S6 Ribosomal Protein (54D2) Mouse mAb | Cell Signaling Technology 2317 product information

product summary

company name :

Cell Signaling Technology

product type :

antibody

product name :

S6 Ribosomal Protein (54D2) Mouse mAb

catalog :

2317

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

54D2

reactivity :

human, mouse, rat, zebrafish , fruit fly

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, other

more info or order :

Cell Signaling Technology product webpage

citations: 132

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:1000; loading ...; fig 6b	Chen Q, Fan K, Chen X, Xie X, Huang L, Song G, et al. Ezrin regulates synovial angiogenesis in rheumatoid arthritis through YAP and Akt signalling. J Cell Mol Med. 2021;25:9378-9389 pubmed publisher
western blot; mouse; 1:1000; loading ...	Kumar P, Zadjali F, Yao Y, Siroky B, Astrinidis A, Gross K, et al. Tsc Gene Locus Disruption and Differences in Renal Epithelial Extracellular Vesicles. Front Physiol. 2021;12:630933 pubmed publisher
western blot; mouse; fig s5d	Hamm M, Sohier P, Petit V, Raymond J, Delmas V, Le Coz M, et al. BRN2 is a non-canonical melanoma tumor-suppressor. Nat Commun. 2021;12:3707 pubmed publisher
western blot; human; 1:1000; loading ...; fig 5	Hao X, Qiu Y, Cao L, Yang X, Zhou D, Liu J, et al. Over-Expression of Centromere Protein U Participates in the Malignant Neoplastic Progression of Breast Cancer. Front Oncol. 2021;11:615427 pubmed publisher
western blot; zebrafish ; 1:1000; loading ...; fig 3d	Ganassi M, Badodi S, Wanders K, Zammit P, Hughes S. Myogenin is an essential regulator of adult myofibre growth and muscle stem cell homeostasis. elife. 2020;9: pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 3c	Kumar A, Xie L, Ta C, Hinton A, Gunasekar S, Minerath R, et al. SWELL1 regulates skeletal muscle cell size, intracellular signaling, adiposity and glucose metabolism. elife. 2020;9: pubmed publisher
western blot; human; 1:1000; loading ...; fig 6a	Silva M, Nandi G, Tentarelli S, Gurrell I, Jamier T, Lucente D, et al. Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons. Nat Commun. 2020;11:3258 pubmed publisher
western blot; human; loading ...; fig 2a	Koundouros N, Karali E, Tripp A, Valle A, Inglese P, Perry N, et al. Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids. Cell. 2020;181:1596-1611.e27 pubmed publisher
western blot; human; loading ...; fig 4a	Feng Y, Mischler W, Gurung A, Kavanagh T, Androsov G, Sadow P, et al. Therapeutic Targeting of the Secreted Lysophospholipase D Autotaxin Suppresses Tuberous Sclerosis Complex-Associated Tumorigenesis. Cancer Res. 2020;80:2751-2763 pubmed publisher
western blot; mouse; 1:1000; loading ...	Alajati A, D Ambrosio M, Troiani M, Mosole S, Pellegrini L, Chen J, et al. CDCP1 overexpression drives prostate cancer progression and can be targeted in vivo. J Clin Invest. 2020;130:2435-2450 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 3b	Liu T, Han S, Dai Q, Zheng J, Liu C, Li S, et al. IL-17A-Mediated Excessive Autophagy Aggravated Neuronal Ischemic Injuries via Src-PP2B-mTOR Pathway. Front Immunol. 2019;10:2952 pubmed publisher
