product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Mnk1 (C4C1) Rabbit mAb
catalog :
2195
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
C4C1
reactivity :
human, mouse
application :
western blot, immunocytochemistry, other, immunohistochemistry knockout validation
more info or order :
Cell Signaling Technology product webpage
citations: 9
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry knockout validation; human; loading ...; fig 2b
  • western blot; human; loading ...; fig 4e
Guo Q, Li V, Nichol J, Huang F, Yang W, Preston S, et al. MNK1/NODAL Signaling Promotes Invasive Progression of Breast Ductal Carcinoma In Situ. Cancer Res. 2019;79:1646-1657 pubmed publisher
  • other; human; loading ...; fig 4c
Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed publisher
  • immunocytochemistry; mouse; 1:100; loading ...; fig 4i
Hu J, Sun F, Handel M. Nuclear localization of EIF4G3 suggests a role for the XY body in translational regulation during spermatogenesis in mice. Biol Reprod. 2018;98:102-114 pubmed publisher
  • western blot; human; loading ...; fig 1e
Zhan Y, Guo J, Yang W, Goncalves C, Rzymski T, Dreas A, et al. MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma. J Clin Invest. 2017;127:4179-4192 pubmed publisher
  • western blot; human; 1:200; fig st1
Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher
  • western blot; human; fig 2
Lock R, Ingraham R, Maertens O, Miller A, Weledji N, Legius E, et al. Cotargeting MNK and MEK kinases induces the regression of NF1-mutant cancers. J Clin Invest. 2016;126:2181-90 pubmed publisher
  • western blot; human; fig s2
Su X, Yu Y, Zhong Y, Giannopoulou E, Hu X, Liu H, et al. Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation. Nat Immunol. 2015;16:838-849 pubmed publisher
  • western blot; human; 1:1000; fig 7
Martínez A, Sesé M, Losa J, Robichaud N, Sonenberg N, Aasen T, et al. Phosphorylation of eIF4E Confers Resistance to Cellular Stress and DNA-Damaging Agents through an Interaction with 4E-T: A Rationale for Novel Therapeutic Approaches. PLoS ONE. 2015;10:e0123352 pubmed publisher
Chen Y, Tan B, Cheng Y, Chen J, Lee S. Differential regulation of CHOP translation by phosphorylated eIF4E under stress conditions. Nucleic Acids Res. 2010;38:764-77 pubmed publisher
product information
SKU :
2195S
Product-Name :
Mnk1 (C4C1) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M
Applications :
Western blot
Product-Category :
Translational Control
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
50
Host :
Rabbit
Target :
Mnk1
Primary-Protein :
Mnk1
Alt-Names :
MAP kinase interacting kinase 1,MAP kinase interacting serine/threonine kinase 1,MAP kinase signal-integrating kinase 1,MAP kinase-interacting serine/threonine kinase 1,MAP kinase-interacting serine/threonine-protein kinase 1,MKNK1,MNK1
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.