| Published Application/Species/Dilution | Reference |
|---|
- western blot (knockdown validation); human; fig s4c
- immunoprecipitation; human; fig s4c
| Kawada M, Inoue H, Ohba S, Yoshida J, Masuda T, Yamasaki M, et al. Stromal cells positively and negatively modulate the growth of cancer cells: stimulation via the PGE2-TNFα-IL-6 pathway and inhibition via secreted GAPDH-E-cadherin interaction. PLoS ONE. 2015;10:e0119415 pubmed publisher |
| Dungan C, Li Z, Wright D, Williamson D. Hyperactive mTORC1 signaling is unaffected by metformin treatment in aged skeletal muscle. Muscle Nerve. 2016;53:107-17 pubmed publisher |
- western blot; mouse; fig s1
| Ben-Sahra I, Hoxhaj G, Ricoult S, Asara J, Manning B. mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle. Science. 2016;351:728-33 pubmed publisher |
- western blot; human; 1:1000; fig s7
| Loayza-Puch F, Rooijers K, Buil L, Zijlstra J, Oude Vrielink J, Lopes R, et al. Tumour-specific proline vulnerability uncovered by differential ribosome codon reading. Nature. 2016;530:490-4 pubmed publisher |
- western blot; mouse; 1:2000
| Dahlhoff M, Schafer M, Muzumdar S, Rose C, Schneider M. ERBB3 is required for tumor promotion in a mouse model of skin carcinogenesis. Mol Oncol. 2015;9:1825-33 pubmed publisher |
- western blot; human; fig 4
| Chow H, Dong B, Duron S, Campbell D, Ong C, Hoeflich K, et al. Group I Paks as therapeutic targets in NF2-deficient meningioma. Oncotarget. 2015;6:1981-94 pubmed |
| Black J, Lopez S, Cocco E, Bellone S, Altwerger G, Schwab C, et al. PIK3CA oncogenic mutations represent a major mechanism of resistance to trastuzumab in HER2/neu overexpressing uterine serous carcinomas. Br J Cancer. 2015;113:1020-6 pubmed publisher |
- western blot; mouse; 1:1000; fig 4
| Conti V, Gandaglia A, Galli F, Tirone M, Bellini E, Campana L, et al. MeCP2 Affects Skeletal Muscle Growth and Morphology through Non Cell-Autonomous Mechanisms. PLoS ONE. 2015;10:e0130183 pubmed publisher |
- western blot; mouse; 1:1000; fig 6
| Qiao S, Dennis M, Song X, Vadysirisack D, Salunke D, Nash Z, et al. A REDD1/TXNIP pro-oxidant complex regulates ATG4B activity to control stress-induced autophagy and sustain exercise capacity. Nat Commun. 2015;6:7014 pubmed publisher |
- western blot; human; 1:1000; fig 2e,4c,7c
| Laberge R, Sun Y, Orjalo A, Patil C, Freund A, Zhou L, et al. MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation. Nat Cell Biol. 2015;17:1049-61 pubmed publisher |
| Yamauchi T, Nishiyama M, Moroishi T, Yumimoto K, Nakayama K. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. Mol Cell Biol. 2014;34:3321-40 pubmed publisher |
- western blot; human; fig 1
| Dufour M, Faes S, Dormond-Meuwly A, Demartines N, Dormond O. PGE2-induced colon cancer growth is mediated by mTORC1. Biochem Biophys Res Commun. 2014;451:587-91 pubmed publisher |
- western blot; human; 1:1000
| Ekmay R, Gatrell S, Lum K, Kim J, Lei X. Nutritional and metabolic impacts of a defatted green marine microalgal (Desmodesmus sp.) biomass in diets for weanling pigs and broiler chickens. J Agric Food Chem. 2014;62:9783-91 pubmed publisher |
- western blot; mouse; 1:1000
| De Filippis B, Nativio P, Fabbri A, Ricceri L, Adriani W, Lacivita E, et al. Pharmacological stimulation of the brain serotonin receptor 7 as a novel therapeutic approach for Rett syndrome. Neuropsychopharmacology. 2014;39:2506-18 pubmed publisher |
- western blot; mouse; 1:1000