western blot; human; loading ...; fig 3d	Wang C, Vegna S, Jin H, Benedict B, Lieftink C, Ramirez C, et al. Inducing and exploiting vulnerabilities for the treatment of liver cancer. Nature. 2019;: pubmed publisher
western blot; human; loading ...; fig 3a, 3b	Wu R, Yun Q, Zhang J, Bao J. Downregulation of KLF13 through DNMT1-mediated hypermethylation promotes glioma cell proliferation and invasion. Onco Targets Ther. 2019;12:1509-1520 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 6h	Teissier T, Quersin V, Gnemmi V, Daroux M, Howsam M, Delguste F, et al. Knockout of receptor for advanced glycation end-products attenuates age-related renal lesions. Aging Cell. 2019;18:e12850 pubmed publisher
western blot; mouse; loading ...; fig 4b	Losier T, Akuma M, McKee Muir O, LeBlond N, Suk Y, Alsaadi R, et al. AMPK Promotes Xenophagy through Priming of Autophagic Kinases upon Detection of Bacterial Outer Membrane Vesicles. Cell Rep. 2019;26:2150-2165.e5 pubmed publisher
western blot; human; loading ...; fig 7a	Guan H, Li N, Wang X, Shan X, Li Z, Lin Z. Role of Paip1 on angiogenesis and invasion in pancreatic cancer. Exp Cell Res. 2019;376:198-209 pubmed publisher
western blot; human; loading ...; fig 6c	Urtishak K, Wang L, Culjkovic Kraljacic B, Davenport J, Porazzi P, Vincent T, et al. Targeting EIF4E signaling with ribavirin in infant acute lymphoblastic leukemia. Oncogene. 2019;38:2241-2262 pubmed publisher
western blot; human; loading ...; fig ev3e	Hartleben G, Muller C, Kramer A, Schimmel H, Zidek L, Dornblut C, et al. Tuberous sclerosis complex is required for tumor maintenance in MYC-driven Burkitt's lymphoma. EMBO J. 2018;37: pubmed publisher
other; human; loading ...; fig 4c	Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed publisher
western blot; human; loading ...; fig 10b	Chennupati V, Veiga D, Maslowski K, Andina N, Tardivel A, Yu E, et al. Ribonuclease inhibitor 1 regulates erythropoiesis by controlling GATA1 translation. J Clin Invest. 2018;128:1597-1614 pubmed publisher
western blot; human; 1:1000; loading ...; fig 2e	Oldrini B, Hsieh W, Erdjument Bromage H, Codega P, Carro M, Curiel García A, et al. EGFR feedback-inhibition by Ran-binding protein 6 is disrupted in cancer. Nat Commun. 2017;8:2035 pubmed publisher
western blot; mouse; loading ...; fig 1a	Urbanska M, Gozdz A, Macias M, Cymerman I, Liszewska E, Kondratiuk I, et al. GSK3β Controls mTOR and Prosurvival Signaling in Neurons. Mol Neurobiol. 2018;55:6050-6062 pubmed publisher
western blot; mouse; 1:1000; fig 6d	Pereira R, Tadinada S, Zasadny F, Oliveira K, Pires K, Olvera A, et al. OPA1 deficiency promotes secretion of FGF21 from muscle that prevents obesity and insulin resistance. EMBO J. 2017;36:2126-2145 pubmed publisher
western blot; human; loading ...; fig 2c	Rozanska A, Richter Dennerlein R, Rorbach J, Gao F, Lewis R, Chrzanowska Lightowlers Z, et al. The human RNA-binding protein RBFA promotes the maturation of the mitochondrial ribosome. Biochem J. 2017;474:2145-2158 pubmed publisher
western blot; human; loading ...; fig 5b	White M, Lin C, Rajapakshe K, Dong J, Shi Y, Tsouko E, et al. Glutamine Transporters Are Targets of Multiple Oncogenic Signaling Pathways in Prostate Cancer. Mol Cancer Res. 2017;15:1017-1028 pubmed publisher
