product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
c-Fos (9F6) Rabbit mAb
catalog :
2250
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
9F6
reactivity :
human, mouse, rat, dogs, bovine
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry - free floating section
citations: 60
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:1000; loading ...; fig 3??s1a
He L, Pratt H, Gao M, Wei F, Weng Z, Struhl K. YAP and TAZ are transcriptional co-activators of AP-1 proteins and STAT3 during breast cellular transformation. elife. 2021;10: pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 1m
Wang Y, Su Y, Yu G, Wang X, Chen X, Yu B, et al. Reduced Oligodendrocyte Precursor Cell Impairs Astrocytic Development in Early Life Stress. Adv Sci (Weinh). 2021;8:e2101181 pubmed publisher
  • western blot; mouse; loading ...; fig 3g
Zheng H, Xu W, Zhou W, Yang R, Chen P, Liu T, et al. Beraprost ameliorates postmenopausal osteoporosis by regulating Nedd4-induced Runx2 ubiquitination. Cell Death Dis. 2021;12:497 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:1000; loading ...; fig 8a
Higa Y, Kashiwadani H, Sugimura M, Kuwaki T. Orexinergic descending inhibitory pathway mediates linalool odor-induced analgesia in mice. Sci Rep. 2021;11:9224 pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig 6a
Han J, Kwon S, Kim Y, Choi J, Kim J, Lee Y, et al. Ablation of STAT3 in Purkinje cells reorganizes cerebellar synaptic plasticity in long-term fear memory network. elife. 2021;10: pubmed publisher
  • immunohistochemistry - free floating section; mouse; loading ...; fig 2f
Fukata Y, Chen X, Chiken S, Hirano Y, Yamagata A, Inahashi H, et al. LGI1-ADAM22-MAGUK configures transsynaptic nanoalignment for synaptic transmission and epilepsy prevention. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig 2a
Han K, Yoon T, Shin J, Um J, Ko J. Differentially altered social dominance- and cooperative-like behaviors in Shank2- and Shank3-mutant mice. Mol Autism. 2020;11:87 pubmed publisher
  • western blot; human; loading ...; fig 3g
Dong X, Feng M, Yang H, Liu H, Guo H, Gao X, et al. Rictor promotes cell migration and actin polymerization through regulating ABLIM1 phosphorylation in Hepatocellular Carcinoma. Int J Biol Sci. 2020;16:2835-2852 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1f
Pati S, Saba K, Salvi S, Tiwari P, Chaudhari P, Verma V, et al. Chronic postnatal chemogenetic activation of forebrain excitatory neurons evokes persistent changes in mood behavior. elife. 2020;9: pubmed publisher
  • immunohistochemistry; mouse; 1:400; loading ...; fig 6b
Hu X, Ikegami K, Vihani A, Zhu K, Zapata M, de March C, et al. Concentration-Dependent Recruitment of Mammalian Odorant Receptors. Eneuro. 2020;7: pubmed publisher
  • immunohistochemistry; mouse; 1:1000; loading ...; fig 3, 4
Gulmez Karaca K, Kupke J, Brito D, Zeuch B, Thome C, Weichenhan D, et al. Neuronal ensemble-specific DNA methylation strengthens engram stability. Nat Commun. 2020;11:639 pubmed publisher
  • western blot; human; loading ...; fig s5a
Yukawa M, Jagannathan S, Vallabh S, Kartashov A, Chen X, Weirauch M, et al. AP-1 activity induced by co-stimulation is required for chromatin opening during T cell activation. J Exp Med. 2020;217: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4b, s1b
Tian M, Gong W, Guo J. Long non-coding RNA SNHG1 indicates poor prognosis and facilitates disease progression in acute myeloid leukemia. Biol Open. 2019;8: pubmed publisher
  • immunohistochemistry; mouse; fig 4c
Ioannou M, Jackson J, Sheu S, Chang C, Weigel A, Liu H, et al. Neuron-Astrocyte Metabolic Coupling Protects against Activity-Induced Fatty Acid Toxicity. Cell. 2019;: pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:400; loading ...; fig 4i
