product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
CDK9 (C12F7) Rabbit mAb
catalog :
2316
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
C12F7
reactivity :
human, mouse, rat, dogs, bovine
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, chromatin immunoprecipitation, immunohistochemistry - paraffin section
citations: 14
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 4e
Huang S, Luo W, Wu G, Shen Q, Zhuang Z, Yang D, et al. Inhibition of CDK9 attenuates atherosclerosis by inhibiting inflammation and phenotypic switching of vascular smooth muscle cells. Aging (Albany NY). 2021;13:14892-14909 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:50; loading ...; fig 1
  • western blot; human; 1:1000; loading ...; fig 4c
He S, Fang X, Xia X, Hou T, Zhang T. Targeting CDK9: A novel biomarker in the treatment of endometrial cancer. Oncol Rep. 2020;44:1929-1938 pubmed publisher
  • western blot; human; loading ...; fig 1g
Muller A, Dickmanns A, Resch C, Schakel K, Hailfinger S, Dobbelstein M, et al. The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis. J Clin Invest. 2020;: pubmed publisher
  • immunoprecipitation; human; loading ...; fig 5e
Kyei G, Meng S, Ramani R, Niu A, Lagisetti C, Webb T, et al. Splicing Factor 3B Subunit 1 Interacts with HIV Tat and Plays a Role in Viral Transcription and Reactivation from Latency. MBio. 2018;9: pubmed publisher
  • chromatin immunoprecipitation; mouse; fig 5b
  • western blot; mouse; fig 5a
  • chromatin immunoprecipitation; human; loading ...; fig 5b
  • western blot; human; loading ...; fig 5a
Sun W, Jiao S, Sun L, Zhou Z, Jin X, Wang J. SUN2 Modulates HIV-1 Infection and Latency through Association with Lamin A/C To Maintain the Repressive Chromatin. MBio. 2018;9: pubmed publisher
  • western blot; human; loading ...; fig 1d
Muhar M, Ebert A, Neumann T, Umkehrer C, Jude J, Wieshofer C, et al. SLAM-seq defines direct gene-regulatory functions of the BRD4-MYC axis. Science. 2018;360:800-805 pubmed publisher
  • western blot; human; loading ...; fig 1c
Liao P, Zeng S, Zhou X, Chen T, Zhou F, Cao B, et al. Mutant p53 Gains Its Function via c-Myc Activation upon CDK4 Phosphorylation at Serine 249 and Consequent PIN1 Binding. Mol Cell. 2017;68:1134-1146.e6 pubmed publisher
  • western blot; human; fig s2c
Pelish H, Liau B, Nitulescu I, Tangpeerachaikul A, Poss Z, Da Silva D, et al. Mediator kinase inhibition further activates super-enhancer-associated genes in AML. Nature. 2015;526:273-276 pubmed publisher
  • western blot; human; fig 1
Moldovan J, Moran J. The Zinc-Finger Antiviral Protein ZAP Inhibits LINE and Alu Retrotransposition. PLoS Genet. 2015;11:e1005121 pubmed publisher
  • western blot; mouse
Ambacher K, Pitzul K, Karajgikar M, Hamilton A, Ferguson S, Cregan S. The JNK- and AKT/GSK3?- signaling pathways converge to regulate Puma induction and neuronal apoptosis induced by trophic factor deprivation. PLoS ONE. 2012;7:e46885 pubmed publisher
Shirasaki R, Matthews G, Gandolfi S, de Matos Simoes R, Buckley D, Raja Vora J, et al. Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins. Cell Rep. 2021;34:108532 pubmed publisher
Nitulescu I, Meyer S, Wen Q, Crispino J, Lemieux M, Levine R, et al. Mediator Kinase Phosphorylation of STAT1 S727 Promotes Growth of Neoplasms With JAK-STAT Activation. EBioMedicine. 2017;26:112-125 pubmed publisher
Thorenoor N, Faltejskova Vychytilova P, Hombach S, Mlcochova J, Kretz M, Svoboda M, et al. Long non-coding RNA ZFAS1 interacts with CDK1 and is involved in p53-dependent cell cycle control and apoptosis in colorectal cancer. Oncotarget. 2016;7:622-37 pubmed publisher
Tsai W, Wang P, Lin S, Wu I, Ko Y, Chen Y, et al. Ser-634 and Ser-636 of Kaposi's Sarcoma-Associated Herpesvirus RTA are Involved in Transactivation and are Potential Cdk9 Phosphorylation Sites. Front Microbiol. 2012;3:60 pubmed publisher
product information
SKU :
2316P
Product-Name :
CDK9 (C12F7) Rabbit mAb
Size :
40 ul
Price-(USD) :
123 USD
Species-x-Reactivity :
H, M, R, Hm, Mk, B, Dg
Applications :
Flow cytometry
Product-Category :
Cell Cycle / Checkpoint Control
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
42, 55
Host :
Rabbit
Target :
Cdk9
Primary-Protein :
CDK9
Alt-Names :
C-2K,CDC2-related kinase,CDC2L4,CDK9,CTK1,Cell division cycle 2-like protein kinase 4,Cell division protein kinase 9,Cyclin-dependent kinase 9,PITALRE,PTEFB,Serine/threonine-protein kinase PITALRE,TAK,serine/threonine protein kinase PITALRE
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.