western blot; mouse; loading ...; fig 3a	Ip W, Hoshi N, Shouval D, Snapper S, Medzhitov R. Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages. Science. 2017;356:513-519 pubmed publisher
western blot; mouse; 1:500; fig 7e	Cai W, Sakaguchi M, Kleinridders A, Gonzalez Del Pino G, Dreyfuss J, O Neill B, et al. Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression. Nat Commun. 2017;8:14892 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 5h	Lee C, Hanna A, Wang H, Dagnino Acosta A, Joshi A, Knoblauch M, et al. A chemical chaperone improves muscle function in mice with a RyR1 mutation. Nat Commun. 2017;8:14659 pubmed publisher
western blot; human; loading ...; fig 2d, s4d	Gupta A, Anjomani Virmouni S, Koundouros N, Dimitriadi M, Choo Wing R, Valle A, et al. PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation. Mol Cell. 2017;65:999-1013.e7 pubmed publisher
western blot; mouse; fig 7c	Samuel S, Ghosh S, Majeed Y, Arunachalam G, Emara M, Ding H, et al. Metformin represses glucose starvation induced autophagic response in microvascular endothelial cells and promotes cell death. Biochem Pharmacol. 2017;132:118-132 pubmed publisher
western blot; mouse; loading ...; fig 2h	Ho T, Warr M, Adelman E, Lansinger O, Flach J, Verovskaya E, et al. Autophagy maintains the metabolism and function of young and old stem cells. Nature. 2017;543:205-210 pubmed publisher
western blot; rat; loading ...; fig 4c	Ercan E, Han J, Di Nardo A, Winden K, Han M, Hoyo L, et al. Neuronal CTGF/CCN2 negatively regulates myelination in a mouse model of tuberous sclerosis complex. J Exp Med. 2017;214:681-697 pubmed publisher
western blot; human; 1:500; loading ...; fig 3d	Cooper H, Yang Y, Ylikallio E, Khairullin R, Woldegebriel R, Lin K, et al. ATPase-deficient mitochondrial inner membrane protein ATAD3A disturbs mitochondrial dynamics in dominant hereditary spastic paraplegia. Hum Mol Genet. 2017;26:1432-1443 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 1a immunohistochemistry - paraffin section; human; 1:1000; loading ...; fig 1b	Muranen T, Iwanicki M, Curry N, Hwang J, DuBois C, Coloff J, et al. Starved epithelial cells uptake extracellular matrix for survival. Nat Commun. 2017;8:13989 pubmed publisher
western blot; mouse; loading ...; fig 9a	Fitter S, Matthews M, Martin S, Xie J, Ooi S, Walkley C, et al. mTORC1 Plays an Important Role in Skeletal Development by Controlling Preosteoblast Differentiation. Mol Cell Biol. 2017;37: pubmed publisher
immunocytochemistry; human western blot; human; fig 1c	Vakana E, Pratt S, Blosser W, Dowless M, Simpson N, Yuan X, et al. LY3009120, a panRAF inhibitor, has significant anti-tumor activity in BRAF and KRAS mutant preclinical models of colorectal cancer. Oncotarget. 2017;8:9251-9266 pubmed publisher
western blot; human; 1:1000; loading ...; fig 6c	Dou N, Yu S, Ye X, Yang D, Li Y, Gao Y. Aberrant overexpression of ADAR1 promotes gastric cancer progression by activating mTOR/p70S6K signaling. Oncotarget. 2016;7:86161-86173 pubmed publisher
immunohistochemistry - frozen section; rat; loading ...; fig 3a	Ayuso M, Martínez Alonso E, Regidor I, Alcazar A. Stress Granule Induction after Brain Ischemia Is Independent of Eukaryotic Translation Initiation Factor (eIF) 2? Phosphorylation and Is Correlated with a Decrease in eIF4B and eIF4E Proteins. J Biol Chem. 2016;291:27252-27264 pubmed publisher