Pluvinage J, Haney M, Smith B, Sun J, Iram T, Bonanno L, et al. CD22 blockade restores homeostatic microglial phagocytosis in ageing brains. Nature. 2019;568:187-192 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 2e
Dong J, Pan Y, Wu X, He L, Liu X, Feng D, et al. A neuronal molecular switch through cell-cell contact that regulates quiescent neural stem cells. Sci Adv. 2019;5:eaav4416 pubmed publisher
  • western blot; mouse; loading ...; fig 3c
Xie C, Zhu J, Wang X, Chen J, Geng S, Wu J, et al. Tobacco smoke induced hepatic cancer stem cell-like properties through IL-33/p38 pathway. J Exp Clin Cancer Res. 2019;38:39 pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig 1d
Luo S, Huang J, Li Q, Mohammad H, Lee C, Krishna K, et al. Regulation of feeding by somatostatin neurons in the tuberal nucleus. Science. 2018;361:76-81 pubmed publisher
  • western blot; human; loading ...; fig 7b
Borlido J, Sakuma S, Raices M, Carrette F, Tinoco R, Bradley L, et al. Nuclear pore complex-mediated modulation of TCR signaling is required for naïve CD4+ T cell homeostasis. Nat Immunol. 2018;19:594-605 pubmed publisher
  • immunohistochemistry; mouse; fig 5a
Alhadeff A, Su Z, Hernandez E, Klima M, Phillips S, Holland R, et al. A Neural Circuit for the Suppression of Pain by a Competing Need State. Cell. 2018;173:140-152.e15 pubmed publisher
  • western blot; mouse; loading ...; fig 2e
Fujita S, Mukai T, Mito T, Kodama S, Nagasu A, Kittaka M, et al. Pharmacological inhibition of tankyrase induces bone loss in mice by increasing osteoclastogenesis. Bone. 2018;106:156-166 pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig 4
Fu C, Xue J, Wang R, Chen J, Ma L, Liu Y, et al. Chemosensitive Phox2b-expressing neurons are crucial for hypercapnic ventilatory response in the nucleus tractus solitarius. J Physiol. 2017;595:4973-4989 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:400; loading ...; fig s4a
Castellano J, Mosher K, Abbey R, McBride A, James M, Berdnik D, et al. Human umbilical cord plasma proteins revitalize hippocampal function in aged mice. Nature. 2017;544:488-492 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2c
Vallejo A, Perurena N, Guruceaga E, Mazur P, Martínez Canarias S, Zandueta C, et al. An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer. Nat Commun. 2017;8:14294 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3a
Hichino A, Okamoto M, Taga S, Akizuki R, Endo S, Matsunaga T, et al. Down-regulation of Claudin-2 Expression and Proliferation by Epigenetic Inhibitors in Human Lung Adenocarcinoma A549 Cells. J Biol Chem. 2017;292:2411-2421 pubmed publisher
  • chromatin immunoprecipitation; mouse
  • western blot; mouse; 1:1000; fig 4
Liu W, Zhou L, Zhou C, Zhang S, Jing J, Xie L, et al. GDF11 decreases bone mass by stimulating osteoclastogenesis and inhibiting osteoblast differentiation. Nat Commun. 2016;7:12794 pubmed publisher
  • immunohistochemistry; mouse; 1:200; fig 4
Hughes S, Rodgers J, Hickey D, Foster R, Peirson S, Hankins M. Characterisation of light responses in the retina of mice lacking principle components of rod, cone and melanopsin phototransduction signalling pathways. Sci Rep. 2016;6:28086 pubmed publisher
  • western blot; human; 1:1000; fig 2
Qiao Y, Qian Y, Wang J, Tang X. Melanoma cell adhesion molecule stimulates yes-associated protein transcription by enhancing CREB activity via c-Jun/c-Fos in hepatocellular carcinoma cells. Oncol Lett. 2016;11:3702-3708 pubmed
  • chromatin immunoprecipitation; human; fig 5
Zhang Y, He Q, Hu Z, Feng Y, Fan L, Tang Z, et al. Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in triple-negative breast cancer. Nat Struct Mol Biol. 2016;23:522-30 pubmed publisher
  • immunohistochemistry; mouse; 1:500; fig 2d
