product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
LEF1 (C18A7) Rabbit mAb
catalog :
2286
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
C18A7
reactivity :
human, mouse
application :
western blot, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section
more info or order :
Cell Signaling Technology product webpage
citations: 17
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:500; loading ...; fig 4d
Ibarra B, Machen C, ATIT R. Wnt-Dependent Activation of ERK Mediates Repression of Chondrocyte Fate during Calvarial Development. J Dev Biol. 2021;9: pubmed publisher
  • western blot; mouse; 1:1000; fig 3e
Ye S, Zhang T, Tong C, Zhou X, He K, Ban Q, et al. Depletion of Tcf3 and Lef1 maintains mouse embryonic stem cell self-renewal. Biol Open. 2017;6:511-517 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:50; fig 4
Bleckmann A, Conradi L, Menck K, Schmick N, Schubert A, Rietkötter E, et al. β-catenin-independent WNT signaling and Ki67 in contrast to the estrogen receptor status are prognostic and associated with poor prognosis in breast cancer liver metastases. Clin Exp Metastasis. 2016;33:309-23 pubmed publisher
  • immunocytochemistry; human; fig 2
  • western blot; human; fig 2
Xiong W, Zhang L, Yu L, Xie W, Man Y, Xiong Y, et al. Estradiol promotes cells invasion by activating β-catenin signaling pathway in endometriosis. Reproduction. 2015;150:507-16 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 2
Bebee T, Park J, Sheridan K, Warzecha C, Cieply B, Rohacek A, et al. The splicing regulators Esrp1 and Esrp2 direct an epithelial splicing program essential for mammalian development. elife. 2015;4: pubmed publisher
Xing S, Gai K, Li X, Shao P, Zeng Z, Zhao X, et al. Tcf1 and Lef1 are required for the immunosuppressive function of regulatory T cells. J Exp Med. 2019;: pubmed publisher
Xu Z, Xing S, Shan Q, Gullicksrud J, Bair T, Du Y, et al. Cutting Edge: β-Catenin-Interacting Tcf1 Isoforms Are Essential for Thymocyte Survival but Dispensable for Thymic Maturation Transitions. J Immunol. 2017;198:3404-3409 pubmed publisher
Tarifeño Saldivia E, Lavergne A, Bernard A, Padamata K, Bergemann D, Voz M, et al. Transcriptome analysis of pancreatic cells across distant species highlights novel important regulator genes. BMC Biol. 2017;15:21 pubmed publisher
Brown Clay J, Shenoy D, Timofeeva O, Kallakury B, Nandi A, Banerjee P. PBK/TOPK enhances aggressive phenotype in prostate cancer via β-catenin-TCF/LEF-mediated matrix metalloproteinases production and invasion. Oncotarget. 2015;6:15594-609 pubmed
Mesa K, Rompolas P, Zito G, Myung P, Sun T, Brown S, et al. Niche-induced cell death and epithelial phagocytosis regulate hair follicle stem cell pool. Nature. 2015;522:94-7 pubmed publisher
de la Roche M, Ibrahim A, Mieszczanek J, Bienz M. LEF1 and B9L shield ?-catenin from inactivation by Axin, desensitizing colorectal cancer cells to tankyrase inhibitors. Cancer Res. 2014;74:1495-505 pubmed publisher
Chen X, Huang Z, Chen D, Yang T, Liu G. MicroRNA-27a is induced by leucine and contributes to leucine-induced proliferation promotion in C2C12 cells. Int J Mol Sci. 2013;14:14076-84 pubmed publisher
Zhou X, Xue H. Cutting edge: generation of memory precursors and functional memory CD8+ T cells depends on T cell factor-1 and lymphoid enhancer-binding factor-1. J Immunol. 2012;189:2722-6 pubmed publisher
Burks T, Cohn R. Role of TGF-? signaling in inherited and acquired myopathies. Skelet Muscle. 2011;1:19 pubmed publisher
Yokoyama N, Pate K, Sprowl S, Waterman M. A role for YY1 in repression of dominant negative LEF-1 expression in colon cancer. Nucleic Acids Res. 2010;38:6375-88 pubmed publisher
Larriba M, Casado Vela J, Pendás Franco N, Peña R, Garcia de Herreros A, Berciano M, et al. Novel snail1 target proteins in human colon cancer identified by proteomic analysis. PLoS ONE. 2010;5:e10221 pubmed publisher
Morine K, Bish L, Pendrak K, Sleeper M, Barton E, Sweeney H. Systemic myostatin inhibition via liver-targeted gene transfer in normal and dystrophic mice. PLoS ONE. 2010;5:e9176 pubmed publisher
product information
SKU :
2286S
Product-Name :
LEF1 (C18A7) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M
Applications :
Flow cytometry
Product-Category :
Developmental Biology
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
25-58 kDa
Host :
Rabbit
Target :
LEF1
Primary-Protein :
LEF-1
Alt-Names :
DKFZp586H0919,FLJ46390,LEF-1,LEF1,Lymphoid enhancer-binding factor 1,T cell-specific transcription factor 1-alpha,TCF1-alpha,TCF1ALPHA
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.