immunocytochemistry; mouse; 1:50; loading ...; fig 3a	Fröhlich D, Suchowerska A, Spencer Z, von Jonquieres G, Klugmann C, Bongers A, et al. In vivocharacterization of the aspartyl-tRNA synthetase DARS: Homing in on the leukodystrophy HBSL. Neurobiol Dis. 2017;97:24-35 pubmed publisher
western blot; human; loading ...; fig 6b	Guillén Boixet J, Buzon V, Salvatella X, Mendez R. CPEB4 is regulated during cell cycle by ERK2/Cdk1-mediated phosphorylation and its assembly into liquid-like droplets. elife. 2016;5: pubmed publisher
western blot; mouse; fig 3	Ren S, Luo Y, Chen H, Warburton D, Lam H, Wang L, et al. Inactivation of Tsc2 in Mesoderm-Derived Cells Causes Polycystic Kidney Lesions and Impairs Lung Alveolarization. Am J Pathol. 2016;186:3261-3272 pubmed publisher
western blot; human; 1:1000; loading ...; fig 4h	Catena V, Bruno T, De Nicola F, Goeman F, Pallocca M, Iezzi S, et al. Deptor transcriptionally regulates endoplasmic reticulum homeostasis in multiple myeloma cells. Oncotarget. 2016;7:70546-70558 pubmed publisher
western blot; human; 1:1000; fig 1	Carbonneau M, M Gagné L, Lalonde M, Germain M, Motorina A, Guiot M, et al. The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway. Nat Commun. 2016;7:12700 pubmed publisher
western blot; mouse; fig 1	Foltz S, Luan J, Call J, Patel A, Peissig K, Fortunato M, et al. Four-week rapamycin treatment improves muscular dystrophy in a fukutin-deficient mouse model of dystroglycanopathy. Skelet Muscle. 2016;6:20 pubmed publisher
western blot; fruit fly ; fig 5	Ahmad M, Xue Y, Lee S, Martindale J, Shen W, Li W, et al. RNA topoisomerase is prevalent in all domains of life and associates with polyribosomes in animals. Nucleic Acids Res. 2016;44:6335-49 pubmed publisher
western blot; mouse; 1:1000; fig 3	Walter C, Clemens L, MÃ¼ller A, Fallier Becker P, Proikas Cezanne T, Riess O, et al. Activation of AMPK-induced autophagy ameliorates Huntington disease pathology in vitro. Neuropharmacology. 2016;108:24-38 pubmed publisher
western blot; human; 1:1000; fig 4	Du R, Liu Z, Hou X, Fu G, An N, Wang L. Trichostatin A potentiates genistein-induced apoptosis and reverses EMT in HEp2 cells. Mol Med Rep. 2016;13:5045-52 pubmed publisher
western blot; human; 1:500; fig 4	Papke B, Murarka S, Vogel H, Martín Gago P, Kovacevic M, Truxius D, et al. Identification of pyrazolopyridazinones as PDE? inhibitors. Nat Commun. 2016;7:11360 pubmed publisher
western blot; human; fig 7f western blot; mouse; fig 6g	Ro S, Xue X, Ramakrishnan S, Cho C, Namkoong S, Jang I, et al. Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis. elife. 2016;5:e12204 pubmed publisher
western blot; mouse	GarcÃa Prat L, MartÃnez Vicente M, Perdiguero E, Ortet L, RodrÃguez Ubreva J, Rebollo E, et al. Autophagy maintains stemness by preventing senescence. Nature. 2016;529:37-42 pubmed publisher
western blot; human; loading ...; fig 4a	Lv H, Zhang Z, Wu X, Wang Y, Li C, Gong W, et al. Preclinical Evaluation of Liposomal C8 Ceramide as a Potent anti-Hepatocellular Carcinoma Agent. PLoS ONE. 2016;11:e0145195 pubmed publisher
western blot; human; fig s2	Yamagishi M, Katano H, Hishima T, Shimoyama T, Ota Y, Nakano K, et al. Coordinated loss of microRNA group causes defenseless signaling in malignant lymphoma. Sci Rep. 2015;5:17868 pubmed publisher