| Barns M, Gondro C, Tellam R, Radley-Crabb H, Grounds M, Shavlakadze T. Molecular analyses provide insight into mechanisms underlying sarcopenia and myofibre denervation in old skeletal muscles of mice. Int J Biochem Cell Biol. 2014;53:174-85 pubmed publisher |
| Chua J, Reddy S, Merry D, Adachi H, Katsuno M, Sobue G, et al. Transcriptional activation of TFEB/ZKSCAN3 target genes underlies enhanced autophagy in spinobulbar muscular atrophy. Hum Mol Genet. 2014;23:1376-86 pubmed publisher |
- western blot; human; 1:1500; fig 1
| Yu P, Laird A, Du X, Wu J, Won K, Yamaguchi K, et al. Characterization of the activity of the PI3K/mTOR inhibitor XL765 (SAR245409) in tumor models with diverse genetic alterations affecting the PI3K pathway. Mol Cancer Ther. 2014;13:1078-91 pubmed publisher |
- western blot; human; 1:1000
| Hinman M, Sharma A, Luo G, Lou H. Neurofibromatosis type 1 alternative splicing is a key regulator of Ras signaling in neurons. Mol Cell Biol. 2014;34:2188-97 pubmed publisher |
| Hasty P, Livi C, Dodds S, Jones D, Strong R, Javors M, et al. eRapa restores a normal life span in a FAP mouse model. Cancer Prev Res (Phila). 2014;7:169-78 pubmed publisher |
- western blot; human; 1:1000
| Jordan N, Dutkowski C, Barrow D, Mottram H, Hutcheson I, Nicholson R, et al. Impact of dual mTORC1/2 mTOR kinase inhibitor AZD8055 on acquired endocrine resistance in breast cancer in vitro. Breast Cancer Res. 2014;16:R12 pubmed publisher |
- western blot; mouse; 1:1000
| Smith H, Matthews K, Oldham J, Jeanplong F, Falconer S, Bass J, et al. Translational signalling, atrogenic and myogenic gene expression during unloading and reloading of skeletal muscle in myostatin-deficient mice. PLoS ONE. 2014;9:e94356 pubmed publisher |
- western blot; mouse; fig 2
| Tan S, Shui G, Zhou J, Shi Y, Huang J, Xia D, et al. Critical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled AKT-FOXO1 signaling pathway. Autophagy. 2014;10:226-42 pubmed publisher |
- western blot; mouse; fig s7
| Gao Y, Wu F, Zhou J, Yan L, Jurczak M, Lee H, et al. The H19/let-7 double-negative feedback loop contributes to glucose metabolism in muscle cells. Nucleic Acids Res. 2014;42:13799-811 pubmed publisher |
| Groenendijk F, Mellema W, van der Burg E, Schut E, Hauptmann M, Horlings H, et al. Sorafenib synergizes with metformin in NSCLC through AMPK pathway activation. Int J Cancer. 2015;136:1434-44 pubmed publisher |
| Tadakawa M, Takeda T, Li B, Tsuiji K, Yaegashi N. The anti-diabetic drug metformin inhibits vascular endothelial growth factor expression via the mammalian target of rapamycin complex 1/hypoxia-inducible factor-1α signaling pathway in ELT-3 cells. Mol Cell Endocrinol. 2015;399:1-8 pubmed publisher |
| Ohtsubo K, Yamada T, Zhao L, Jin T, Takeuchi S, Mouri H, et al. Expression of Akt kinase-interacting protein 1, a scaffold protein of the PI3K/PDK1/Akt pathway, in pancreatic cancer. Pancreas. 2014;43:1093-100 pubmed publisher |
| Wang Y, Lv Y, Lu L, Cai L. Oridonin inhibits mTOR signaling and the growth of lung cancer tumors. Anticancer Drugs. 2014;25:1192-200 pubmed publisher |
| Verbrugge I, Gasparini A, Haynes N, Hagekyriakou J, Galli M, Stewart T, et al. The curative outcome of radioimmunotherapy in a mouse breast cancer model relies on mTOR signaling. Radiat Res. 2014;182:219-29 pubmed publisher |