Zhu X, Liu X, Sun S, Zhuang H, Yang J, Henkemeyer M, et al. Ephrin-B3 coordinates timed axon targeting and amygdala spinogenesis for innate fear behaviour. Nat Commun. 2016;7:11096 pubmed publisher
  • chromatin immunoprecipitation; human; 1:40; fig 3
Weigel C, Veldwijk M, Oakes C, Seibold P, Slynko A, Liesenfeld D, et al. Epigenetic regulation of diacylglycerol kinase alpha promotes radiation-induced fibrosis. Nat Commun. 2016;7:10893 pubmed publisher
  • immunohistochemistry - frozen section; rat; 1:2000; fig 7
Hsu T, Hahn J, Konanur V, Noble E, Suarez A, Thai J, et al. Hippocampus ghrelin signaling mediates appetite through lateral hypothalamic orexin pathways. elife. 2015;4: pubmed publisher
  • chromatin immunoprecipitation; rat; fig 4
Wang J, Cao Y, Li Q, Yang Y, Jin M, Chen D, et al. A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in dopamine D2 and D3 receptor agonist-induced autophagy activation. Autophagy. 2015;11:2057-2073 pubmed publisher
  • western blot; dogs; 1:1000; fig 1b
Neumann Z, Pondenis H, Masyr A, Byrum M, Wycislo K, Fan T. The Association of Endothelin-1 Signaling with Bone Alkaline Phosphatase Expression and Protumorigenic Activities in Canine Osteosarcoma. J Vet Intern Med. 2015;29:1584-94 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 4,5
Gingras S, Earls L, Howell S, Smeyne R, Zakharenko S, Pelletier S. SCYL2 Protects CA3 Pyramidal Neurons from Excitotoxicity during Functional Maturation of the Mouse Hippocampus. J Neurosci. 2015;35:10510-22 pubmed publisher
  • western blot; mouse
He L, Zang A, Du M, Ma D, Yuan C, Zhou C, et al. mTOR regulates TLR-induced c-fos and Th1 responses to HBV and HCV vaccines. Virol Sin. 2015;30:174-89 pubmed publisher
  • immunocytochemistry; rat; 1:1000; fig 4
Cohen S, Li B, Tsien R, Ma H. Evolutionary and functional perspectives on signaling from neuronal surface to nucleus. Biochem Biophys Res Commun. 2015;460:88-99 pubmed publisher
  • western blot; human
Teng Y, Radde B, Litchfield L, Ivanova M, Prough R, Clark B, et al. Dehydroepiandrosterone Activation of G-protein-coupled Estrogen Receptor Rapidly Stimulates MicroRNA-21 Transcription in Human Hepatocellular Carcinoma Cells. J Biol Chem. 2015;290:15799-811 pubmed publisher
  • western blot; human; fig  3
Dong A, Wodziak D, Lowe A. Epidermal growth factor receptor (EGFR) signaling requires a specific endoplasmic reticulum thioredoxin for the post-translational control of receptor presentation to the cell surface. J Biol Chem. 2015;290:8016-27 pubmed publisher
  • western blot; mouse; loading ...; fig 4c
Shiheido H, Aoyama T, Takahashi H, Hanaoka K, Abe T, Nishida E, et al. Novel CD3-specific antibody induces immunosuppression via impaired phosphorylation of LAT and PLC?1 following T-cell stimulation. Eur J Immunol. 2014;44:1770-80 pubmed publisher
Whitaker L, Warren B, Venniro M, Harte T, McPherson K, Beidel J, et al. Bidirectional Modulation of Intrinsic Excitability in Rat Prelimbic Cortex Neuronal Ensembles and Non-Ensembles after Operant Learning. J Neurosci. 2017;37:8845-8856 pubmed publisher
Xu Y, Qin L, Sun T, Wu H, He T, Yang Z, et al. Twist1 promotes breast cancer invasion and metastasis by silencing Foxa1 expression. Oncogene. 2017;36:1157-1166 pubmed publisher
Lu Y, Zhong C, Wang L, Wei P, He W, Huang K, et al. Optogenetic dissection of ictal propagation in the hippocampal-entorhinal cortex structures. Nat Commun. 2016;7:10962 pubmed publisher
Juan De Solis A, Baquero A, Bennett C, Grove K, Zeltser L. Postnatal undernutrition delays a key step in the maturation of hypothalamic feeding circuits. Mol Metab. 2016;5:198-209 pubmed publisher
Chiba Y, Yamada T, Tsukita S, Takahashi K, Munakata Y, Shirai Y, et al. Dapagliflozin, a Sodium-Glucose Co-Transporter 2 Inhibitor, Acutely Reduces Energy Expenditure in BAT via Neural Signals in Mice. PLoS ONE. 2016;11:e0150756 pubmed publisher