western blot; human; 1:1000; fig s10	Kim H, An S, Ro S, Teixeira F, Park G, Kim C, et al. Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains. Nat Commun. 2015;6:10025 pubmed publisher
western blot; mouse; fig 5	Nikonova A, Deneka A, Eckman L, Kopp M, Hensley H, Egleston B, et al. Opposing Effects of Inhibitors of Aurora-A and EGFR in Autosomal-Dominant Polycystic Kidney Disease. Front Oncol. 2015;5:228 pubmed publisher
western blot; mouse; fig 5	Antonucci L, Fagman J, Kim J, Todoric J, Gukovsky I, Mackey M, et al. Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress. Proc Natl Acad Sci U S A. 2015;112:E6166-74 pubmed publisher
western blot; human; fig 3	Knoll M, Macher Goeppinger S, Kopitz J, Duensing S, Pahernik S, Hohenfellner M, et al. The ribosomal protein S6 in renal cell carcinoma: functional relevance and potential as biomarker. Oncotarget. 2016;7:418-32 pubmed publisher
western blot; human; fig 6c	BarbÃ¡chano A, FernÃ¡ndez Barral A, Pereira F, Segura M, OrdÃ³Ã±ez MorÃ¡n P, Carrillo de Santa Pau E, et al. SPROUTY-2 represses the epithelial phenotype of colon carcinoma cells via upregulation of ZEB1 mediated by ETS1 and miR-200/miR-150. Oncogene. 2016;35:2991-3003 pubmed publisher
western blot; human; fig 1a	Thijssen R, Ter Burg J, van Bochove G, de Rooij M, Kuil A, Jansen M, et al. The pan phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor SAR245409 (voxtalisib/XL765) blocks survival, adhesion and proliferation of primary chronic lymphocytic leukemia cells. Leukemia. 2016;30:337-45 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 6	Conde Perez A, Gros G, Longvert C, Pedersen M, Petit V, Aktary Z, et al. A caveolin-dependent and PI3K/AKT-independent role of PTEN in Î²-catenin transcriptional activity. Nat Commun. 2015;6:8093 pubmed publisher
western blot; human; fig 4f	Schipany K, Rosner M, Ionce L, HengstschlÃ¤ger M, Kovacic B. eIF3 controls cell size independently of S6K1-activity. Oncotarget. 2015;6:24361-75 pubmed
western blot; mouse	He L, Zang A, Du M, Ma D, Yuan C, Zhou C, et al. mTOR regulates TLR-induced c-fos and Th1 responses to HBV and HCV vaccines. Virol Sin. 2015;30:174-89 pubmed publisher
western blot; mouse; loading ...; fig 1c immunohistochemistry; human; loading ...; fig 2c	Zidek L, Ackermann T, Hartleben G, Eichwald S, Kortman G, Kiehntopf M, et al. Deficiency in mTORC1-controlled C/EBPÎ²-mRNA translation improves metabolic health in mice. EMBO Rep. 2015;16:1022-36 pubmed publisher
western blot; human; fig 2	Kemmerer M, Finkernagel F, Cavalcante M, Abdalla D, MÃ¼ller R, BrÃ¼ne B, et al. AMP-Activated Protein Kinase Interacts with the Peroxisome Proliferator-Activated Receptor Delta to Induce Genes Affecting Fatty Acid Oxidation in Human Macrophages. PLoS ONE. 2015;10:e0130893 pubmed publisher
western blot; human	Zhao J, Zhao D, Poage G, Mazumdar A, Zhang Y, Hill J, et al. Death-associated protein kinase 1 promotes growth of p53-mutant cancers. J Clin Invest. 2015;125:2707-20 pubmed publisher
western blot; mouse; fig 1, 6	Mauro Lizcano M, Esteban MartÃnez L, Seco E, Serrano Puebla A, García Ledo L, Figueiredo Pereira C, et al. New method to assess mitophagy flux by flow cytometry. Autophagy. 2015;11:833-43 pubmed publisher