| Zimmerman E, Turner D, Buaboonnam J, Hu S, Orwick S, Roberts M, et al. Crenolanib is active against models of drug-resistant FLT3-ITD-positive acute myeloid leukemia. Blood. 2013;122:3607-15 pubmed publisher |
| Wu M, Liu H, Fannin J, Katta A, Wang Y, Arvapalli R, et al. Acetaminophen improves protein translational signaling in aged skeletal muscle. Rejuvenation Res. 2010;13:571-9 pubmed publisher |
| Kitada M, Koya D. The use of calorie restriction mimetics to study aging. Methods Mol Biol. 2013;1048:95-107 pubmed publisher |
| Yamada T, Takeuchi S, Fujita N, Nakamura A, Wang W, Li Q, et al. Akt kinase-interacting protein1, a novel therapeutic target for lung cancer with EGFR-activating and gatekeeper mutations. Oncogene. 2013;32:4427-35 pubmed publisher |
| Ito N, Nishibori Y, Ito Y, Takagi H, Akimoto Y, Kudo A, et al. mTORC1 activation triggers the unfolded protein response in podocytes and leads to nephrotic syndrome. Lab Invest. 2011;91:1584-95 pubmed publisher |
| van Vliet E, Forte G, Holtman L, den Burger J, Sinjewel A, de Vries H, et al. Inhibition of mammalian target of rapamycin reduces epileptogenesis and blood-brain barrier leakage but not microglia activation. Epilepsia. 2012;53:1254-63 pubmed publisher |
| Sully K, Akinduro O, Philpott M, Naeem A, Harwood C, Reeve V, et al. The mTOR inhibitor rapamycin opposes carcinogenic changes to epidermal Akt1/PKBα isoform signaling. Oncogene. 2013;32:3254-62 pubmed publisher |
| Oyabu J, Yamaguchi O, Hikoso S, Takeda T, Oka T, Murakawa T, et al. Autophagy-mediated degradation is necessary for regression of cardiac hypertrophy during ventricular unloading. Biochem Biophys Res Commun. 2013;441:787-92 pubmed publisher |
| Shimamura T, Perera S, Foley K, Sang J, Rodig S, Inoue T, et al. Ganetespib (STA-9090), a nongeldanamycin HSP90 inhibitor, has potent antitumor activity in in vitro and in vivo models of non-small cell lung cancer. Clin Cancer Res. 2012;18:4973-85 pubmed publisher |
| Possemato R, Marks K, Shaul Y, Pacold M, Kim D, Birsoy K, et al. Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature. 2011;476:346-50 pubmed publisher |
| Guertin D, Stevens D, Saitoh M, Kinkel S, Crosby K, Sheen J, et al. mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice. Cancer Cell. 2009;15:148-59 pubmed publisher |
| Rajan M, Fagerholm S, Jonsson C, Kjølhede P, Turkina M, Stralfors P. Phosphorylation of IRS1 at serine 307 in response to insulin in human adipocytes is not likely to be catalyzed by p70 ribosomal S6 kinase. PLoS ONE. 2013;8:e59725 pubmed publisher |
| Suo L, Zhao L, Si J, Liu J, Zhu W, Chai B, et al. Predictable chronic mild stress in adolescence increases resilience in adulthood. Neuropsychopharmacology. 2013;38:1387-400 pubmed publisher |
| Deming D, Leystra A, Farhoud M, Nettekoven L, Clipson L, Albrecht D, et al. mTOR inhibition elicits a dramatic response in PI3K-dependent colon cancers. PLoS ONE. 2013;8:e60709 pubmed publisher |
| Yang S, Xiao X, Meng X, Leslie K. A mechanism for synergy with combined mTOR and PI3 kinase inhibitors. PLoS ONE. 2011;6:e26343 pubmed publisher |
| Kanari Y, Sato Y, Aoyama S, Muta T. Thioredoxin-interacting protein gene expression via MondoA is rapidly and transiently suppressed during inflammatory responses. PLoS ONE. 2013;8:e59026 pubmed publisher |
| Fuchs G, Diges C, Kohlstaedt L, Wehner K, Sarnow P. Proteomic analysis of ribosomes: translational control of mRNA populations by glycogen synthase GYS1. J Mol Biol. 2011;410:118-30 pubmed publisher |
