Phospho-MEK1/2 (Ser221) (166F8) Rabbit mAb | Cell Signaling Technology 2338 product information

product summary

company name :

Cell Signaling Technology

product type :

antibody

product name :

Phospho-MEK1/2 (Ser221) (166F8) Rabbit mAb

catalog :

2338

clonality :

monoclonal

host :

rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

clone name :

166F8

reactivity :

human, mouse, rat, dog

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Cell Signaling Technology product webpage

citations: 20

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:2000; loading ...; fig 8b western blot; human; 1:2000; loading ...; fig 8a	Zhang S, Liu W, Yang Y, Sun K, Li S, Xu H, et al. Tmem30a Deficiency in endothelial cells impairs cell proliferation and angiogenesis. J Cell Sci. 2019;: pubmed publisher
western blot; human; 1:1000; fig 4a	Yang X, Qi L, Lin F, Ou Z. The role of the chemokine receptor XCR1 in breast cancer cells. Breast Cancer (Dove Med Press). 2017;9:227-236 pubmed publisher
immunohistochemistry - paraffin section; mouse; loading ...; fig s1i	Genovese G, Carugo A, TEPPER J, Robinson F, Li L, Svelto M, et al. Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer. Nature. 2017;542:362-366 pubmed publisher
western blot; human; 1:2000; fig 5e	Zhang Y, Velez Delgado A, Mathew E, Li D, Mendez F, Flannagan K, et al. Myeloid cells are required for PD-1/PD-L1 checkpoint activation and the establishment of an immunosuppressive environment in pancreatic cancer. Gut. 2017;66:124-136 pubmed publisher
western blot; human; loading ...; fig 3b	Bigenzahn J, Fauster A, Rebsamen M, Kandasamy R, Scorzoni S, Vladimer G, et al. An Inducible Retroviral Expression System for Tandem Affinity Purification Mass-Spectrometry-Based Proteomics Identifies Mixed Lineage Kinase Domain-like Protein (MLKL) as an Heat Shock Protein 90 (HSP90) Client. Mol Cell Proteomics. 2016;15:1139-50 pubmed
immunohistochemistry - paraffin section; human	Kumar A, Pathak P, Purkait S, Faruq M, Jha P, Mallick S, et al. Oncogenic KIAA1549-BRAF fusion with activation of the MAPK/ERK pathway in pediatric oligodendrogliomas. Cancer Genet. 2015;208:91-5 pubmed publisher
western blot; mouse; fig s2	Guillaumond F, Bidaut G, Ouaissi M, Servais S, Gouirand V, Olivares O, et al. Cholesterol uptake disruption, in association with chemotherapy, is a promising combined metabolic therapy for pancreatic adenocarcinoma. Proc Natl Acad Sci U S A. 2015;112:2473-8 pubmed publisher
immunohistochemistry - frozen section; rat; 1:200 western blot; rat; 1:1000	Cheng C, Lin J, Su S, Tang N, Kao S, Hsieh C. Electroacupuncture-like stimulation at Baihui and Dazhui acupoints exerts neuroprotective effects through activation of the brain-derived neurotrophic factor-mediated MEK1/2/ERK1/2/p90RSK/bad signaling pathway in mild transient focal cerebral ischemi. BMC Complement Altern Med. 2014;14:92 pubmed publisher
western blot; mouse	Park E, Kim B, Lee E, Chang E, Kim D, Choi S, et al. Targeting of receptor for advanced glycation end products suppresses cyst growth in polycystic kidney disease. J Biol Chem. 2014;289:9254-62 pubmed publisher
immunohistochemistry - paraffin section; human; 1:50 western blot; human	Kucherlapati M, Esfahani S, Habibollahi P, Wang J, Still E, Bronson R, et al. Genotype directed therapy in murine mismatch repair deficient tumors. PLoS ONE. 2013;8:e68817 pubmed publisher
western blot; human	Nowaczyk M, Thompson B, Zeesman S, Moog U, Sanchez Lara P, Magoulas P, et al. Deletion of MAP2K2/MEK2: a novel mechanism for a RASopathy?. Clin Genet. 2014;85:138-46 pubmed publisher
	Lun X, Szklarczyk D, Gábor A, Dobberstein N, Zanotelli V, Saez Rodriguez J, et al. Analysis of the Human Kinome and Phosphatome by Mass Cytometry Reveals Overexpression-Induced Effects on Cancer-Related Signaling. Mol Cell. 2019;74:1086-1102.e5 pubmed publisher
	White S, Avantaggiati M, Nemazanyy I, Di Poto C, Yang Y, Pende M, et al. YAP/TAZ Inhibition Induces Metabolic and Signaling Rewiring Resulting in Targetable Vulnerabilities in NF2-Deficient Tumor Cells. Dev Cell. 2019;49:425-443.e9 pubmed publisher
	Schroyer A, Stimes N, Abi Saab W, Chadee D. MLK3 phosphorylation by ERK1/2 is required for oxidative stress-induced invasion of colorectal cancer cells. Oncogene. 2017;: pubmed publisher
	Birner P, Berghoff A, Dinhof C, Pirker C, Capper D, Schoppmann S, et al. MAP kinase activity supported by BRAF (V600E) mutation rather than gene amplification is associated with ETV1 expression in melanoma brain metastases. Arch Dermatol Res. 2014;306:873-84 pubmed publisher
	Schoppmann S, Ricken G, Ilhan Mutlu A, Nirtl N, Streubel B, Preusser M, et al. Downregulation of CIC does not associate with overexpression of ETV1 or MAP kinase pathway activation in gastrointestinal stromal tumors. Cancer Invest. 2014;32:363-7 pubmed publisher
	Schoppmann S, Beer A, Nirtl N, Ba Ssalamah A, Brodowicz T, Streubel B, et al. Downregulation of phosphatidylethanolamine binding protein 1 associates with clinical risk factors in gastrointestinal stromal tumors, but not with activation of the RAF-1-MEK-ETV1 pathway. Cancer Lett. 2013;335:26-30 pubmed publisher
	Lee J, Huang S, Lee M, Lee S, Ryu M, Kim S, et al. Dual specificity phosphatase 6 as a predictor of invasiveness in papillary thyroid cancer. Eur J Endocrinol. 2012;167:93-101 pubmed publisher
	Falco A, Festa M, Basile A, Rosati A, Pascale M, Florenzano F, et al. BAG3 controls angiogenesis through regulation of ERK phosphorylation. Oncogene. 2012;31:5153-61 pubmed publisher
	Fei Z, Bera T, Liu X, Xiang L, Pastan I. Ankrd26 gene disruption enhances adipogenesis of mouse embryonic fibroblasts. J Biol Chem. 2011;286:27761-8 pubmed publisher

product information

SKU :

2338S

Product-Name :

Phospho-MEK1/2 (Ser221) (166F8) Rabbit mAb

Size :

100 ul

Price-(USD) :

274 USD

Species-x-Reactivity :

H, M, R, Mk, (Dg)

Applications :

Flow cytometry

Product-Category :

MAP Kinase Signaling

Shipping-Temp :

AMBIENT

Storage-Temp :

-20°C

Product-Type :

Monoclonal Antibody

MW :

Host :

Rabbit

Target :

MEK1 (Ser222) phosphate/MEK2 (Ser226) phosphate

more info or order :

Cell Signaling Technology product webpage