western blot; human	RoffÃ© M, Lupinacci F, Soares L, Hajj G, Martins V. Two widely used RSK inhibitors, BI-D1870 and SL0101, alter mTORC1 signaling in a RSK-independent manner. Cell Signal. 2015;27:1630-42 pubmed publisher
western blot; mouse; fig f6	Chung J, Bauer D, Ghamari A, Nizzi C, Deck K, Kingsley P, et al. The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability. Sci Signal. 2015;8:ra34 pubmed publisher
western blot; mouse; 1:1000; fig s3	Iervolino A, Trepiccione F, Petrillo F, Spagnuolo M, ScarfÃ² M, Frezzetti D, et al. Selective dicer suppression in the kidney alters GSK3Î²/Î²-catenin pathways promoting a glomerulocystic disease. PLoS ONE. 2015;10:e0119142 pubmed publisher
western blot; human; 1:1000; fig 1,2,3,4,5,6,7	Desantis A, Bruno T, Catena V, De Nicola F, Goeman F, Iezzi S, et al. Che-1-induced inhibition of mTOR pathway enables stress-induced autophagy. EMBO J. 2015;34:1214-30 pubmed publisher
immunocytochemistry; human	Ren H, Wang J, Yang F, Zhang X, Wang A, Sun L, et al. Cytoplasmic TRAF4 contributes to the activation of p70s6k signaling pathway in breast cancer. Oncotarget. 2015;6:4080-96 pubmed
western blot; human; 1:1000; fig 2c	Stolze B, Reinhart S, Bulllinger L, FrÃ¶hling S, Scholl C. Comparative analysis of KRAS codon 12, 13, 18, 61, and 117 mutations using human MCF10A isogenic cell lines. Sci Rep. 2015;5:8535 pubmed publisher
western blot; mouse; fig 2	Boj S, Hwang C, Baker L, Chio I, Engle D, Corbo V, et al. Organoid models of human and mouse ductal pancreatic cancer. Cell. 2015;160:324-38 pubmed publisher
western blot; human; fig 2	Cebulla J, Huuse E, Pettersen K, van der Veen A, Kim E, Andersen S, et al. MRI reveals the in vivo cellular and vascular response to BEZ235 in ovarian cancer xenografts with different PI3-kinase pathway activity. Br J Cancer. 2015;112:504-13 pubmed publisher
western blot; human; fig 5	Qin J, Rajaratnam R, Feng L, Salami J, Barber Rotenberg J, Domsic J, et al. Development of organometallic S6K1 inhibitors. J Med Chem. 2015;58:305-14 pubmed publisher
western blot; human; loading ...; fig 1b	Alayev A, Berger S, Kramer M, Schwartz N, Holz M. The combination of rapamycin and resveratrol blocks autophagy and induces apoptosis in breast cancer cells. J Cell Biochem. 2015;116:450-7 pubmed publisher
western blot; human; fig 4	Kocher B, White L, Piwnica Worms D. DAPK3 suppresses acini morphogenesis and is required for mouse development. Mol Cancer Res. 2015;13:358-67 pubmed publisher
immunoprecipitation; human; fig 3d western blot; human; fig 3a western blot; mouse; fig 3h	Kazyken D, Kaz Y, Kiyan V, Zhylkibayev A, Chen C, Agarwal N, et al. The nuclear import of ribosomal proteins is regulated by mTOR. Oncotarget. 2014;5:9577-93 pubmed
western blot; rat	Rodriguez Martin T, Cuchillo Ibanez I, Noble W, Nyenya F, Anderton B, Hanger D. Tau phosphorylation affects its axonal transport and degradation. Neurobiol Aging. 2013;34:2146-57 pubmed publisher
	Chang J, Zhang W, Yeh H, Park M, Yao C, Shi Y, et al. An integrative model for alternative polyadenylation, IntMAP, delineates mTOR-modulated endoplasmic reticulum stress response. Nucleic Acids Res. 2018;46:5996-6008 pubmed publisher
