2015;43:9776-87 pubmed publisher
  • western blot; human; fig 4
Huang P, Yang J, Ning J, Wang M, Song Q. Atrazine Triggers DNA Damage Response and Induces DNA Double-Strand Breaks in MCF-10A Cells. Int J Mol Sci. 2015;16:14353-68 pubmed publisher
  • western blot; human; 1:1000
Ortega-Atienza S, Green S, Zhitkovich A. Proteasome activity is important for replication recovery, CHK1 phosphorylation and prevention of G2 arrest after low-dose formaldehyde. Toxicol Appl Pharmacol. 2015;286:135-41 pubmed publisher
  • western blot; human; fig 2d
Fukumoto Y, Morii M, Miura T, Kubota S, Ishibashi K, Honda T, et al. Src family kinases promote silencing of ATR-Chk1 signaling in termination of DNA damage checkpoint. J Biol Chem. 2014;289:12313-29 pubmed publisher
  • western blot; human; 1:1000; fig 2a
Martino-Echarri E, Henderson B, Brocardo M. Targeting the DNA replication checkpoint by pharmacologic inhibition of Chk1 kinase: a strategy to sensitize APC mutant colon cancer cells to 5-fluorouracil chemotherapy. Oncotarget. 2014;5:9889-900 pubmed
  • western blot; human; 1:1000; fig 4a
Zhang P, Wei Y, Wang L, Debeb B, Yuan Y, Zhang J, et al. ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1. Nat Cell Biol. 2014;16:864-75 pubmed publisher
  • western blot; human
Day T, Palle K, Barkley L, Kakusho N, Zou Y, Tateishi S, et al. Phosphorylated Rad18 directs DNA polymerase η to sites of stalled replication. J Cell Biol. 2010;191:953-66 pubmed publisher
Schults M, Timmermans L, Godschalk R, Theys J, Wouters B, Van Schooten F, et al. Diminished carcinogen detoxification is a novel mechanism for hypoxia-inducible factor 1-mediated genetic instability. J Biol Chem. 2010;285:14558-64 pubmed publisher
Buscemi G, Carlessi L, Zannini L, Lisanti S, Fontanella E, Canevari S, et al. DNA damage-induced cell cycle regulation and function of novel Chk2 phosphoresidues. Mol Cell Biol. 2006;26:7832-45 pubmed
Batchelor E, Loewer A, Mock C, Lahav G. Stimulus-dependent dynamics of p53 in single cells. Mol Syst Biol. 2011;7:488 pubmed publisher
Nam E, Zhao R, Glick G, Bansbach C, Friedman D, Cortez D. Thr-1989 phosphorylation is a marker of active ataxia telangiectasia-mutated and Rad3-related (ATR) kinase. J Biol Chem. 2011;286:28707-14 pubmed publisher
product information
SKU :
2344P
Product-Name :
Phospho-Chk1 (Ser317) Antibody
Size :
40 ul
Price-(USD) :
123 USD
Species-x-Reactivity :
H, R, Mk, Mi
Applications :
Western blot
Product-Category :
Cell Cycle / Checkpoint Control
Shipping-Temp :
COLD
Storage-Temp :
-20°C
Product-Type :
Polyclonal Antibody
MW :
56
Host :
Rabbit
Target :
Chk1 (Ser317) phosphate
Primary-Protein :
Chk1
Alt-Names :
CHEK1,CHK1,CHK1 checkpoint homolog (S. pombe),Checkpoint, S. pombe, homolog of, 1,Serine/threonine-protein kinase Chk1
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.