product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
SPAK Antibody
catalog :
2281
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - frozen section, western blot knockout validation
more info or order :
Cell Signaling Technology product webpage
citations: 8
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; mouse; fig 4
Yang S, Huang C, Chen H, Tung C, Shih H, Liu Y. Effects of SPAK knockout on sensorimotor gating, novelty exploration, and brain area-dependent expressions of NKCC1 and KCC2 in a mouse model of schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2015;61:30-6 pubmed publisher
  • western blot; human; loading ...; fig 4e
AlAmri M, Kadri H, Alderwick L, Simpkins N, Mehellou Y. Rafoxanide and Closantel Inhibit SPAK and OSR1 Kinases by Binding to a Highly Conserved Allosteric Site on Their C-terminal Domains. ChemMedChem. 2017;12:639-645 pubmed publisher
Saint Paul L, Nguyen C, Buffière A, Pais de Barros J, Hammann A, Landras Guetta C, et al. CD45 phosphatase is crucial for human and murine acute myeloid leukemia maintenance through its localization in lipid rafts. Oncotarget. 2016;7:64785-64797 pubmed publisher
Wong C, Jiang H, Abel P, Scofield M, Xie Y, Wei T, et al. Phorbol myristate acetate suppresses breast cancer cell growth via down-regulation of P-Rex1 expression. Protein Cell. 2016;7:445-9 pubmed publisher
Pan D, Barber M, Hornigold K, Baker M, Toth J, Oxley D, et al. Norbin Stimulates the Catalytic Activity and Plasma Membrane Localization of the Guanine-Nucleotide Exchange Factor P-Rex1. J Biol Chem. 2016;291:6359-75 pubmed publisher
Matsumoto T, Urushido M, Ide H, Ishihara M, Hamada Ode K, Shimamura Y, et al. Small Heat Shock Protein Beta-1 (HSPB1) Is Upregulated and Regulates Autophagy and Apoptosis of Renal Tubular Cells in Acute Kidney Injury. PLoS ONE. 2015;10:e0126229 pubmed publisher
Welch H. Regulation and function of P-Rex family Rac-GEFs. Small Gtpases. 2015;6:49-70 pubmed publisher
Centritto F, Paroni G, Bolis M, Garattini S, Kurosaki M, Barzago M, et al. Cellular and molecular determinants of all-trans retinoic acid sensitivity in breast cancer: Luminal phenotype and RARα expression. EMBO Mol Med. 2015;7:950-72 pubmed publisher
product information
SKU :
2281S
Product-Name :
SPAK Antibody
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R, Mk
Applications :
Immunofluorescence (Frozen)
Product-Category :
Cytoskeletal Signaling
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Polyclonal Antibody
MW :
65
Host :
Rabbit
Target :
SPAK
Primary-Protein :
STLK3
Alt-Names :
DCHT,DKFZp686K05124,PASK,SPAK,STE20/SPS1-related proline-alanine-rich protein kinase,STK39,Serine/threonine-protein kinase 39,Ste-20-related kinase,Ste20-like protein kinase,proline-alanine-rich STE20-related kinase,serine threonine kinase 39 (STE20/SPS1 homolog, yeast),small intestine SPAK-like kinase
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.