	Wang Y, Wong C, Yan M, Li L, Liu T, Or P, et al. Differential regulation of the pro-inflammatory biomarker, YKL-40/CHI3L1, by PTEN/Phosphoinositide 3-kinase and JAK2/STAT3 pathways in glioblastoma. Cancer Lett. 2018;429:54-65 pubmed publisher
	Romano G, Chen P, Song P, McQuade J, Liang R, Liu M, et al. A Preexisting Rare PIK3CAE545K Subpopulation Confers Clinical Resistance to MEK plus CDK4/6 Inhibition in NRAS Melanoma and Is Dependent on S6K1 Signaling. Cancer Discov. 2018;8:556-567 pubmed publisher
	Beadnell T, Nassar K, Rose M, Clark E, Danysh B, Hofmann M, et al. Src-mediated regulation of the PI3K pathway in advanced papillary and anaplastic thyroid cancer. Oncogenesis. 2018;7:23 pubmed publisher
	Al Ali H, Ding Y, Slepak T, Wu W, Sun Y, Martinez Y, et al. The mTOR Substrate S6 Kinase 1 (S6K1) Is a Negative Regulator of Axon Regeneration and a Potential Drug Target for Central Nervous System Injury. J Neurosci. 2017;37:7079-7095 pubmed publisher
	Ma S, Wan X, Deng Z, Shi L, Hao C, Zhou Z, et al. Epigenetic regulator CXXC5 recruits DNA demethylase Tet2 to regulate TLR7/9-elicited IFN response in pDCs. J Exp Med. 2017;214:1471-1491 pubmed publisher
	Martins T, Eusebio N, Correia A, Marinho J, Casares F, Pereira P. TGFβ/Activin signalling is required for ribosome biogenesis and cell growth in Drosophila salivary glands. Open Biol. 2017;7: pubmed publisher
	Cervia D, Assi E, De Palma C, Giovarelli M, Bizzozero L, Pambianco S, et al. Essential role for acid sphingomyelinase-inhibited autophagy in melanoma response to cisplatin. Oncotarget. 2016;7:24995-5009 pubmed publisher
	Kiessling M, Curioni Fontecedro A, Samaras P, Lang S, Scharl M, Aguzzi A, et al. Targeting the mTOR Complex by Everolimus in NRAS Mutant Neuroblastoma. PLoS ONE. 2016;11:e0147682 pubmed publisher
	Young C, Arteaga C, Cook R. Dual inhibition of Type I and Type III PI3 kinases increases tumor cell apoptosis in HER2+ breast cancers. Breast Cancer Res. 2015;17:148 pubmed publisher
	Mahankali M, Farkaly T, Bedi S, Hostetler H, Gomez Cambronero J. Phosphatidic Acid (PA) can Displace PPARÎ±/LXRÎ± Binding to The EGFR Promoter Causing its Transrepression in Luminal Cancer Cells. Sci Rep. 2015;5:15379 pubmed publisher
	Hatfield I, Harvey I, Yates E, Redd J, Reiter L, Bridges D. The role of TORC1 in muscle development in Drosophila. Sci Rep. 2015;5:9676 pubmed publisher
	Ayuso M, Martínez Alonso E, Salvador N, Bonova P, Regidor I, AlcÃ¡zar A. Dissociation of eIF4E-binding protein 2 (4E-BP2) from eIF4E independent of Thr37/Thr46 phosphorylation in the ischemic stress response. PLoS ONE. 2015;10:e0121958 pubmed publisher
	Miettinen T, BjÃ¶rklund M. Modified ribosome profiling reveals high abundance of ribosome protected mRNA fragments derived from 3' untranslated regions. Nucleic Acids Res. 2015;43:1019-34 pubmed publisher
	Akin D, Wang S, Habibzadegah Tari P, Law B, Ostrov D, Li M, et al. A novel ATG4B antagonist inhibits autophagy and has a negative impact on osteosarcoma tumors. Autophagy. 2014;10:2021-35 pubmed publisher
	Micel L, Tentler J, Tan A, Selby H, Brunkow K, Robertson K, et al. Antitumor activity of the MEK inhibitor TAK-733 against melanoma cell lines and patient-derived tumor explants. Mol Cancer Ther. 2015;14:317-25 pubmed publisher