Adhikari A, Lerner T, Finkelstein J, Pak S, Jennings J, Davidson T, et al. Basomedial amygdala mediates top-down control of anxiety and fear. Nature. 2015;527:179-85 pubmed publisher
Jain P, Hassan A, Koyani C, Mayerhofer R, Reichmann F, Farzi A, et al. Behavioral and molecular processing of visceral pain in the brain of mice: impact of colitis and psychological stress. Front Behav Neurosci. 2015;9:177 pubmed publisher
Ren H, Cook J, Kon N, Accili D. Gpr17 in AgRP Neurons Regulates Feeding and Sensitivity to Insulin and Leptin. Diabetes. 2015;64:3670-9 pubmed publisher
Zhong T, Guo Q, Zou W, Zhu X, Song Z, Sun B, et al. Neonatal isoflurane exposure induces neurocognitive impairment and abnormal hippocampal histone acetylation in mice. PLoS ONE. 2015;10:e0125815 pubmed publisher
Wei P, Liu N, Zhang Z, Liu X, Tang Y, He X, et al. Processing of visually evoked innate fear by a non-canonical thalamic pathway. Nat Commun. 2015;6:6756 pubmed publisher
Spiesz E, Thorpe C, Chaudhry S, Riley G, Birch H, Clegg P, et al. Tendon extracellular matrix damage, degradation and inflammation in response to in vitro overload exercise. J Orthop Res. 2015;33:889-97 pubmed publisher
Kovacheva M, Zepp M, Berger S, Berger M. Sustained conditional knockdown reveals intracellular bone sialoprotein as essential for breast cancer skeletal metastasis. Oncotarget. 2014;5:5510-22 pubmed
Chen Y, Thang M, Chan Y, Huang Y, Ma N, Yu A, et al. Global assessment of Antrodia cinnamomea-induced microRNA alterations in hepatocarcinoma cells. PLoS ONE. 2013;8:e82751 pubmed publisher
Gómez Sánchez R, Gegg M, Bravo San Pedro J, Niso Santano M, Alvarez Erviti L, Pizarro Estrella E, et al. Mitochondrial impairment increases FL-PINK1 levels by calcium-dependent gene expression. Neurobiol Dis. 2014;62:426-40 pubmed publisher
Nakamura A, Kobayashi M, Kuraoka M, Yuasa K, Yugeta N, Okada T, et al. Initial pulmonary respiration causes massive diaphragm damage and hyper-CKemia in Duchenne muscular dystrophy dog. Sci Rep. 2013;3:2183 pubmed publisher
Watanabe T, Hiasa Y, Tokumoto Y, Hirooka M, Abe M, Ikeda Y, et al. Protein kinase R modulates c-Fos and c-Jun signaling to promote proliferation of hepatocellular carcinoma with hepatitis C virus infection. PLoS ONE. 2013;8:e67750 pubmed publisher
Saito T, Uda S, Tsuchiya T, Ozaki Y, Kuroda S. Temporal decoding of MAP kinase and CREB phosphorylation by selective immediate early gene expression. PLoS ONE. 2013;8:e57037 pubmed publisher
Zhao X, Ross E, Wang Y, Horwitz B. Nfkb1 inhibits LPS-induced IFN-? and IL-12 p40 production in macrophages by distinct mechanisms. PLoS ONE. 2012;7:e32811 pubmed publisher
Le H, Zhang Y, Liu H, Ma L, Jin Y, Huang Q, et al. eena Promotes myeloid proliferation through stimulating ERK1/2 phosphorylation in zebrafish. J Biol Chem. 2008;283:17652-61 pubmed publisher
Wang J, Ko C, Chen L, Wang W, Chang W. Functional role of NF-IL6beta and its sumoylation and acetylation modifications in promoter activation of cyclooxygenase 2 gene. Nucleic Acids Res. 2006;34:217-31 pubmed
product information
SKU :
2250P
Product-Name :
c-Fos (9F6) Rabbit mAb
Size :
40 ul
Price-(USD) :
123 USD
Species-x-Reactivity :
H, M, R, (Hm, B, Pg)
Applications :
Chromatin Immunoprecipitation
Product-Category :
MAP Kinase Signaling
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
62
Host :
Rabbit
Target :
Fos
Primary-Protein :
Fos
Alt-Names :
AP-1,C-FOS,Cellular oncogene fos,FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS),FBJ murine osteosarcoma viral oncogene homolog,FOS,G0/G1 switch regulatory protein 7,G0S7,Proto-oncogene c-Fos,activator protein 1,cellular oncogene c-fos,v-fos FBJ murine osteosarcoma viral oncogene homolog
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.