product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
DARPP-32 (19A3) Rabbit mAb
catalog :
2306
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
19A3
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - frozen section, immunohistochemistry - free floating section
more info or order :
Cell Signaling Technology product webpage
citations: 15
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - free floating section; mouse; 1:250; loading ...; fig 4d
Zeitler B, Froelich S, Marlen K, Shivak D, Yu Q, Li D, et al. Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington's disease. Nat Med. 2019;25:1131-1142 pubmed publisher
  • western blot; mouse; fig 1a
Zhu F, Zhu Q, Ye D, Zhang Q, Yang Y, Guo X, et al. Sin3a-Tet1 interaction activates gene transcription and is required for embryonic stem cell pluripotency. Nucleic Acids Res. 2018;46:6026-6040 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; loading ...
Parsons M, Vanni M, Woodard C, Kang R, Murphy T, Raymond L. Real-time imaging of glutamate clearance reveals normal striatal uptake in Huntington disease mouse models. Nat Commun. 2016;7:11251 pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig 3a
Jeon J, Kim W, Jang J, Isacson O, Seo H. Gene therapy by proteasome activator, PA28γ, improves motor coordination and proteasome function in Huntington's disease YAC128 mice. Neuroscience. 2016;324:20-8 pubmed publisher
  • immunohistochemistry; mouse; 1:500; fig 1
Wu J, Ryskamp D, Liang X, Egorova P, Zakharova O, Hung G, et al. Enhanced Store-Operated Calcium Entry Leads to Striatal Synaptic Loss in a Huntington's Disease Mouse Model. J Neurosci. 2016;36:125-41 pubmed publisher
  • immunohistochemistry; human; 1:1000
Feng J, Shao N, Szulwach K, Vialou V, Huynh J, Zhong C, et al. Role of Tet1 and 5-hydroxymethylcytosine in cocaine action. Nat Neurosci. 2015;18:536-44 pubmed publisher
  • immunohistochemistry; mouse; fig 2
West A, Cowell R, Daher J, Moehle M, Hinkle K, Melrose H, et al. Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents. J Comp Neurol. 2014;522:2465-80 pubmed publisher
Gaj T, Staahl B, Rodrigues G, Limsirichai P, Ekman F, Doudna J, et al. Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery. Nucleic Acids Res. 2017;45:e98 pubmed publisher
Ryskamp D, Wu J, Geva M, Kusko R, Grossman I, Hayden M, et al. The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease. Neurobiol Dis. 2017;97:46-59 pubmed publisher
Qian Y, Forssberg H, Diaz Heijtz R. Motor Skill Learning Is Associated with Phase-Dependent Modifications in the Striatal cAMP/PKA/DARPP-32 Signaling Pathway in Rodents. PLoS ONE. 2015;10:e0140974 pubmed publisher
Carty N, Berson N, Tillack K, Thiede C, Scholz D, Kottig K, et al. Characterization of HTT inclusion size, location, and timing in the zQ175 mouse model of Huntington's disease: an in vivo high-content imaging study. PLoS ONE. 2015;10:e0123527 pubmed publisher
Sader Mazbar O, Loboda Y, Rabey M, Finberg J. Increased L-DOPA-derived dopamine following selective MAO-A or -B inhibition in rat striatum depleted of dopaminergic and serotonergic innervation. Br J Pharmacol. 2013;170:999-1013 pubmed publisher
Proenca C, Stoehr N, Bernhard M, Seger S, Genoud C, Roscic A, et al. Atg4b-dependent autophagic flux alleviates Huntington's disease progression. PLoS ONE. 2013;8:e68357 pubmed publisher
Keilani S, Chandwani S, Dolios G, Bogush A, Beck H, Hatzopoulos A, et al. Egr-1 induces DARPP-32 expression in striatal medium spiny neurons via a conserved intragenic element. J Neurosci. 2012;32:6808-18 pubmed publisher
Herzig M, Kolly C, Persohn E, Theil D, Schweizer T, Hafner T, et al. LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice. Hum Mol Genet. 2011;20:4209-23 pubmed publisher
product information
SKU :
2306S
Product-Name :
DARPP-32 (19A3) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
M, R, (H)
Applications :
Immunofluorescence (Frozen)
Product-Category :
Neuroscience
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
32
Host :
Rabbit
Target :
DARPP-32
Primary-Protein :
DARPP-32
Alt-Names :
DARPP-32,DARPP32,Dopamine- and cAMP-regulated neuronal phosphoprotein,FLJ20940,PPP1R1B,PPR1B,Protein phosphatase 1 regulatory subunit 1B,dopamine and cAMP regulated phosphoprotein,dopamine and cAMP-regulated neuronal phosphoprotein 32,protein phosphatase 1, regulatory (inhibitor) subunit 1B,protein phosphatase 1, regulatory (inhibitor) subunit 1B (dopamine and cAMP regulated phosphoprotein, DARPP-32)
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.