	Katayama R, Friboulet L, Koike S, Lockerman E, Khan T, Gainor J, et al. Two novel ALK mutations mediate acquired resistance to the next-generation ALK inhibitor alectinib. Clin Cancer Res. 2014;20:5686-96 pubmed publisher
	Knight Z, Schmidt S, Birsoy K, Tan K, Friedman J. A critical role for mTORC1 in erythropoiesis and anemia. elife. 2014;3:e01913 pubmed publisher
	Wei F, Leung K, Li G, Qin J, Chow S, Huang S, et al. Low intensity pulsed ultrasound enhanced mesenchymal stem cell recruitment through stromal derived factor-1 signaling in fracture healing. PLoS ONE. 2014;9:e106722 pubmed publisher
	Asnaghi L, Lin M, Lim K, Lim K, Tripathy A, Wendeborn M, et al. Hypoxia promotes uveal melanoma invasion through enhanced Notch and MAPK activation. PLoS ONE. 2014;9:e105372 pubmed publisher
	Lehmann B, Bauer J, Schafer J, Pendleton C, Tang L, Johnson K, et al. PIK3CA mutations in androgen receptor-positive triple negative breast cancer confer sensitivity to the combination of PI3K and androgen receptor inhibitors. Breast Cancer Res. 2014;16:406 pubmed publisher
	Wolfe A, Singh K, Zhong Y, Drewe P, Rajasekhar V, Sanghvi V, et al. RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer. Nature. 2014;513:65-70 pubmed publisher
	Romaker D, Kumar V, Cerqueira D, Cox R, Wessely O. MicroRNAs are critical regulators of tuberous sclerosis complex and mTORC1 activity in the size control of the Xenopus kidney. Proc Natl Acad Sci U S A. 2014;111:6335-40 pubmed publisher
	Bitting R, Healy P, Creel P, Turnbull J, Morris K, Wood S, et al. A phase Ib study of combined VEGFR and mTOR inhibition with vatalanib and everolimus in patients with advanced renal cell carcinoma. Clin Genitourin Cancer. 2014;12:241-50 pubmed publisher
	Zhao X, Lu S, Nie J, Hu X, Luo W, Wu X, et al. Phosphoinositide-dependent kinase 1 and mTORC2 synergistically maintain postnatal heart growth and heart function in mice. Mol Cell Biol. 2014;34:1966-75 pubmed publisher
	Wang C, Bajikar S, Jamal L, Atkins K, Janes K. A time- and matrix-dependent TGFBR3-JUND-KRT5 regulatory circuit in single breast epithelial cells and basal-like premalignancies. Nat Cell Biol. 2014;16:345-56 pubmed publisher
	Manzoni C, Mamais A, Dihanich S, McGoldrick P, Devine M, Zerle J, et al. Pathogenic Parkinson's disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation. Biochem Biophys Res Commun. 2013;441:862-6 pubmed publisher
	Yogev O, Williams V, Hinits Y, Hughes S. eIF4EBP3L acts as a gatekeeper of TORC1 in activity-dependent muscle growth by specifically regulating Mef2ca translational initiation. PLoS Biol. 2013;11:e1001679 pubmed publisher
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product information

SKU :

2317S

Product-Name :

S6 Ribosomal Protein (54D2) Mouse mAb

Size :

100 ul

Price-(USD) :

235 USD

Species-x-Reactivity :

H, M, R, Mk, Dm

Applications :

Flow cytometry

Product-Category :

Translational Control

Shipping-Temp :

COLD

Storage-Temp :

-20°C

Product-Type :

Monoclonal Antibody

MW :

Host :

Mouse

Target :

S6 Ribosomal Protein

Primary-Protein :

Alt-Names :

40S ribosomal protein S6,Phosphoprotein NP33,RPS6,RS6,ribosomal protein S6

more info or order :

Cell Signaling Technology product webpage