product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Phospho-MEK1/2 (Ser221) (166F8) Rabbit mAb
catalog :
2338S
quantity :
100 ul
price :
274 USD
clonality :
monoclonal
host :
rabbit
antigen modification :
phosphorylated
reactivity :
human, mouse, rat, dog
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
Cell Signaling Technology product webpage
citations: 11
Published Application/Species/DilutionReference
  • immunohistochemistry - paraffin section; human
Kumar A, Pathak P, Purkait S, Faruq M, Jha P, Mallick S, et al. Oncogenic KIAA1549-BRAF fusion with activation of the MAPK/ERK pathway in pediatric oligodendrogliomas. Cancer Genet. 2015;208:91-5 pubmed publisher
  • western blot; human
Nowaczyk M, Thompson B, Zeesman S, Moog U, Sanchez-Lara P, Magoulas P, et al. Deletion of MAP2K2/MEK2: a novel mechanism for a RASopathy?. Clin Genet. 2014;85:138-46 pubmed publisher
  • western blot; mouse
Park E, Kim B, Lee E, Chang E, Kim D, Choi S, et al. Targeting of receptor for advanced glycation end products suppresses cyst growth in polycystic kidney disease. J Biol Chem. 2014;289:9254-62 pubmed publisher
  • immunohistochemistry - frozen section; rat; 1:200
  • western blot; rat; 1:1000
Cheng C, Lin J, Su S, Tang N, Kao S, Hsieh C. Electroacupuncture-like stimulation at Baihui and Dazhui acupoints exerts neuroprotective effects through activation of the brain-derived neurotrophic factor-mediated MEK1/2/ERK1/2/p90RSK/bad signaling pathway in mild transient focal cerebral ischemia in . BMC Complement Altern Med. 2014;14:92 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:50
  • western blot; human
Kucherlapati M, Esfahani S, Habibollahi P, Wang J, Still E, Bronson R, et al. Genotype directed therapy in murine mismatch repair deficient tumors. PLoS ONE. 2013;8:e68817 pubmed publisher
Birner P, Berghoff A, Dinhof C, Pirker C, Capper D, Schoppmann S, et al. MAP kinase activity supported by BRAF (V600E) mutation rather than gene amplification is associated with ETV1 expression in melanoma brain metastases. Arch Dermatol Res. 2014;306:873-84 pubmed publisher
Schoppmann S, Ricken G, Ilhan-Mutlu A, Nirtl N, Streubel B, Preusser M, et al. Downregulation of CIC does not associate with overexpression of ETV1 or MAP kinase pathway activation in gastrointestinal stromal tumors. Cancer Invest. 2014;32:363-7 pubmed publisher
Schoppmann S, Beer A, Nirtl N, Ba-Ssalamah A, Brodowicz T, Streubel B, et al. Downregulation of phosphatidylethanolamine binding protein 1 associates with clinical risk factors in gastrointestinal stromal tumors, but not with activation of the RAF-1-MEK-ETV1 pathway. Cancer Lett. 2013;335:26-30 pubmed publisher
Fei Z, Bera T, Liu X, Xiang L, Pastan I. Ankrd26 gene disruption enhances adipogenesis of mouse embryonic fibroblasts. J Biol Chem. 2011;286:27761-8 pubmed publisher
Falco A, Festa M, Basile A, Rosati A, Pascale M, Florenzano F, et al. BAG3 controls angiogenesis through regulation of ERK phosphorylation. Oncogene. 2012;31:5153-61 pubmed publisher
Lee J, Huang S, Lee M, Lee S, Ryu M, Kim S, et al. Dual specificity phosphatase 6 as a predictor of invasiveness in papillary thyroid cancer. Eur J Endocrinol. 2012;167:93-101 pubmed publisher
product information
SKU :
2338S
Product-Name :
Phospho-MEK1/2 (Ser221) (166F8) Rabbit mAb
Size :
100 ul
Price-(USD) :
274 USD
Species-x-Reactivity :
H, M, R, Mk, (Dg)
Applications :
Flow cytometry
Product-Category :
MAP Kinase Signaling
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
45
Host :
Rabbit
Target :
MEK1 (Ser222) phosphate/MEK2 (Ser226) phosphate
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.