product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
LEF1 (C12A5) Rabbit mAb
catalog :
2230S
quantity :
100 ul
price :
235 USD
clonality :
monoclonal
host :
rabbit
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, EMSA, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
Cell Signaling Technology product webpage
citations: 15
Published Application/Species/DilutionReference
  • EMSA; human; fig 2h
Guo Y, Wang L, Li B, Xu H, Yang J, Zheng L, et al. Wnt/β-catenin pathway transactivates microRNA-150 that promotes EMT of colorectal cancer cells by suppressing CREB signaling. Oncotarget. 2016;: pubmed publisher
  • immunocytochemistry; mouse; 1:100; fig s3d
Yang N, Li L, Eguether T, Sundberg J, Pazour G, Chen J. Intraflagellar transport 27 is essential for hedgehog signaling but dispensable for ciliogenesis during hair follicle morphogenesis. Development. 2015;142:2194-202 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500; fig 6n-s
Gay M, Valenta T, Herr P, Paratore-Hari L, Basler K, Sommer L. Distinct adhesion-independent functions of β-catenin control stage-specific sensory neurogenesis and proliferation. BMC Biol. 2015;13:24 pubmed publisher
  • western blot; human
Zhu Z, Liu Y, Li K, Liu J, Wang H, Sun B, et al. Protein tyrosine phosphatase receptor U (PTPRU) is required for glioma growth and motility. Carcinogenesis. 2014;35:1901-10 pubmed publisher
  • western blot; human; fig 5
Azzolin L, Panciera T, Soligo S, Enzo E, Bicciato S, Dupont S, et al. YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response. Cell. 2014;158:157-70 pubmed publisher
  • chromatin immunoprecipitation; mouse
Landin Malt A, Cesario J, Tang Z, Brown S, Jeong J. Identification of a face enhancer reveals direct regulation of LIM homeobox 8 (Lhx8) by wingless-int (WNT)/β-catenin signaling. J Biol Chem. 2014;289:30289-301 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:75
Lewis A, Vasudevan H, O'Neill A, Soriano P, Bush J. The widely used Wnt1-Cre transgene causes developmental phenotypes by ectopic activation of Wnt signaling. Dev Biol. 2013;379:229-34 pubmed publisher
  • immunohistochemistry - paraffin section; mouse
Xu Y, Xu Y, Liao L, Zhou N, Theissen S, Liao X, et al. Inducible knockout of Twist1 in young and adult mice prolongs hair growth cycle and has mild effects on general health, supporting Twist1 as a preferential cancer target. Am J Pathol. 2013;183:1281-92 pubmed publisher
  • western blot; mouse; 1:1000
Wallmen B, Schrempp M, Hecht A. Intrinsic properties of Tcf1 and Tcf4 splice variants determine cell-type-specific Wnt/β-catenin target gene expression. Nucleic Acids Res. 2012;40:9455-69 pubmed publisher
Bankhead E, Colasanto M, Dyorich K, Jamrich M, Murtaugh L, Fuhrmann S. Multiple requirements of the focal dermal hypoplasia gene porcupine during ocular morphogenesis. Am J Pathol. 2015;185:197-213 pubmed publisher
Shang D, Bi R, Han T, Wang D, Tian Y, Liu Y. Expression and proliferation-promoting role of lymphoid enhancer-binding factor 1 in human clear cell renal carcinoma. Cancer Invest. 2014;32:368-74 pubmed publisher
Wang W, Yao Y, Jiang L, Hu T, Ma J, Ruan Z, et al. Increased LEF1 expression and decreased Notch2 expression are strong predictors of poor outcomes in colorectal cancer patients. Dis Markers. 2013;35:395-405 pubmed publisher
Walther N, Ulrich A, Vockerodt M, von Bonin F, Klapper W, Meyer K, et al. Aberrant lymphocyte enhancer-binding factor 1 expression is characteristic for sporadic Burkitt's lymphoma. Am J Pathol. 2013;182:1092-8 pubmed publisher
Luderer H, Gori F, Demay M. Lymphoid enhancer-binding factor-1 (LEF1) interacts with the DNA-binding domain of the vitamin D receptor. J Biol Chem. 2011;286:18444-51 pubmed publisher
Kriegl L, Horst D, Reiche J, Engel J, Kirchner T, Jung A. LEF-1 and TCF4 expression correlate inversely with survival in colorectal cancer. J Transl Med. 2010;8:123 pubmed publisher
product information
SKU :
2230S
Product-Name :
LEF1 (C12A5) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R
Applications :
Flow cytometry
Product-Category :
Developmental Biology
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
25-58 kDa
Host :
Rabbit
Target :
LEF1
Primary-Protein :
LEF-1
Alt-Names :
DKFZp586H0919,FLJ46390,LEF-1,LEF1,Lymphoid enhancer-binding factor 1,T cell-specific transcription factor 1-alpha,TCF1-alpha,TCF1ALPHA
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.